เครื่องจ่ายยาอัตโนมัติเเละตรวจสอบความถูกต้องด้วยโมเดล YOLOv5 by ปิ่นพงษ์ เรืองระวีนุกิจ, ธนกฤต นูพิมพ์, อนุชา ลือบางใหญ่, พลวัต ช่อผูก

“…ความคลาดเคลื่อนทางยาคือปัญหาสำคัญที่ส่งผลต่อความปลอดภัยของผู้ป่วยทั่วโลก และเป็นสาเหตุหนึ่งของการเสียชีวิตจากการใช้ยาไม่ถูกต้อง ปัญหานี้ยิ่งเพิ่มความซับซ้อนสำหรับผู้ที่ต้องการการรักษาด้วยสูตรยาที่มีความซับซ้อน การวิจัยนี้มุ่งเน้นที่การพัฒนาเครื่องจ่ายยาอัตโนมัติที่ใช้ Raspberry Pi เพื่อปรับปรุงประสิทธิภาพในการจ่ายยา ลดความผิดพลาดโดยการใช้ปัญญาประดิษฐ์ ระบบที่พัฒนาสามารถรับรายการคำสั่งจ่ายยาจากแพทย์โดยตรง และใช้ YOLOv5 เป็นเครื่องมือปัญญาประดิษฐ์ (AI) ในการตรวจสอบความถูกต้องของรายการยา ผลลัพธ์จากการพัฒนาโมเดลแสดงให้เห็นว่า โมเดลที่สามมีประสิทธิภาพสูงสุดที่ 64% การตรวจสอบความถูกต้องโดยใช้ AI มีความแม่นยำถึง 90%ซึ่งทำให้มีผลความคลาดเคลื่อนทางยาอยู่ที่ 11%…”
Get full text

Effect of Electroacupuncture at Shenting and Baihui Acupoints on Ability of Learning and Memory and Expression of Autophagy Related Genes and Proteins in Cerebral Ischemia-reperfus... by Lingli GAO, Xiaodong FENG

“…Morris water maze experiment was used to observe learning and memory ability of rats, TTC staining was used to observe the change of brain infarction area of rats, RT-PCR and Western Blot were used to detect the expression of autophagy related genes and proteins in hippocampus.Results:④Morris water maze outcomes showed that compared with the model group, the escape latency time of rats in the EA group was obviously shortened, the number of across-platform was increased and the distance was shortened (<italic>P</italic>&lt;0.05).④Compared with the model group, the nerve defect scale of brain ischemia-reperfusion injury rats in the EA group was decreased (<italic>P</italic>&lt;0.05).④TTC staining results showed that the area of brain infarction in the EA group and model group was respectively higher than that in the sham operation group, and the volume of brain infarction in the EA group was reduced compared with the model group (<italic>P</italic>&lt;0.05).④Compared with the model group, the levels of Beclin 1, LC3Ⅰ/Ⅱand PI3K mRNA and protein in the left side of hippocampus in the EA group were increased (<italic>P</italic>&lt;0.05).Conclusion:EA at the DU24 and DU20 acupoints can reduce the cerebral infarction, and improve animal behaviors, and protect the neuronal injury. …”
Get full text

Is human-like decision making explainable? Towards an explainable artificial intelligence for autonomous vehicles by Jiming Xie, Yan Zhang, Yaqin Qin, Bijun Wang, Shuai Dong, Ke Li, Yulan Xia

“…In the second stage, we draw inspiration from the field of brain-like trusted AI to construct a robust, in-depth, and unbiased evaluation and interpretability framework involving three dimensions: Permutation Importance (PI) analysis, Partial Dependence Plot (PDP) analysis, and model complexity analysis. …”
Get full text

Intelligent Controller Design and Fault Prediction Using Machine Learning Model by Kailash Kumar, Suyog Vinayak Pande, T. Ch. Anil Kumar, Parvesh Saini, Abhay Chaturvedi, Pundru Chandra Shaker Reddy, Krishna Bikram Shah

