Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention by Fuli Fan, Shubei Liu, Bin Wang, Xiaojian Song, Wei Wang

“…This study aimed to characterize transcriptomic features, immune phenotypes and potential signaling pathways of AMB, and also to confirm its alternations in systemic rheumatic diseases via combined transcriptome analyses. …”
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A Case Series on Cardiac and Skeletal Involvement in Two Families with PRKAG2 Mutations by Anita Sri, Piers Daubeney, Sanjay Prasad, John Baksi, Maria Kinali, Inga Voges

“…This case report demonstrates that the PRKAG2 mutation presents with various phenotypes already in pediatric patients. Case Summary. …”
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Genetic evaluation of breeding efficiency estimated by Tomar ‎equation in Holstein cattle by F.R. Al-Samarai

“…Heritability of breeding efficiency was 0.08, whereas phenotypic trend for the same trait was positive and significant (P < 0.01), being 0.07%/year. …”
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Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic by Christian Diamant Mossoro-Kpinde, Alexandre Manirakiza, Jean-Robert Mbecko, Pembé Misatou, Alain Le Faou, Thierry Frank

“…Typhimurium could be amplified genically. Only phenotypic resistance to tetracycline and aminosides was found. …”
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Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases by Leay-Kiaw Er, Semon Wu, Lung-An Hsu, Ming-Sheng Teng, Yu-Ching Sun, Yu-Lin Ko

“…Clinical and metabolic phenotypes, 13 inflammatory markers, 5 adipokines, and 6 single-nucleotide polymorphisms (SNPs) covering the RARRES2 region were analyzed. …”
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Development and validation of PCR marker array for molecular selection towards spring, vernalization-independent and winter, vernalization-responsive ecotypes of white lupin (Lupin... by Anna Surma, Michał Książkiewicz, Wojciech Bielski, Bartosz Kozak, Renata Galek, Sandra Rychel-Bielska

“…A recent genome-wide association study highlighted several loci significantly associated with the most contrasting phenotypes, including deletions in the promoter of the FLOWERING LOCUS T homolog, LalbFTc1, and some DArT-seq/silicoDArT loci. …”
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Comparative analysis of allele frequencies for DNA polymorphisms associated with disease and economically important traits in the genomes of Russian and foreign cattle breeds by A. V. Igoshin, G. A. Romashov, E. N. Chernyaeva, N. P. Elatkin, N. S. Yudin, D. M. Larkin

“…To date, many loci controlling significant phenotypes have been identified, which is successfully used in the world practice of marker-assisted selection to improve breed properties. …”
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Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in C. neoformans during thermal stress by David Goich, Amanda L. M. Bloom, Sean R. Duffy, Maritza N. Ventura, John C. Panepinto

“…Using a combination of molecular assays and phenotypic analysis, we show that increased output from the Gcn2 pathway in a Hog1 deletion mutant is associated with rescue of thermal stress adaptation at both molecular and phenotypic scales. …”
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Role of metabolism, resistance, and/or antagonism as drivers of endomicrobiomes assemblage in Origanum heracleoticum L by Giulia Semenzato, Francesco Vitali, Arcangela Frascella, Ludovica Lollini, Stefano Mocali, Alessio Papini, Renato Fani, Giovanni Emiliani

“…In this study, we performed a phenotypic characterization of bacterial endophytes isolated from the medicinal plant Origanum heracleoticum, together with the determination of the antibiotic resistance profiles and the antagonistic interactions of communities within and across different plant organs. …”
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I tweet, therefore I am: a systematic review on social media use and disorders of the social brain by Nancy Yang, Bernard Crespi

“…What implications do these recent changes have for socio-cognitive phenotypes and mental disorders? We have conducted a systematic review on the relationships between social media use and mental disorders involving the social brain. …”
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Leaf spot resistance in sweet and sour cherries by M. S. Lenivtseva, A. P. Kuznetsova, E. E. Radchenko

