Exercise promotes peripheral glycolysis in skeletal muscle through miR-204 induction via the HIF-1α pathway by Sang R. Lee, Kang Joo Jeong, Moeka Mukae, Jinhee Lee, Eui-Ju Hong

“…These findings suggest a novel physiological role for miR-204 in promoting skeletal muscle glycolysis, particularly in situations where insulin action is limited.…”
Get full text

A Reinforcement Learning Model for Optimal Treatment Strategies in Intensive Care: Assessment of the Role of Cardiorespiratory Features by Cristian Drudi, Maximiliano Mollura, Li-wei H. Lehman, Riccardo Barbieri

“…Given the potentially continuous availability of cardiorespiratory features extracted from bedside physiological waveform monitoring, the proposed framework paves the way for a real time recommendation system for sepsis treatment.…”
Get full text

Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms by Yue Xiao, Yingxuan Feng, Jianxin Zhao, Wei Chen, Wenwei Lu

“…Gut microbiota has emerged as a novel target in various host physiological disorders including aging. Comprehensive understanding on changes of gut microbiota during aging, in particular gut microbiota characteristics of centenarians, can provide us possibility to achieving healthy aging or intervene pathological aging through gut microbiota-directed strategies. …”
Get full text

Electrocardiographic Assessment of National-Level Triathletes: Sinus Bradycardia and Other Electrocardiographic Abnormalities by Mike Climstein, Kenneth S. Graham, Michael Stapelberg, Joe Walsh, Mark DeBeliso, Kent Adams, Trish Sevene, Chad Harris

“…These findings highlight the need for comprehensive cardiac evaluation in athletes to distinguish between physiological and pathological adaptations.…”
Get full text

Body Mind Therapy Improving Mental Health in Teenager by Putu Intan Daryaswanti, Ni Made Sri Muryani, Ni Made Diah Pusparini Pendet

“…Conclusion: This intervention can be relied upon to improve adolescents' physical and mental health, particularly in reducing physiological stress and improving aspects of mental health such as emotional difficulties. …”
Get full text

Factors Predicting Ventilator Dependence in Patients with Ventilator-Associated Pneumonia by Chia-Cheng Tseng, Kuo-Tung Huang, Yung-Che Chen, Chin-Chou Wang, Shih-Feng Liu, Mei-Lien Tu, Yu-Hsiu Chung, Wen-Feng Fang, Meng-Chih Lin

“…Eligibility was evaluated according to the criterion for VAP, Sequential Organ Failure Assessment (SOFA) score, Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) score. …”
Get full text

Dynamics in the activity of peroxidase and its isoforms in leaves of different apple cultivars by A. E. Mishko, E. O. Lutskiy

“…Various approaches are used for identification of the most resistant fruit crop cultivars, including the analysis of different physiological and biochemical indicators. In Krasnodar Territory, Russia, one of the major stressors in summer is the hydrothermal stress. …”
Get full text

Sevuparin strongly reduces hepcidin expression in cells, mice, and healthy human volunteers by Michela Asperti, Andrea Denardo, Magdalena Gryzik, Kristina E. M. Persson, Göran Westerberg, John Öhd, Maura Poli

“…Abnormally high hepcidin levels resulting from inflammation in chronic diseases cause iron restriction with the onset of anemia. Restoring physiological levels of hepcidin could contribute to ameliorating anemia in these patients. …”
Get full text

TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress by Veronica Tisato, Stefania Gallo, Elisabetta Melloni, Claudio Celeghini, Angelina Passaro, Giorgio Zauli, Paola Secchiero, Carlo Bergamini, Alessandro Trentini, Gloria Bonaccorsi, Giuseppe Valacchi, Giovanni Zuliani, Carlo Cervellati

“…The oxinflammatory pathway has been recently suggested to play a crucial role in regulating the activity of TNF-related apoptosis-inducing ligand (TRAIL), a TNF superfamily member that can mediate multiple signals in physiological and pathological processes. Therefore, we investigated the associations between TRAIL and key players of vascular redox homeostasis. …”
Get full text

From fibrosis to granuloma: drug induced systemic sarcoidosis-like reaction after rituximab in a patient with primary Sjögren’s syndrome by Rui Rua Coelho, Sara Xavier Pires, José Ricardo Brandão, Inês Furtado

“…Moreover, granulomatous lymphocytic interstitial lung disease associated with common variable immunodeficiency and immune reconstitution syndrome in patients wirh human immunodeficiency virus show clinical similarities to DISR and can help unveil new cytogenic and physiologic pathways. To the authors’ knowledge this is the first report of a systemic sarcoidosis-like reaction with necrotizing granulomas following an anti-CD20 therapy and also the first described in a pSS patient - underlining the importance of recognizing necrotizing sarcoid granulomatous processes in the diferential diagnosis of patients with caseous inflammation. …”
Get full text

