Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge by Shahram Darabi, Enam Alhagh Charkhat Gorgich, Fatemeh Moradi, Auob Rustamzadeh

“…Amyloid-beta (Aβ) production is a normal physiological process, essential for neuronal function. …”
Get full text

Exploration of interstitial fluid proteome in Homo sapiens forearm through a cutting edge intradermal microdialysis and high-throughput proteomics approach: a pilot study by Yu Sakamoto, Naoto Fujii, Junko Shibato, Ravi Gupta, Cheol Woo Min, Sun Tae Kim, Ranjith Kumar Bakku, Randeep Rakwal

“…Abstract There has been increasing interest in utilizing biofluids in combination with high-throughput omics to identify biomarkers, to unravel mechanisms underlying internal physiological environments. Interstitial fluid (ISF) is noted as a high potential biofluid for continuous monitoring of cellular microenvironment where various metabolic processes occur. …”
Get full text

Characterization of the C5H11ORF96 gene in chickens: cloning, tissue distribution and investigation of its potential function in stress response regulation by Yiping Wan, Jiannan Zhang, Xiao Zhang, Jiliang He, Ningkun Shi, Yuanyou Li, Juan Li, Yajun Wang

“…Meanwhile, our finding provides essential insights into the physiological functions of C11ORF96 gene in vertebrates.…”
Get full text

Salicylic Acid Improved the Growth of <i>Dunaliella salina</i> and Increased the Proportion of <i>9-cis</i>-β-Carotene Isomers by Shuaicheng Xiang, Xiaoting Qiu, Xiaojun Yan, Roger Ruan, Pengfei Cheng

“…Moreover, SA can not only improve the salt tolerance of <i>D. salina</i>, but also increase the proportion of <i>9-cis</i> isomer, with higher physiological activity in β-carotene, thereby enhancing the application value of <i>D. salina</i>.…”
Get full text

Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis, calcium storage, and protein folding and processing. A number of physiological and pathological conditions, as well as a variety of pharmacological agents, are able to disturb proper ER function and thereby cause ER stress, which severely impairs protein folding and therefore poses the risk of proteotoxicity. …”
Get full text

Interactive effects of multiple stressors in coastal ecosystems by Shubham Krishna, Shubham Krishna, Carsten Lemmen, Serra Örey, Serra Örey, Serra Örey, Jennifer Rehren, Julien Di Pane, Moritz Mathis, Miriam Püts, Sascha Hokamp, Himansu Kesari Pradhan, Himansu Kesari Pradhan, Matthias Hasenbein, Jürgen Scheffran, Kai W. Wirtz

“…Climate warming is identified as the most dominant stressor which, in combination, with other stressors such as ocean acidification, eutrophication, and metal pollution exacerbate adverse effects on physiological traits such as growth rate, fitness, basal respiration, and size. …”
Get full text

Comparative response of fennel, ajwain, and anise in terms of osmolytes accumulation, ion imbalance, photosynthetic and growth functions under salinity by Javad Nouripour-Sisakht, Parviz Ehsanzadeh, Mohammad H. Ehtemam

“…Even though certain genotype- and species-specificities were observed in the salt-induced modifications of these physiological attributes, decreasing in growth, plant dry mass, root volume, relative water content, and K+ concentration concomitant to increasing in the catalase, ascorbate peroxidase, and guaiacol peroxidase activities, malondialdehyde, total soluble carbohydrates, proline and Na+ concentrations, Na+/K+, and essential oil were common to the examined species and genotypes. …”
Get full text

Impact of religious fasting on ocular dryness: objective and subjective assessment by Amal F. Alomari, Sara Issa, Asma Musleh, Mohammad Abusamak, Mohammad Abusamak, Omar Bdair, Omar Bdair, Saif Aldeen AlRyalat, Saif Aldeen AlRyalat, Alanoud Al-Wakfi, Mohammed Jaber, Ahmad Alloubani, Haitham Sahawneh, Haitham Sahawneh, Muhannd El-Faouri, Ayman Abdul Aziz, Muawyah Al Bdour

“…Lack of fluid intake may alter multiple physiological parameters, which can influence the ocular system. …”
Get full text

Proline Promotes Drought Tolerance in Maize by Pirzada Khan, Ashraf M. M. Abdelbacki, Mohammed Albaqami, Rahmatullah Jan, Kyung-Min Kim

“…Drought stress significantly affects maize (<i>Zea mays</i> L.) growth by disrupting vital physiological and biochemical processes. This study investigates the potential of proline supplementation to alleviate drought-induced stress in maize plants. …”
Get full text

MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…EMT is involved in multiple physiological and pathological processes in the human body. …”
Get full text

The relationship between physical activity and sleep quality among college students: The chain-mediating effects of self-control and mobile phone addiction. by Zhonggen Yin, Chengbo Yang, Tong Liu, Jialiang Yu, Xiaomei Yu, Shuting Huang, Yanhong Zhang

“…The psychological and physiological health of undergraduates was correlated with the sleep quality, which can be improved through increasing physical activity. …”
Get full text

Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F by P. H. Voermans, K. G. Go, G. J. Ter Horst, M. H. J. Ruiters, E. Solito, L. Parente

“…The results indicated that Anx-1 mRNA transcription is upregulated by either steroid, and that in the untreated animals there is a resting level of Anx-1 mRNA transcription, presumably reflecting physiological influences on Anx-1 expression.…”
Get full text

A novel cytoprotective organ perfusion platform for reconstructing homeostasis of DCD liver while alleviating IRI injury by Tingting Lan, Mingxing Yu, Tao Ming, Hong Wang, Juan Deng, Shuhan Cheng, Zhongyang Shen, Deling Kong

“…The development of BBGs demonstrates the feasibility of recreating physiological liquid–gas circulation in vitro, offering an alternative platform for isolated organ perfusion, especially for applications involving cell therapy.…”
Get full text

Effects of Different Cultivation Modes on the Storage Quality and Flavor of Harvested Chinese Leek by ZHOU Xinyuan, TAO Jiejie, LIU Mingchi, ZUO Jinhua, WU Zhanhui, ZHENG Yanyan, KANG Xinna, LIANG Hao, MU Jianlou, CHEN Jie, JI Yanhai

“…In order to explore the effects of different cultivation modes (hydroponics, soil culture and substrate culture) on the postharvest quality and flavor substances of Chinese leek during storage, ‘Hangyan 791’ Chinese leek grown in hydroponics, soil culture or substrate culture were stored at 20 ℃ and relative humidity of 80%–85% after harvest and evaluated for changes in physiological quality and flavor substances. The results showed that soil culture and substrate culture better maintained the mass loss rate and decay rate of Chinese leek during storage, while hydroponics resulted in higher mass loss rate and decay rate. …”
Get full text

Hydrogen sulfide attenuates disturbed flow-induced vascular remodeling by inhibiting LDHB-mediated autophagic flux by Xia Wang, Xiying Huang, Yongya Zhang, Huanhuan Huo, Guo Zhou, Linghong Shen, Long Li, Ben He

“…Hydrogen sulfide (H2S) is involved in physiological processes within the cardiovascular system. …”
Get full text

miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells by Virginie Joris, Elizabeth R. Balmayor, Martijn van Griensven

“…In conclusion, miR-125b affinity for targets implicated in bone remodeling changed depending on the in vitro models used to induce mineralization and led to opposite physiological effects. This work shows the complexity of drugs such as dexamethasone and opens the door for new in vitro models of mineralization.…”
Get full text

Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology by Alexandra Chera, Mircea Stancu-Cretu, Nicolae Radu Zabet, Octavian Bucur

“…Abstract DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable elements) and pathological processes (cancer and repetitive sequences-associated diseases) are regulated. …”
Get full text

Effects of repetitive or consecutive fasting-induced weight loss on glucose tolerance in rats fed high-fat diet by Yudai Nonaka, Makoto Inai, Shuhei Nishimura, Shogo Urashima, Shin Terada

“…Our previous study found that weight loss from 3 consecutive days of fasting led to deteriorated glucose tolerance, but it is not clear whether this was due either to the physiological stress associated with consecutive fasting or fasting itself. …”
Get full text

The Timing of Femur Fracture Fixation is an Important Factor for Prolonged Mechanical Ventilation by Hyung Chul Choi, Kwang Hwan Jung, Kyu Hyouck Kyoung, Seong Ho Choi

“…The surgical correction of long bone fractures plays a critical role not only in improving functional outcomes, but also in reducing physiological derangements, including MV duration. This study investigated the factors affecting prolonged MV (PMV) in severely injured patients with femur fractures. …”
Get full text

Bacillus velezensis A-27 as a potential biocontrol agent against Meloidogyne incognita and effects on rhizosphere communities of celery in field by Yanan Yao, Liyi Wang, Haozhen Zhai, Hailong Dong, Jianming Wang, Zengqi Zhao, Yumei Xu

“…In this study, strain A-27 was identified as Bacillus velezensis based on its morphological, physiological, and molecular characteristics, including 16 S rRNA and gyrA sequencing. …”
Get full text