Showing 141 - 160 results of 3,155 for search '"phenotype"', query time: 0.11s Refine Results
  1. 141
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    Phenotypic detection of carbapenem-resistant Enterobacterales in clinical isolates at a tertiary care hospital by Astha Sinha, Mamta Gour, Riti Jain Seth

    Published 2024-01-01
    “…The maximum carbapenem resistance was seen in the age group of 16–45 years and the most number of CRE isolates were from ICUs. Phenotypic test results indicated that 54.28% (38/70) of isolates were positive for carbapenemase production by either of the phenotypic methods. …”
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  4. 144

    A continuous phenotype space model of RNA virus evolution within a host by Andrei Korobeinikov, Conor Dempsey

    Published 2014-02-01
    “…Due to their very high replication and mutation rates, RNA virusescan serve as an excellent testing model for verifying hypothesis andaddressing questions in evolutionary biology.In this paper, we suggest a simple deterministic mathematical modelof the within-host viral dynamics, where a possibility for random mutations incorporates.This model assumes a continuous distribution of viral strainsin a one-dimensional phenotype space where random mutations aremodelled by Brownian motion (that is, by diffusion).Numerical simulations show that randommutations combined with competition for a resource result in evolutiontowards higher Darwinian fitness: a stable pulse traveling waveof evolution, moving towards higher levels of fitness,is formed in the phenotype space.The advantage of this model, compared with the previously constructedmodels, is that this model is mechanistic and is based on commonlyaccepted model of virus dynamics within a host, and thus it allowsan incorporation of features of the real-life host-virus system such as immuneresponse, antiviral therapy, etc.…”
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  5. 145

    Phenotypic insights into genetic risk factors for immune-related adverse events in cancer immunotherapy by Haochuan Ma, Dili Song, Haibo Zhang, Taidong Li, Xing Jin

    Published 2024-11-01
    “…To address the urgent need for identifying risk factors associated with irAEs, we conducted a comprehensive phenotype-wide Mendelian randomization analysis (MR-PheWAS). …”
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  6. 146

    Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype by Li-jun Xie, Dan-dan Ruan, Jian-hui Zhang, Yi Li, Li Chen, Mao-lin Yan, Ming-dian Yu, Jie-wei Luo, Hui-zhen Zhang

    Published 2021-01-01
    “…Two subjects presented a rare common bile duct polyp phenotype. No extraintestinal manifestations were observed. …”
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  7. 147

    Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

    Published 2025-01-01
    “…Here, we present a network-based statistical approach, Pathopticon, that uses CMap to build cell type-specific gene-drug perturbation networks and integrates these networks with cheminformatic data and diverse disease phenotypes to prioritize drugs in a cell type-dependent manner. …”
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  8. 148

    Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance by Maristela Ruberti, Luis Gustavo Romani Fernandes, Patricia Ucelli Simioni, Dirce Lima Gabriel, Áureo Tatsumi Yamada, Wirla Maria da Silva Cunha Tamashiro

    Published 2012-01-01
    “…In this work, we evaluated the effects of administration of OVA on phenotype and function of intraepithelial lymphocytes (IELs) from small intestine of transgenic (TGN) DO11.10 and wild-type BALB/c mice. …”
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  9. 149

    Species evolution: cryptic species and phenotypic noise with a particular focus on fungal systematics by Anusha H. Ekanayaka, Anusha H. Ekanayaka, Samantha C. Karunarathna, Samantha C. Karunarathna, Saowaluck Tibpromma, Arun Kumar Dutta, Danushka Sandaruwan Tennakoon, Anuruddha Karunarathna, Ekachai Chukeatirote, Dong-Qin Dai, Steven L. Stephenson, Sajeewa S. N. Maharachchikumbura, Chao Liu, Alan J. L. Phillips

