Identification of a metabolic brain network characterizing essential tremor by Solange Volnov, Hamzah Baagil, Oliver Winz, Hans-Juergen Kaiser, Sanne Katherina Meles, Joerg Bernhard Schulz, Kathrin Reetz, Felix Manuel Mottaghy, Florian Holtbernd

“…Our findings suggest ET is characterized by an abnormal brain network associated with disease phenotype.…”
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Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species by Kristopher J. L. Irizarry, Doug Bryant, Jordan Kalish, Curtis Eng, Peggy L. Schmidt, Gini Barrett, Margaret C. Barr

“…Unlike model organisms in which considerable scientific resources are used to experimentally validate genotype-phenotype relationships, endangered species typically lack the necessary sample sizes and economic resources required for such studies. …”
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IITA’s genebank, cowpea diversity on farms, and farmers’ welfare in Nigeria by Abel-Gautier Kouakou, Ademola Ogundapo, Melinda Smale, Nelissa Jamora, Julius Manda, Michael Abberton

“…In addition, “Helium”, a multi-platform pedigree visualization tool with phenotype display was used to gather information about improved cowpea breeding lines and their pedigrees. …”
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Case Report: The first Korean familial case of BCAP31-related deafness, dystonia, and cerebral hypomyelination by Yoong-A Suh, Jisun Hwang, Go Hun Seo, Rin Khang, Jang Hoon Lee, Moon Sung Park, Young Bae Sohn

“…This report expands the understanding of genotype-phenotype correlations in DDCH syndrome and highlights the variable phenotypes in manifesting females.…”
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T-Cell Large Granular Lymphocytic Leukemia with Extremely Rare Immunophenotype (CD4/CD8 Double-Positive) Followed by Multiple Myeloma Diagnosis by Dina Soliman, Sherin Sallam, Susanna Akiki, Deena Mudawi, Feryal Ibrahim

“…CD4/CD8 double-positive T-large granular leukemia is the first case reported in the literature. This rare phenotype is either underreported or a truly rare clinical entity. …”
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CRYβB2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line by Amr A. Waly, London Harper, Jodie M. Fleming, Lindsey M. Costantini

“…These findings provide a novel link between a previously identified differentially expressed gene, CRYβB2, in driving breast cancer phenotypes by modulating a class of adhesion proteins.…”
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Customers’ Preferences for Crape Myrtle (<i>Lagerstroemia</i> L.) Across Geographical Regions: Evidence from China by Siwen Hao, Donglin Zhang, Yafeng Wen

“…In northeast China, flower color and planting form played pivotal roles, while in northwest China, spatial ambiance and plant phenotype were significant in shaping preferences. …”
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Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection by Rong Li, Xiao-xia Jiang, Lin-fang Zhang, Xiao-ming Liu, Ting-zi Hu, Xiu-juan Xia, Ming Li, Can-xia Xu

“…In conclusion, our results indicated that ILC2-mediated innate immune response might play a potential role in dominant type 2 phenotype and immunosuppressive microenvironment in H. pylori infection.…”
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Unraveling the Genetic Heartbeat: Decoding Cardiac Involvement in Duchenne Muscular Dystrophy by Valeria Novelli, Francesco Canonico, Renzo Laborante, Martina Manzoni, Alessandra Arcudi, Giulio Pompilio, Eugenio Mercuri, Giuseppe Patti, Domenico D’Amario

“…Assessing the genetic origin of the phenotypic variability of the disease in both the onset and progression of cardiomyopathy in DMD would be extremely helpful in managing these patients. …”
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The role of IFN-γ/CXCL10 axis in Mycoplasma pneumonia infection by Yanxia Zou, Feng Huang, Jiying Sun, Yidan Zheng, Ge Dai, Ting Wang, Canhong Zhu, Yongdong Yan, Renzheng Wang, Zhengrong Chen

“…Moreover, numbers of macrophages, predominantly with a M1 phenotype, were significantly increased in BALFs of children of MPP. …”
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Identification and validation of depression-associated genetic variants in the UK Biobank cohort with transcriptome and DNA methylation analyses in independent cohorts by Muataz S. Lafta, Aleksandr V. Sokolov, Gull Rukh, Helgi B. Schiöth

“…The transcriptome and methylation analyses suggested nominal significance for some gene probes (TNXB- and NCAM1) with depressed phenotype. The present study identified six protein-coding genes associated with depression and primarily involved in inflammation (TNXB), neuroplasticity (NCAM1 and LTBP3), immune response (BTN3A2), cell survival (DAG1) and circadian clock modification (FHIT). …”
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Assessing bnAb potency in the context of HIV-1 envelope conformational plasticity. by Caio Foulkes, Nikolas Friedrich, Branislav Ivan, Emanuel Stiegeler, Carsten Magnus, Daniel Schmidt, Umut Karakus, Jacqueline Weber, Huldrych F Günthard, Chloé Pasin, Peter Rusert, Alexandra Trkola

