Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…BB (500 and 250 mg/kg) could improve pulmonary histopathological changes, decrease the lung index and suppress the mRNA expression of CXCL1/KC, TNF-α, CXCL9/MIG and IL-1β in vivo.Conclusion: BB has a protective effect on PR8-induced acute lung injury (ALI) probably via inhibition of apoptosis process and interfering with TLR3, p38 MAPK and PI3K-AKT signaling pathways. This study provided a potential treatment for influenza from BB, and network pharmacology provided a strategy to explore active components and mechanism of TCMs against influenza virus infection. …”
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The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion by Ping Wang, Min Cong, Tianhui Liu, Aiting Yang, Guangyong Sun, Dong Zhang, Jian Huang, Shujie Sun, Jia Mao, Hong Ma, Jidong Jia, Hong You

“…Signal pathway analysis revealed that TGF-β1 impaired the pathways of cell cycle and cytochrome P450 detoxification, and EGF reverted TGF-β1 effects through activating MAPK and PI3K-Akt pathway. EGF reverses the characteristics impaired by TGF-β1 in hepatic oval cells, serving as a protective cytokine to hepatic progenitors.…”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…RNA sequencing revealed enriched pathways related to cancer, notably PI3K-Akt and MAPK signaling pathways, in MutCMs and UM cells compared to NCMs, providing insights into molecular changes in GNAQ Q209L -mutated pre-cancer cell models and UM cells. …”
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Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation by Lingyu Song, Yali Huang, Lu Liu, Xuebing Chang, Laying Hu, Guifang Wang, Lifen Xu, Tian Zhang, Yuanyuan Wang, Ying Xiao, Hong Yang, Suye Ran, Qing Shi, Tuanlao Wang, Mingjun Shi, Yuxia Zhou, Bing Guo

“…Mechanistically, Metrnl exerted dual effects by promoting triglyceride (TG) transportation by the phosphatidylinositol 3-kinase (PI3K)/Akt/Sp1/cytidylyltransferase α (CCTα) axis, thereby increasing the biosynthesis of phosphatidylcholine (PC) to facilitate TG secretion from the liver while facilitating AMP-activated protein kinase (AMPK)-dependent fatty acid oxidation (FAO). …”
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Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma by Junchen Liu, Junchen Liu, Kun Dai, Kun Dai, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan

“…Mechanistically, VPA upregulated NKG2D ligands expression via the PI3K/Akt signaling pathway. Additionally, VPA treatment augmented the antitumor activity of NKG2D CAR-T cells in a glioblastoma xenograft model in vivo. …”
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Jiangu Granules Regulates Endoplasmic Reticulum Stress-Induced Apoptosis in UMR-106 Cells by Modulating the PERK/eIF2α/ATF4/CHOP Pathway by CHEN Sainan, ZHOU Fen, HUANG Yunmei, LIN Yanping

“…Late apoptosis rate was determined using Annexin V-FITC/PI in the four groups. Additionally, mRNA transcription level and protein expression of ERS related markers GRP78, PERK, eIf2α, ATF4, and CHOP were detected using qPCR and Western blot methods.ResultsIn comparison to the 0 μmol/L group, it was found that 0.03 μmol/L of GSK2606414 had no impact on cell viability after 12 hours of intervention in UMR-106 cells, and this concentration was chosen for subsequent experiments. …”
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A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points by Anna Procopio, Annarita Tedesco, Fabrizio Lo Regio, Giuseppe Cesarelli, Leandro Donisi, Carlo Ricciardi, Alessio Merola, Alfonso Maria Ponsiglione, Maria Romano, Francesco Montefusco, Carlo Cosentino, Francesco Amato

“…To this regard, in this paper, the existence, possible uniqueness and stability properties of the homeostatic equilibrium points of the general model are investigated; the theoretical framework is then illustrated through two real-world case-studies: (i) the PI3K/AKT/mTOR pathway nonlinear dynamics, a critical regulator of cellular growth, proliferation, and survival; (ii) the control mechanism of the neuromuscular stretch reflex, among the prime triggers implicated in postural control. …”
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EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis by Yang Chen, Shanshan Dong, Xin Zeng, Qing Xu, Mingwei Liang, Guangneng Liao, Lan Li, Bin Shen, Yanrong Lu, Haibo Si, Peifang Wei

