Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence by Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Giovanni Galano, Roberto De Rosa, Mariarosa AB Melone, Gianfranco Peluso, Umberto Galderisi

“…Senescent cells secrete several molecules, collectively named senescence-associated secretory phenotype (SASP). In the SASP of cells that became senescent following several in vitro chemical and physical stress, we identified the IGFBP-4 protein that can be considered a general stress mediator. …”
Get full text

Problems and possibilities of studying malting quality in barley using molecular genetic approaches by N. V. Trubacheeva, L. A. Pershina

“…Most of these components are under the control of quantitative trait loci (QTLs) and are affected by environmental conditions, which complicates their study and precise localization. In addition, the phenotypic assessment of malting quality traits requires elaborate, expensive phenotypic analyses. …”
Get full text

Clinical and genetic analysis of epilepsy with myoclonic-atonic seizures caused by SLC6A1 gene variant by Zhen Li, Zhen Li, Changming Han, Hongwei Zhao

“…For previously identified patients, high-throughput sequencing was utilized, whereas Sanger sequencing was employed for the parents to determine the site of the gene mutation and examine the connection between genotype and phenotype.ResultsThe male child showed delays in intellectual and language development before the disease began. …”
Get full text

CD109, a master regulator of inflammatory responses by Adel Batal, Adel Batal, Setareh Garousi, Setareh Garousi, Kenneth W. Finnson, Kenneth W. Finnson, Anie Philip, Anie Philip

“…CD109 exerts its effects by modulating processes such as cytokine secretion, immune cell recruitment, macrophage polarization, T helper cell function and cancer cell phenotype and function. Here, we review CD109’s regulatory functions in inflammatory responses in these various tissues and cell types. …”
Get full text

PPAR-α regulates metabolic remodelling and participates in myocardial fibrosis in patients with atrial fibrillation of rheumatic heart disease by Xiaoying Hu, Daisong Jiang, Zheng Zhang, Zhenmei An

“…After stimulation with PPAR-α agonist GW7647, the phenotypic differentiation of myocardial fibro- blasts into myofibroblasts was inhibited. …”
Get full text

Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase by Thomas Große-Steffen, Thomas Giese, Nathalia Giese, Thomas Longerich, Peter Schirmacher, G. Maria Hänsch, Matthias M. Gaida

“…Because in pancreatic cancers the transition to a mesenchymal phenotype coincides with the PMN infiltrate, a contribution of the inflammatory response to the induction of EMT and—by implication—to tumor progression is possible.…”
Get full text

Bacterial quorum sensing and the role of algae in bacterial diseases control in aquaculture by . Wiyoto, Julie Ekasari

“…This activity will activate a certain target gene which further resulted in the expression of a phenotype by the bacteria. With regard to this characteristic, one of the methods to control bacterial diseases is by quorum sensing disruption. …”
Get full text

Low-density SNP marker sets for genetic variation analysis and variety identification in cultivated citrus by Phuong Linh Nguyen, Jin-Kee Jung, Jee-Soo Park, Sung-Chur Sim

“…The resulting SNP sets are a resource to enhance the phenotype-based DUS testing by developing a DNA barcode system and thus facilitate new variety breeding and protection in citrus.…”
Get full text

Identification of Houge type of X-linked syndromic mental retardation caused by CNKSR2 truncated variants by Si-Hua Chang, Jie-Yuan Jin, Yi-Qiao Hu, Run-Yan Wang, Rong Xiang, Xia Wang

“…However, the genotype-phenotype correlation and variants characteristics of CNKSR2 need further investigation and improvement. …”
Get full text

High antimony resistance strain Enterobacter sp. Z1 mediates biomineralization of antimony trioxide by Zijie Zhou, Hongbo Yu, Gejiao Wang, Mingshun Li, Kaixiang Shi

“…However, this impaired phenotype was rescued by complementing the aceE gene or introducing purified AceE into the bacterial lysates. …”
Get full text

Lymphocytes as an Indicator for Initial Kidney Function: A Single Center Analysis of Outcome after Alemtuzumab or Basiliximab Induction by Annemarie Weissenbacher, Theresa Hautz, Michael Kimelman, Rupert Oberhuber, Hanno Ulmer, Claudia Bösmüller, Manuel Maglione, Stefan Schneeberger

