Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Then the in vivo sensitivity of these transfected C6-TK and C6-sr39TK cells to GCV was determined by 3-(4,5)-dimethylthiahiazo-(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) colorimetric assay and Hoechst-propidium iodide (PI) staining. Finally, a subcutaneously C6 xenograft tumor model was established in the nude mice to test the in vitro efficacy of TK/GCV gene therapy. …”
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Lived experiences of people with chronic kidney disease on maintenance dialysis: a systematic review and thematic synthesis of qualitative studies by Maya Annie Elias, Wim Van Damme, Grace Marie V Ku, Mahesh Kadammanavar, Edwin Wouters

“…Methods Adhering to PRISMA and PiCO guidelines for systematic review, we identified original studies published between 2000 and 2024, focusing on the lived experience of patients with CKD on dialysis, across PubMed, Web of Science, and Scopus databases. …”
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Direct Effect of Two Naphthalene-Sulfonyl-Indole Compounds on Toxoplasma gondii Tachyzoite by Qasem Asgari, Hossein Keshavarz, Mostafa Rezaeian, Mohammad Hossein Motazedian, Saeedeh Shojaee, Mehdi Mohebali, Ramin Miri

“…Then, they were stained by PI and analyzed by FACS. To evaluate the infectivity, 2×106 tachyzoites exposed to the concentrations mentioned above were intraperitoneally inoculated into five mice from each group. …”
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A Dual-Stage Processing Architecture for Unmanned Aerial Vehicle Object Detection and Tracking Using Lightweight Onboard and Ground Server Computations by Odysseas Ntousis, Evangelos Makris, Panayiotis Tsanakas, Christos Pavlatos

“…The UAV is equipped with a Raspberry Pi for onboard data processing, utilizing an Intel Neural Compute Stick 2 (NCS2) for accelerated object detection. …”
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Neural network quantification for solar radiation prediction: An approach for low power devices by Brenda Alejandra Villamizar-Medina, Angelo Joseph Soto Vergel, Byron Medina-Delgado, Darwin Orlando Cardozo-Sarmiento, Dinael Guevara-Ibarra, Oriana Alexandra Lopez-Bustamante

“…This paper proposes a quantized neural network model for solar radiation prediction, considering the hardware limitations of low-power devices like the Raspberry Pi RP2040 microcontroller. The methodology involves five stages: hardware and software selection, neural network development and quantization, microcontroller implementation, model validation, and result analysis. …”
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Characterizing the pan-cancer role of exosomal miRNAs in metastasis across cancers by Piyush Agrawal, Gulden Olgun, Arashdeep Singh, Vishaka Gopalan, Sridhar Hannenhalli

“…Our analysis recapitulated exomiRs associated with M2 macrophage differentiation and chemoresistance, such as miR-21 and miR-222–3p, regulating signaling pathways like PTEN/PI3/Akt, NF-kB, etc. Additionally, Cox regression analysis in TCGA indicated that exomiR targets are significantly associated with better overall survival of patients. …”
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Efficacy of oral irrigators compared to other interdental aids for managing peri-implant diseases: a systematic review by Gargi Gandi, Bhoomika Sai Laxmi Masanam, Ananya Sudhakaran Nair, Nidhi Semani, Aditi Chopra, Venkitachalam Ramanarayan

“…Results Oral irrigator along with mechanical brushing was found to be more effective than mechanical brushing alone in reducing the plaque index (PI), gingival index (GI), and bleeding on probing (BOP). …”
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Synthesis and protective effect of pyrazole conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and a... by Zang Binbin, Wang Lihui

“…It showed attenuation of NF-ĸB and apoptosis in Western blot and annexin--PI assay, resp. Compound 3h also reduced the production of bronchoalveolar lavage fluid from the lung and provided a protective effect against lung injury. …”
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Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer by Noah Sasa, Toshihiro Kishikawa, Masashi Mori, Rie Ito, Yumie Mizoro, Masami Suzuki, Hirotaka Eguchi, Hidenori Tanaka, Takahito Fukusumi, Motoyuki Suzuki, Yukinori Takenaka, Keisuke Nimura, Yukinori Okada, Hidenori Inohara

“…Heterozygous loss of ataxia-telangiectasia mutated (ATM) was observed in 67% of tumors, with its downregulation confirmed by single-cell RNA sequencing and immunohistochemistry, suggesting ATM haploinsufficiency contributes to carcinogenesis. PI3K activation was the major oncogenic mutation, with JAK-STAT activation in tumors with clonal integration and NF-kappa B activation in those without. …”
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The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway by Sen Wang, Zhengwei Duan, Zihua Li, Dong Yang, Hengli Lu, Yiwei Zhang, Yuesong Fu, Yonghao Guan, Guodong Li, Feng Qian, Tianyang Xu

