Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…Notably, the Wnt signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, and AMPK signaling pathway are implicated in the metabolic processes of glucose dysregulation and lipid homeostasis, as well as the pathogenesis of hypertension associated with OSAHS. …”
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Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy by Ya Qiu, Yan Ma, Min Jiang, Sulei Li, Jibin Zhang, Haixu Chen, Mengqi Xu, Shan Gao, Lei Tian, Bo Tao, Yabin Wang, Dong Han, Feng Cao

“…Specifically, Mel profoundly alleviated LPS-induced cell pyroptosis, as evidenced by decreased propidium iodide (PI) and active caspase-1 double-positive cell rates; suppressed the expression of NLRP3, cleaved caspase-1 (activated form of caspase-1), and GSDMD-NT (functional N-terminal fragment of GSDMD) expression; and inhibited the production of the cleaved IL-1β and cleaved IL-18 cytokines. …”
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Use of α-Lactalbumin and Caseinoglycomacropeptide as Biopeptide Precursors and as Functional Additives in Milk Beverages Fermented by L. helveticus by Katarzyna Skrzypczak, Emilia Fornal, Dorota Domagała, Waldemar Gustaw, Ewa Jabłońska-Ryś, Aneta Sławińska, Wojciech Radzki, Anna Kononiuk, Adam Waśko

“…Moreover, CGMP-containing fermented products were characterized by a generally higher value of the proteolysis index (PI) than analogous variants containing α-la. The use of analyzed strains and the selected protein preparations has a positive effect on the texture of fermented milk beverages and might contribute to an increase in the health-promoting potential of such products.…”
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lncRNA HHIP-AS1 Promotes the Osteogenic Differentiation Potential and Inhibits the Migration Ability of Periodontal Ligament Stem Cells by Qianyi Qin, Haoqing Yang, Chen Zhang, Xiao Han, Jing Guo, Zhipeng Fan, Jie Guo

“…Bioinformatic analysis revealed several biological processes and signaling pathways related to HHIP-AS1 functions, including the PI3K-Akt signaling pathway and JAK-STAT signaling pathway. …”
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Upregulation of GSTP1 mediated by chimeric TFE3 promotes TFE3-tRCC progression by targeting JNK signaling pathway by Weixu Chen, Mengtong Wu, Lin Du, Changhua Fang, Hao Wang, Wendi Wang, Chengwei Zhang, Hongqian Guo, Gutian Zhang

“…MTT and colony formation assays were used to detect cell proliferation. Annexin V/PI staining was used to evaluate cell apoptosis. …”
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Ameliorative effect of curcuminoids in liver fibrosis rat model via regulating GIPC1 gene and modulating MMP-8/TIMP-3 balance mediated by miR-483-5p by Rana Mostafa Adel, Sara Mostafa Kamal, Eman Adel Sherif, Sara Hatem El-shafiey

“…All these enhancements were mirrored in Annexin V/PI (Annexin V Propidium Iodide) assay as massive improvements in % of apoptotic and necrotic cells, plus, in H&E (hematoxylin and eosin) and Masson’s trichrome histopathological examinations that showed near to normal liver architecture with no collagen bands deposition. …”
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LIPUS promotes osteogenic differentiation of rat BMSCs and osseointegration of dental implants by regulating ITGA11 and focal adhesion pathway by Chao Liang, Yuqing Zhang, Yuwei Yan, Wei Geng, Jun Li, Xiu Liu

“…In addition, LIPUS significantly increased ALP expression and mineralized nodule formation in rat BMSCs by upregulating ITGA11 and increasing the activity of FAK/PI3K/AKT/GSK3β/β-catenin pathway. Conclusions LIPUS can effectively promote implant osseointegration in rats and improve rat BMSC osteogenic differentiation by upregulating ITGA11 and increasing the activity of the downstream focal adhesion pathway.…”
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Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia by Fei Xie, Ting-juan Zhang, Xin-long Zhang, Zi-jun Xu, Liang Qiao, Yun Wang, Yang-jing Zhao, Jun Qian, Jing-dong Zhou

“…Bioinformatics analysis demonstrated the association of HOXA9 expression with diverse leukemia-related genes (HOXAs, SOSTDC1, MEG3, miR-10a, miR-381 and miR-193b) and signaling pathways (PI3K-Akt signaling) in AML. Subsequently, we further validate the hypomethylation pattern of HOXA9 in AML patients and the epigenetic regulation of HOXA9 methylation in AML cell-lines. …”
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Stress granules sequester autophagy proteins to facilitate plant recovery from heat stress by Xibao Li, Jun Liao, Ka Kit Chung, Lei Feng, Yanglan Liao, Zhixin Yang, Chuanliang Liu, Jun Zhou, Wenjin Shen, Hongbo Li, Chengwei Yang, Xiaohong Zhuang, Caiji Gao

“…In this study, we provide compelling evidence for the translocation of key autophagy components, including the ATG1/ATG13 kinase complex (ATG1a, ATG13a), PI3K complex (ATG6, VPS34), and ATG8-PE system (ATG5), to HS-induced stress granules (SGs) in Arabidopsis thaliana. …”
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Integrated metabolomics and proteomics analysis to provide insights into muscle atrophy of turbot Scophthalmus maximus by dietary Clostridium autoethanogenum protein by Shihui Pan, Nan Bai, Zezheng Qi, Chuwen Chen, Daisong Ma, Zhenlin Liang, Min Gu

