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    Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice by Yuki Nakamura, Kayoko Ishimaru, Yu Tahara, Shigenobu Shibata, Atsuhito Nakao

    Published 2014-01-01
    “…In mammals, the central clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus synchronizes and entrains peripheral circadian clock present in virtually all cell types via neural and endocrine pathways, thereby driving the daily rhythms in behavior and physiology. We found that mechanical disruption of the SCN resulted in the absence of a time of day-dependent variation in passive systemic anaphylactic (PSA) reaction in mice, associated with loss of daily variations in serum histamine, MCP-1 (CCL2), and IL-6 levels. …”
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    Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions by Jo M. Zelis, Pim A. L. Tonino, Nico H. J. Pijls, Bernard De Bruyne, Richard L. Kirkeeide, K. Lance Gould, Nils P. Johnson

    Published 2020-01-01
    “…With the increasing prevalence of aortic stenosis (AS) due to a growing elderly population, a proper understanding of its physiology is paramount to guide therapy and define severity. …”
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