“…The optimization of a controller model is proposed by modifying a PI controller taken from a commercial one. With the use of IEEE 39 standard buses, the proposed controller is tested. …”
Get full text

Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells by Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

“…After combination therapy, cell viability was analyzed by CCK-8, and cell death was analyzed by Annexin-V-FITC/PI and caspases activation. Immuno-staining and co-immuno-precipitation were used to examine the interaction between p62 and caspase-8. …”
Get full text

Modeling Soil Behavior with Machine Learning: Static and Cyclic Properties of High Plasticity Clays Treated with Lime and Fly Ash by Gebrail Bekdaş, Yaren Aydın, Sinan Melih Nigdeli, İnci Süt Ünver, Wook-Won Kim, Zong Woo Geem

“…There are 14 inputs, including specific gravity (Gs), void ratio (eo), sieve analysis (+No.4, −No.200), clay size, LL, plastic limit (PL), plasticity index (PI), linear shrinkage (Ls), shrinkage limit (SL), cure day, agent, clay type, and agent percentage. …”
Get full text

Adaptation of Anopheles Vectors to Anthropogenic Malaria-Associated Rubber Plantations and Indoor Residual Spraying: Establishing Population Dynamics and Insecticide Susceptibility by Suntorn Pimnon, Adisak Bhumiratana

“…The study MRP ecotope elicited the population ratio (pi) of Anopheles vectors: An. campestris (0.747), An. dirus (0.168), An. minimus (0.037), An. barbirostris (0.027), and An. pseudowillmori (0.002), and of An. jamesii nonvector (0.019). …”
Get full text

Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma by Leanne Stevenson, Lauren Cairns, Xiaodun Li, Sriganesh Jammula, Harriet Taylor, Rosalie Douglas, Niamh McCabe, Gerald Gavory, Xavier Jacq, Rebecca C. Fitzgerald, Richard D. Kennedy, Timothy Harrison, Richard C. Turkington

“…Hyperactivation of the PI3K-AKT-mTOR pathway is a common occurrence in OAC, driving cell survival, proliferation and resistance to chemotherapeutic agents. …”
Get full text

Protective mechanism of safflower yellow injection on myocardial ischemia-reperfusion injury in rats by activating NLRP3 inflammasome by Lingmei Li, Ce Cao, Hao Guo, Li Lin, Lei Li, Yehao Zhang, Gaojie Xin, Zixin Liu, Shujuan Xu, Xiao Han, Qiong Zhang, Jianhua Fu

“…However, the contents of inflammatory factors and the expression of inflammatory-related proteins, p62/SQSTM1 and mTOR were increased, while PI3K, p-AKT, LC3-II/LC3-I were significantly decreased in OGD/R + SYI + CQ group. …”
Get full text

Diagnosing and Treating ANCA-Associated Vasculitis within the COVID-19 Era: A Challenging Case Report by Erjola Likaj, Larisa Shehaj, Deniona Nunci, Lordian Nunci, Irda Rrugeja, Merita Rroji, Saimir Seferi, Nertila Gjonaj, Alma Idrizi, Arjana Strakosha

“…Renal manifestations often present as pauci-immune focal and segmental necrotizing crescentic glomerulonephritis (PI-NCGN), which can progress to acute or chronic kidney failure and multiorgan involvement. …”
Get full text

EDITORIAL by Rafael dos Reis Ferreira, João Antonio de Moraes, Pedro Bravo de Souza, Marcelo Marconato Magalhães, Camila da Cruz Silva, Matheus Barreto Pazos de Oliveira, Felipe Eleutério Pereira, Ricardo Pereira Tassinari

Get full text

Design of An Automatic Temperature Recorder for Fishery Vessels Using Internet of Things Technology by Hadi Purwanto, Maman Hermawan, Chandra Nainggolan, Berbudi Wibowo