“…At last, the levels of AMPK, PI3K, AKT1, Ldh, Myod, Chrna1, and Chrnd were notably decreased after AMPK inhibitor treatment, while the levels of Lcad and Mcad were up-regulated by AMPK inhibitor. …”
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Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms by Ali Mohammadkhanizadeh, Mohammad Sheibani, Soroush Taherkhani, Davood Nourabadi, Seyed Mahdi Mohamadi-Zarch, Farnaz Nikbakht, Yaser Azizi

“…In addition, apigenin has been shown to activate the PI3K/Akt signaling pathway, which is involved in promoting neuronal survival and preventing apoptosis. …”
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ESO-Based Direct Model-Free Adaptive Predictive Compensation Control for Permanent Magnet Synchronous Motors by Yang Liu, Guangxu Zhou, Lei Guo, Zibo Sun

“…Finally, the simulation results demonstrate that, compared to PI control, sliding mode control (SMC), and model-free adaptive predictive control (MFAPC), the proposed method offers superior dynamic performance while significantly enhancing the anti-disturbance capabilities of the PMSM system.…”
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A Real-Time Vision Transformers-Based System for Enhanced Driver Drowsiness Detection and Vehicle Safety by Anwar Jarndal, Hissam Tawfik, Ali I. Siam, Imad Alsyouf, Ali Cheaitou

“…Furthermore, the system was successfully deployed on a Raspberry Pi microcomputer, integrated with an infrared camera, a GSM/GPS module, and a buzzer to alert the driver and report the drowsiness condition to the vehicle owner. …”
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A multi-channel bioimpedance-based device for Vietnamese hand gesture recognition by Nhat-Minh Than, Son-Thuy Nguyen, Dang-Nguyen Huynh, Thao-Nguyen Tran, Nguyen-Khoa Le, Huu-Xuan Mai, Cao-Dang Le, Tan-Thi Pham, Quang-Linh Huynh, Trung-Hau Nguyen

“…The developed device, powered by a Raspberry Pi and connected to electrodes for impedance data acquisition, employs an impedance chip for data collection. …”
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The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils by Lee Josephson PhD, Nancy Stratman MS, YuTing Liu MS, Fang Qian MS, Steven H. Liang PhD, Neil Vasdev PhD, Shil Patel PhD

“…Affinities of BF-227-like compounds (expressed as K i ) for α-Syn and Aβ fibrils were determined, along with 5 reference compounds (flutafuranol, flutemetamol, florbetapir, BF-227, and PiB). Selectivity for α-Syn binding, defined as the K i (Aβ)/K i (α-Syn) ratio, was 0.23 for BF-227. …”
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Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain by N. David Åberg, Katarina Gustafson Brywe, Jörgen Isgaard

“…It appears that the MAPK signaling pathway is required for IGF-Istimulated proliferation in vitro, whereas the PI3K/Akt or MAPK/Erk signaling pathway appears to mediate antiapoptotic effects. …”
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Assessing the Use of Crushed Rock Aggregate and Carbon Black for Laterite Soil Stabilization in Road Construction. by Turyamureeba, Emmanuel

“…Graphical analysis of the results revealed that a blend of 50% lateritic soil, 40% aggregates, and 10% carbon black was the most effective, yielding a CBR of 63.0 at 98% relative compaction and a Plasticity Index (PI) of 6.5. These results meet the General Specifications for Roads and Bridges by Uganda’s Ministry of Works, Housing, and Communication, which require a CBR above 60%. …”
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Comparing spirometry, impulse oscillometry with computed tomography for assessing small airway dysfunction in subjects with and without chronic obstructive pulmonary disease by Suyin Huang, Fan Wu, Zhishan Deng, Jieqi Peng, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Xiaohui Wu, Qi Wan, Gaoying Tang, Shengtang Chen, Changli Yang, Yongqing Huang, Shuqing Yu, Pixin Ran, Yumin Zhou

“…Only spirometry-defined SAD group had more lower lung function (FEV1/FVC: adjusted difference=-10.7%, 95% CI: -13.5% to -7.8%, p < 0.001) and increased airway wall thickness (Pi 10: adjusted difference = 0.3 mm, 95% CI: 0 to 0.6 mm, p = 0.046) than only CT-defined SAD group. …”
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CLOVES Syndrome: A Review of Clinical, Genetic, and Therapeutic Aspects by Julianna Podolec, Silvia Ciraolo, Joanna Wojda, Adam Sobiński, Zuzanna Kościuszko, Katarzyna Kurza, Agnieszka Kulczycka-Rowicka, Matylda Czerwonka, Katarzyna Lesiczka-Fedoryj, Anna Walczak

“…It focuses on the role of PIK3CA gene mutations, challenges in diagnosis, and treatment options, including PI3K/AKT/mTOR pathway inhibitors. Research Materials and Methods: This article is based on a review of the current literature and clinical reports from various sources. …”
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Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis by Wenlong Liu, Li Deng, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Huabin Li, Renzhong Luo

“…Our results also showed that IL-37b downregulated Th2 cytokine expressed by PBMCs and this modulation was through mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathway. We also found that intranasal mometasone furoate therapy can promote nasal IL-37b expression. …”
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