IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta. by Marjo K Hytönen, Julius Rönkkö, Sruthi Hundi, Tarja S Jokinen, Emilia Suonto, Eeva Teräväinen, Jonas Donner, Rita La Rovere, Geert Bultynck, Emil Ylikallio, Henna Tyynismaa, Hannes Lohi

“…These findings highlight the first spontaneous mammalian phenotype caused by a nonsense variant in ITPR3, leading to the loss of IP3R3. …”
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Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice by Hua Yang, Mengjie Zhang, Jiahao Shi, Yunhe Zhou, Zhipeng Wan, Yicheng Wang, Yinghan Wan, Jun Li, Zhugang Wang, Jian Fei

“…We showed that SNAP-25 conditional knockout (cKO) mice exhibited typical schizophrenia-like phenotype. A significantly elevated extracellular glutamate level was detected in the cerebral cortex of the mouse model. …”
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Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis by Ludmila V. Sakhno, Ekaterina Ya. Shevela, Marina A. Tikhonova, Sergey D. Nikonov, Alexandr A. Ostanin, Elena R. Chernykh

“…The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-anergic patients). …”
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An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Dis... by Eduardo Riquelme, Jorge Abarca, Jorge M. Campusano, Gonzalo Bustos

“…These results support the idea that a functional coupling between NMDA receptors and BDNF/trkB signalling may be important for the maintenance of the dopaminergic phenotype in SNc during presymptomatic stages of PD.…”
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Influence of allelic polymorphism in the 3’ untranslated region of the <i>StTCP23</i> gene on the tolerance of potato cultivars to the potato spindle tuber viroid by N. V. Mironenko, A. V. Kochetov, O. S. Afanasenko

“…It is known that the pathological phenotype of potato plants can be mediated by complementary interactions between the genomic RNA of PSTVd and mRNA of some regulatory genes, which consequently lead to RNA interference, the synthesis of small interfering RNAs (vd-sRNA PSTVd), and impaired morphogenesis. …”
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Dias-Logan syndrome with a p.Leu360Profs*212 heterozygous pathogenic variant of in a Chinese patient: A case report by Yizhuo Shu, Xiaoling Chen, Zhuoqun Wei, Chunyue Chen

“…So far, a comprehensive understanding of the phenotypic spectrum of Dias-Logan syndrome and the impact of genotypic variation on disease severity is still lacking. …”
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Metabolite Profiling of Sorghum Seeds of Different Colors from Different Sweet Sorghum Cultivars Using a Widely Targeted Metabolomics Approach by Yaxing Zhou, Zhenguo Wang, Yan Li, Zhigang Li, Hui Liu, Wei Zhou

“…Generally, our findings provide a comprehensive comparison of the metabolites between the three phenotypes of S. bicolor and an interpretation of phenotypic differences from the point of metabolomics.…”
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Skin Cell and Tissue Responses to Cross-Linked Hyaluronic Acid in Low-Grade Inflammatory Conditions by Benjamin Sanchez, Sandra Ferraro, Audrey Josset-Lamaugarny, Aurélie Pagnon, Charlie K. Hee, Lauren Nakab, Dominique Sigaudo-Roussel, Bérengère Fromy

“…To further characterize HA responses, we used a novel in vivo murine model exhibiting a systemic low-grade inflammatory phenotype. The intradermal injection of VYC-15L and its degradation products induced an inflammation and cell infiltration into the skin that was more pronounced than those by HYC-24L+. …”
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The Krushinsky – Molodkina genetic rat strain as a unique experimental model of seizure states by I. I. Poletaeva, Z. A. Kostyna, N. M. Surina, I. B. Fedotova, Z. A. Zorina

“…Accumulation of knowledge concerning the functions of genes, which are expressed in the CNS and are involved in the specific brain functions determined now by the success of molecular genetics, but it could not overshadow the importance of phenotype expression investigation of genetically determined traits, especially pathological ones. …”
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Hereditary predisposition of water voles (Arvicola amphibius L.) to seizures in response to handling by G. G. Nazarova, L. P. Proskurnyak

“…Genes that control the occurrence of seizures have a pleiotropic effect on life span, since individuals with seizures live longer in vivarium conditions than individuals with a normal phenotype. The water vole can serve as a suitable model object for studying the nature of convulsive states and the evolution of longevity.…”
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Innate Immune Response of Human Embryonic Stem Cell-Derived Fibroblasts and Mesenchymal Stem Cells to Periodontopathogens by Gopu Sriram, Vaishali Prakash Natu, Intekhab Islam, Xin Fu, Chaminda Jayampath Seneviratne, Kai Soo Tan, Tong Cao

