The Maize Corngrass1 miRNA-Regulated Developmental Alterations Are Restored by a Bacterial ADP-Glucose Pyrophosphorylase in Transgenic Tobacco by Ayalew Ligaba-Osena, Kay DiMarco, Tom L. Richard, Bertrand Hankoua

“…A possible mechanism of the Cg1 phenotype is discussed. However, a more detailed study including genome-wide transcriptome and metabolic analysis is needed to determine the underlying genetic elements and pathways regulating the observed developmental and metabolic changes.…”
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Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…This is due in part to immune dysfunction resulting from monocyte exhaustion, a phenotype of reduced antigen presentation, altered CD14/CD16 inflammatory subtypes, and disrupted cytokine production. …”
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The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke by Katherine Hernandez, Nathan Jones, Sterling B. Ortega

“…Additionally, an assessment of neuroinflammation revealed no changes in CD4 T-cell cellularity or phenotype.DiscussionThese findings, alongside prior studies, suggest that the therapeutic efficacy of PNU may be contingent upon the timing of administration, dosage, and pharmacokinetics.…”
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Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticu... by Taina Viheriälä, Heidi Hongisto, Lyydia Saari, Marika Oksanen, Tanja Ilmarinen, Suvi Väärämäki, Hannu Uusitalo, Pasi Nevalainen, Heli Skottman

“…Data demonstrated that PXE-specific high-quality hiPSC lines can be established from a skin biopsy regardless of the skin-related disease phenotype and disease-specific RPE differentiation is feasible. …”
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Gene expression of psychiatric disorder-related kinesin superfamily proteins (Kifs) is potentiated in alternatively activated primary cultured microglia by Suguru Iwata, Mitsuhiro Hyugaji, Yohei Soga, Momo Morikawa, Tetsuya Sasaki, Yosuke Takei

“…Furthermore, the microglia derived from a mouse line which possesses a mutation inducing truncated KIF17 indicated disrupted morphological phenotype of alternatively activated microglia. These results suggest that the potentiation of specific molecular motor expression is required to maintain the function of alternatively activated microglia.…”
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How Normal Is the Liver in Which the Inflammatory Type Hepatocellular Adenoma Develops? by Jing Han, Marius C. van den Heuvel, Hironori Kusano, Koert P. de Jong, Annette S. H. Gouw

“…Both mutations lead to a similar morphologic phenotype and to increased expression of C-reactive protein (CRP) and/or serum amyloid-A (SAA). …”
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Physical and Biological Characterizations of Injectable Thermosensitive Poly(N-Isopropylacrylamide)-Collagen I Hydrogels Intended for Meniscus Repair by Chunhai Ke, Xuanyuan Lu, Jiahua Ni, Ruicong Li, Qi Chen, Zhaoxiang Peng

“…In contrast, the expressions of collagen II protein and collagen II a1 gene were less prominent (respectively, 2.36-fold and 3.34-fold in the PNIPAm-0.5Coll group compared with the PNIPAm group). This phenotyping was believed to be conducive to the regeneration of meniscal tissues. …”
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Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The Human Genome Project assumes: development of the human genome variations database (HapMap; Human Variome Project), interpretation of human phenotype differences (Encyclopedia Of DNA Elements), modeling of human phenomenon (RECON), interpretation of epigenetic variants and hereditary changes in phenotypical manifestations. …”
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Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations by Antonio Ieni, Valeria Barresi, Giovanni Branca, Rosario Alberto Caruso, Giovanni Tuccari

“…Mast cells had mature phenotype and showed full complement of granules with homogeneous, scroll, particle, and mixed pattern. …”
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Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults by Anna Koumarianou, Panagiota Oikonomopoulou, Margarita Baka, Dimitrios Vlachodimitropoulos, Stylianos Argentos, Theodoros Piperos, Maria-Ioanna Christodoulou, Kakoulis Theodoulou, Theodoros Mariolis-Sapsakos

“…The emerging prognostic role of MYCN phenotype of this disease is currently under investigation as it may redefine MYCN amplified subgroups. …”
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Drought Tolerance in Modern and Wild Wheat by Hikmet Budak, Melda Kantar, Kuaybe Yucebilgili Kurtoglu

“…Drought is currently the leading threat on world's food supply, limiting crop yield, and is complicated since drought tolerance is a quantitative trait with a complex phenotype affected by the plant's developmental stage. …”
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High Lyso-Gb3 Plasma Levels Associated with Decreased miR-29 and miR-200 Urinary Excretion in Young Non-Albuminuric Male Patient with Classic Fabry Disease by Sebastián Jaurretche, Germán R. Perez, Graciela Venera

“…In addition to its usefulness as a phenotype marker, Lyso-Gb3 has been proposed as an indicator of therapeutic response. …”
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Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity by Sameer Bahal, Maha E. Houssen, Ania Manson, Lorena Lorenzo, Mark A. Russell, Noel G. Morgan, Fariba Tahami, Sofia Grigoriadou

“…Respiratory tract infections were not a feature of the clinical phenotype and a high resolution thoracic CT scan was unremarkable. …”
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The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…Senolytics, a class of drugs targeting and eliminating senescent cells, address the accumulation of dysfunctional cells that contribute to tissue degradation and chronic inflammation through the senescence-associated secretory phenotype. This scoping review examines the intersection of epigenetic mechanisms and senolytic therapies in aging, focusing on their combined potential for therapeutic interventions. …”
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Directed Evolution of Proteins through In Vitro Protein Synthesis in Liposomes by Takehiro Nishikawa, Takeshi Sunami, Tomoaki Matsuura, Tetsuya Yomo

“…IVC establishes the link between genetic information (genotype) and the protein translated from the information (phenotype), which is essential for all directed evolution methods, by encapsulating both in a nonliving microcompartment. …”
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Reversibility of Frailty after Lung Transplantation by Elyn Montgomery, Peter S. Macdonald, Phillip J. Newton, Sungwon Chang, Kay Wilhelm, Sunita R. Jha, Monique Malouf

“…Frailty was defined by the presence of ≥ 3 domains of the modified Fried Frailty Phenotype (mFFP). Results. We performed 166 lung transplants (frail patients, n = 27, 16%). …”
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Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population by Incheol Seo, Seong-Il Suh, Min-Ho Suh, Won-Ki Baek

“…However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies.…”
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Regulatory Role of the RUNX2 Transcription Factor in Lung Cancer Apoptosis by Camila Bernal, Andrea Otalora, Alejandra Cañas, Alfonso Barreto, Karol Prieto, Martin Montecino, Adriana Rojas

“…Several transcription factors important in embryonic development are abnormally expressed in adult tissues and thus participate in the activation of signaling pathways related to the acquisition of the tumor phenotype. RUNX2 is the transcription factor responsible for osteogenic differentiation in mammals. …”
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Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report by Zhengping Cheng, Yang Song, Shuqi Zhao, Xiaowen Sui, Lili Xie, Hongling Zhao, Xin Pan, Li Cui, Xinran Huang, Shubei Ma

“…Conclusions This case suggests that involuntary movements and psychiatric symptoms may represent novel phenotypes of anti-GluK2 antibody-associated autoimmune encephalitis. …”
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Culture and Characterization of Microglia from the Adult Murine Retina by Gayathri Devarajan, Mei Chen, Elizabeth Muckersie, Heping Xu

“…To develop a protocol for isolating and culturing murine adult retinal microglia and to characterize the phenotype and function of the cultured cells. Method. …”
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