Miniaturization and characterization of patient derived hepatocellular carcinoma tumor organoid cultures for cancer drug discovery applications by David A. Close, Paul A. Johnston

“…Complimenting cell viability readouts with multiple HCI parameters including morphological features and dead cell staining improved the analysis of drug impact and enhanced the value that could be extracted from these more physiologically relevant three-dimensional HCC organoid cultures.…”
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Improved Estimation of Aboveground Biomass in Rubber Plantations Using Deep Learning on UAV Multispectral Imagery by Hongjian Tan, Weili Kou, Weiheng Xu, Leiguang Wang, Huan Wang, Ning Lu

“…Our study highlights the great potential of combining UAV-based multispectral imagery with DL techniques to improve AGB estimation in rubber plantations, offering a new perspective for estimating the physiological and biochemical growth parameters of forests.…”
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The choice of the content of training process for mass-category athletes in view of the subjectivity of competitive activity by Orlov, Andrey I., Talantseva, Valentina K., Shilenko, Olga V., Petrova, Tatyana N., Kudratova, Lola A.

“…In this context, it is noted that the most common classifications of sports, reflecting mainly the biomechanical and physiological characteristics of competitive activity, do not allow the phenomenology of a particular sport to be fully realized. …”
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Predictors for recurrence of chronic osteomyelitis following long bones cavity defect replacement with synthetic materials by Alexander V. Afanasyev, Svetlana A. Bozhkova, Vasily A. Artyukh

“…The following factors affecting the treatment outcome were assessed: location (r=0.205, p=0.019); duration of osteomyelitis (r=0.23, p=0.007); history of debridement operations (r=0.264, p=0.002); bone defect volume (r=0.175, p=0.045); physiological class according to Cierny-Mader (r=0.188, p=0.004); anatomical type of osteomyelitis according to Cierny-Mader (r=0.15, p=0.086); nature of the pathogen (r=0.123, p=0.162). …”
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Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women by Maha Sellami, Shamma Almuraikhy, Khaled Naja, Najeha Anwardeen, Hadaia Saleh Al-Amri, Mohammad Shoaib Prince, Amina Ali Aden, Alexander Doemling, Mohamed A. Elrayess

“…This study aims to explore the effects of 4 and 8 weeks of moderate-intensity aerobic exercise on glucose metabolism, lipid profiles, and associated metabolic changes in young female students with insulin resistance and varying body mass, seeking to determine the optimal duration for physiological adaptations. Twenty-eight physically semi-active female students were randomly assigned to 4-week (G4, n = 13, age = 23.31 ± 5.19, BMI = 24.78 ± 5.87) and 8-week (G8, n = 15, age = 21.8 ± 2.56, BMI = 24.95 ± 4.81) training groups. …”
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A novel LC-MS/MS analysis of vitamin D metabolites in mice serum and hair: impact of diet and light exposure by Muhammad K. Hakeem, Asma Al-Menhali, Sampath K. Elangovan, Iltaf Shah

“…IntroductionNumerous physiological systems, such as the functioning of the immune system, bone health, and the regulation of expression of genes, depend critically on vitamin D. …”
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The effect of acute branched-chain amino acids ingestion on rate of force development in different time intervals: a controlled crossover study by Xi-Nuan Zhang, Long-Ji Li, Yan-Hao Tu, Li-Feng Zhang, Hua-Yu Shang, Meng Liu, Ming-Da Li

“…Additional outcome measures, including strength and jump tests, agility and sprinting tests, and physiological responses, were also assessed. A two-way repeated measures ANOVA was employed to evaluate the impact of supplements (BCAAs and placebo) on RFD and other related outcome measures.ResultsAnalysis of the 50 ms RFD demonstrated significant main effects of BCAA supplementation (p = 0.003). …”
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Microbiome Understanding in Maternity Study (MUMS), an Australian prospective longitudinal cohort study of maternal and infant microbiota: study protocol by Amanda Henry, Emad M El-Omar, Lynne M Roberts, Georgina L Hold, Maria E Craig, Katie Harris, Daniella Susic, Gregory Davis, Anthony J O' Sullivan, Emily McGovern, George Mangos

“…Introduction Pregnancy induces significant physiological and cardiometabolic changes, and is associated with alterations in the maternal microbiota. …”
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Seasonal Variations in the Biological Value of Kyrgyz Donkey’s Milk Proteins by Nadira K. Turganbaeva, Mukarama M. Musulmanova, Nurudin A. Kydyraliev

“…Due to its protein component, donkey’s milk is a multifunctional product with a wide range of beneficial physiological properties. It is known for its antioxidant, anti-inflammatory, rejuvenating, antimicrobial, and antitumor effects. …”
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Unlocking the full potential of resistance training: a comparative analysis of low- and high-intensity effects on neurotrophic growth factors and homocysteine by Chongwen Zuo, Yi Yin, Zhiyang Zheng, Ren Mu, Yuxin Liang, Shan Wang, Chaoqun Ye

