Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma by Meng-Zhe Yang, Bei-Bei Zhang, Jian-Chun Huang, Xian-Yu Bai, Zhen-Qiang Liang, Xiang Yi, Ning Xu, Yuan-Jiao Huang, Ai-Jun Jiao

“…In addition, the anti-NPC effects of polyphyllin II mainly involved in the pathways related to cancer, especially in the PI3K-Akt signaling indicated by the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. …”
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The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis by Ying He, Ying He, Yongqing Liu, Min Zhang

“…It can also attenuate the regulation of antiapoptosis phosphoinositide 3-kinases (PI3K) signaling and increase the expression of mitogen-activated protein kinases (MAPKs) to induce endogenous production of ROS. …”
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Efecto del momento y tipo de poda sobre el rendimiento y calidad del fruto en arándano altos del sur (Vaccinium corymbosum) var. O´Neal en la provincia de Buenos Aires by M PESCIE, M BORDA, P FEDYSZAK, C LÓPEZ

“…O´Neal en el norte de la Provincia de Buenos Aires: 1) en invierno (PI), 2) en invierno y despunte de verano (PIDV), 3) intensa en verano (PIV) y 4) testigo sin podar (testigo). …”
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Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell by Feng-Fei Li, Bi-Jun Chen, Wei Li, Ling Li, Min Zha, S. Zhou, M. G. Bachem, Zi-Lin Sun

“…The 5-ethynyl-2′-deoxyuridine-positive INS-1 cells treated with ISC-SN were decreased. Propidium iodide- (PI-) positive INS-1 cells were 2.6-fold higher than those in control groups. …”
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Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential by Panting Wang, Panting Wang, Zixi Li, Yixuan Song, Bowei Zhang, Chaofeng Fan, Chaofeng Fan

“…Conversely, it can promote M2 polarization or suppress M1 polarization by inhibiting the NF-κB signaling pathway or activating the PI3K/Akt and AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. …”
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Temporal and spatial characterization of keratinocytes supporting orf virus replication by Byung-Joon Seung, Sushil Khatiwada, Daniel L. Rock, Gustavo Delhon

“…Using in situ hybridization, immunohistochemistry, confocal microscopy, qPCR, and a full-thickness wound/infection model in sheep, the natural host, we show that during an initial 2-day eclipse phase viral transcription and viral DNA replication are not detected. Between days 2 and 3 pi, viral transcription is first detected in keratinocytes of the stratum granulosum and upper stratum spinosum in the proliferative zone at the wound margin. …”
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Transient Characteristics and Operation Regulation of Grid‐Connected Variable Speed Pumped Storage‐Wind‐Solar Hybrid Power System by Yanhao Li, Fanchao Song, Wencheng Guo

“…The regulation effect of the control link PI‐1 plays a dominant role in the frequency converter. …”
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Cytogenetic Evolution of Human Ovarian Cell Lines Associated with Chemoresistance and Loss of Tumorigenicity by Stéphanie Struski, Martine Doco‐Fenzy, Michael Koehler, Ilse Chudoba, Francis Levy, Linda Masson, Nicole Michel, Evelyne Ulrich, Nadine Gruson, Jean Bénard, Gérard Potron, Pascale Cornillet‐Lefebvre

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Spectroscopic Analysis of a Theropod Dinosaur (Reptilia, Archosauria) from the Ipubi Formation, Araripe Basin, Northeastern Brazil by João Hermínio da Silva, Francisco Eduardo de Sousa Filho, Antônio Álamo Feitosa Saraiva, Nádia Amanda Andrade, Bartolomeu Cruz Viana, Juliana Manso Sayão, Bruno Tavares de Oliveira Abagaro, Paulo de Tarso Cavalcante Freire, Gilberto Dantas Saraiva

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Networking Salt Inducible Kinase 1 Regulatory Perturbations on Type 2 Diabetes- Breast Cancer Co-Morbidity Associated Molecular Bridge by Durrani I.A., John P., Bhatti A.

