Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…In Iba1 + cells in both control and acute EAE tissue, we find that TSPO is co-expressed with markers of antigen presentation (CD74), early activation (MRP14), phagocytosis (CD163) and anti-inflammatory phenotype (Arg1); a high level of TSPO expression is not restricted to a particular microglial phenotype. …”
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STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren’s Syndrome: Association with Disease Susceptibility and Clinical Aspects by Serena Colafrancesco, Cinzia Ciccacci, Roberta Priori, Andrea Latini, Giovanna Picarelli, Francesca Arienzo, Giuseppe Novelli, Guido Valesini, Carlo Perricone, Paola Borgiani

“…A case-control association study and a phenotype-genotype correlation analysis were performed. …”
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Identification and functional analysis of a novel SMARCC2 splicing variant in a family with syndromic neurodevelopmental disorder by Ming Li, Jingqi Lin, Hongjun Fei, Jinyu Liu, Yiyao Chen, Xu Han, Yanlin Wang, Jian Wang, Renyi Hua, Shuyuan Li, Niu Li

“…An analysis of genotype-phenotype correlations indicated that our patients displayed neurological phenotypes of greater severity than those observed in patients with truncating variants, instead aligning more closely with the characteristics of the missense/in-frame variant group. …”
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Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…Antitumor activity was quantified by caliper measurement and bioluminescence signal and used anti-human vimentin to measure residual PSCs.Results H84T BanLec CAR was successfully transduced and expressed by T cells which had robust expansion and retained central memory phenotype in both CD4 and CD8 compartments. H84T CAR T cells targeted and eliminated PDAC tumor cell lines. …”
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Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review by Diletta Camussi, Maria Marchese, Ferdinando Nicoletti, Filippo Maria Santorelli, Asahi Ogi

“…This review first sets out to examine the existing literature on adult social behavior in the zebrafish VPA-induced model of autism, and the authors also aim to identify the ideal VPA dosage able to induce a persistent and long-lasting ASD-like phenotype while minimizing the suffering and distress of research animals in compliance with the principles of replacement, refinement, and reduction (3Rs).…”
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Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Here we review the many possible mechanisms of action that could contribute to resistance, and novel therapies to prevent or reverse the resistant phenotype. Moreover, we provide a critical role for Notch signaling cross-talk with overlapping or new signaling networks in trastuzumab-resistant breast.…”
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Susceptibility Genes in Thyroid Autoimmunity by Yoshiyuki Ban, Yaron Tomer

“…Most likely, these loci interact and their interactions may influence disease phenotype and severity.…”
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PD-L1 knockout or ZG16 overexpression inhibits PDAC progression and modulates TAM polarization by Hui Meng, Manman Nan, Yizhen Li, Yi Ding, Xiaokun Fang, Weiqian Ma, Mingzhi Zhang

“…Both methods promoted the polarization of tumor-associated macrophages (TAMs) to the M1 phenotype, as indicated by increased levels of the M1 marker CD11c+ in vitro and in vivo. …”
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Tumor venéreo transmissível canino com resistência quimioterápica e metástase esplênica. Relato de caso by A. P. Duzanski, A. D. Ortiz, H. B. Fêo, M. W. Fonseca, M. M. Flórez, L. T Rodrigues, F. Michelon, N. S. Rocha

“…The tumor typically responds well to vincristine sulfate chemotherapy, although there are cases of resistance to the drug correlated with the tumoral phenotype. We describe herein a genital mixed TVTC case with metastases at spleen and failure at vincristine sulfate chemotherapeutic treatment in a five years old Australian Cattle Dog female. …”
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Investigation of Splicing Quantitative Trait Loci in by Wonseok Yoo, Sungkyu Kyung, Seonggyun Han, Sangsoo Kim

“…The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. …”
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Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless. by Weronika Fic, François Juge, Johann Soret, Jamal Tazi

“…When over-produced in the eye imaginal disc, this isoform induces a small eye phenotype, whereas the isoform lacking the alternative exon triggers eye over-growth and strong disorganization. …”
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Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. by Lucy B Ochola, Bethsheba R Siddondo, Harold Ocholla, Siana Nkya, Eva N Kimani, Thomas N Williams, Johnstone O Makale, Anne Liljander, Britta C Urban, Pete C Bull, Tadge Szestak, Kevin Marsh, Alister G Craig

“…In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases.…”
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Reverse Genetic Strategies in Caenorhabditis elegans: Towards Controlled Manipulation of the Genome by Howard A. Baylis, Rafael P. Vázquez-Manrique

“…., moving from gene to phenotype. Fundamental to this aim is the ability to alter the structure of particular genes by means that are not accessible to classical genetic strategies. …”
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Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma by Daniel Benharroch, Miriam Zekzer, Karen Nalbandyan

“…One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. …”
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Challenges in the Diagnosis and Management of Patients with Fibrosing Interstitial Lung Disease by Leslie B. Tolle

“…The tyrosine kinase inhibitor nintedanib has been approved for the treatment of idiopathic pulmonary fibrosis, other chronic fibrosing ILDs with a progressive phenotype, and systemic sclerosis-associated ILD. The three case studies described in this article illustrate the challenges in the diagnosis and management of patients with fibrosing ILDs and the importance of taking a multidisciplinary and individualized approach to care, including regular monitoring and consideration of whether a patient’s drug regimen needs to be changed when there is evidence of disease progression.…”
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The Use of Pulsed Electromagnetic Fields to Promote Bone Responses to Biomaterials In Vitro and In Vivo by Carlo Galli, Giuseppe Pedrazzi, Monica Mattioli-Belmonte, Stefano Guizzardi

“…Hence, we have the hypothesis that PEMFs may also ameliorate cell responses to biomaterials, improving their growth, differentiation, and the expression of a mature phenotype and therefore increasing the tissue integration of the implanted devices and their clinical success. …”
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Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish by Mallika Pathania, Elena V. Semina, Melinda K. Duncan

“…We report analysis of the ocular lens phenotype of the recessive, larval lethal zebrafish mutant, lama1a69/a69. …”
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Astrocytes and Developmental Plasticity in Fragile X by Connie Cheng, Mary Sourial, Laurie C. Doering

“…With overall synaptic function standing as a prominent link to the expression of the disease phenotype in a number of neurodevelopmental disorders and knowing that astrocytes influence synapse development and function, this paper highlights the current knowledge of astrocyte biology with a focus on their involvement in fragile X syndrome.…”
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Rare diagnosis of an Epstein-Barr virus-positive extracavitary/solid variant of primary effusion lymphoma by duodenal endoscopic biopsy in a human immunodeficiency virus-seronegati... by Beril Guler, Guven Cetin

“…LCA-positive lymphoid neoplasia had a plasmacytoid/anaplastic morphology and null cell phenotype. HHV-8 and Epstein-Barr virus-encoded small RNAs (EBER) were diffuse positive. …”
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Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia by Aditya Kishore, Susanna A. McRae, David Telio, Monica C. Beaulieu

“…These deposits vary and can be broadly grouped as containing a substructure or being non-organised. Their clinical phenotype can include proteinuria, haematuria, kidney injury and tubulopathies resulting in electrolyte changes. …”
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