The effects of SN Ps in the regions of positioning RNA polymerase II on the TBP/promoter affinity in the genes of human circadian clock by O. A. Podkolodnaya, D. A. Rasskazov, N. L. Podkolodnyy, N. N. Podkolodnaya, V. V. Suslov, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

“…Genetic variability in the genes of circadian clock is manifested as the phenotypic variability of physiological functions and behavior as well as disorders of the function of not only the clock but also other systems, leading to the development of a pathologies. …”
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Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn’s Disease by Aditi Kumar, Hafid O. Al-Hassi, Helen Steed, Oliver Phipps, Matthew J. Brookes

“…Bile acids help maintain the physiological balance of the gut microbiome and the integrity of the intestinal epithelial barrier. …”
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Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role of <i>ACE2</i>, <i>IFI44</i>, and <i>NDUFAF4</i> in Long-Lasting Olfactory Dysfunction by Beatrice Spedicati, Alessandro Pecori, Maria Pina Concas, Aurora Santin, Romina Ruberto, Giuseppe Giovanni Nardone, Andrea D’Alessandro, Giancarlo Tirelli, Paolo Boscolo-Rizzo, Giorgia Girotto

“…The analysis highlighted how an increased gene score in the <i>ACE2</i> gene is associated with a worse olfactory performance, while an increased gene score in the <i>IFI44</i> and <i>NDUFAF4</i> genes is associated with a better olfactory function. Considering the physiological role of the proteins encoded by these genes, it can be hypothesized that a reduced expression of <i>ACE2</i> may be associated with a protracted and severe inflammatory response in the olfactory epithelium, thus worsening patients’ smell abilities. …”
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Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies by Armin Sepp, Morris Muliaditan

“…Surprisingly, the predicted tissue concentrations of both these targets exceed the Kd values of their respective therapeutic mAbs. Physiologically based pharmacokinetic (PBPK) modeling indicates that in these conditions only about 0.05% of the dosed mAb is likely to reach the solid tumor target cells. …”
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Modelling Cell Origami via a Tensegrity Model of the Cytoskeleton in Adherent Cells by Lili Wang, Weiyi Chen

“…The results demonstrate that the inclusion of the NSK can increase the folding angle of the microplate, indicating that the cell is closer to its physiological environment, while increased complexity can reduce the folding angle of the microplate since the folding angle is depended on the cell types. …”
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The Algorithm for Predicting the Numerical Value of Salivary Cortisol Based on Heart Rate Variations in the Healthy Men by Mohammad Reza Noruzi, Marzieh Barzegar, Mahdi Alizadeh, Boshra Hatef

“…Conclusion: In this study, it was found that a set of linear and non-linear indicators of HRV with high power can predict the amount of salivary cortisol in the best case with a low error percentage of 7.43 by the RBF algorithm, and instead of stress self-report that does not cover the physiological part. It can be a more accurate tool in the intelligent evaluation of the stress system.…”
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Evaluation of Pulse Rate, Oxygen Saturation, and Respiratory Effort after Different Types of Feeding Methods in Preterm Newborns by Dipen Vasudev Patel, Dharti Shah, Kunjal A. Kantharia, Mayur K. Shinde, Jaishree Ganjiwale, Kushal Shah, Somashekhar Marutirao Nimbalkar

“…This prospective observational study was carried out at a tertiary care neonatal unit. Participants. Physiologically stable preterm newborns with PMA less than 37 weeks on full enteral feeds were included in the study. …”
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The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases by Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman

“…The Pah1-CC (catalytic core) variant, which lacks regulatory sequences, was inhibited by both drugs in accordance with molecular docking data. That Pah1 is a physiological target of sertraline in S. cerevisiae is supported by the observations that the overexpression of PAH1 rescued the sertraline-mediated inhibition of pah1Δ mutant cell growth, the lethal effect of overexpressing Pah1-CC was rescued by sertraline supplementation, and that a sublethal dose of the drug resulted in a 2-fold decrease in TAG content.…”
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Formyl Met-Leu-Phe-Stimulated FPR1 Phosphorylation in Plate-Adherent Human Neutrophils: Enhanced Proteolysis but Lack of Inhibition by Platelet-Activating Factor by Algirdas J. Jesaitis, Jeannie Gripentrog, Jovanka M. Voyich

“…We examined a microtiter plate format for measurement of FPR1 phosphorylation in adherent PMN at high densities and found that a new phosphosensitive FPR1 fragment, 25K-FPR1, accumulates in SDS-PAGE extracts. 25K-FPR1 is fully inhibited by diisopropylfluorophosphate PMN pretreatment but is not physiologic, as its formation failed to be significantly perturbed by ATP depletion, time and temperature of adherence, or adherence mechanism. 25K-FPR1 was minimized by extracting fMLF-exposed PMN in lithium dodecylsulfate at 4°C prior to reduction/alkylation. …”
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The potential impact of glycine supplementation on the process of aging by Michalina Wójcikiewicz, Julia Kulbacka, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia-Ileczko, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“…These combined effects may help preserve physiological function, slow the onset of age-associated diseases, and promote healthspan. …”
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Dynamic Demodulation Algorithm for Bio-radar Sensors Based on Range Tapper by Changyu LIU, Hao ZHANG, Fanglin GENG, Zhongrui BAI, Peng WANG, Zhenfeng LI, Lidong DU, Xianxiang CHEN, Zhen FANG

