Design and Investigation of a Passive-Type Microfluidics Micromixer Integrated with an Archimedes Screw for Enhanced Mixing Performance by Muhammad Waqas, Arvydas Palevicius, Vytautas Jurenas, Kestutis Pilkauskas, Giedrius Janusas

“…The experimental designs generated by DoE are then numerically simulated aiming to determine Mixing Index (<i>MI</i>) and Performance Index (<i>PI</i>). For this purpose, COMSOL Multiphysics with two physics modules—laminar and transport diluted species—is used. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Special attention was given to the various pathways involved, pointing out the ability of the phytoagents to hinder the deleterious ones (especially those leading to, driven by, or associated with TGF-β activation, SREBP, Smad, MAPK, PKC, NF-κB, NLRP3 inflammasome, and caspase), to promote the protective ones (PPAR-α, PPAR-γ, EP4/Gs/AC/cAMP, Nrf2, AMPK, and SIRT1), and to favorably modulate those with potentially dual effect (PI3K/Akt). Many phytomedicines have emerged as potentially useful out of in vitro and in vivo studies, but the scarcity of human trials seriously undermines their usage in the current clinical practice—an issue that stringently needs to be addressed.…”
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Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 by Letícia Penna Braga, Cássia Cristina Pinto Mendicino, Edna Afonso Reis, Ricardo Andrade Carmo, Cristiane Menezes de Pádua

“…Women (aHR = 1.62; p=0.022) and patients on protease inhibitor- (PI-) based regimens (aHR = 2.70; p<0.001) were at higher risk of ART modification.…”
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Synergistic anticancer effects of cisplatin and phenolic aglycones of the aerial part of Rumex dentatus L. in tongue squamous cell carcinoma: insights from network pharmacology and... by Amany E. Ragab, Ghada M. Al-Ashmawy, Sherin R. El Afify, Ola A. El-Feky, Amera O. Ibrahim

“…KEGG analysis indicated that the drug combination might work through pathways like PI3K-Akt signaling, microRNAs in cancer, and EGFR tyrosine kinase inhibitor resistance. …”
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Herbal Mouthwash Containing Extracts of Baccharis dracunculifolia as Agent for the Control of Biofilm: Clinical Evaluation in Humans by Vinícius Pedrazzi, Mateus Freire Leite, Reisla Cristina Tavares, Sandra Sato, Glauce Crivelaro do Nascimento, João Paulo Mardegan Issa

“…In measuring the time after use of mouthwash (t=1), there was no difference between products (P=0.602); that is, subjects in the study had a similar PI after the first use. After one week (t=2), there was no difference between the four products evaluated (P=0.674), so, all research individuals completed the study with a similar reduction in dental biofilm between themselves but it was different from initial state (Friedman test). …”
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Source apportionment, ecological and health risks of potentially toxic elements in street dusts across different land uses in city of Kermanshah, Iran by Ali Asgari, Soheil Sobhanardakani, Mehrdad Cheraghi, Bahareh Lorestani, Maryam Kiani Sadr

“…The computed mean values for the geo-accumulation index (I-geo) and the pollution index (PI) ranged from − 6.07 to 2.67 and from 0.023 to 9.58, respectively, indicating ‘unpolluted’ to ‘moderately to heavily polluted’, and ‘slight to very high polluted’ pollution levels, respectively. …”
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Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways by Jinjia Liu, Songhao Tian, Jixiang Wang, Qing Sang, Wenting Su, Jinqiang Wu, Fenglei Zai

“…Mechanistically, PEE appeared to exert hepatoprotective effects by modulating the insulin resistance pathway, particularly through the PI3K-AKT/PP1 signaling axis, thereby enhancing glycogen synthesis in the damaged liver. …”
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Effect of Right Median Nerve Stimulation on Clinical Efficacy and Prognosis of Patients with Consciousness Disorder Caused by Traumatic Brain Injury by Kun ZHAO, Aixian LIU

“…The β-endorphin (β-EP) and pulsatility index (PI) of the two groups decreased (<italic>P</italic>&lt;0.05), while that of the experimental group was lower than that of the control group, with statistically significant difference (<italic>P</italic>&lt;0.05). …”
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Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML by Dan Liu, Silu Liu, Yujie Ji, Ziyan Jin, Zhewei He, Mengjia Hou, Dongyang Li, Xiao Ma

“…The study also suggested PI3K inhibitors and Pevonedistat as possible therapeutic options to modulate immune cell infiltration. …”
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Ankara Üniversitesi Diş Hekimliği Fakültesine Başvuran Hastaların Periodontal Hastalık Öz Bildirim Geçerliliğinin Değerlendirilmesi by Fatma Karacaoğlu, Ezgi Ertümer, Murat Akkaya

