Fine mapping and expression characteristics analysis of male-sterile gene BrRNR1 in Chinese cabbage (Brassica rapa L. ssp. pekinensis) by Meihui Xue, Jiahang Li, Ruiqi Liao, Junjie Xu, Mingwei Zhou, Runpeng Yao, Zhiyong Liu, Hui Feng, Shengnan Huang

“…Genetic analysis showed that a single recessive nuclear gene controlled the sterile phenotype of mutant msm7. Cytological observation indicated that the anther abortion of mutant msm7 was caused by the degenarated microspores and premature degradation of tapetum. …”
Get full text

Comparative Genomics of the First and Complete Genome of “Actinobacillus porcitonsillarum” Supports the Novel Species Hypothesis by Valentina Donà, Vincent Perreten

“…“Actinobacillus porcitonsillarum” is considered a nonpathogenic member of the Pasteurellaceae family, which phenotypically resembles the pathogen Actinobacillus pleuropneumoniae. …”
Get full text

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity by Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung

“…The associations identified by these studies are usually drug, phenotype, and ethnic specific. The drug presentation models that explain how small drug antigens might interact with HLA and T cell receptor (TCR) molecules in drug hypersensitivity include the hapten theory, the p-i concept, the altered peptide repertoire model, and the altered TCR repertoire model. …”
Get full text

Neuron-Specific Fluorescence Reporter-Based Live Cell Tracing for Transdifferentiation of Mesenchymal Stem Cells into Neurons by Chemical Compound by Do Won Hwang, Hyun Woo Kwon, Jaeho Jang, Hee Jung Jung, Kwang Rok Kim, Dong Soo Lee

“…Two days after NHPDQC treatment, MSCs showed neuron-like phenotype with neurite outgrowth and high expression of neuron-specific markers in more than 95% cells. …”
Get full text

The external validity of machine learning-based prediction scores from hematological parameters of COVID-19: A study using hospital records from Brazil, Italy, and Western Europe. by Ali Safdari, Chanda Sai Keshav, Deepanshu Mody, Kshitij Verma, Utsav Kaushal, Vaadeendra Kumar Burra, Sibnath Ray, Debashree Bandyopadhyay

“…The external performance was reduced when the model was trained on datasets from Italy and tested on Brazil (AUC score 69%) and Western Europe (AUC score 65%); presumably affected by factors, like, ethnicity, phenotype, immunity, reference ranges, across the populations. …”
Get full text

Impact of bedaquiline resistance probability on treatment decision for rifampicin-resistant TB by T.P.H. Trang, R. Kessels, T. Decroo, A. Van Rie

“…CONCLUSION: Given the uncertainty of genotype-phenotype associations, physicians valued prBDQ R for BDQ decision-making in rifampicin-resistant TB treatment.…”
Get full text

Alterations in Monocyte CD16 in Association with Diabetes Complications by Danqing Min, Belinda Brooks, Jencia Wong, Robert Salomon, Wensheng Bao, Brian Harrisberg, Stephen M. Twigg, Dennis K. Yue, Susan V. McLennan

“…These results suggest that the circulating monocyte phenotype is altered by diabetic complications status. …”
Get full text

Exploring the potential of aerial drone imagery to distinguish breeding Adélie (Pygoscelis adeliae), chinstrap (Pygoscelis antarcticus) and gentoo (Pygoscelis papua) penguins in An... by Christian Pfeifer, Stefan Knetsch, Jakob Maercker, Osama Mustafa, Marie-Charlott Rümmler, Alexander Brenning

“…We investigate the spatial resolution required to distinguish species based on their phenotype. Additionally, we explore the possibility and reliability of discriminating species by analysing differences in guano cover appearance, spatial distribution of individuals, posture, and the presence of chicks. …”
Get full text

Ageing leads to selective type II myofibre deterioration and denervation independent of reinnervative capacity in human skeletal muscle by Oscar Horwath, Marcus Moberg, Sebastian Edman, Andrew Philp, William Apró

“…However, our understanding of the aged muscle phenotype might be confounded by factors secondary to ageing per se, such as inactivity and adiposity. …”
Get full text

Iron metabolism in a mouse model of hepatocellular carcinoma by Dilay Yilmaz, Umesh Tharehalli, Rossana Paganoni, Paul Knoop, Andreas Gruber, Yuexin Chen, Rui Dong, Frank Leithäuser, Thomas Seufferlein, Kerstin Leopold, André Lechel, Maja Vujić Spasić

“…All liver cancers with a p53-deficient background exhibited a local iron-poor phenotype with a “high transferrin receptor 1 (Tfr1) and low hepcidin (Hamp)” signature. …”
Get full text

Occurrence of multi-antibiotic resistant bacteria isolated from food handlers' hands and utensils at different restaurants in Dhaka, Bangladesh by Sumi Akter, Ratna Akter, Md. Abdus Salam

