Momordica Charantia Polysaccharides Attenuates MPP+-Induced Injury in Parkinson’s Disease Mice and Cell Models by Regulating TLR4/MyD88/NF-κB Pathway by Dengjun Guo, Jie Zhou, Meng Zhang, Reyisha Taximaimaiti, Xiaoping Wang, Hai Wang

“…Moreover, flow cytometry, PI staining, and fluorescence were used to observe cell apoptosis. …”
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Effect of Different Cooking Methods on Lipid Content and Fatty Acid Profile of Red Mullet ( Mullus barbatus ) by Francesca Biandolino, Ermelinda Prato, Asia Grattagliano, Isabella Parlapiano

“…Atherogenicity index value decreased significantly after the cooking particularly in fried fish. The polyene index (PI), as a measure of PUFA damage, was in the range of 0.42–1.18. …”
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XPO1抑制剂KPT-8602对U937细胞增殖和凋亡的影响 by 肖晓慧, 李益清, 黄克智, 谢双锋, 肖洁, 马丽萍, 尹松梅, 聂大年

“…【结论】KPT-8602能抑制U937细胞增殖，使细胞周期阻滞于G1期，诱导细胞凋亡；其机制可能与下调XPO1表达，抑制PI3K/AKT通路有关。…”
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Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin by Zhipeng Yu, Sijia Wu, Wenzhu Zhao, Long Ding, David Shiuan, Fuping Zheng, Jianrong Li, Jingbo Liu

“…Molecular docking revealed that KLPGF contacted with the residues of BACE1’s active sites through twelve hydrogen bonds interactions, two hydrophobic interactions, one electrostatic interaction, and two Pi-cation interactions. The 5 ns molecular dynamics simulations confirmed that the structure of KLPGF with BACE1 was stable. …”
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Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS by Zhigang Zhao, Zhidan Luo, Peijian Wang, Jing Sun, Hao Yu, Tingbing Cao, Yinxing Ni, Jing Chen, Zhencheng Yan, Daoyan Liu, Zhiming Zhu

“…These effects were also abolished by inhibition of PPARγ, PPARδ, or PI3K. In conclusion, rosiglitazone improved endothelial function through both PPARγ- and PPARδ-mediated phosphorylation of Akt and eNOS, which might help to reconsider the complex effects and clinical applications of rosiglitazone.…”
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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities by Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu

“…It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ). …”
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A New Model for Predicting Flow in Fractured-Vuggy Carbonate Reservoirs under Pseudosteady State Condition by Nai Cao, Gang Lei, Yuan Su, Hong Li, Jiali Zhang, Ci Zhang

“…The characterization of fluid flow in the fractured-vuggy carbonate reservoir under pseudosteady state condition is of significance in describing the productivity index (PI) of the well. However, due to complex mechanisms (e.g., stress dependency of reservoir properties and crossflow between different systems of the reservoirs) during flow in fractured-vuggy carbonate reservoirs, researches on productivity prediction in fractured-vuggy carbonate reservoirs under pseudosteady state are very limited. …”
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Interpretable machine learning model for predicting clinically significant prostate cancer: integrating intratumoral and peritumoral radiomics with clinical and metabolic features by Wenjun Zhao, Mengyan Hou, Juan Wang, Dan Song, Yongchao Niu

“…SHAP analysis revealed that the intra-rad-score, PSAD, peri-rad-score, and PI-RADS score were the most important predictors of the combined model. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…Furthermore, the proteomic signature associated with iLGS highlights the functional pathway upstream of the PI3K-Akt that can be effectively targeted to slow down aging and extend lifespan.…”
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Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects by Kaitlin Garofano, Vera Mariani, Kameron Rashid, Sumanun Suwunnakorn, Alfateh Sidahmed, Anelia Horvath, Sanjay B. Maggirwar, Travis J. O’Brien, Minoli A. Perera, Michael Whalen, Norman H. Lee

“…Expression of key genes in signaling pathways promoting platelet activation/aggregation, such as the PI3K/AKT, protein kinase A, phospholipase C, and α-adrenergic and GP6 receptor pathways, was missing or under-expressed in PLPs. …”
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High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1 by Wenjun Zhu, Qihong Qiu, Haoyuan Luo, Fuping Zhang, Juan Wu, Xiaorui Zhu, Min Liang

“…Cell apoptosis was assessed by annexin V/PI staining. Protein expression was detected by western blotting. …”
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Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia by Onur Guralp, Nevin Tuten, Mahmut Oncul, Serdar A Acikgoz, Hakan Ekmekci, Abdullah Tuten

“…Neutrophil gelatinase-associated lipocalin had a positive correlation with systolic and diastolic blood pressure and the umbilical-artery PI and RI. Serum neutrophil gelatinase-associated lipocalin had a positive correlation with serum urea (r=0.416, p=0.031) however had no significant correlation with birth-weight, Apgar-scores, uric acid and amount of proteinuria in women with preeclampsia. …”
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Conformal and Flexible Antennas in Ultra-High Frequencies: Prospects and Challenges for Partial Discharge Diagnostics by M. A. Taher, Mohamadariff Othman, Hazlee Azil Illias, Tarik Abdul Latef, Tengku Faiz Tengku Mohmed Noor Izam, S. M. Kayser Azam, Muhammad Ubaid Ullah, Mohamed Alkhatib, Mousa I. Hussein