“…Second, CAP inhibited mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K) pathways to down-regulate mTOR pathways and protein synthesis. …”
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Whole-genome sequencing-based characterization of Salmonella enterica Serovar Enteritidis and Kentucky isolated from laying hens in northwest of Iran, 2022–2023 by Shirin Vakili, Mehri Haeili, Adel Feizi, Kiarash Moghaddasi, Maryam Omrani, Arash Ghodousi, Daniela Maria Cirillo

“…A total of 11 different Salmonella Pathogenicity Islands (SPIs) including SPIs-1, to 5, 9, 10, 13, 14, C63PI, CS54 and several virulence genes related to type III secretion system, adhesins, iron and magnesium uptake, serum and antimicrobial peptide resistance were detected among the isolates. …”
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Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms by Jua Kim, Jeremy L. Gilbert, William W. Lv, Ping Du, Haobo Pan

“…Depending on the corrosion rate, Mg modulates HIF1α and many signaling pathways like PI3K/AKT/mTOR, mitophagy, cell cycle, and oxidative phosphorylation. …”
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Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 Axis: A Potential Novel Pathway to Regulate Immune Response against COVID-19 by Zahra Firoozi, Elham Mohammadisoleimani, Abbas Shahi, Mohammad Mehdi Naghizadeh, Ebrahim Mirzaei, Ali Ghanbari Asad, Zahra Salmanpour, Seyed Mohamad Javad Nouri, Yaser Mansoori

“…Then, bioinformatics tools revealed the role of hsa_circ_0000479/hsa-miR-149-5p/RIG-I, IL-6 axis in PI3K-AKT and STAT3 signaling pathways. Conclusion. …”
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Arctiin alleviates knee osteoarthritis by suppressing chondrocyte oxidative stress induced by accumulated iron via AKT/NRF2/HO-1 signaling pathway by Junzheng Yang, Delong Chen, Qi He, Baihao Chen, Zhaofeng Pan, Gangyu Zhang, Miao Li, Shaocong Li, Jiacong Xiao, Haibin Wang, Peng Chen, Zhantian An

“…CCK-8 assay was performed to detect chondrocyte viability. Annexin V-FITC/PI staining determined the cell apoptosis rate. …”
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人参皂苷Rb1通过Sirt3/SOD2通路延缓高糖诱导的人脐静脉内皮细胞衰老 by 柯世业, 石光耀, 刘定辉, 吴琳, 温仁辉, 朱洁明, 钱孝贤

“…【方法】建立高糖（40mmol/L葡萄糖）诱导的HUVEC早熟性衰老模型，根据衰老相关β-半乳糖苷酶（SA-β-Gal）阳性率及Ⅰ型纤溶酶原激活物抑制因子（PAI-1）和P16表达评估HUVEC衰老，并采用AnnexinV-FITC/PI排除细胞凋亡的发生。采用Westernblot检测各组Sirt3与SOD2表达的变化。同时检测细胞内丙二醛（MDA）及SOD2活性的水平。…”
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Evaluation of Rapeseed Leave Segmentation Accuracy Using Binocular Stereo Vision 3D Point Clouds by Lili Zhang, Shuangyue Shi, Muhammad Zain, Binqian Sun, Dongwei Han, Chengming Sun

“…Finally, using the region-growing algorithm during the seedling stage with a normal angle threshold set at 5.0/180.0* M_PI and a curvature threshold set at 1.5 helps to avoid the under-segmentation and over-segmentation issues, achieving complete segmentation of rapeseed seedling leaves, while the LCCP clustering method fully segments rapeseed leaves at the bolting stage. …”
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Patient‐derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways by Katharina Bischof, Andrea Cremaschi, Lena Eroukhmanoff, Johannes Landskron, Lise‐Lotte Flage‐Larsen, Alexandra Gade, Line Bjørge, Alfonso Urbanucci, Kjetil Taskén

“…We also show that AAFs induce time‐ and concentration‐dependent activation of downstream signalling to signal transducer and activator of transcription 3 (STAT3), and concomitantly altered phosphorylation of mitogen‐activated protein kinase kinase (MEK), phosphoinositide 3‐kinase (PI3K)–protein kinase B (AKT) and nuclear factor NF‐kappa‐B (NFκB). …”
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Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells by Sukannika Tubtimsri, Tiraniti Chuenbarn, Suwisit Manmuan

“…Quercetin’s ability to stop the cell cycle was evaluated via PI staining and the flow cytometer. The examination included anti-proliferative, anti-migration, and anti-invasion activities. …”
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Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma by Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin

“…Staple GBM phenotypes, such as GBM stem cells and increased activation of the PI3K/Akt/NF-κB pathway, have been implicated in the expression of several ABC transporters. …”
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A Lightweight YOLO Model for Rice Panicle Detection in Fields Based on UAV Aerial Images by Zixuan Song, Songtao Ban, Dong Hu, Mengyuan Xu, Tao Yuan, Xiuguo Zheng, Huifeng Sun, Sheng Zhou, Minglu Tian, Linyi Li

“…When deployed on a Raspberry Pi 5, YOLO-Rice achieved 2.233 frames per second (FPS) on full-sized images, reducing the average detection time per image by 81.7% compared to YOLOv8n. …”
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