“…The expression of the histone methyltransferase enhancer of zeste homolog 2 (EZH2), microRNA-142-3p (miR-142-3p), and high mobility group box 1 (HMGB1) and the levels of ER stress, pyroptosis, and metabolic markers in normal and OA chondrocytes were investigated by western blotting, quantitative polymerase chain reaction, immunohistochemistry, fluorescence in situ hybridization, fluorescein amidite-tyrosine-valine-alanine-aspartic acid-fluoromethyl ketone (FAM-YVAD-FMK)/Hoechst 33342/propidium iodide (PI) staining, lactate dehydrogenase (LDH) release assays, and cell viability assessments. …”
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Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…RNA interference-mediated knockdown of hsp90 affected PI3K/AKT pathway signaling, which downregulated the downstream genes akt and apoptosis-inhibiting bcl-xl, bcl-2, and creb, and upregulated the apoptosis-promoting genes casp1 and casp9. …”
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Peptide platform for 3D-printed Ti implants with synergistic antibacterial and osteogenic functions to enhance osseointegration by Chenying Cui, Yifan Zhao, Jingyu Yan, Ziyang Bai, Guning Wang, Yingyu Liu, Yurong Xu, Lihong Zhou, Kaifang Zhang, Yanling Mi, Binbin Zhang, Xiuping Wu, Bing Li

“…Transcriptome sequencing further explored the molecular mechanisms underlying the synergistic effects of 3DTi-NFP, revealing activation of the focal adhesion and PI3K-Akt signaling pathways-key contributors to cell adhesion, matrix formation, and new bone formation. …”
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An integrative analysis reveals cancer risk associated with artificial sweeteners by Jumin Xie, Ying Zhu, Zixuan Yang, Zhang Yu, Mingzhi Yang, Qingzhi Wang

“…KEGG enrichment analysis of these core targets revealed associations with several cancer types and the PI3K-Akt signaling pathway. Molecular docking and dynamics simulations confirmed interactions between AS and these core targets. …”
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تغییر سطح بیماریزایی Phytium ultimum در گلرنگ تحت شرایط متفاوت آزمایشگاه، گلخانه و مزرعه by محمد هادی پهلوانی, سید اسماعیل رضوی, آزاد احمدی, الهام پالوج

“…هیچ ژنوتیپی یافت نگردید که در هر سه آزمایش برتری خویش را نسبت به سایرین از نظر پوسیدگی بذر ناشی از این عامل بیماری زا حفظ نماید ولی سه ژنوتیپ  250537PI-، Hartman و اراک 2811 کمترین درصد پوسیدگی و عدم جوانه زنی بذر به ترتیب در شرایط گلخانه، آزمایشگاه و مزرعه نشان دادند. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Mechanistically, neuronal CCL21 was shown to regulate microglial cell migration, proliferation, and activation in a CCR7-dependent manner through both canonical (PI3K/AKT) and non-canonical (ERK1/2/JNK) signaling pathways. …”
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The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis by Xue Gu, Bingfeng Chen, Shengcan Zhang, Xinyu Zhai, Ying Hu, Hui Ye

“…The result showed that genes in blue module were associated with cytokine–cytokine receptor interaction, chemokine, and PI3K − Akt pathways. The results of tumor-infiltrating lymphocytes proportion, immunostimulators, and major histocompatibility complexes were significantly positive in CCL17 high-expression. …”
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Cloning, Characterization and Expression Regulation in Response to High-Temperature Stress of TRAF7 Gene in the Sea Cucumber Apostichopus japonicus by Yanfeng ZHAO, Meijie LIAO, Jianlong GE, Jinjin WANG, Yingeng WANG, Xiaojun RONG, Bin LI, Yanting TAN

