High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…The physiological role of a-synuclein (a-syn), an intrinsically disordered presynaptic neuronal protein, is believed to impact the release of neurotransmitters through interactions with the SNARE complex. …”
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Heterologous Expression of a Potential ‘<i>Paulownia fortunei</i>’ MYB Factor Gene, <i>PfMYB90</i>, Improves Salt and Cold Tolerance in <i>Arabidopsis</i> by Hongling Wang, Shizheng Shi, Guijie Luo, Ruifang Huang, Dezong Sui, Yunpeng Gao, Lei Wang

“…By measuring the corresponding physiological indexes after stress and detecting the expression levels of corresponding stress genes (<i>AtNHX1</i>, <i>AtSOS1</i>, <i>AtSOS2</i>, <i>AtSOS3</i>, <i>AtCBF1</i>, <i>AtCBF3</i>, <i>AtCOR15a</i>, <i>AtRD29a</i>), it was found that after <i>PfMYB90</i> gene transfer, <i>Arabidopsis</i> showed strong tolerance to salt and cold stresses. …”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…Men had higher serum BFRs concentrations than women, and the association between BFRs and NAFLD was also more prominent in men, which may be related to physiological differences between the sexes. Conclusions: Our findings offer evidence for single and mixed associations of BFRs and NAFLD in ordinary US adults. …”
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Assessment of Zinc Alpha-2 Glycoprotein Level in Gestational Diabetes Woman in Respect to Glycemic Status with and without Treatment by Bara Nahdh Saleem, Manal Khalid Abdulridha, Hind Abdalkhaliq Showman, Manal Sabbar

“…Adipocytes secrete a particular type of adipocytokine called zinc a2 glycoprotein (ZAG), and numerous reasearches have suggested that ZAG is involved in crucial physiological processes such as glucose metabolism. …”
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Blood loss in one-stage bilateral total knee arthroplasty: cruciate-retaining vs. posterior stabilized. A propensity score-matched analysis by Laoruengthana Artit, Tantimethanon Thanawat, Santisathaporn Nopparat, Inta-ngam Thisayapong, Pongpirul Krit, Rattanaprichavej Piti

“…Cruciate retaining (CR) TKA may theoretically result in less blood loss, offer better proprioception, and more physiologic kinematics compared to posterior stabilized (PS) TKA. …”
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Neovascular Glaucoma from Ocular Ischemic Syndrome Treated with Serial Monthly Intravitreal Bevacizumab and Panretinal Photocoagulation: A Case Report by Hassaan Asif, Zhuangjun Si, Steven Quan, Pathik Amin, David Dao, Lincoln Shaw, Dimitra Skondra, Mary Qiu

“…Therefore, in patients with open-angle NVG secondary to OIS, serial monthly anti-VEGF injections may be necessary combined with PRP to suppress underlying neovascular drive and regress anterior segment neovascularization, maintain physiologic IOP, and prevent synechial angle closure.…”
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Mechanistic studies on regulation of the activity of GPI-anchored serine protease testisin by WAN Jiahui, ZHOU Aiwu

“…Objective·To explore the activation methods and activity regulation mechanisms of the testisin zymogen in vitro, laying a foundation for further research on the physiological functions of testisin in organisms.Methods·The eukaryotic expression plasmid for the mouse-derived testisin (mTN) zymogen was constructed through full-gene synthesis and subsequently transfected into eukaryotic HEK293S cells for expression. …”
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Metabolic phenotype of adult mice offspring obtained from different variants of embryo transfer by M. V. Anisimova, Ya. Gong, N. S. Yudin, Yu. M. Moshkin, L. A. Gerlinskaya

“…ART procedures include the development of early embryos outside the mother’s body and the high probability of incomplete synchronization of the physiological state of the surrogate mother and transplanted embryos. …”
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Green remediation of lead (pb) from Pb-toxic soil by combined use of silicon nanomaterials and leguminous Lens culinaris L. plants by Tayyaba Naz, Muhammad Mazhar Iqbal, Bilal Raza, Muhammad Asad Mubeen, Muhammad Ather Nadeem, Abdullah Ahmed Al-Ghamdi, Mohamed S Elshikh, Muhammad Rizwan, Rashid Iqbal

“…Whereas Si and nano-Si lessened the negative effect of Pb toxicity by significantly reducing its concentration in plant roots and shoot, and improved agro-physiological traits of lentil in normal and Pb-toxic soil conditions. …”
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Molecular Mechanisms of Grain Chalkiness Variation in Rice Panicles by Zhong Li, Min Xi, Youzun Xu, Xueyuan Sun, Debao Tu, Yongjin Zhou, Yalan Ji, Linsheng Yang