“…To systematically investigate the impact of variability in Env conformation on bnAb potency we screened 126 JR-CSF point mutants for generalized neutralization sensitivity to weakly neutralizing antibodies (weak-nAbs) depending on trimer opening and plasma from people with chronic HIV-1 infection. 23 mutations resulted in a highly neutralization sensitive phenotype, which was associated with de-stabilization of the closed, prefusion conformation. …”
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Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome by Jonah J. Scott-McKean, Adriano L. Roque, Krystyna Surewicz, Mark W. Johnson, Witold K. Surewicz, Alberto C. S. Costa

“…Memantine, however, did not rescue this phenotype. Because 4xHFS-induced LTP had not yet been characterized in Ts65Dn mice, we also investigated the effects of picrotoxin, amyloid beta oligomers, and soluble recombinant human prion protein (rPrP) on this form of LTP. …”
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Dissecting the genetic architecture of sunflower disc diameter using genome‐wide association study by Yavuz Delen, Ravi V. Mural, Semra Palali‐Delen, Gen Xu, James C. Schnable, Ismail Dweikat, Jinliang Yang

“…Upon aggregating the phenotypic data from multiple years, we estimated the broad sense heritability (H2) of the disc diameter trait to be 0.88. …”
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Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank by Jaegyun Jung, Sangyeon Lee, Jeong Ho Lee, Doheon Lee

“…Results A total of 28 923 subjects with depression phenotypes were included in the study. In retrospective cohort analysis, the moderate and highly active groups were at lower risk of self-harm behaviour. …”
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Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases by Simona Delia Nicoară, Sergiu Șușman, Oana Tudoran, Otilia Bărbos, Gabriela Cherecheș, Simion Aștilean, Monica Potara, Olga Sorițău

“…However, their translation into the clinical realm is limited by various factors: the immunogenicity of the cells, the stability of the cell phenotype, the predilection of SCs to form tumors in situ, the abnormality of the microenvironment, and the association of a synaptic rewiring. …”
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Automated craniofacial biometry with 3D T2w fetal MRI. by Jacqueline Matthew, Alena Uus, Alexia Egloff Collado, Aysha Luis, Sophie Arulkumaran, Abi Fukami-Gartner, Vanessa Kyriakopoulou, Daniel Cromb, Robert Wright, Kathleen Colford, Maria Deprez, Jana Hutter, Jonathan O'Muircheartaigh, Christina Malamateniou, Reza Razavi, Lisa Story, Joseph V Hajnal, Mary A Rutherford

“…<h4>Objectives</h4>Evaluating craniofacial phenotype-genotype correlations prenatally is increasingly important; however, it is subjective and challenging with 3D ultrasound. …”
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Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway by Ruina Han, Dongyang Zhou, Ning Ji, Zhifeng Yin, Jian Wang, Qin Zhang, Hao Zhang, Jinlong Liu, Xinru Liu, Han Liu, Qinglin Han, Jiacan Su

“…Our in vitro findings indicate that FA-GDEVs promote the polarization towards a reparative M2 macrophage phenotype by modulating the PI3K-AKT pathway. Further corroboration comes from in vivo studies, which demonstrate that FA-GDEVs not only concentrate efficiently in the affected joints but also markedly reduce the manifestations of RA. …”
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A Disentangled Representation-Based Multimodal Fusion Framework Integrating Pathomics and Radiomics for KRAS Mutation Detection in Colorectal Cancer by Zhilong Lv, Rui Yan, Yuexiao Lin, Lin Gao, Fa Zhang, Ying Wang

“…Recently, the advancement of machine learning, especially deep learning, has greatly promoted the development of KRAS mutation detection from tumor phenotype data, such as pathology slides or radiology images. …”
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Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene by Marcella M. Baldewijns, Iris J. H. van Vlodrop, Kim M. Smits, Peter B. Vermeulen, Gert G. Van den Eynden, Fiona Schot, Tania Roskams, Hein van Poppel, Manon van Engeland, Adriaan P. de Bruïne

“…Differences in angiogenic activity within the group of ccRCCs were reported and strong genotype-phenotype correlations were found in patients with VHL disease, raising a question about the importance of VHL inactivation status in angiogenic behaviour and tumour progression.…”
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