“…In this investigation, we thoroughly analyse five substrate materials, namely polyimide (PI), polydimethylsiloxane (PDMS), Rogers laminates, polytetrafluoroethylene (PTFE), and polyethylene terephthalate (PET), and several types of UHF antennas including planar monopole, spiral antenna, Hilbert antenna, biconical antenna, and so on. …”
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Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn’s disease by Chitra Karki, Gary Hantsbarger, Erika Turkstra, Elisabetta Fenu, Ken Genenz, Inmaculada Gilaberte, Julián Panés

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Impact of peer interaction on maternal health service utilization in rural northwest China by Liuchun Xiang, Liuchun Xiang, Dan Li, Junhao Wu, Jun Chen, Jie Yang, Haisong Nie

“…This study used propensity score matching (PSM) to analyze the effects of peer interaction (PI) on maternal health service utilization, including maternal system management rate (Y1), prenatal screening rate (Y2), and postpartum visit rate (Y3). …”
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RETRACTED ARTICLE: hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer by Olivia Crociani, Francesca Zanieri, Serena Pillozzi, Elena Lastraioli, Matteo Stefanini, Antonella Fiore, Angelo Fortunato, Massimo D'Amico, Marika Masselli, Emanuele De Lorenzo, Luca Gasparoli, Martina Chiu, Ovidio Bussolati, Andrea Becchetti, Annarosa Arcangeli

“…The effect is modulated by the human ether-à-go-go related gene 1 (hERG1) K+ channel. hERG1 recruits and activates PI3K and Akt. This in turn increases the Hypoxia Inducible Factor (HIF)-dependent transcription of VEGF-A and other tumour progression genes. …”
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Pathological variants in HPV-independent vulvar tumours by Sanja A. Farkas, Alvida Qvick, Gisela Helenius, Gabriella Lillsunde-Larsson

“…The main outcome of this study show that vulvar cancer harbour genetic variations of different types and specifically, HPV-independent tumours are molecularly very heterogeneous and harboured more SNVs while HPV-associated tumors more frequently presented with gene amplifications. The PI3K/AKT/mTOR1 pathway was affected in both the groups as well as the cell cycle regulation pathway. …”
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Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies by Jean-Jacques Rouby, Jing Xia, Jayesh Dhanani, Gianluigi Li Bassi, Antoine Monsel, Antoni Torres, Kostoula Arvaniti, Mona Assefi, Matteo Bassetti, Stijn Blot, Matthieu Boisson, Adrien Bouglé, Jean-Michel Constantin, Jayesh Dhanani, George Dimopoulos, Jonathan Dugernier, Pauline Dureau, Stephan Ehrmann, Timothy Felton, Marin Kollef, Antonia Koutsoukou, Anna Kyriakoudi, Pierre-François Laterre, Marc Leone, Victoria Lepère, Gianluigi Li Bassi, Xuelian Liao, Shakti Bedanta Mishra, Olivier Mimoz, Antoine Monsel, Girish B Nair, Michael Niederman, Lucy B Palmer, Jose Manuel Pereira, Konstantinos Pontikis, Garyphalia Poulakou, Jérôme Pugin, Chuanyun Qian, Jie-ming Qu, Jordi Rello, Jason Roberts, Jean-Jacques Rouby, Christina Routsi, Gerald C. Smaldone, Antoni Torres, Melda Türkoğlu, Tobias Welte, Michel Wolff, Xia Jing, Li Yang, Ting Yang, Ying-gang Zhu

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Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model by Zhuo-ma Dawa, Zhuo-ma Dawa, Ting Zhai, Ting Zhai, Chuan-chuan Liu, Chuan-chuan Liu, Hai-ning Fan, Hai-ning Fan

“…PAB suppressed the expression of matrix metalloproteinases (MMPs 1, 2, 3, 9, 13) and the activation of the PI3K/AKT signaling pathway in the host tissue surrounding the metacestodes.ConclusionPAB has a significant killing effect on E. multilocularis, suggesting that it is a potential candidate for the treatment of AE.…”
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EZH1/2抑制剂UNC1999对肝癌细胞的影响 by 唐秀鑫

“…【方法】实验设2个组：DMSO（对照组）、UNC1999组，分别加入不同浓度的DMSO、UNC1999并作用不同时间，用CCK-8法检测细胞OD值，筛选药物较佳的作用浓度及时间；EdU细胞增殖实验及克隆形成实验分别检测细胞增殖和克隆形成能力；划痕实验检测细胞迁移能力；Transwell侵袭、迁移实验检测细胞侵袭及迁移的能力；Annexin V-FITC/PI双染法检测细胞凋亡；流式细胞术检测的细胞周期。RNA-seq检测UNC1999对细胞转录组的影响；qRT-PCR法检测药物作用相关基因（EZH1、EZH2）以及转录水平显著差异基因（NECTIN4）的相对表达量；Western Blot法检测EZH1、EZH2、H3K27me3表达情况。…”
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