“…This study conducted a genetic and physiological analysis of grains situated at distinct positions (upper, middle, and bottom primary branches of the rice panicle, denoted as Y1, Y2, and Y3) within a rice panicle using the Yangdao 6 variety. …”
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Wood Ash Liquid Fertilizer as Sustainable Soil Nutritional Supplement Modulates Changes on Growth and Fruits Nutritional Compositions of Capsicum frutescens L. by Racheal Tope-akinyetun, Zainab Mustapha, Musa Hussaini, Temitayo Kelani, Anthony Ojewumi

“…Ordinary water served as control. Agronomical, physiological, and fruit nutritional parameters of the pepper were determined. …”
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Biotechnological methods as a tool for efficient sugar beet breeding by T. P. Zhuzhzhalova, E. O. Kolesnikova, E. N. Vasilchenko, N. N. Cherkasova

“…A close association between morphological and physiological changes in in vitro cultured organs and tissues, on the one hand, and breeding traits, on the other hand, which allows the development of experimental systems for non-amphimictic plant reconstruction is shown. …”
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EEG alpha/beta features as a biomarker for quantifying pain in patients with lumbar disk herniation by Rumei Li, Wanqi Shao, Shumei Zhao, Lingli Wang, Chao Yu, Lanying Liu, Kuiying Yin

“…IntroductionAn objective and precise pain evaluation is of significant clinical value, and electroencephalography as a non-invasive physiological signal has been demonstrated to correlate with subjective pain perception. …”
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Isolation, screening and in-vitro characterization of plant growth-promoting Bradyrhizobium isolates from the nodules of Bambara groundnut (Vigna subterranean) for potential use as... by Osman Abdulai Seidu, Stephen Mwangi Githiri, John Mwibanda Wesonga, Victoria Wambui Ngumi

“…The isolates were assessed further on their ability to grow in varied physiological conditions. Among them, P4A6 and P4A18 demonstrated higher growth potential under pH 3, pH 5, pH 9, pH 11, 1% NaCl, 3% NaCl, 5% NaCl and high temperature range of 40°C–50°C than the rest of the isolates. …”
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Strategies to Promote ResiliencY (SPRY): a randomised embedded multifactorial adaptative platform (REMAP) clinical trial protocol to study interventions to improve recovery after s... by Derek C Angus, Jennifer Holder-Murray, Katherine Moll Reitz, Christopher W Seymour, Jennifer Vates, Melanie Quintana, Kert Viele, Michelle Detry, Michael Morowitz, Alison Morris, Barbara Methe, Jason Kennedy, Brian Zuckerbraun, Timothy D Girard, Oscar C Marroquin, Stephen Esper, Anne B Newman, Scott Berry, Matthew Neal

“…Introduction As the population ages, there is interest in strategies to promote resiliency, especially for frail patients at risk of its complications. The physiological stress of surgery in high-risk individuals has been proposed both as an important cause of accelerated age-related decline in health and as a model testing the effectiveness of strategies to improve resiliency to age-related health decline. …”
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Effect of melatonin on the contents of fatty acids and antioxidants of saffron by Mohammad Mehdi Samim, Ali Sorooshzadeh, Ali Mokhtassi-Bidgoli, Mohammad Sadegh Sabet

“…These findings highlight the promising role of melatonin in improving the physiological and biochemical attributes of saffron plants.…”
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An Innovative Drug Delivery System Loaded with a Modified Combination of Triple Antibiotics for Use in Endodontic Applications by Ardavan Parhizkar, Hanieh Nojehdehian, Fahimeh Tabatabaei, Saeed Asgary

“…PPCMs demonstrated pH close to normal physiological environment and antibacterial activity against E. faecalis and A.a in the first 2 days. …”
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Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands by Bárbara Marques, Diogo M. Engrácia, João Franco Machado, Jaime A. S. Coelho, Filipa Mendes, Tânia S. Morais

“…Stability studies confirmed the robustness of both complexes in biological media, with compound 1 maintaining good stability in buffer solutions mimicking physiological (pH 7.4) and tumor-like (pH 6.8) environments. …”
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E46K α-Synuclein Mutation Fails to Promote Neurite Outgrowth by Not Inducing Cdc42EP2 Expression, Unlike Wild-Type or A53T α-Synuclein in SK-N-SH Cells by Hyunja Jung, Seonghan Kim

“…Conclusions: Our findings suggest that WT and mutant α-syn are linked to Cdc42EP2 production in neuritogenesis, implying α-syn involvement in the physiological function of axon growth and synapse formation. …”
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Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases by Yichen Peng, Li Zhou, Yaju Jin, Danli Wu, Na Chen, Chengcai Zhang, Hongpeng Liu, Chunlan Li, Rong Ning, Xichen Yang, Qiuyue Mao, Jiaxin Liu, Pengyue Zhang

“…The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels. Mitochondria-associated endoplasmic reticulum membranes serve as physical contact channels between the endoplasmic reticulum membrane and the mitochondrial outer membrane, formed by various proteins and protein complexes. …”
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