Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation by Alberto Jiménez-Martín, Alberto Pineda-Santaella, Rebeca Martín-García, Rodrigo Esteban-Villafañe, Alix Matarrese, Jesús Pinto-Cruz, Sergio Camacho-Cabañas, Daniel León-Periñán, Antonia Terrizzano, Rafael R. Daga, Sigurd Braun, Alfonso Fernández-Álvarez

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Mild drought conditions at the tillering stage promote dry matter accumulation and increase grain weight in drip-irrigated spring wheat (Triticum aestivum L.) by Yilin Ma, Jingyi Cai, Shuting Bie, Ziqiang Che, Guiying Jiang, Jianguo Liu

“…IntroductionIn order to elucidate the physiological mechanism of post-flowering assimilate transport regulating the formation of yields in arid regions and to provide technological support for further water-saving and high yields in the wheat region in Xinjiang, we conducted a study on the effects of different fertility periods and different degrees of drought and re-watering on the post-flowering dry matter accumulation and transport of spring wheat and the characteristics of grain filling.MethodsIn two spring wheat growing seasons in 2023 and 2024, a split-zone design was used, with the drought-sensitive variety Xinchun 22 (XC22) and drought-tolerant variety Xinchun 6 (XC6) as the main zones and a fully irrigated control during the reproductive period [CK, 75%~80% field capacity (FC)], with mild drought at the tillering stage (T1, 60%~65% FC), moderate drought at the tillering stage (T2, 45%~50% FC), mild drought at the jointing stage (J1, 60%~65% FC), and mild drought at the jointing stage (J2, 45%~50% FC) as the sub-zones. …”
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Effects of Enterobacter cloacae extract, selenium nanoparticles and methyl jasmonate on shoot liquid cultures of Sarcocornia fruticosa under salinity stress by Fathia Salem, Raoufa Abdel Rahman, Amel Tammam

“…This study aimed to evaluate the effects of NaCl salinity (700 mM and 1000 mM) on Sarcocornia fruticosa shoot cultures and assess the influence of different elicitors-Enterobacter cloacae extract (BE), selenium nanoparticles (SeNPs) and methyl jasmonate (MeJA) -on the plants growth, physiological and biochemical responses, and isorhamnetin production. …”
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Influence of Cosmetic Skincare Products with pH < 5 on the Skin Microbiome: A Randomized Clinical Evaluation by Ciska Janssens-Böcker, Claudia Doberenz, Marta Monteiro, Marta de Oliveira Ferreira

“…Research suggests that products with non-physiological pH levels may disrupt the skin microbiota. …”
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Enteral Nutrition Practices and Complications in ICU Settings: A Cross-Sectional Study of Healthcare Professionals&rsquo; Perspectives in Saudi Arabia by Zaher S, Alhindi R, Alturki L, Alsobhi E, Alahmadi L, Aldhowayan HA

“…Box 344, Madinah, 42353, Kingdom of Saudi Arabia, Email Sz332@cam.ac.uk; szaher@taibahu.edu.saBackground: Enteral Nutrition (EN) is the preferred method for providing nutritional support in intensive care units (ICUs) compared to parenteral nutrition (PN) due to its physiological advantages, safety profile, and cost-effectiveness compared to parenteral nutrition (PN). …”
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Comparative analysis of consistency of adaptations to interval interventions individualized using sport-specific techniques in well-trained soccer players by Hongjun Zhang, Sheng Li, Bingyuan Yang

“…Overall, by facilitating more homogenous stress, HIITvIFT results in more identical physiological demands and more uniform adaptations in ventilatory threshold and anaerobic power than SSG.…”
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Sensory quality and nutritional composition of carrot (Daucus carota L.) genotypes as affected by fertilization in production system in Cameroon by Maxime Merlin Tonfack Djoufack, Eric Bertrand Kouam, Edith Marius Kouam Foko, Mariette Anoumaa, Pierre Marie Kaktcham, François Ngoufack Zambou

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Characterizing Flow and Structure of Diabetic Retinal Neovascularization after Intravitreal Anti-VEGF Using Optical Coherence Tomography Angiography: A Pilot Study by Christof Haensli, Katrin Fasler, Daniel Barthelmes, Sandrine A. Zweifel

“…We propose this measurement method as a more physiological and possibly more comparable metrics.…”
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Problems of improving the national legislation on labor protection by K. Yu. Melnyk