“…Abstract Objective Resistance training has been demonstrated an effective approach for preventing the cognitive function decline through physiological mechanisms; however, the effect of acute resistance training at different intensities on growth factor and homocysteine levels remains unclear. …”
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Evaluating a novel team learning approach for integrating drugs in sports education in preclinical medical training by Samuel Pelobello, Grayson Potter, Daniel K. Rogstad, Andrew J. Mock, Sean M. Wilson

“…Future iterations will focus on emphasizing drug pharmacology, mechanisms of action, and physiological effects for MS1 students, while providing opportunities for more comprehensive knowledge integration through the case studies for MS2 students. …”
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Assessment of the Effects of Newly Fabricated CaO, CuO, ZnO Nanoparticles on Callus Formation Maintenance of <i>Alfalfa</i> (<i>Medicago sativa</i> L.) Under In Vitro Salt Stress by Mustafa Akçay, Merve Simsek Geyik, Busra Yazicilar, Fatma Boke, Hayrunnisa Nadaroglu, Okkes Atıcı, İsmail Bezirganoğlu

“…In this study, the physiological and histological responses of CuO, ZnO, and CaO nanoparticle (NP) applications on callus tissues developed from two <i>alfalfa</i> lines (Erzurum and Muş) exposed to salt (NaCl) stress were evaluated. …”
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The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…The activating receptor belonging to the NKG2D is stimulated by specific ligands: in humans these are major histocompatibility complex (MHC) class I polypeptide–related sequence A (MICA) and MHC class I polypeptide-related sequence B (MICB) proteins and UL16 binding 1–6 proteins (ULBP1-6). Under physiological conditions, the aforementioned ligands are expressed at low or undetectable levels but can be induced in response to stress factors. …”
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Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity by Stefanie Hoffmann, Philip Hewitt, Isabel Koscielski, Dorota Kurek, Wouter Strijker, Kinga Kosim

“…With the development of advanced microphysiological systems (MPS) more in vivo like conditions can be generated which increase the physiological nature and also the predictive validity of these models. …”
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Optimizing Cucumber (<i>Cucumis sativus</i> L.) Fruit Metabolomics Under Elevated CO₂ and High-Temperature Stress in the Greenhouse by Xian Du, Yang Song, Lu Pan, Shimao Cui

“…We used untargeted metabolomics methods to analyze the effects of varying temperatures (normal temperatures of 25 to 35 °C and high temperatures of 35 to 45 °C) and CO₂ concentrations (400 ± 20 µmol/mol and 1200 ± 20 µmol/mol) on the morpho-physiological traits, yield-associated traits, and metabolomic profiles of cucumber fruits. …”
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Photosynthetic performance and carbon metabolism in the ear organs of oats under drought stress by Jiaqi Fang, Yuan Zhan, Baowen Zhao, Yan Zhao, Youjun Chen, Qingping Zhou, Hui Wang

“…The results suggest that oats can tolerate a certain degree of drought without affecting the ears’ physiological function and yield, and ear organs can maintain water status and photosynthetic performance, which plays a major role in the maintenance of seed yield under drought stress conditions.…”
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Imprint of ancestral and modern threats in human mind – experience of fear, disgust, and anger by Eva Landová, Eva Landová, Jakub Polák, Jakub Polák, Markéta Janovcová, Iveta Štolhoferová, Šárka Peterková, Aleksandra Chomik, Daniel Frynta

“…Animal and human ancestors developed complex physiological and behavioral response systems to cope with two types of threats: immediate physical harm from predators or conspecifics, triggering fear, and the risk of infections from parasites and pathogens leading to the evolution of the behavioral immune system (BIS) with disgust as the key emotion. …”
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Leveraging Smart Telemedicine Technology to Enhance Nursing Care Satisfaction and Revolutionize COVID-19 Care: Prospective Cohort Study by You-Lung Chang, Chi-Ying Lin, Jiun Hsu, Sui-Ling Liao, Chun-Ti Yu, Hung-Chueh Peng, Chung-Yu Chen, Matthew Huei-Ming Ma, Juey-Jen Hwang

“…More than 800 cases were monitored using the QOCA remote home care system, a telemedicine platform that enables remote monitoring of physiological data—including heart rate, blood pressure, temperature, and oxygen levels—through Internet of Things devices and a 4G-connected tablet. …”
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How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review by Luke Gray, Peter Ladlow, Russell J Coppack, Robyn P Cassidy, Lynn Kelly, Sarah Lewis, Nick Caplan, Robert Barker-Davies, Alexander N Bennett, Luke Hughes

“…Main Body Blood flow restriction (BFR) exercise has demonstrated beneficial morphological and physiological adaptions in load-compromised populations, as well as being able to elicit acute hypoalgesia. …”
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Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus by Rebecca G. Biltz, Wenyuan Yin, Ethan J. Goodman, Lynde M. Wangler, Amara C. Davis, Braedan T. Oliver, Jonathan P. Godbout, John F. Sheridan

“…Repeated Social Defeat (RSD) in mice recapitulates several key physiological, immune, and behavioral changes evident after chronic stress in humans. …”
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