“…AjTRAF7 has a total length of 2, 576 bp, an ORF length of 1, 770 bp, a 5´UTR length of 345 bp, a 3´UTR length of 461 bp, and encodes 589 amino acids; the molecular weight of the predicted protein is 65.6 kDa, the theoretical isoelectric point (pI) is 7.52, the instability coefficient is 32.34, and the total average hydrophilicity is –0.150. …”
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Nicotine’s impact on platelet function: insights into hemostasis mechanisms by Xiayu Wu, Xiayu Wu, Yongjun Liu, Changhao Zou, Changhao Zou, Fuqin He, Fuqin He, Fang Guo, Fang Guo, Sijia Liu, Sijia Liu, Yi Fan, Yi Fan, Xuedong Zhu, Xuedong Zhu, Qianyi Zhou, Qianyi Zhou, Dan Shu, Dan Shu

“…Through the examination of alterations in the downstream signaling pathways of PAR4 receptors, it was determined that nicotine promo-facilitates the phosphorylation of PI3K, AKT, and ERK1/2 proteins, subsequently contributing to the activation of αIIbβ3 receptors in platelets. …”
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Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma by Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet

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اثر تنش شوری بر پارامترهای رشدی و فتوسنتزی دو رقم هیبرید و ایرانی اسفناج by مینا بیارش, محمود رقامی

“…صفاتی مانند وزن تر و خشک اندام هوایی و ریشه، سطح برگ، تعداد برگ، رنگیزه‌های فتوسنتزی (کلروفیل a,b)، کلروفیل کل، شاخص سبزینگی، کاروتنوئید، نرخ فتوسنتز، نرخ تعرق، هدایت روزنه‌ای، نسبت فلورسانس متغیر به فلورسانس حداکثر (Fv/Fm) و شاخص کارآیی دستگاه فتوسنتزی (PI) مورد مطالعه قرار گرفتند.یافته‌ها: نتایج این پژوهش نشان داد که شاخص‌های رشدی هر دو رقم اسفناج نظیر تعداد برگ، سطح برگ وزن‌تر ریشه، وزن خشک ریشه، وزن‌تر اندام هوایی و وزن خشک اندام هوایی در شرایط تنش شوری کاهش یافت. …”
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Saberes Rizomáticos em Educação by Adriana Aparecida de Lima Terçariol, Patrícia Aparecida Bioto

“…Na   seção   Artigos,   encontram-se   textos,   os   quais   discorrem   sobre   temáticas diversificadas, dentre elas: uma jornada sapiens-demens a partir de vários olhares; um olhar sobre as relações dialógicas na perspectiva freireana e suas contribuições para a educação na/da infância; aceitabilidade de preparações sem adição de açúcares para alimentação escolar de pré-escolares; cultura lúdica: a influência do brincar por meio dos objetos ribeirinhos na aprendizagem da criança; a singularidade do ser que nasce para o mundo: um diálogo com Bakhtin e outras vozes; cineclube (re)existência apresenta: uma pi(n)tada de teoria queer na escola; o assembleísmo como via de democratização da escola pública: a experiência dos Bachilleratos Populares na Argentina; pedagogia voltada para o futuro: a contribuição de Bogdan Suchodolski para pensar a educação; gestão escolar em contextos vulneráveis: contribuições ao debate, e emoções em sala de aula no contexto universitário. …”
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Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells by Xiaoming Kang, Xiaoming Kang, Lu Ma, Lu Ma, Lu Ma, Jie Wen, Jie Wen, Wei Gong, Wei Gong, Xianlin Liu, Xianlin Liu, Yihan Hu, Yihan Hu, Zhili Feng, Zhili Feng, Qiancheng Jing, Qiancheng Jing, Yuexiang Cai, Yuexiang Cai, Sijun Li, Xinzhang Cai, Kai Yuan, Yong Feng, Yong Feng, Yong Feng, Yong Feng, Yong Feng

“…Furthermore, significant alterations were noted in the PI3K-Akt signaling pathway and the calcium signaling pathway, which could potentially influence gap junction function and contribute to hearing loss. …”
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