“…However, the commonly used range Fast Fourier Transform (FFT) presents certain limitations: The breathing amplitude of the subject may cross the range bin boundary, compromising signal integrity, while breathing movements can cause amplitude modulation of physiological signals, hindering waveform recovery. To address these reasons, we propose an algorithm architecture featuring range tap reconstruction and dynamic demodulation. …”
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Design of the Multi-Bioactive Graphene-Oxide/Gelatin/Alginate Scaffolds as Dual ECM-Mimetic and Specific Wound Healing Phase-Target Therapeutic Concept for Advanced Wound Healing by Marko Demenj, Martina Žabčić, Marija Vukomanović, Tatjana Ilić-Tomić, Dušan Milivojević, Simonida Tomić, Dubravka Živanović, Marija M. Babić Radić

“…<b>Results:</b> The scaffolds exhibited a highly porous interconnected morphology with adjustable porosity (93–96%) and mechanical strength (1.10–2.90 MPa), hydrophilic nature with high capacity to absorb physiological fluids, and stable adhesion to the skin tissue. …”
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Sex Differences in Parent and Child Pain Ratings during an Experimental Child Pain Task by Erin C Moon, Christine T Chambers, Anne-Claire Larochette, Kelly Hayton, Kenneth D Craig, Patrick J McGrath

“…The first objective of the present study was to examine the effect of the presence of mothers versus fathers on children’s subjective ratings, facial expressions and physiological responses to acute pain. The second objective was to examine whether child and parent sex influence parents’ proxy ratings of their children’s pain. …”
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Determination of mutagenicity of chemical compounds, physical factors and environmental pollutants by the Drosophila melanogaster wing somatic mutation and recombination test by L. P. Zakharenko, I. K. Zakharov

“…SMART can be used to evaluate the effect of various factors on the genome: physical (temperature, various types of radiation, electromagnetic fields), biogenic (genetic, physiological, infectious factors) and a wide range of chemical compounds. …”
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PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling by Koji Hashimoto, Yuji Kamijo, Takero Nakajima, Makoto Harada, Makoto Higuchi, Takashi Ehara, Hidekazu Shigematsu, Toshifumi Aoyama

“…Peroxisome proliferator-activated receptor α (PPARα), a member of the steroid/nuclear receptor superfamily, is known to perform various physiological functions. Recently, we reported that PPARα in activated mesangial cells exerted anti-inflammatory effects and that the deficiency of PPARα resulted in high susceptibility to glomerulonephritis. …”
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Real-Time Facial Expression Recognition Based on Image Processing in Virtual Reality by Qingzhen Gong, Xuefang Liu, Yongqiang Ma

“…More and more people are getting into VR, meaning that objective physiological measures to assess a user's emotional state automatically are becoming more critical. …”
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The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation by Xiaowei Chen, Yu Wang, Fang Xu, Xiaofei Wei, Junfang Zhang, Chuang Wang, Hua Wei, Shujun Xu, Peiyun Yan, Wenhua Zhou, Istvan Mody, Xiaohong Xu, Qinwen Wang

“…Bisphenol-A (BPA), a widely used synthetic compound in plastics, disrupts endocrine function and interferes with physiological actions of endogenous gonadal hormones. …”
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What a women desire: Application of conjoint analysis for analysing the choice of menstrual hygiene products and factors influencing their consummatory behaviour by Tiwari Abhay Kumar, Patel Vaishali, Saroj Chitra

“…Background/Aim: Middle-aged adolescent girls and women experience menstruation, a normal and physiologic occurrence. Using the myths and beliefs that were already prevalent, they created their own approach of dealing with the menstrual cycle. …”
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Dietetics students' opinion on food and their future profession by Priscila Koritar, Maria Clara de Moraes Prata Gaspar, Cristina Larrea-Killinger, Marle dos Santos Alvarenga

“…Two main categories were defined for food: biological and psycho-sociocultural aspects, and two for nutritionists: health promoter and integral health promoter; 69% indicated the function of food as only biological and 61,3% see the dietitian to be only a health promoter, considering only physiological aspects. Students from public institutions responded more for psycho-sociocultural aspects and integral health promotion (p<0.0001). …”
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Bedside cerebral microvascular imaging of patients with disorders of consciousness: a feasibility study by Qianqian Ge, Lijie Huang, Qiang Fu, Shuai Han, Rui Wang, Jianghong He, Changhui Li, Changhui Li, Jianwen Luo, Long Xu

“…We compared the imaging results from uPDI with traditional PDI and identified the physiological and pathological conditions with uPDI.ResultsDetailed microvascular images of both cortical and subcortical areas were obtained using uPDI through the craniectomy window. …”
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