“…Hatch temperature recorder, MAX 31865 module, and PT100 thermocouple sensor use ESP 32 as a microprocessor. Raspberry Pi4 controls, displays, and stores data. This fish hatch temperature recorder has a GPS module for coordinates. …”
Get full text

The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes by Gabriele Forlani, Carlo Giorda, Roberta Manti, Natalia Mazzella, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida, AMD-Annals Study Group

Get full text

Cytotoxicity and genotoxicity of orthodontic bands after aging: an in-vitro study by Maryam Karandish, Bahar Khademi, Golnaz Ziaei, Nasrollah Erfani, Leila Moezi, Zahra Faghih

“…Abstract Background This investigation sought to evaluate cytotoxic and genotoxic effects of two different types of orthodontic bands after aging in acidic and neutral artificial saliva using human gingival fibroblast-like (HGF1-PI 1) cell lines. Methods Two commercial brands of orthodontic molar bands (American orthodontic (AO) and 3 S-dental bands), commonly used by orthodontists, were tested. …”
Get full text

Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria by Omer Abdalla Ahmed Hamdi, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, Sri Nurestri Abd Malek

“…Curcumenone (3) and curcumenol (5) displayed strong antiproliferative activity (IC50=8.3±1.0 and 9.3±0.3 μg/mL, resp.) and were found to induce apoptotic cell death on MCF-7 cells using phase contrast and Hoechst 33342/PI double-staining assay. Thus, the present study provides basis for the ethnomedical application of Curcuma zedoaria in the treatment of breast cancer.…”
Get full text

Anti-obesity mechanisms elucidation of essential oil components from Artemisiae Argyi Folium (Aiye) by the integration of GC-MS, network pharmacology, and molecular docking by Yongxiang Liu, Jinhai Luo, Maninder Meenu, Baojun Xu

“…The network pharmacology analysis revealed that the essential oil components may combat obesity through the Wnt signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, prolactin signaling pathway, and cAMP signaling pathway, etc. …”
Get full text

100 Gy 60Co γ-Ray Induced Novel Mutations in Tetraploid Wheat by Chuntao Yang, Jianshu Zhu, Yun Jiang, Xiaolu Wang, Mengxue Gu, Yi Wang, Houyang Kang, Xing Fan, Lina Sha, Haiqin Zhang, Pu Xuan, Yonghong Zhou

“…With 1 seed germinated (5%), T. dicoccum (PI434999) is the most sensitive to this dose of radiation. …”
Get full text

Silymarin: a promising modulator of apoptosis and survival signaling in cancer by Ujjawal Sharma, Praveen Kumar Sahni, Bunty Sharma, Madhu Gupta, Damandeep Kaur, Darin Mansor Mathkor, Shafiul Haque, Sabiha Khatoon, Hardeep Singh Tuli, Astha Mishra, Faraz Ahmad

“…The present review centres on the function of silymarin in controlling important signalling pathways related to apoptosis and survival, such as the JAK/STAT pathway, PI3K/Akt/mTOR, Bcl-2/Bax, and Fas/FasL. It is emphasised that silymarin's capacity to target these pathways is a key mechanism behind its anticancer effects against a variety of malignancies. …”
Get full text

Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review by Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao

“…This is mainly in terms of signaling pathways (NF-κB, AMPK, Nrf2, JAK/STAT, PPAR, SREBP-1c, PI3K/Akt and TLR) and gut microbiota. Furthermore, some emerging mechanisms such as microRNA potential biomarker therapies may provide therapeutic avenues for NAFLD. …”
Get full text

Discrete choice modelling of hypertension patients’ preferences for attributes of a public medical facility in Ibadan, Nigeria by Oluwaseun Aramide Otekunrin, Tekiyat Abiola Adebisi, Sururoh Adeniran-Babatunde, Olutosin Ademola Otekunrin

Get full text