Membrane Bound CRT Fragment Accelerates Tumor Growth of Melanoma B16 Cell In Vivo through Promoting M2 Polarization via TLR4 by Hong-Min Wang, Zhe Zhou, Jie Miao, Bo Zhu, Xiao-Qiu Dai, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…The tumor associated macrophages infiltrated in tumors were mainly M2 phenotype. Regulatory T cells (Tregs) were also expanded more in bearing mice. …”
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The BnaBPs gene regulates flowering time and leaf angle in Brassica napus by Jiang Yu, Yi‐Xuan Xue, Rehman Sarwar, Shi‐Hao Wei, Rui Geng, Yan‐Feng Zhang, Jian‐Xin Mu, Xiao‐Li Tan

“…On the contrary, overexpression plants displayed a phenotype that was the inverse of these characteristics. …”
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PWS/AS MS-MLPA Confirms Maternal Origin of 15q11.2 Microduplication by Angelika J. Dawson, Janice Cox, Karine Hovanes, Elizabeth Spriggs

“…In order to determine the significance of this microduplication to the clinical phenotype, the parent-of-origin needed to be identified. …”
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What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs by V. Spallone, C. Ciccacci, A. Latini, P. Borgiani

“…Finally, the concept and the data of genotype-phenotype association for polymorphism of miRNA genes were described. …”
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Proteomic Profiling of Ex Vivo Expanded CD34-Positive Haematopoetic Cells Derived from Umbilical Cord Blood by Heiner Falkenberg, Teja Falk Radke, Gesine Kögler, Kai Stühler

“…Enrichment analysis of biological processes clearly showed a proteomic change toward a protein biosynthesis phenotype already within the first three days of expression.…”
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The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells by Chenyi Ling, Marc D. Cook, Heather Grimm, Maitha Aldokhayyil, Dulce Gomez, Michael Brown

“…With aerobic exercise, the vessel wall is exposed to chronic high laminar shear stress (HiLSS) that shifts the endothelium phenotype towards an anti-inflammatory, antioxidant, antiapoptotic, and antiproliferative environment. …”
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Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain by Aiguo Xin, Mingwang Zhu, Zhenqi Peng, Qi Hu, Chenhong Shi, Defang Liao, Jihua Wang, Huachun Li

“…These substitutions, alone or in combination, may be responsible for the attenuated phenotype of the ZB strain in cattle. This will contribute to elucidation of attenuating molecular basis of the FMDV ZB strain.…”
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POLYMORPHIC VARIANTS OF SUNFLOWER <i> RFL-PPR </i> GENES AS MOLECULAR GENETIC MARKERS by I. N. Anisimova, Yu. I. Karabitsina, N. V. Alpatieva, E. B. Kuznetsova, V. A. Gavrilova, E. E. Radchenko

“…A sample of 131 sunflower lines from VIR genetic collection which differed for the ability to suppression of the CMS phenotype was studied using molecular markers specific for the CMS PET1 associated mitochondrial locus orfH522 and Rf1 nuclear gene, and also for CAPS-markers developed on the bases of single nucleotide polymorphism of RFL-PPR genes homologs. …”
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Atherogenic Cytokines Regulate VEGF-A-Induced Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells by Izuagie Attairu Ikhapoh, Christopher J. Pelham, Devendra K. Agrawal

“…Addition of Ang II to VEGF-A and IL-6 or TNFα was sufficient to rescue the EC phenotype. Thus, Ang II promotes but IL-6 and TNFα inhibit VEGF-A-induced differentiation of MSCs into ECs. …”
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Generation, interrogation, and future applications of microglia-containing brain organoids by Julia Di Stefano, Federica Di Marco, Ilaria Cicalini, Una FitzGerald, Damiana Pieragostino, Marleen Verhoye, Peter Ponsaerts, Elise Van Breedam

“…Therefore, our main focus here is to provide a comprehensive overview of assays to measure microglial phenotype and function within brain organoids, with an outlook on how these findings could better understand neuronal network development or restoration, as well as the influence of physical stress on microglia-containing brain organoids. …”
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Lymphoproliferation and hyper-IgM as the first manifestation of activated phosphoinositide 3-kinase δ syndrome: A case report by Mónica Fernandes-Pineda, Andrés F. Zea-Vera