“…Tüm hastaların Ramfjord dişlerinden33 plak indeksi (PI) ve gingival indeks (GI) alındı. CPI ölçümü 6 sekstantta yapılıp her bir sekstant için en yüksek skor kaydedildi. …”
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Anti-Inflammatory Effects of Aster incisus through the Inhibition of NF-κB, MAPK, and Akt Pathways in LPS-Stimulated RAW 264.7 Macrophages by Daniel Ngabire, Yeong-Ae Seong, Maheshkumar Prakash Patil, Irvine Niyonizigiye, Yong Bae Seo, Gun-Do Kim

“…Additionally, further Western blot results indicated that Aster incisus inhibited the expression of p-PI3K, p-IκBα, p-p65 NF-κB, p-ERK1/2, p-SAPK/JNK, and p-Akt. …”
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Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenviro... by Denghao Huang, Jie Lei, Xingrui Li, Zhonghao Jiang, Maoxuan Luo, Yao Xiao

“…Cell Counting Kit-8 was used for cell proliferation assay. Annexin V-PI-FITC was used for cell apoptosis through flow cytometry. …”
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Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff by Siyuan Su, Xiang Ding, Yiling Hou, Binbin Liu, Zhouhe Du, Junfeng Liu

“…The results of transcriptome sequencing analysis illustrated that total 46 genes enriched in MAPK and total 34 genes enriched in PI3K/Akt signaling pathways in BRS-X group. The protein VEGF and VEGFR expression were significantly reduced under the treatment with BRS-X. …”
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JAK/STAT3信号通路参与白细胞介素-17诱导的支气管平滑肌细胞增殖与迁移 by 蓝引乐, 朱妤, 王建华, 凌元亮

“…随后使用MTT检测细胞活力，BrdU染色观察细胞增殖状态，并使用PI染色流式细胞仪检测细胞周期。进一步利用细胞迁移实验检测细胞迁移能力。使用Westernblot实验检测IL-17处理后BSMC的JAK、p-JAK、STAT3、p-STAT3蛋白表达量。…”
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藤黄酸诱导Ｂｕｒｋｉｔｔ淋巴瘤细胞株凋亡及增殖抑制的分子学机制

“…【方法】 用不同剂量藤黄酸处理细胞，采用ＭＴＳ法对淋巴瘤细胞进行细胞活力及增殖抑制测定；０．２５、０．５、０．７５ μｍｏｌ／Ｌ藤黄酸分别处理细胞２４ ｈ，０．７５ μｍｏｌ／Ｌ藤黄酸分别处理细胞６、１２、２４ｈ后收集细胞，采用ＡｎｎｅｘｉｎⅤ－ＦＴＩＣ／ＰＩ流式细胞术检测藤黄酸剂量依赖性细胞凋亡情况；利用Ｗｅｓｔｅｒｎ ｂｌｏｔ方法检测凋亡相关蛋白和细胞增殖信号通路相关蛋白剂量与时间依赖的变化情况。…”
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Optimizing Heat Pump Control in an NZEB via Model Predictive Control and Building Simulation by Christian Baumann, Philipp Wohlgenannt, Wolfgang Streicher, Peter Kepplinger

“…Moreover, compared to the reference PI controller, the MPC scenarios enhanced indoor comfort by reducing room temperature fluctuations and lowering the average percentage of people dissatisfied by 1% pt., resulting in more stable indoor conditions. …”
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Applying reproductive technologies and genome resource banking to laboratory animals by S. Ya. Amstislavsky, E. Yu. Brusentsev, T. O. Abramova, D. S. Ragaeva, I. N. Rozhkova, T. N. Igonina, E. A. Kizilova, V. A. Naprimerov, N. Yu. Feoktistoiva

“…Double staining by SYBR Green/PI and subsequent confocal microscopy demonstrated that more than 40 % of amur cat semen retained viability after cryopreservation. …”
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A Multi-Resonant based reference feedforward adaptive voltage control for Grid-Forming inverter in island mode to compensate system uncertain and harmonic distortions by Renzhi Huang, Zaijun Wu, Xueyong Xu, Xiangjun Quan, Mingfei Li, Zichen Wang, Mengnan Liu

“…Compared with classical PI/PR methods or other adaptive ones, this newly proposed adaptive control method synthesizes high robustness, excellent voltage regulation performance, and low total harmonic distortion under nonlinear loads in island mode. …”
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Neutrinoless double beta decay from scalar leptoquarks: interplay with neutrino mass and flavor physics by P. S. Bhupal Dev, Srubabati Goswami, Chayan Majumdar, Debashis Pachhar

“…We find that the most stringent constraint on the parameter space comes from μ → e conversion in nuclei and K + → π + ν ν ¯ $$ {K}^{+}\to {\pi}^{+}\nu \overline{\nu} $$ decay. We also point out a tension between the muon and electron (g – 2) anomalies in this context. …”
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Genome-wide identification and expression analysis of GRAS transcription factors under cold stress in diploid and triploid Eucalyptus by Jiannan Liu, Hao Chen, Chenhe Li, Kang Du, Jun Yang

“…The physical and chemical properties of the proteins encoded by EgrGRAS genes vary, but the ranges of amino acid numbers, molecular weights, and isoelectric points (pI) are similar to those of GRAS proteins from other species. …”
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