Female Brain and Endocrinological Research-Veteran (FemBER-Vet) study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health ou... by Tamlyn Watermeyer, Elliott Atkinson, Glyn Howatson, Gill McGill, Christina Dodds, Paul Ansdell, Chinedu Udeh-Momoh

“…<h4>Methods</h4>The Female Brain and Endocrinological Research-Veteran (FemBER-Vet) Study will create a highly-phenotyped readiness cohort of ex-service persons as well as non-veterans to assess the impacts of, and risks associated with, military service on brain health, using state-of-the-art non-invasive cognitive, physiological and biomarker capture techniques. FEMBER-Vet will include 90 participants across three study groups (30 female veterans, 30 male veterans, 30 female civilians) to delineate the precise biological, socio-demographic, health, lifestyle, military-related, and life-course determinants of brain health outcomes (psychosocial, cognitive, neurophysiological, and other biomarkers).…”
Get full text

A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine by Nalú Navarro-Alvarez, Beatriz M. M. Gonçalves, Alec R. Andrews, David H. Sachs, Christene A. Huang

“…In addition, the side effects of CFA injections were evaluated based on clinical findings, behavioral changes, physiologic state, and (histo)pathologic lesions. Pigs were injected with CFA at the back of the neck’s skin at different depths. …”
Get full text

Impact of trypanosomiasis on male camel infertility by Sara Salah Abdel-Hakeem, Gaber Megahed, Ahmed M. Al-Hakami, Mohammed E. M. Tolba, Yasser F. M. Karar

“…A marked reduction in testosterone levels and a high expression of HSP70 in spermatogonia, spermatocytes, Sertoli cells, and Leydig cells were observed.DiscussionConsequently, a combination of physiological and hormonal analyses may serve as a reliable indicator of Trypanosoma infection.…”
Get full text

The development of preterm infants from low socio-economic status families: The combined effects of melatonin, autonomic nervous system maturation and psychosocial factors (ProMote... by Theano Kokkinaki, Nicole Anagnostatou, Maria Markodimitraki, Theano Roumeliotaki, Manolis Tzatzarakis, Elena Vakonaki, Giorgos Giannakakis, Aristidis Tsatsakis, Eleftheria Hatzidaki

“…Maternal perinatal mental health disorders have persistent effects on behavioral and physiological functioning throughout the lifespan and may even be evident across generations. …”
Get full text

Nanoparticles assisted drug delivery for effective management of Glioblastoma by Mansi Damani, Nagesh Nilawar, Munira Momin, Raghumani Singh Ningthoujham, Tabassum Khan

“…Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are often limited by the ability of the tumor to circumvent therapeutic effects and by the physiological barriers that restrict drug delivery to the brain parenchyma. …”
Get full text

Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol by David A McAllister, Frances S Mair, Peter Hanlon, Isabella Fauré, Neave Corcoran, Elaine Butterly, Jim Lewsey

“…Frailty is associated with older age and describes a state of increased susceptibility to decompensation in response to physiological stress. A range of measures have been used to quantify frailty. …”
Get full text

Effect of Football on Fatigue of Patients with Breast Cancer Treated with Nano-Chemotherapy by Yu Zhang, Haonan Niu, Zhiwei Peng

“…Football can improve the fatigue, physiological, psychological, and psychological states of breast cancer patients after nano-chemotherapy; reduce fatigue, anxiety, and depression; improve sleep; and ultimately improve the quality of life.…”
Get full text

Expression profile of cannabinoid receptor 2 in ovine ileum during prenatal development by Mehmet Özbek, Hidayet Tutun, Emel Ergün, Feyzullah Beyaz, Levent Ergün

“…CB2 expression was determined in epithelial cells, smooth muscles, enteric neurons and Peyers patches in ileum fetal sheep under physiological conditions. Considering the morphology of epithelial cells with intense CB2 staining and previous findings, CB2 may be a possible marker for enteroendocrine cells during the prenatal period.…”
Get full text

Assessment of seed quality and identifying sources of contaminants for maize seed across seed generations accessed through different seed source in Northwest Amhara. by Tilaye Anbes, Dereje Abebe, Melkamu Elmihun, Semagn Asredie, Wasihune Ewenetu, Yematew Chanie

“…The objectives of the study are to clearly put sources of contaminants at each seed class level and suggest possible recommendations to maintain seed quality and to test the physical and physiological quality parameters of each seed classes. …”
Get full text

Correlations between Achilles tendon moment arm and plantarflexor muscle architecture variables. by Logan Faux-Dugan, Stephen J Piazza

“…Ultrasound-based measurements were made of the architecture (fascicle length, muscle volume, physiological cross-sectional area, and anatomical cross-sectional area) of the lateral and medial gastrocnemius and the Achilles tendon moment arm was assessed using a technique that combined ultrasound imaging and motion analysis. …”
Get full text