In Vitro Model for Studying Malignancy Associated Changes by Xiao Rong Sun, Yonghong Zheng, Calum MacAulay, Stephen Lam, Alexei Doudkine, Branko Palcic

“…Malignancy associated changes (MAC) can be defined as subtle morphological and physiologic changes that are found in ostensibly normal cells of patients harboring malignant disease. …”
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Parameter space exploration within dynamic simulations of signaling networks by Cristina De Ambrosi, Annalisa Barla, Lorenzo Tortolina, Nicoletta Castagnino, Raffaele Pesenti, Alessandro Verri, Alberto Ballestrero, Franco Patrone, Silvio Parodi

“…It turns out that our MIM is a non-isomorphic directed graph. For non physiological directions of propagation of the signal the network is quite resistant to perturbations. …”
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Multifaceted roles of melatonin: Investigating coffee leaf melatonin concentration as a potential indicator of vegetative growth by Siswanto Dian, Nanda Aldian Dwi, Muwahida Imroatin, Istiqomah Nurul, Munawarti Aminatun, Mastuti Retno

“…Results showed that all leaf samples—young, middle-aged, and old—from both species exhibited melatonin, confirming its role in various physiological processes. LC-MS analysis revealed melatonin concentrations of 0.72% and 0.58% in young and middle-aged Liberica leaves, respectively. …”
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Taxonomy and Polyphasic Characterization of Alkaline Amylase Producing Marine Actinomycete Streptomyces rochei BTSS 1001 by Aparna Acharyabhatta, Siva Kumar Kandula, Ramana Terli

“…A comprehensive study of morphological, physiological parameters, cultural characteristics, and biochemical studies was performed. …”
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Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit by Waqas Badar, Sheetal R. Inamdar, Peter Fratzl, Tim Snow, Nicholas J. Terrill, Martin M. Knight, Himadri S. Gupta

“…Extracting the 3D fibril structure from 2D small‐angle X‐ray scattering before and during physiological compression reveals of dominant deformation modes, including crystallinity transitions, lateral fibril compression, and reorientation, which vary in a coupled, nonlinear, and correlated manner across the cartilage‐bone interface. …”
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The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study by Zhengli Tang, Yuanyuan Lu, Yiming Hao, Robert Morris, Di Kang, Fang Wang, Lin Fan, Weijian Wang, Yiqin Wang, Feng Cheng

“…The ΔbaPWV value, defined as the absolute value of the difference between bilateral baPWV, also showed a positive correlation with aging. Many underlying physiological conditions such as hyperlipidemia, hypertension, diabetes, and hyperglycemia have previously been shown to elevate baPWV and contribute to the decline of arterial function. …”
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Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains by Arun John, Vetrivel Umashankar, Subramanian Krishnakumar, Perinkulam Ravi Deepa

“…This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. …”
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High-Fat Diet-Induced Alterations in the Feeding Suppression of Low-Dose Nisoxetine, a Selective Norepinephrine Reuptake Inhibitor by Nicholas T. Bello, Amy L. Walters, Jessica L. Verpeut, Priscila P. Cunha

“…Central noradrenergic pathways are involved in feeding and cardiovascular control, physiological processes altered by obesity. The present studies determined how high-fat feeding and body weight gain alter the sensitivity to the feeding suppression and neural activation to a selective norepinephrine reuptake inhibitor, nisoxetine. …”
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Comprehensive analysis of advanced glycation end-products in commonly consumed foods: presenting a database for dietary AGEs and associated exposure assessment by Qiaozhi Zhang, Huatao Li, Ruixing Zheng, Lili Cao, Shufen Zhang, Shuifeng Zhang, Huadong Sheng, Yuhao Jiang, Yanbo Wang, Linglin Fu

“…The presented AGE database allows accurate assessment of dietary exposure to these glycotoxins to explore their physiological impacts on human health.…”
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Exploring pattern-specific components associated with hand gestures through different sEMG measures by Yangyang Yuan, Jionghui Liu, Chenyun Dai, Xiao Liu, Bo Hu, Jiahao Fan

“…Additionally, we intuitively visualized the heatmaps of pattern-specific components based on the topological position of electrode arrays and explored their physiological interpretability by examining the correspondence between the heatmaps and muscle activation areas.…”
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Hemoglobin: A Nitric-Oxide Dioxygenase by Paul R. Gardner

“…The mechanism of NOD catalysis by representative single domain hemoglobins and multidomain flavohemoglobin occurs through a multistep mechanism involving O2 migration to the heme pocket, O2 binding-reduction, NO migration, radical-radical coupling, O-atom rearrangement, nitrate release, and heme iron re-reduction. Unraveling the physiological functions of multiple NODs with varying expression in organisms and the complexity of NO as both a poison and signaling molecule remain grand challenges for the NO field. …”
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Biting force and tongue muscle strength as useful indicators for eating and swallowing capability assessment among elderly patients by Xinmiao Wang, Gangying Zheng, Mingsong Su, Yanqiu Chen, Hua Xie, Weijia Han, Qing Yang, Jianqin Sun, Jianshe Chen