“…An increase was observed in the frequencies of virulence phenotypes capable of strongly affecting donors used in breeding for resistance. …”
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Burden of Sickle Cell Disease in Ghana: The Korle-Bu Experience by Eugenia V. Asare, Ivor Wilson, Amma A. Benneh-Akwasi Kuma, Yvonne Dei-Adomakoh, Fredericka Sey, Edeghonghon Olayemi

“…During the period under review 5,451 patients were seen at the GICG, with 20,788 clinic visits. The phenotypes were HbSS (55.7%) and HbSC (39.6%) with other sickle cell phenotypes (4.7%). …”
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Structuring the genetic collection of sunflower by V. A. Gavrilova, I. N. Anisimova, N. V. Alpatieva, E. A. Porokhovinova

“…New data were obtained on the phenotypic diversity of sunflower and stability of its agronomic traits across the growing seasons.Conclusion. …”
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Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis by Selma Maacha, Heba Sidahmed, Shana Jacob, Giusy Gentilcore, Rita Calzone, Jean-Charles Grivel, Chiara Cugno

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Natural selection and evolution: evolving concepts by Andre J. van Wijnen, Eric Lewallen

“…Evolution is an overarching framework that incorporates the laws of natural selection and clarifies why phenotypic variation can increase in prevalence and result in species adaptations. …”
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Prevalence of and Risk Factors for Self-Reported Chronic Bronchitis in a Canadian Population: The Canadian Community Health Survey, 2007 To 2008 by Chandima Karunanayake, Briana Hagen, James Dosman, Punam Pahwa

“…BACKGROUND: Chronic bronchitis (CB) represents one of the respiratory disease phenotypes that affect the Canadian health care system significantly. …”
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Cardiomyopathy Classification: Ongoing Debate in the Genomics Era by Charles McCartan, Robert Mason, S. R. Jayasinghe, Lyn R. Griffiths

“…Traditionally cardiomyopathies were defined according to phenotypical appearance. Now, as our understanding of the pathophysiology of the different entities classified under each of the different phenotypes improves and our knowledge of the molecular and genetic basis for these entities progresses, the traditional classifications seem oversimplistic and do not reflect current understanding of this myriad of diseases and disease processes. …”
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Landscape connectivity alters the evolution of density-dependent dispersal during pushed range expansions by Dahirel, Maxime, Bertin, Aline, Calcagno, Vincent, Duraj, Camille, Fellous, Simon, Groussier, Géraldine, Lombaert, Eric, Mailleret, Ludovic, Marchand, Anaël, Vercken, Elodie

“…Here we used descendants from these experimental landscapes to look at how the range expansion process and connectivity interact to shape phenotypic evolution. Interestingly, we found no clear and consistent phenotypic shifts, whether along expansion gradients or between reference and low connectivity replicates, when we focused on low-density trait expression. …”
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Insufficient gene expression and lost gene regulatory network may underlie the mechanism of Hirschsprung Disease in 5p–syndrome by Yizhao Luan, Peng Li, Yuanyuan Luo, Hong Zhang, Xiaochun Zhu, Yan Zhang, Aihua Yin, Qiang Wu, Chengwei Chai

“…Taken together, our study reveals the genetic basis of HSCR or intestinal phenotypes in 5p minus patients, highlighting the importance of studying gene regulatory relationships to explain phenotypic heterogeneity.…”
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Evaluating Dose- and Time-Dependent Effects of Vitamin C Treatment on a Parkinson’s Disease Fly Model by Huynh Man Anh, Dao My Linh, Vuu My Dung, Dang Thi Phuong Thao

“…Previous studies demonstrated that curcumin at 1 mM and vitamin C at 0.5 mM could improve PD-like phenotypes induced by this knockdown. With the purpose of further investigating the efficiency of vitamin C in PD treatment, we used dUCH knockdown Drosophila model to examine the dose- and time-dependent effects of vitamin C on PD-like phenotypes. …”
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