Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL by Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong

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Explore the properties of $$\Lambda (1670)$$ Λ ( 1670 ) in the Cabibbo-favored process $$\Lambda ^+_c \rightarrow p K^- \pi ^+$$ Λ c + → p K - π + by Sheng-Chao Zhang, Man-Yu Duan, Wen-Tao Lyu, Guan-Ying Wang, Jing-Yu Zhu, En Wang

“…Abstract Recently, the Belle and LHCb Collaborations have measured the $$\Lambda ^+_c \rightarrow p K^- \pi ^+$$ Λ c + → p K - π + decay and reported the $$K^- p$$ K - p invariant mass distribution, which shows a clear cusp structure around the $$\eta \Lambda $$ η Λ threshold. …”
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Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice by Yan Peng, Rui Chi, Gang Liu, Weijie Tian, Jun Zhang, Rihui Zhang

“…The molecular mechanism may involve activation of the PI3K/Akt/GSK-3β signaling pathway.…”
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The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

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Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway by Attalla Farag El-kott, Ali A. Shati, Mohammed Ali Al-kahtani, Sultan Alqahtani

“…In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF-κB. …”
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Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway by Ruina Han, Dongyang Zhou, Ning Ji, Zhifeng Yin, Jian Wang, Qin Zhang, Hao Zhang, Jinlong Liu, Xinru Liu, Han Liu, Qinglin Han, Jiacan Su

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Annexin A5 knockdown inhibits cardiomyocyte apoptosis and alleviates cardiac hypertrophy via activating the PI3K/AKT/Bcl-2 signaling pathway by Lina Zhao, Hongjuan Cao, Yao Yuan, Chunyan Liao, Dan Huang, Xiaoyi Li, Yueyao Zhao, Quanfeng Huang, Sha Li, Bei Zhang

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PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

“…Conclusion. sGC/cGMP/PKG and PI3K/AKT signals act on PPARγ synergistically to attenuate hypoxia-induced HSC activation.…”
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The Evaluation of Tau Deposition with [18F]PI-2620 by Using a Semiquantitative Method in Cognitively Normal Subjects and Patients with Mild Cognitive Impairment and Alzheimer’s Disease by Attapon Jantarato, Sira Vachatimanont, Natphimol Boonkawin, Sukanya Yaset, Anchisa Kunawudhi, Chetsadaporn Promteangtrong, Jintana Assanasen, Nithi Mahanonda, Chanisa Chotipanich

“…Some studies have reported the effectiveness of [18F]PI-2620 as an effective tau-binding radiotracer; however, few reports have applied semiquantitative analysis to the tracer. …”
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SDF-1/CXCR4激活ERK和PI3K/AKT通路介导髓核致炎根性疼痛 by 魏明, 高凤娇, 杨琳, 孙来保, 邹学农, 黄文起

“…结论SDF-1/CXCR4通过激活ERK和PI3K/AKT通路介导髓核致炎根性疼痛。…”
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A Combined MPC and PI Control Strategy for Bidirectional Interleaved Totem Pole PFC Converters in Electric Vehicle G2V and V2G Applications by Lassioui Abdellah, Kabba Abdelaziz, El Ancary Marouane, Hasni Anwar, El Asri Yassine, El Idrissi Zakariae, El Fadil Hassan

“…Meanwhile, the PI controller regulates the DC-side voltage. It is worth noting that the MPC’s design eliminates the need for a comparator to generate the Pulse Width Modulation (PWM) signal, simplifying the control architecture. …”
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Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis by Lei Xiang, Qingzhou Li, Zhiwei Guan, Guilin Wang, Xiankuo Yu, Xianwen Zhang, Guochen Zhang, Jushan Hu, Xue Yang, Mingrui Li, Xilinqiqige Bao, Yumei Wang, Dong Wang

“…These effects were associated with decreased GPX4 expression and suppression of EGFR, phosphorylated PI3K, and phosphorylated AKT. ORes inhibited tumour growth, enhanced iron deposition, and reduced GPX4 expression in tumour tissues in vivo. …”
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Flow Unit Model of Channel Sand Body and Its Effect on Remnant Oil Distribution: A Case Study of PI Formation in the Eastern Transition Zone of Daqing Oilfield by Yue Zhang, You-liang Ji, Hui-jian Wen, Shi-zhong Ma, Dong-lai Bai, Bin-chi Zhang, Ben-kang Xing

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RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells by Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M

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Revisiting $$B\rightarrow K^*\pi $$ B → K ∗ π and $$B\rightarrow K\rho $$ B → K ρ decays using the modified perturbative QCD approach by Ru-Xuan Wang, Mao-Zhi Yang

“…Abstract We revisit $$B\rightarrow K^*\pi $$ B → K ∗ π and $$B\rightarrow K\rho $$ B → K ρ decay processes using the modified perturbative QCD approach, which is developed based on the perturbative QCD approach with a few improvements. …”
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NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats by Yonglian Liu, Wenjuan Wang, Bing Liang, Zhonglan Zou, Aihua Zhang

“…Notably, these arsenic-induced effects were reversed by MCC950, an NLRP3 inflammasome inhibitor, and Extendin-4, an agonist of the IRS-1/PI3K/AKT signaling pathway. Collectively, these findings demonstrate that NLRP3 inflammasome activation disrupts the IRS-1/PI3K/AKT signaling pathway, contributing to arsenic-induced pancreatic beta cells dysfunction in rats.…”
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Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…These therapeutic effects are mediated through the activation of the PI3K/Akt/mTOR signaling pathway and regulation of apoptosis-related proteins. …”
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Effects of Exercise Preconditioning Mediating Oxidative Stress to Regulate PI3K/Akt and Nrf2/HO-1 Pathways to Alleviate Cognitive and Learning Disorders in Rats by KONG Haijun, LI Xinlong, WANG Fenghua, CHEN Xiaoan

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circSLC6A6 Sponges miR-497-5p to Promote Endometrial Cancer Progression via the PI4KB/Hedgehog Axis by Juan Hu, Xing Peng, Weina Du, Yichuan Huang, Chun Zhang, Xian Zhang

“…Besides, a mechanistic study demonstrated that circSLC6A6 could regulate tumor-associated signaling PI4KB/hedgehog pathway by sponging miR-497-5p. Conclusion. …”
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Des pieds de moutons dans la citerne du sanctuaire de Corent (Veyre-Monton, Puy-de-Dôme) : rejet détritique ou dépôt rituel ? by Sylvain Foucras

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