Rosuvastatin effects on the HDL proteome in hyperlipidemic patients by Vavlukis Ana, Mladenovska Kristina, Davalieva Katarina, Vavlukis Marija, Dimovski Aleksandar

“…The ELISA validation of PFN1 segregated the subjects into responders and non-responders, as PFN1 levels after rosuvastatin were shown to mostly depend on the subjects’ inflammatory phenotype. Findings from this study introduce novel insights into the HDL proteome and statin pleiotropism.…”
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Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation by Wenlong Shang, Guilin Chen, Yinxiu Li, Yujuan Zhuo, Yuhong Wang, Zhicai Fang, Ying Yu, Huiwen Ren

“…Notably, SMF promoted the wound healing by skewing the macrophage polarization towards M2 phenotype, thus facilitating the resolution of inflammation. …”
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Clinical manifestations in Egyptian Pompe disease patients: Molecular variability and enzyme replacement therapy (ERT) outcomes by Mohamed Abdelghafar Hussein, Heba ElTaher, Ranim Mahmoud, Donia Sobh, Mohammad Al-Haggar

“…Methods The aim of the study is to share our experience through cross sectional study of patients with infantile-onset Pompe disease (IOPD) with different genetic variations, resulting in diverse clinical presentations. We evaluated their phenotype, genotype, radiological and laboratory findings including their cross-reactive immunologic material (CRIM) status. …”
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Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway by Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen Rennert, Boxian Huang, Hoi-Hung Cheung

“…Results In this study, we profiled the signaling pathways altered in WRN-deficient MSC and applied pharmacological method to activate the AKT signaling in these cells and examined their cellular phenotype related to aging. We found that the AKT signaling in WRN-deficient MSCs was significantly suppressed while the AKT upstream phosphatases (SHIP1/2) were upregulated. …”
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The first cases of collagenous sprue successfully treated with thioguanine by Chris J J Mulder, Gerd Bouma, Tom van Gils, Tine van de Donk, Foke van Delft, E Andra Neefjes-Borst

“…Based on the lack of typical HLA phenotyping and the absence of coeliac-specific antibodies, there seems to be no relation with coeliac disease in these 4 cases. …”
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Mouse Mesenchymal Progenitor Cells Expressing Adipogenic and Osteogenic Transcription Factors Suppress the Macrophage Inflammatory Response by Natalie Fernandez, Heather Renna, Lauren McHugh, Katie Mazolkova, William Crugnola, Jodi F. Evans

“…Progenitors from bone marrow and adipose tissue regulate the macrophage (MΦ) inflammatory response by promoting the switch from an inflammatory to an anti-inflammatory phenotype. Conversely, mesenchymal progenitors from the mouse aorta (mAo) support and contribute to the MΦ response under inflammatory conditions. …”
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BMI1, ALDH1A1, and CD133 Transcripts Connect Epithelial-Mesenchymal Transition to Cancer Stem Cells in Lung Carcinoma by Ana Koren, Matija Rijavec, Izidor Kern, Eva Sodja, Peter Korosec, Tanja Cufer

“…Evidences from lung cancer cellular models show EMT can trigger conversion to a cancer stem cell (CSC) phenotype. In this study, we assessed mRNA expression levels of EMT-inducing transcription factors (BMI1, TWIST1), CSC (CD133, ALDH1A1), and epithelial (EpCAM) markers in primary tumor and whole blood samples obtained from 57 patients with operable non-small-cell lung cancer (NSCLC) as well as in circulating tumor cells (CTCs) of 13 patients with metastatic disease; then possible associations between marker expressions were evaluated. …”
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Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A by Mujahed I. Mustafa, Naseem S. Murshed, Abdelrahman H. Abdelmoneim, Miyssa I. Abdelmageed, Nafisa M. Elfadol, Abdelrafie M. Makhawi

“…SPG3A gene mutations and the phenotype-genotype correlations have not yet been recognized. …”
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Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia In Vitro by Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh

“…However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. …”
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Role of autophagy defects and significance of adherent-invasive <i>Escherichia coli</i> in Crohn's disease development by I. V. Mayev, D. N. Andreev, D. V. Rakitina, Yu. P. Baykova