“…The author’s definition of the term “safety and health protection of employees at work” is substantiated as a system of measures to prevent and/or reduce the impact of dangerous and harmful production factors, aimed at preserving the life, physiological and psychological functions of the body, and the optimal working capacity of an individual who works at on the basis of an employment contract, at the place of her employment. …”
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Investigation of Information Overload in Electronic Health Records: Protocol for Usability Study by Saif Khairat, Jennifer Morelli, Marcella H Boynton, Thomas Bice, Jeffrey A Gold, Shannon S Carson

“…MethodsOur study collected physiological and objective data through the use of a screen-mounted eye-tracker. …”
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Methodology for the organisation of professional training of senior citizens: general concept by T. M. Rezer

“…The conceptual model for the organisation of professional training of senior citizens is developed from the point of system-based approach and includes the following elements: 1) clarification of conceptual apparatus of senior adult education; 2) determination of anatomical and physiological features of senior citizens; 3) argumentation of the need of senior citizens for professional training; 4) determination of the peculiarities of professional training for senior citizens; 5) development of prerequisites list for successful learning of senior citizens; 6) formulation of learning objectives and tasks for its organisation; 7) choice of approaches for building the model of training and its principles as well as methodology for determining the quality and results of training.Practical significance. …”
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Cas12e orthologs evolve variable structural elements to facilitate dsDNA cleavage by Danyuan Li, Shouyue Zhang, Shuo Lin, Wenjing Xing, Yun Yang, Fengxia Zhu, Dingding Su, Chunlai Chen, Jun-Jie Gogo Liu

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Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models by Luisa Maria Nieto Ramirez, Carolina Mehaffy, Karen Marie Dobos

“…Immunomodulatory drugs targeting autophagy and other mechanisms were studied, exhibiting their potential as therapeutic alternatives.ConclusionSimpler, physiologically relevant, and ethically sound models, such as G. mellonella, are needed for studying innate responses in MTBC infection. …”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Copper, one of the most prolific transition metals in the body, is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations. …”
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On the Energy Efficiency of Indoor Air Conditioning by S. N. Osipov, A. V. Zakharenko, E. M. Shirokova

“…The air conditioning process is quite energy-intensive, but the growth of well-being in many republics of the former USSR, as well as the increasing complexity of the physiological adaptation of the human body to rising outdoor temperatures make it possible (and at the same time necessary) to implement these systems on a large scale. …”
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mRNA-lncRNA gene expression signature in HPV-associated neoplasia and cervical cancer by E. D. Kulaeva, E. S. Muzlaeva, E. V. Mashkina

“…Changes in gene activity in tumors reflect the biological diversity of cellular phenotype and physiological functions and can be an important diagnostic marker. …”
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Peripheral oxygen saturation levels as a guide to avoid hyperoxia: an observational study by Renate Stolmeijer, Jan C. ter Maaten, Jack Ligtenberg, Ewoud ter Avest

“…Abstract Background As iatrogenic hyperoxia has been related to adverse outcomes in critically ill patients, guidelines advise to titrate oxygen to physiological levels. In the prehospital setting where partial arterial oxygen (PaO2) values are often not readily available, titration of oxygen is based on peripheral oxygen saturations (SpO2). …”
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Antimicrobial peptide LL37 is potent against non-growing Escherichia coli cells despite a slower action rate by Salimeh Mohammadi, Derek Saucedo, Sattar Taheri-Araghi

“…However, the relationship between the action of AMPs and the physiological state of their target cells has been unclear, with recent reports offering conflicting views on the efficacy of AMPs against bacteria in a stationary phase. …”
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Experimental study of cognitive function against the background of partial food derivation and its correction by A.A. Kushta

“…After weight loss, rats were divided into 4 groups depending on the dietary adjustment schemes: 1 group - control animals, nutrition according to physiological needs; Group 2, partial food derivation (PFD), without compensatory nutrition; Group 3 – compensatory enteral nutrition with food mixture "Peptamen" (PFD+EX); Group 4 – enteral nutrition and the drug Glutargin (PFD+EX+Glutargin). …”
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Second-line systemic treatment for metastatic colorectal cancer: A systematic review and Bayesian network meta-analysis based on RCT. by Chengyu Sun, Enguo Fan, Luqiao Huang, Zhengguo Zhang

“…However, the therapeutic effect may be affected by the patient's physiological state, and clinicians should apply it based on actual conditions.…”
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