    Published 2025-02-01
    “…The evolution of a species can be understood in the context of two major concepts—the cryptic species concept and the phenotypic noise concept. The former represents morphologically indistinguishable but genetically distinct evolutionary lineages, while the latter represents the phenotypic variations of an isogenic population. …”
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    Phenotyping determination of cyp1a2 enzyme activity using caffeine in sheep by Kamil Uney, Bünyamin Tras

    “…Correlations between the plasma (PX/CF)MR&#8594;3-16 h and (PX/CF)AUC ratios were determined to investigate of the CYP1A2 phenotyping by single blood sampling in practice.<p> <b>Results:</b> It was determined that the more reliable sampling time within the plasma (PX/CF)MR&#8594;3-16 h ratios in the determination of the CYP1A2 phenotyping was 10 h after CF administration. …”
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  12. 152

    Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR by Francisco J. Rios, Marianna M. Koga, Mateus Pecenin, Matheus Ferracini, Magnus Gidlund, S. Jancar

    Published 2013-01-01
    “…Since PAFR in macrophages is associated with suppressor function, we examined the effect of oxLDL on macrophage phenotype. It was found that the presence of oxLDL during macrophage differentiation induced high mRNA levels to IL-10, mannose receptor, PPARγ and arginase-1 and low levels of IL-12 and iNOS. …”
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  13. 153

    Altered Phenotype of Circulating Dendritic Cells and Regulatory T Cells from Patients with Acute Myocarditis by Paola del Carmen Guerra-de-Blas, Daniela Cruz-González, Elena B. Martínez-Shio, Roberto González-Amaro, Héctor González-Pacheco, Esther Layseca-Espinosa, Carlos D. Escobedo-Uribe, Adriana E. Monsiváis-Urenda

    Published 2022-01-01
    “…However, a particular DC phenotype in this disease has not been assessed. Herein, we aim to evaluate myeloid (mDCs) and plasmacytoid DC (pDC) phenotype, as well as Treg levels from myocarditis patients and healthy controls. …”
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    Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks by Kishore Hari, Pradyumna Harlapur, Aashna Saxena, Kushal Haldar, Aishwarya Girish, Tanisha Malpani, Herbert Levine, Mohit Kumar Jolly

    Published 2025-02-01
    “…This low dimensionality in phenotypic space arises from extensive feedback loops in these networks arranged to effectively enable the formation of two teams of mutually inhibiting nodes. …”
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  16. 156

    Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

    Published 2025-01-01
    “…Gaining traction in this field is the use of disease data linking genes with pathological phenotypes and combining this with drugtarget interaction data.MethodsWe introduce methodology to associate drugs with effects, both intended and adverse, using a tripartite network approach that combines drug-target and target-phenotype data, in which targets can be represented as proteins and protein domains.ResultsWe were able to detect associations for over 140,000 ChEMBL drugs and 3,800 phenotypes, represented as Human Phenotype Ontology (HPO) terms. …”
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  17. 157

    Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype by I. A. Goncharova, E. Yu. Bragina, I. Zh. Zhalsanova, M. B. Freidin, M. S. Nazarenko

    Published 2022-01-01
    “…The risk of developing a comorbid phenotype of AD and AH is associated with the A allele of rs7038716 and the T allele of rs7025144 of the TLR4/AL160272.2 genes, the A allele of rs1010461 of the ANG gene and the C allele of rs2022318 of the ABTB2/CAT genes. …”
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    MOLECULAR MARKING OF SUNFLOWER LINES WITH DIFFERENT ABILITY TO SUPPRESSION OF THE CYTOPLASMIC MALE STERILITY PHENOTYPE by Yu. I. Karabitsina, I. N. Anisimova, V. A. Gavrilova, N. V. Alpatieva, A. G. Pinaev, E. B. Kuznetsova, V. T. Rozhkova

    Published 2018-06-01
    “…Ninety five lines of sunflower genetic collection differing by their ability to suppress the CMS phenotype were molecularly marked with the use of 7 primer pairs. …”
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