Artificial cells with all-aqueous droplet-in-droplet structures for spatially separated transcription and translation by Kanji Tomohara, Yoshihiro Minagawa, Hiroyuki Noji

“…We show that these processes proceed independently within each compartment, maintaining genotype-phenotype correspondence. This approach provides a practical tool for exploring complex systems of artificial organelles within large ensembles of artificial cells.…”
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Restenosis and Therapy by Laszlo Denes, Laszlo Entz, Veronika Jancsik

“…Various insults are shown to initiate the phenotype switch of VSMCs. The pathological process, leading to activated inflammatory process, complement activation, and release of growth factors, initiate the proliferation of VSMCs in the media and cause luminal narrowing and impaired vascular function. …”
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Preclinical Studies of Chemotherapy Using Histone Deacetylase Inhibitors in Endometrial Cancer by Noriyuki Takai, Hisashi Narahara

“…HDACIs were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in a variety of endometrial cancer cell lines. …”
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Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity? by Ulfat Baig, Prajakta Belsare, Milind Watve, Maithili Jog

“…The association of low birth weight with obesity in later life caused a shift in the concept from thrifty gene to thrifty phenotype or anticipatory fetal programming. The assumption of thriftiness is implicit in obesity research. …”
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Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy by Irina Arutyunyan, Andrey Elchaninov, Andrey Makarov, Timur Fatkhudinov

“…The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. …”
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Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS by Sebastián Beltrán-Castillo, Jaime Eugenín, Rommy von Bernhardi

“…A mild chronic inflammatory state, like that observed in aged individuals, affects microglial function, inducing a dysfunctional phenotype that potentiates neuroinflammation and cytotoxicity instead of neuroprotection in response to additional challenges. …”
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Novel Homozygous TTI2 Variant Causing Autosomal Recessive Syndromic Intellectual Disability and Primary Microcephaly from Pakistan: A Case Report (Exome Report) by Zul Qarnain, Fatima Khan, Fizza Akbar, Salman Kirmani

“…We describe a male patient with a novel TTI2 variant, which has not been previously associated with a human phenotype. His features include intellectual disability, primary microcephaly, delayed psychomotor development, speech delay, short stature, dysmorphic facial features, esotropia, kyphoscoliosis, and behavior abnormalities (Figure). …”
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Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer by Isabel López de Silanes, María Paz Quesada, Manel Esteller

“…Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enhance the malignant phenotype of cancer cells. A thorough understanding of these alterations and their impact upon 3′UTR-directed posttranscriptional gene regulation will uncover promising new targets for therapeutic intervention.…”
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A Pilot Proteomic Analysis of Huntington’s Disease by Functional Capacity by Andrew McGarry, Ruin Moaddel

“…<b>Conclusions:</b> Consistently identified targets that correlate with phenotype or progression may have value, if validated, as enrichment tools in clinical trials and potentially as markers of therapeutic response.…”
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The Histone Modification Code in the Pathogenesis of Autoimmune Diseases by Yasuto Araki, Toshihide Mimura

“…Histone modifications regulate the chromatin states and gene transcription without any change in the DNA sequence, possibly resulting in phenotype alteration in several different cell types. …”
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Functional mechanism on stem cells by tea (Camellia sinensis) bioactive compounds by Yao Cheng, Jiachen Sun, Hui Zhao, Hongxing Guo, Jianying Li

“…Stem cells (SCs) are the immature and undifferentiated cells by a varying capacity for proliferation, self-renewal and the capability to differentiate into one or more different derivatives with specialized function or maintain their stem cell phenotype. Herein, a thorough review is conducted of the functional mechanism on SCs by tea bioactive compounds.…”
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Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy by Marc Baay, Anja Brouwer, Patrick Pauwels, Marc Peeters, Filip Lardon

“…Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and metastasis of a variety of cancers, most likely through polarization of TAMs to the M2 (alternative) phenotype. The interaction between tumor cells and macrophages provides opportunities for therapy. …”
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Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases by Junio Dort, Paul Fabre, Thomas Molina, Nicolas A. Dumont

“…Particularly, the transition of macrophages from their proinflammatory to their anti-inflammatory phenotype was shown to regulate inflammation, myogenesis, fibrosis, vascularization, and return to homeostasis. …”
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Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease by Hugh J Freeman

“…Over 80% of patients had concomitant colonic and/or gastroduodenal involvement with Crohn's disease, suggesting that this entity may represent a specific clinical phenotype of extensive disease localization. Classification of Crohn's disease behaviour using the Vienna classification schema revealed that virtually all patients in this study suffered from intestinal stricture formation or penetrating disease complications. …”
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Sex Differences in Parkinson’s Disease: A Narrative Review by Carlo Cattaneo, Javier Pagonabarraga

“…Research has been performed using multiple databases and scientific journals; this review summarizes the available evidence on sex differences in PD regarding epidemiology, risk factors, genetics, clinical phenotype, social impact, and therapeutic management. …”
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circICMT upregulates and suppresses the malignant behavior of bladder cancer by Xin Luo, FangMei Xie, Guoqiang Qin, Ge Zou, Xu Lu, Chaofeng Zhang, Zeping Han, Ying Zhao, Xiaoyu Song, WenFeng Luo, Yongsheng Li, JinHua He, Jian Shen

“…Conclusion: circICMT is significantly highly expressed in bladder cancer, and intervening circICMT expression affects the malignant phenotype of bladder cancer cells in vivo and in vitro, which may provide potential biomarkers and therapeutic targets for the management of bladder cancer.…”
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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…Mechanistically, the S1PR3 antagonist improved CAR-T cell activation, regulated the central memory phenotype, and reduced CAR-T cell exhaustion in vitro. …”
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…Results SBR suppressed macrophage polarization toward the M1 phenotype while enhancing their polarization toward the M2 phenotype. …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…We assessed the effects of β-endorphin on the inflammatory response and monocyte adhesion in human umbilical vein endothelial cells (HUVECs), foam cell formation, and the inflammatory phenotype in THP-1 monocyte-derived macrophages, and migration and proliferation of human aortic smooth muscle cells (HASMCs) in vitro. …”
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Clinicopathological and predictive value of MAIT cells in non-small cell lung cancer for immunotherapy by Dongyan Shi, Lin Lin, Yun Chen, Jian Liu, Lin Shi, Jinying Lu, Da Zhong, Meijuan Song, Wenhua You, Wen-Hui Li

“…Both peripheral and tumor-infiltrating MAIT cells displayed an exhausted phenotype with upregulated PD-1, TIM-3, and IL-17A while less IFN-γ. …”
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