“…Interestingly, these were enriched for KEGG pathways PI3K-AKT signalling, and pathways in cancer. Furthermore, ClinVar disease terms particularly included T2DM and BC, highlighting their potential implication in co-morbidity. …”
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Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma by Xiong SS

“…The ability of 6c to induce apoptosis was detected by Annexin V-FITC/PI double staining and Hoechst 33342 staining experiment. …”
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CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer. by Qilu Fang, Qichuan Fang, Rui Cheng, Tingting Feng, Wenxiu Xin

“…Western blot, TUNEL and Annexin V-FITC/PI staining methods were employed to assess cell apoptosis. …”
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A stretched polar vortex increased mid-latitude climate variability during the Last Glacial Maximum by Y. Zhang, H. Renssen, H. Seppä, Z. Li, X. Li

“…Here, by systematically analysing SPV changes in four sets of PMIP4 (Paleoclimate Modelling Intercomparison Project – Phase 4) simulations for the Last Glacial Maximum (LGM) and the pre-industrial (PI) period, we explore how the SPV changed during the glacial climate and how it influenced climate variability. …”
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Relationship between personality portraits of university students and interpersonal conflict resolution strategies: a latent profile analysis by Bingbing Zhong, Jun Yan, Haichun Sun, Hao Chen, Baole Tao, Yueyan Jiang, Hanwen Chen, Tianci Lu, Zhichao Ding

“…In this study, a Latent Profile Analysis (LPA) was conducted on 975 university students using the Chinese Congress Five Personality Inventory (CBF-PI-B) measure as an indicator to explore their personality subtypes and the Student Version of the Rahim Organizational Conflict Inventory-II (ROCI-II) was utilized to measure the four types of conflict resolution strategies, namely collaboration, compliance, dominance, and avoidance. …”
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Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review by Mardiana L, Milanda T, Hadisaputri YE, Chaerunisaa AY

“…This enhanced bioavailability facilitates more effective inhibition of cancer pathways, including NF-κB and PI3K/AKT, leading to increased anticancer efficacy in preclinical models.Conclusion: Phytosome technology has demonstrated its potential to overcome bioavailability challenges, resulting in safer and more effective therapeutic options for cancer treatment. …”
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Photochemical corneal cross-linking: Evaluating the potential of a hand-held biopen by Nadina Usseglio, Julia López de Andrés, Juan Antonio Marchal, Lorenzo Moroni, Daniel Nieto

“…The mechanical properties of cornea are imitated by tuning the proposed (GelMA/PEGDA/PI) bioink composition and crosslinking parameters, which envisage the potential for being translated to a clinical environment to corneal wound closure.…”
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Measurement of the production cross section of prompt $$\Xi ^0_{\textrm{c}}$$ Ξ c 0 baryons in p–Pb collisions at $$\sqrt{s_{{\textrm{NN}}}}=5.02$$ s NN = 5.02  TeV by ALICE Collaboration

“…Abstract The transverse momentum ( $$p_{\textrm{T}}$$ p T ) differential production cross section of the promptly produced charm-strange baryon $$\mathrm {\Xi _{c}^{0}}$$ Ξ c 0 (and its charge conjugate $$\overline{\mathrm {\Xi _{c}^{0}}}$$ Ξ c 0 ¯ ) is measured at midrapidity via its hadronic decay into $$\mathrm{\pi ^{+}}\Xi ^{-}$$ π + Ξ - in p–Pb collisions at a centre-of-mass energy per nucleon–nucleon collision $$\sqrt{s_{\textrm{NN}}}~=~5.02$$ s NN = 5.02  TeV with the ALICE detector at the LHC. …”
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Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via GSDMD-mediated pyroptosis by JianFeng Liu, Chenyang Han, Jian Shen, Yingcong Lin, Heping Shen, Genghuan Wang

“…In vitro, primary microglia were used, and AM intervention was applied to detect the levels of cellular inflammatory factors, and fluorescence staining was used to detect GSDMD-NT, and propidium iodide (PI) was used to detect the level of pyroptosis. …”
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…Metformin, an antidiabetic drug, is effective for endometrial cancer through inhibition of the PI3K-Akt-mTOR pathway by activating LKB1-AMPK and reduction of insulin and insulin-like growth factor-1 due to AMPK activation. …”
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Genetic Variants Associated with Chronic Obstructive Pulmonary Disease Risk: Cumulative Epidemiological Evidence from Meta-Analyses and Genome-Wide Association Studies by Caiyang Liu, Ran Ran, Xiaoliang Li, Gaohua Liu, Xiaoyang Xie, Ji Li

“…Cumulative epidemiological evidence of an association was graded as strong for 10 variants in 8 genes (GSTM1, CHRNA, ADAM33, SP-D, TNF-α, VDBP, HMOX1, and HHIP), moderate for 6 variants in 5 genes (PI, GSTM1, ADAM33, TNF-α, and VDBP), and weak for 40 variants in 23 genes. …”
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