“…A detailed analysis of phenotype and function of lymphocytes after alemtuzumab induction together with a correlation with the clinical course is warranted.…”
Get full text

Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ by Babak Baban, Hesam Khodadadi, Kumar Vaibhav, Cristina Marchetti, Carlo Riccardi, Mahmood S. Mozaffari

“…Collectively, the results indicate that both cannabidiol and GILZ regulate ILC frequency and phenotype, in acute kidney injury, and that the effects of cannabidiol likely relate to modulation of endogenous GILZ.…”
Get full text

Morphometric Analysis of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Determining the Maturation State of a Population by Quantifying Parameters in Individual Cell... by Harvey Y. S. Chan, Wendy Keung, Ronald A. Li, Andrew L. Miller, Sarah E. Webb

“…We demonstrated that oleic acid or isoproterenol alone, or a combination of the two, induced a more elongated hESC-vCM phenotype than the untreated controls. In addition, cells treated with isoproterenol alone exhibited a similar level of myofibrillar organization as the controls, but those treated with oleic acid with/without isoproterenol exhibited a more organized (parallel) orientation of myofibrils. …”
Get full text

Huntington’s disease modeling on HEK293 cell line by D. V. Sharipova, T. B. Malankhanova, A. A. Malakhova

“…We showed that mutant cells partially reproduce the pathological phenotype, that is, they have reduced proliferation activity, an increased level of apoptosis and high sensitivity to treatment with 5μM MG132 proteasome inhibitor compared to the original HEK293 Phoenix cell line. …”
Get full text

Successful Treatment of Linear Psoriasis With the IL-17a-Antagonist Ixekizumab: A Case Report by Christov S, Ohm F, Augustin M, Wagner JN

“…In addition, the findings emphasize the need for systematic studies to develop evidence-based treatment strategies for this rare psoriasis phenotype.Keywords: psoriasis, linear psoriasis, biologics, genodermatosis, ILVEN, IL-17A-antagonist, ixekizumab…”
Get full text

Upregulated Solute Carrier SLC39A1 Promotes Gastric Cancer Proliferation and Indicates Unfavorable Prognosis by Dan Yu, Yong Chen, Ming Luo, Yanjin Peng, Shengen Yi

“…High SLC39A1 is critical for a more aggressive tumor phenotype by promoting cell proliferation and invasion. …”
Get full text

Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas by Arjen H. G. Cleven, Manon van Engeland, Bradly G. Wouters, Adriaan P. de Bruïne

“…Background: Hypoxia modifies the phenotype of tumors in a way that promotes tumor aggressiveness and resistance towards chemotherapy and radiotherapy. …”
Get full text

Chemical Chaperone of Endoplasmic Reticulum Stress Inhibits Epithelial-Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium via the c-Src Pathway by Heung-Man Lee, Ju-Hyung Kang, Jae-Min Shin, Seoung-Ae Lee, Il-Ho Park

“…Epithelial-mesenchymal transition (EMT) is a biological process that allows epithelial cells to assume a mesenchymal cell phenotype. EMT is considered as a therapeutic target for several persistent inflammatory airway diseases related to tissue remodeling. …”
Get full text

Non-modifiable and Modifiable Risk Factors in Vascular Ageing Extremes: The African-PREDICT Study by Donavan Rooi, Ruan Kruger, Esmé Jansen van Vuren, Yolandi Breet

“…Therefore, we aimed to phenotype young South African adults stratified by cfPWV extremes in terms of non-modifiable and modifiable risk factors. …”
Get full text

Importance of complement system components in ovarian endometriomas. A comparative cohort study by Anna V. Chizhova, Elena V. Kudryavtseva, Larisa G. Polushina, Maksim A. Kopenkin

“…It may indicate that surgical treatment of endometrioma affects the overall immunological phenotype. Conclusion. C3 and C4 levels in women with ovarian endometriomas are higher compared to those in patients with other benign ovarian masses. …”
Get full text