“…Differential response of the two hESC progenies implies a phenotype-dependent response to periodontopathogens and supports the concept of immunomodulatory properties of MSCs.…”
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Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal/Stem Cells by Kimberly Thando Peta, Melvin Anyasi Ambele, Michael Sean Pepper

“…MSCs in chronic wounds promote a switch in macrophage phenotype from proinflammatory (M1) to anti-inflammatory (M2), thereby suppressing T, B, and natural killer cells, consequently promoting wound healing. …”
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REDERIVATION BY EMBRYO TRANSFER IN STRAINS OF LABORATORY MICE AND RATS by S. Ya. Amstislavsky, T. N. Igonina, I. N. Rozhkova, E. Yu. Brusentsev, A. A. Rogovaya, D. S. Ragaeva, V. A. Naprimerov, E. A. Litvinova, I. Z. Plyusnina, A. L. Markel

“…It should be noticed that the effectiveness of the procedure met international standards, and characteristic features of phenotype were retained in all the three strains after rederivation.…”
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Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration by Daxue Zhu, Zhaoheng Wang, Shijie Chen, Yanhu Li, Xuewen Kang

“…Human NP cells were cultured and treated with IL-1β to induce a pyroptotic phenotype. Western blotting, Immunofluorescence (IF), and immunohistochemistry (IHC) assessed the expression levels of relevant proteins. …”
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A Small-Sized Population of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Shows High Stemness Properties and Therapeutic Benefit by Miyeon Kim, Yun Kyung Bae, Soyoun Um, Ji Hye Kwon, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Hye Jin Jin

“…Further investigation of this phenotype is required to develop cell therapies with improved clinical efficacy. …”
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Epigenetic Regulation of Stromal and Immune Cells and Therapeutic Targets in the Tumor Microenvironment by Kang Liu, Yue Li, Minmin Shen, Wei Xu, Shanshan Wu, Xinxin Yang, Bo Zhang, Nengming Lin

“…Recent studies have illuminated how epigenetic mechanisms integrate external cues and downstream signals, altering the phenotype of stromal cells and immune cells. This remolds the area surrounding tumor cells, ultimately fostering an immunosuppressive microenvironment. …”
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Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells by Lidan Xue, Lili Huang, Yajing Tian, Xin Cao, Yu Song

“…The CCK8 assay was then used to assess cell proliferation; wound healing, cell migration, and tube formation assays were used to verify changes in cell phenotype. ZO-1 expression was determined using immunofluorescence and western blotting. …”
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Multiple mutations in polyketide synthase led to disruption of Psittacofulvin production across diverse parrot species by Shatadru Ghosh Roy, Jindřich Brejcha, Petr Maršík, Anna Bakhrat, Moty Abdu, Roberto Arbore, Pedro Miguel Araújo, Sandra Afonso, Miguel Carneiro, Iris Grossman-Haham, Uri Abdu

“…In domesticated budgerigars and lovebirds, the same amino acid substitution (R644W) within malonyl/acetyltransferase (MAT) domain of this enzyme has been shown to cause the blue phenotype with no psittacofulvin pigmentation, proposing a strong evolutionary constraint on the mechanism. …”
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Bioceramic Surface Topography Regulating Immune Osteogenesis by Jianxin Hao, Lin Du, Yuening He, Chengtie Wu

“…The reason is that the large spacing micro-groove structure can induce directional arrangement of macrophage so as to change the phenotype and cytokine secretion. Further researches show that macrophage of the large spacing micro-groove structure can promote the osteogenic differentiation of bone mesenchymal stem cells, which can benefit osteogenesis and osteointegration. …”
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Inhibition of Histone Methyltransferase, Histone Deacetylase, and β-Catenin Synergistically Enhance the Cardiac Potential of Bone Marrow Cells by Jinpu Yang, Keerat Kaur, John G. Edwards, Carol A. Eisenberg, Leonard M. Eisenberg

“…Previously, we reported that treatment with the G9a histone methyltransferase inhibitor BIX01294 causes bone marrow mesenchymal stem cells (MSCs) to exhibit a cardiocompetent phenotype, as indicated by the induction of the precardiac markers Mesp1 and brachyury. …”
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