“…Besides that intestinal dysbiotic disorders associated with elevation of quantity of microorganisms, possessing pathogenic potential, in particular AIEC is characteristic for CD. This phenotype of microorganisms has capacity of adhesion to mucosal epithelial cells, invasion, and active replication inside macrophages. …”
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Different Pathological Roles of Toll-Like Receptor 9 on Mucosal B Cells and Dendritic Cells in Murine IgA Nephropathy by Tadahiro Kajiyama, Yusuke Suzuki, Masao Kihara, Hitoshi Suzuki, Satoshi Horikoshi, Yasuhiko Tomino

“…To address this, we nasally challenged cell-specific CpG DNA ((i): dendritic cell: (DC), (ii): B cell, (iii): both), known as ligand for TLR9, to IgAN prone mice and analyzed disease phenotype of each group. After 8 times of the weekly administration, every group showed deterioration of glomerular damage. …”
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DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis by Leilei Xia, Ye Wang, Shengyun Cai, Mingjuan Xu

“…DGAT1 expression is associated with the clinical phenotype of ovarian cancer. We suggest that DGAT1 has potential implications in the treatment of ovarian cancer.…”
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Protective mechanism of Coprinus comatus polysaccharide on acute alcoholic liver injury in mice, the metabolomics and gut microbiota investigation by Jinyan Yu, Jianguang Sun, Min Sun, Weidong Li, Dongmei Qi, Yongqing Zhang, Chunchao Han

“…All these findings suggested that CCP treatment reversed the phenotype of ethanol-induced liver injury and the associated metabolites pathways.…”
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Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…Biologic therapies have achieved exciting and notable effects in clinical treatment but are not applicable for all phenotypes of asthma. At present, some new approaches are under exploration to lessen side effects and improve curative effects. …”
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Fibroblast Growth Factor 18 Increases the Trophic Effects of Bone Marrow Mesenchymal Stem Cells on Chondrocytes Isolated from Late Stage Osteoarthritic Patients by Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian Wu

“…Chondrocytes isolated from late stage osteoarthritic patients usually lost their phenotype of producing cartilaginous matrix. Fibroblast growth factor 18 is believed to redifferentiate OA chondrocyte into functionally active chondrocytes. …”
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Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis by Zhang Q, Zhao YX, Li LF, Fan QQ, Huang BB, Du HZ, Li C, Li W

“…This condition contributes to the formation of a distinct phenotype, termed metabolic syndrome-associated osteoarthritis (MetS-OA),which differs from other metabolically related diseases by its unique pathophysiological mechanisms and clinical presentation. …”
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Adult classic Bartter syndrome: a case report with 5-year follow-up and literature review by Le Jiang, Dongmei Li, Qiansha Guo, Yunfeng Li, Lei Zan, Rihan Ao

“…Because the onset of BS is more common in children than in adults, the diagnosis, treatment outcomes, genotype/phenotype association, and follow-up of adult-onset BS Type 3 are limited. …”
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Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value. by Ann Mari Rosager, Mia D Sørensen, Rikke H Dahlrot, Steinbjørn Hansen, David L Schonberg, Jeremy N Rich, Justin D Lathia, Bjarne W Kristensen

“…Double-immunofluorescence stainings were established to determine the phenotype of cells expressing these markers. We found that TfR1, FTH, and FTL were expressed by tumor cells in all grades. …”
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Functional resting state connectivity is differentially associated with IL-6 and TNF-α in depression and in healthy controls by Christian N. Schmitz, Gebhard Sammer, Elena Neumann, Carlo Blecker, Gerhard Gründer, Hana Adolphi, Eva Kathrin Lamadé, Bruno Pedraz-Petrozzi

“…Results of this imaging study revealed that both DMN and SAL resting state networks are differentially associated with distinct immunological pathways depending on whether a person has a depressive phenotype or is healthy. While the DMN FC correlated with the concentration of the cytokine IL-6 in healthy subjects, SAL FC’s connectivity correlated with the cytokine TNF-α's concentration. …”
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Multigene Panel Testing in Turkish Hereditary Cancer Syndrome Patients by Esra ARSLAN ATES, Ayberk TURKYILMAZ, Ceren ALAVANDA, Ozlem YILDIRIM, Ahmet Ilter GUNEY

“…Conclusions: This study contributes to genotype-phenotype correlation in HCSs and expands the variation spectrum by introducing three novel pathogenic variations. …”
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