“…This work measured occlusal force and tongue muscle strength of elderly patients and then assessed whether correlations existed between oral physiological properties and the eating and swallowing capability. …”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…At genetically sensitive animals inflammatory bowel diseases (IBD) develop at various effects on innate and adaptive systems of immune defense (knock-out and transgenic mice), causing changes of expression of significant immunologic factors with distortion of pro- and anti-inflammatory cells and molecules ratio at their contact to microbiota structures. The physiological state of intestine is characterized by balanced interaction of effector (Th1, Th2, Th17) and regulatory (Treg) cells determining presence of immune tolerance to resident microflora antigens. …”
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The Role of Cardiopulmonary Exercise Test in IPF Prognosis by Christina Triantafillidou, Effrosyni Manali, Panagiotis Lyberopoulos, Likourgos Kolilekas, Konstantinos Kagouridis, Sotirios Gyftopoulos, Konstantinos Vougas, Anastasia Kotanidou, Manos Alchanatis, Anna Karakatsani, Spyros A. Papiris

“…The integration of oxygen consumption and diffusing capacity proved to be a reliable predictor of survival because both variables reflect major underlying physiologic determinants of exercise limitation.…”
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Dual Regulation of Ionic Effect on <i>Zostera marina</i> L. Seed Germination and Leaf Differentiation in Low-Salinity Conditions by Peilong Li, Yaping Gao, Zengjie Jiang, Linjie Wang, Xiaoli Sun, Jiaqi Wang, Jing Wang, Haidong Sui, Junwei Wang, Yitao Zhang

“…Different salinity conditions lead to morphological and physiological differences. To investigate the impacts of salinity and osmotic pressure on the germination and early development of <i>Zostera marina</i> seeds, this study utilized seawater with different salinity conditions and PEG-6000 solutions to simulate various non-ionic osmotic pressures and examine the germination, cotyledon growth, and leaf differentiation over 28 days, as well as determine the biochemical traits on days 1, 3, 5, and 7. …”
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Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice by Tatsuhito Himeno, Hideki Kamiya, Keiko Naruse, Zhao Cheng, Sachiko Ito, Taiga Shibata, Masaki Kondo, Jiro Kato, Tetsuji Okawa, Atsushi Fujiya, Hirohiko Suzuki, Tetsutaro Kito, Yoji Hamada, Yutaka Oiso, Kenichi Isobe, Jiro Nakamura

“…Angioblast-like cells were obtained from mouse embryonic stem cells and transplantation of these cells improved several physiological impairments in diabetic polyneuropathy: hypoalgesia, delayed nerve conduction velocities, and reduced blood flow in sciatic nerve and plantar skin. …”
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Thermal strain and fluid balance during a 72-km military route march in a field setting by Beng Hoong Poon, Suriya Prakaash, Ya Shi Teo, Priscilla Weiping Fan, Jason Kai Wei Lee

“…Introduction: A physiological profiling study was conducted to evaluate thermal strain as well as fluid and electrolyte balances on heat-acclimatised men performing a 72-km route march in a field setting. …”
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Partly cloudy with a chance of mosquitoes: Developing a flexible approach to forecasting mosquito populations by Travis McDevitt‐Galles, Arthur T. Degaetano, Sarah C. Elmendorf, John R. Foster, Howard S. Ginsberg, Mevin B. Hooten, Shannon LaDeau, Katherine M. McClure, Sara Paull, Erin Posthumus, Ilia Rochlin, Daniel Grear

“…We describe four primary life history and physiological traits that can be used to constrain models and demonstrate how this prior information can be harnessed to develop a more general understanding of how mosquito activity will shift under changing climates. …”
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Selection of Nonlethal Early Biomarkers to Predict Gilthead Seabream (Sparus aurata) Growth by Rafael Angelakopoulos, Andreas Tsipourlianos, Katerina A. Moutou, Alexia E. Fytsili, Anthi Tsingene, Eleni Galliopoulou, Leonidas Papaharisis, Zissis Mamuris, Themistoklis Giannoulis, Arkadios Dimitroglou

“…The goal of the present study was to develop a toolbox for rapidly anticipating the dynamics of fish growth following the introduction of a new feed; nonlethal, biochemical, and molecular markers that provide insights into physiological changes in the fish. A nutritional challenge by feeding a conventional feed rich in FM protein (FM diet) versus an experimental feed rich in plant protein (PP) and low FM inclusion (PP diet), in 20 different families of gilthead sea bream (Sparus aurata) was performed. …”
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A Novel, Cell-Compatible Hyaluronidase Activity Assay Identifies Dextran Sulfates and Other Sulfated Polymeric Hydrocarbons as Potent Inhibitors for CEMIP by Anja Schmaus, Sofia Spataro, Paul Sallmann, Stephanie Möller, Leonardo Scapozza, Marco Prunotto, Jonathan P. Sleeman

“…One of these is heparin, a sulfated glycosaminoglycan produced by mast cells that constitutes the first described physiological CEMIP inhibitor. The most potent inhibitor (IC₅₀ of 1.8 nM) is dextran sulfate, a synthetic sulfated polysaccharide. …”
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