“…We present a case involving a 15-year-old male who displayed an immunological phenotype that bore a striking resemblance to hyper-IgM syndrome. …”
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Absence of Substantial Copy Number Differences in a Pair of Monozygotic Twins Discordant for Features of Autism Spectrum Disorder by Marina Laplana, José Luis Royo, Anton Aluja, Ricard López, Damiàn Heine-Sunyer, Joan Fibla

“…Despite the large amount of studies described so far, the high clinical diversity affecting the autism phenotype remains poorly explained. Recent studies suggest that rare genomic variations, in particular copy number variation (CNV), may account for a significant proportion of the genetic basis of ASD. …”
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Identification of Malignancy-Associated Changes in Histologically Normal Tumor-Adjacent Epithelium of Patients with HPV-Positive Oropharyngeal Cancer by James Jabalee, Anita Carraro, Tony Ng, Eitan Prisman, Cathie Garnis, Martial Guillaud

“…We analyzed the nuclear phenotype of matched tumor, tumor-adjacent normal, and contralateral normal tissues from biopsies of nine HPV+ OPC patients. …”
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Live Visualization of Calcified Bones in Zebrafish and Medaka Larvae and Juveniles Using Calcein and Alizarin Red S by Rina Koita, Sae Oikawa, Taisei Tani, Masaru Matsuda, Akinori Kawamura

“…The advent of CRISPR-Cas9 technology has greatly enhanced our capability to produce specific gene mutants in zebrafish and medaka. Analyzing the phenotypes of these mutants is essential for elucidating gene function, though such analyses often yield unexpected results. …”
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Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells by Lu Han, Yi-Man Shang, Yong-Ping Song, Quan-Li Gao

“…In this study, we investigated the impact of RetroNectin on the proliferation, phenotype alternation, cytokine secretion, and cytotoxic activity of CIK cells from pancreatic cancer patients. …”
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Selective Immunoglobulins deficiency in relatives antibody deficiency patient by Yralys Naranjo Herrera, María del Carmen Chávez Alfonso, Valia Concepción Ulloa, Cándido Marcos León Márquez, Grace Alicia De Lara García, Ernesto Gabriel Caraballosa Yero

“…Asymptomatic disease was the most frequent phenotype.…”
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Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles by Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira

“…Herein, we propose the use of retinoic acid-loaded polymeric nanoparticles (RA-NP) as a means to modulate microglia response towards an anti-inflammatory and neuroprotective phenotype (M2). RA-NP were first confirmed to be internalized by N9 microglial cells; nanoparticles did not affect cell survival at concentrations below 100 μg/mL. …”
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3p14 De Novo Interstitial Microdeletion in a Patient with Intellectual Disability and Autistic Features with Language Impairment: A Comparison with Similar Cases by Ana Belén de la Hoz, Hiart Maortua, Ainhoa García-Rives, María Jesús Martínez-González, Maitane Ezquerra, María-Isabel Tejada

“…To date, few cases of 3p proximal interstitial deletions have been reported and the phenotype and genotype correlation is not well understood. …”
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Biofilm-associated metabolism via ERG251 in Candida albicans. by Liping Xiong, Nivea Pereira De Sa, Robert Zarnowski, Manning Y Huang, Caroline Mota Fernandes, Frederick Lanni, David R Andes, Maurizio Del Poeta, Aaron P Mitchell

“…Finally, the hypersensitivity of efg1Δ/Δ mutants to the ergosterol inhibitor fluconazole is reversed by ERG251 overexpression, arguing that reduced ERG251 expression contributes to this efg1Δ/Δ phenotype. Our results indicate that ERG251 is required for biofilm formation because its high expression levels are necessary for ergosterol synthesis in a biofilm-like environment.…”
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Distribution and Characteristics of Bacteria Isolated from Cystic Fibrosis Patients with Pulmonary Exacerbation by Soroor Erfanimanesh, Mohammad Emaneini, Mohammad Reza Modaresi, Mohammad Mehdi Feizabadi, Shahnaz Halimi, Reza Beigverdi, Vajiheh Sadat Nikbin, Fereshteh Jabalameli

“…For P. aeruginosa isolates the highest resistance was to cefepime (38.3%) and levofloxacin (33.3%) and 20% showed MDR phenotype. Conclusion. Our study demonstrated a significant decline in the prevalence of P. aeruginosa infections in comparison to previous studies. …”
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