“…Among the examined isolates, 75% of bacterial isolates showed MDR phenotype, while 90% of isolates recorded a MARI value greater than 0.2. …”
Get full text

Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats by Charissa E. van den Brom, Chantal A. Boly, Carolien S. E. Bulte, Rob F. P. van den Akker, Rick F. J. Kwekkeboom, Stephan A. Loer, Christa Boer, R. Arthur Bouwman

“…WD-feeding resulted in a prediabetic phenotype characterized by obesity, hyperinsulinemia, hyperlipidemia, glucose intolerance, and hyperglycemia. …”
Get full text

The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…Liver metabolism failure has been proposed as a core element in underlying endocrine disorders through persistent inflammation and highly fibrotic phenotype. Methods. In this study, the outcomes of PTP1B inhibition using trodusquemine (MSI-1436) on key equine metabolic syndrome (EMS)-related alterations including inflammation, fibrosis, and glucose uptake have been analyzed in liver explants collected from EMS-affected horses using various analytical techniques, namely, flow cytometry, RT-qPCR, and Western blot. …”
Get full text

Psychological Aspects of Androgen Insensitivity Syndrome: Two Cases Illustrating Therapeutical Challenges by Filippa Pritsini, Georgios A. Kanakis, Ioannis Kyrgios, Eleni P. Kotanidou, Eleni Litou, Konstantina Mouzaki, Aggeliki Kleisarchaki, Dimitrios G. Goulis, Assimina Galli-Tsinopoulou

“…Androgen Insensitivity Syndrome (AIS) and its heterogeneous phenotypes comprise the pieces of a challenging clinical problem. …”
Get full text

Investigating the functional and structural effect of non-synonymous single nucleotide polymorphisms in the cytotoxic T-lymphocyte antigen-4 gene: An in-silico study. by Md Mostafa Kamal, Kazi Fahmida Haque Shantanu, Shamiha Tabassum Teeya, Md Motiar Rahman, A K M Munzurul Hasan, Douglas P Chivers, Tanveer A Wani, Atekah Hazzaa Alshammari, Mahesh Rachamalla, Francisco Carlos da Silva Junior, Md Munnaf Hossen

“…Further, experimental studies are needed to analyze the effect of these nsSNPs on the susceptibility of pathological phenotype populations.…”
Get full text

Chloride intracellular channel CLIC3 mediates fibroblast cellular senescence by interacting with ERK7 by Changjiao Luan, Yue Gao, Jun Zhao, Xiaohui Zhang, Chaofan Wang, Wentao Sun, Yucheng Li, Xinxing Yang, Jiaxiao Chen, Weili Liu, Weijuan Gong, Xingjie Ma

“…Furthermore, our findings revealed that the knockdown of CLIC3 mitigated intracellular chloride ion lose, mitochondrial dysfunction, nuclear enlargement, DNA damage, CS progression, and expression of senescence-associated secretory phenotype (SASP) triggered by bleomycin. Mechanistically, CLIC3 controls CS by translocating to the membrane where it interacts with extracellular signal-regulated kinase 7 (ERK7). …”
Get full text

Weight trajectories in aging humanized APOE mice with translational validity to human Alzheimer's risk population: A retrospective analysis. by Francesca Vitali, Jean-Paul Wiegand, Lillian Parker-Halstead, Allan Tucker, Roberta Diaz Brinton

“…Autoregressive Hidden Markov Model (AHMM) incorporating age, sex, and APOE genotype was employed to identify emergent weight trajectories and phenotypes. In the hAPOE-AD mouse cohort, five distinct weight trajectories emerged: three trajectories were associated with a weight loss phenotype (36% of mice, n = 426), one with weight gain (13% of mice, n = 152), and one trajectory of no change in weight (34% of mice, n = 403). …”
Get full text

Development of Murine Hepatic NK Cells during Ontogeny: Comparison with Spleen NK Cells by Xian Wu, Yongyan Chen, Haiming Wei, Rui Sun, Zhigang Tian

“…The phenotype of developing liver NK cells (CD3−NK1.1+) was investigated during mouse ontogeny comparing with spleen NK cells. …”
Get full text

Search for differentially methylated regions in ancient and modern genomes by D. D. Borodko, S. V. Zhenilo, F. S. Sharko

“…Epigenetic mechanisms, such as DNA methylation, play a significant role in evolutionary processes, as their changes have a faster impact on the phenotype compared to mutagenesis. In this study, we attempted to develop an algorithm for identifying differentially methylated regions associated with metabolic syndrome, which have undergone methylation changes in humans during the transition from a hunter­gatherer to a sedentary lifestyle. …”
Get full text

Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…These findings suggest that VCR exposure during childhood, particularly in males, triggers neuroimmune responses in the bladder and Ls-DRG, amplifying responsiveness to neurotransmitters in the bladder, thereby contributing to LUT dysfunction characterized by a mixed bladder phenotype as a late effect during survivorship.…”
Get full text