Early life gut microbiome and its impact on childhood health and chronic conditions by Harold Nunez, Pamela A. Nieto, Ruben A. Mars, Maryam Ghavami, Cheryl Sew Hoy, Kimberley Sukhum

“…Based on human and animal data, we conclude that the early-life microbiome is a determinant of long-term health, impacting physiological, metabolic, and immune processes. The early-life gut microbiome field faces challenges. …”
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Successful management of a Comatose Patient with Traumatic Brain Exposure with a fronto-Parieto-occipital flap by Charles Chidiebele Maduba, Ugochukwu Uzodimma Nnadozie

“…The dilemma when deciding whether to perform a definitive reconstruction is how long to wait for physiological recovery before an intervention complicates the situation. …”
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Monitoring in the Intensive Care by Eric Kipnis, Davinder Ramsingh, Maneesh Bhargava, Erhan Dincer, Maxime Cannesson, Alain Broccard, Benoit Vallet, Karim Bendjelid, Ronan Thibault

“…The present paper will describe the physiological basis, interpretation of, and clinical use of the major endpoints of perfusion/oxygenation adequacy and of temperature, respiratory, nutritional, and metabolic monitorings.…”
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Donor-Recipient Size Mismatch in Paediatric Renal Transplantation by J. Donati-Bourne, H. W. Roberts, R. A. Coleman

“…The transplantation of an adult kidney into a size mismatched paediatric recipient significantly reduces waiting times for surgery; however, it presents further challenges in terms of both the surgical procedure and the post-operative management of the patient’s physiological parameters.…”
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Functional Constipation in Children: overview and new outcomes by Kamila Stępień, Maria Przygoda, Joanna Śnieżna, Gabriela Trestka, Sabina Adamczyk, Urszula Zelik, Jakub Dziewic, Wojciech Florczak, Wiktoria Domino, Jagienka Włodyka, Karol Dzwonnik

“…A multidisciplinary approach is essential for effective treatment, addressing both physiological and psychological aspects to optimize long-term health outcomes for children with FC. …”
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Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling by Jayalakshmi Krishnan, Sangdun Choi

“…A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. …”
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Orthodontic retainers: are they all the same? by Telma Martins de ARAUJO, Paula Paes FERREIRA, Izabelle Alice Pinheiro Barros LISBOA, Carlos Jorge VOGEL, Carolina Ribeiro STARLING

“…ABSTRACT Introduction: It is known that the stability of the results obtained with orthodontic treatment depends, in addition to the functional and aesthetic aspects, also on the adequate planning of the retention devices, the patient’s compliance with this new phase, and the physiological changes that the human body experiences over the years, throughout the craniofacial aging process. …”
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Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy by Fengyao Sun, Wen Li, Ruihang Du, Mingchan Liu, Yi Cheng, Jianxing Ma, Siyuan Yan

“…While the DDR plays a pivotal role in preserving genomic stability, thus resisting cellular senescence and cell death under both physiological and radio-chemotherapy conditions. Recently, an increasing number of studies have shown closely correlation between these two biological processes, and then promoting tumor progression. …”
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The Populus MYB transcription factor PSAR1 negatively regulates salt stress and is a repressor of ABA signaling by Qing Fang, Caiyun Zhang, Jingjie Liu, Zhi Zeng, Yanke Lu

“…Overall, these results illuminate the Populus PSAR1 mediates environmental conditions, gene expression, and physiological ABA status.…”
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Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice by Jiyeon Hwang, Sangbhin Lee, Junichi Okada, Li Liu, Jeffrey E. Pessin, Streamson C. Chua, Gary J. Schwartz, Young-Hwan Jo

“…Abstract The visceral organ-brain axis, mediated by vagal sensory neurons, is essential for maintaining various physiological functions. Here, we investigate the impact of liver-projecting vagal sensory neurons on energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions. …”
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Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse by Luciana Garbugino, Eleonora Centofante, Francesca R. D’Amato

“…Environmental enrichment has been proven to have positive effects on both behavioral and physiological phenotypes in rodent models of mental and neurodevelopmental disorders. …”
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The Role of Oxidative Stress in the Aging Process by Barbara F. Oliveira, José Augusto Nogueira-Machado, Míriam M. Chaves

“…Although reactive oxygen species (ROS) are predominantly implicated in causing cell damage, they also play a major physiological role in several aspects of intracellular signaling and regulation. …”
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Gut-Heart Axis: Microbiome Involvement in Restrictive Cardiomyopathies by Samuel Jaimez-Alvarado, Itzel Ivonn López-Tenorio, Javier Barragán-De los Santos, Dannya Coral Bello-Vega, Francisco Javier Roldán Gómez, Amedeo Amedei, Enrique Alexander Berrios-Bárcenas, María Magdalena Aguirre-García

“…The human microbiome, composed of billions of microorganisms, influences various physiological and pathological processes, including cardiovascular health. …”
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SensoTrust: Trustworthy Domains in Wireless Sensor Networks by Pedro Castillejo, José-Fernán Martínez-Ortega, Lourdes López, José Antonio Sánchez Alcón

“…Since private data is being shared (physiological measures, medical records, etc.), implementing security mechanisms in these networks has become a major challenge. …”
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Engineering cardiology with miniature hearts by Xiaojun Xia, Miner Hu, Wenyan Zhou, Yunpeng Jin, Xudong Yao

“…We discuss the methodologies for creating cardiac organoids, including self-organization techniques, biomaterial-based scaffolds, 3D bioprinting, and organ-on-chip platforms, which have significantly enhanced the structural complexity and physiological relevance of in vitro cardiac models. We examine their applications in fundamental research and medical innovations, highlighting their potential to transform our understanding of cardiac biology and pathology. …”
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Gastroesophageal Reflux Disease and Tooth Erosion by Sarbin Ranjitkar, John A. Kaidonis, Roger J. Smales

“…Although gastroesophageal reflux is a normal physiologic occurrence, excessive gastric and duodenal regurgitation combined with a decrease in normal protective mechanisms, including an adequate production of saliva, may result in many esophageal and extraesophageal adverse conditions. …”
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Pore Geometry Optimization of Titanium (Ti6Al4V) Alloy, for Its Application in the Fabrication of Customized Hip Implants by Sandipan Roy, Debojyoti Panda, Niloy Khutia, Amit Roy Chowdhury

“…The present study investigates the mechanical response of representative volume elements of porous Ti-6Al-4V alloy, to arrive at a desired range of pore geometries that would optimize the reduction in stiffness necessary for biocompatibility with the stress concentration arising around the pore periphery, under physiological loading conditions with respect to orthopedic hip implants. …”
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Is the BCG Vaccine Safe for Undernourished Individuals? by Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Thais Graziela Donegá França, Raphael Sanches Peres, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Alexandrina Sartori

“…These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers. …”
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Zebrafish as a model for human epithelial pathology by Ahmed Abu-Siniyeh, Moayad Khataibeh, Walid Al-Zyoud, Majed Al Holi

“…Abstract Zebrafish (Danio rerio) have emerged as an influential model for studying human epithelial pathology, particularly because of their genetic similarity to humans and their unique physiological traits. This review explores the structural and functional homology between zebrafish and human epithelial tissues in organs, such as the gastrointestinal system, liver, and kidneys. …”
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Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus by Lusha Cen, Fengling Xing, Liying Xu, Yi Cao

“…The distinct structure of NFAT5 governs its physiological and pathogenic roles, indicating its opposing functions. …”
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