PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

“…The effects of PTOV1 on the tumor-associated phenotypes of CRC were detected by several in vitro assays and in vivo mouse models. …”
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Mosaic Turner Variant Adult Female Presenting with XO/XY Karyotype by Sigin George, Vikas Karamchand Dagar, N. Nagaraja, Barun Kumar Chakrabarty

“…Patients with 45,X/46,XY mosaicism may have a phenotypic variation of the external genitalia and exhibit features ranging from normal male to ambiguous to female genitalia with features of TS. …”
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The Differentiation Potential of Apical Papilla Cells in Relation to Tenascin-C and Syndecan-1 Expression and Their Potential Role in Regeneration by K. Kodonas, A. Fardi, S. Papadimitriou, C. Gogos

“…Conclusions: Cell differentiation potential in the developing swine apex is progressively restricted to the newly formed dental pulp, whereas phenotypic expression of apical papilla cells remains undetermined unless the new microenvironment triggers cell differentiation towards the odontoblastic lineage.…”
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Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging by Chen Zhu, Youfa Wang, Xiaosong Yang, Qiran Zhao, Wenyan Xu, Xiaolu Wang, Yanjun Liang, Qihui Chen, Shenggen Fan

“…Plant-based food consumption correlates with increased telomere length and reduced phenotypic age, while animal-based food intake is linked to adverse aging effects. …”
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Unveiling alfalfa root rot resistance genes through an integrative GWAS and transcriptome study by Fei He, Ming Xu, Hao Liu, Yanchao Xu, Ruicai Long, Junmei Kang, Qingchuan Yang, Lin Chen

“…Results Under conditions of inoculation with Fusarium oxysporum, we conducted a statistical analysis of six phenotypic traits in alfalfa. Significant phenotypic variation was observed among different alfalfa varieties. …”
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Detection of bla NDM-1 Encoding Imepenemase among the Imipenem-Resistant Gram-Negative Bacilli Isolated from Various Clinical Samples at a Tertiary Care Hospital of Eastern Nepal:... by S. Gautam, N. R. Bhattarai, K. Rai, A. Poudyal, B. Khanal

“…These were screened for metallo-β-lactamase (MBL) production by phenotypic assays such as double-disc synergy test (DDST) and combined disc diffusion test (CDDT). …”
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Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma by Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese, Rosa Terracciano, Rosario Maselli

“…Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic inflammatory patterns. …”
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Chemogenomics for steroid hormone receptors (NR3) by Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A. Marschner, Daniel Merk

“…Endoplasmic reticulum stress resolving effects of N3 CG subsets in proof-of-concept application validate suitability of the set to connect phenotypic outcomes with targets and to explore NR3 receptors from a translational perspective.…”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…Given the clinical phenotypes observed in patients with Nprl2 mutations, in this study, we sought to investigate the neuronal cell type contributions of Nprl2 to NDD behaviors. …”
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Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. …”
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Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy by Cheng-Zhi Wang, Robert A. Kazmierczak, Abraham Eisenstark

“…We compare the means by which these therapeutic candidate strain models were selected for study, their tumor targeting and tumor destruction phenotypes in vitro and in vivo, and what is currently known about the mechanisms by which they target and destroy tumors.…”
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In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways by Erik Skoglund, Henrietta Abodakpi, Rafael Rios, Lorena Diaz, Elsa De La Cadena, An Q. Dinh, Javier Ardila, William R. Miller, Jose M. Munita, Cesar A. Arias, Vincent H. Tam, Truc T. Tran

“…Phenotypic assays showed that ceftolozane/tazobactam resistance in the strain with AmpCV213A variant was associated with increased β-lactamase hydrolysis activity. …”
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How does the mode of evolutionary divergence affect reproductive isolation? by De Sanctis, Bianca, Schneemann, Hilde, Welch, John J.

“…When divergent populations interbreed, the outcome will be affected by the genomic and phenotypic differences that they have accumulated. In this way, the mode of evolutionary divergence between populations may have predictable consequences for the fitness of their hybrids, and so for the progress of speciation. …”
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Physical health and ecological momentary assessments during COVID-19: Data from the ‘Corona Health’ app usersZenodo by Johannes Allgaier, Felizitas Eichner, Stefan Störk, Peter Heuschmann, Rüdiger Pryss

“…The dataset incorporates Ecological Momentary Assessments (EMA), Patient-reported Outcome Measures (PROMs), GPS data, and digital phenotyping from app users who consented. The data includes responses from 1805 mostly German users who completed baseline and follow-up questionnaires, capturing their physical health status over time. …”
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Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency by Nanis S. Marzuki, Firman P. Idris, Hannie D. Kartapradja, Alida R. Harahap, Jose R. L. Batubara

“…Although we were unable to identify clear correlations between genotypic and phenotypic characteristics in this study, we clearly showed that individuals who were homozygous or compound heterozygous for any of the harmful mutations were more likely to exhibit classic 5ARD2 phenotypes, lower EMS, female assignment at birth, and virilisation during puberty. …”
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Role of Monoclonal Antibodies in the Treatment of Asthma by Paul M O’Byrne

“…New treatment approaches developed to manage some of the phenotypes of severe refractory asthma have included humanized monoclonal antibodies (hMabs).…”
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Missed rifampicin and isoniazid resistance by commercial molecular assays by L Richards, F Ismail, J Nel, S V Omar

“…We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by molecular testing and were only identified by phenotypic testing. …”
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A Successful Treatment of Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization for Hydrocephalus in Walker-Warburg Syndrome by Tomoko Tanaka, Catharine J. Harris, Sarah S. Barnett, N. Scott Litofsky

“…Mutations in these genes result in a broad phenotypic spectrum ranging from the severe WWS to a mild congenital muscular dystrophy with no brain involvement. …”
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Genotype by Environment Interaction on Grain Yield Stability and Iron and Zinc Content in OPV of Pearl Millet in Ghana Using the AMMI Method by Peter Anabire Asungre, Richard Akromah, Alexander Wireko Kena, Prakash Gangashetty

“…Genotypic variance (σ2g) contributed a greater proportion of the phenotypic variance (σ2p) for plant height (530.31) and grain Fe content (34.72). …”
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Case report: Discovery of novel CTNNB1 mutations and comparison of clinical characteristics in two patients with NEDSDV by Eojin Lee, Ja Young Choi, Shin-Seung Yang

“…Both patients shared common NEDSDV features; however, distinct phenotypic variations were observed depending on the type of genomic variant. …”
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