LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Consequently, LBP-CD155L NVs can potentiate the efficacy of prophylactic and therapeutic administration in a mouse CRC model, as evidenced by decreased infiltration of myeloid-derived suppressor cells (MDSCs) and Tregs, reprogrammed the macrophage phenotypes, which promoted polarization from M2-like macrophages to M1-like macrophages, increased infiltration of effector T cells. …”
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Tracking the Prevalence of Antibiotic Resistance in <i>Enterococcus</i> Within the Spanish Poultry Industry: Insights from a One Health Approach by Josep Garcia-Llorens, Isaac Monroy, Jan Torres-Boncompte, Jose M. Soriano, Pablo Catalá-Gregori, Sandra Sevilla-Navarro

“…<b>Methods</b>: A total of 215 <i>Enterococcus</i> isolates were analyzed. Phenotypic assessments were conducted to determine resistance rates and metabolic capacities, while genotypic characterization focused on detecting vancomycin-resistance genes (<i>vanA</i>, <i>vanB</i>, <i>vanC</i>, and <i>vanD</i>). …”
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High clinical burden of classical homocystinuria in the United States: a retrospective analysis by Mahim Jain, Mehul Shah, Kamlesh M. Thakker, Andrew Rava, Agnes Pelts Block, Colette Ndiba-Markey, Lionel Pinto

“…To obtain a study population most likely to have HCU, stratifications by tHcy levels, clinical characteristics, and phenotypic expressions were applied to refine the cohort. …”
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Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children by Xue Tang, Ju Gao, Xia Guo, Zhi Wan, Jing‐jing Sun

“…Currently, the correlation between clinical phenotypes and molecular alterations in childhood LCH, besides the BRAFV600E mutation, has not been sufficiently studied. …”
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Inheritance patterns of pomological traits in walnut hybridization breeding: influence of parental varieties on nut traits by Akide Özcan, Huri Taşcı, Şakir Burak Bükücü, İlker Büşah Ayaz, Mehmet Sütyemez

“…In reciprocal cross, understanding the genetic contributions of both maternal and paternal parents is crucial, as these contributions significantly influence the phenotypic traits of the resulting progeny. This knowledge allows breeders to predict and select genotypes that best meet the desired breeding objectives, ultimately enhancing agricultural productivity and sustainability. …”
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Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease. by Magdaléna Neřoldová, Elżbieta Ciara, Janka Slatinská, Soňa Fraňková, Petra Lišková, Radana Kotalová, Janka Globinovská, Markéta Šafaříková, Lucie Pfeiferová, Hana Zůnová, Lenka Mrázová, Viktor Stránecký, Alena Vrbacká, Ondřej Fabián, Eva Sticová, Daniela Skanderová, Jan Šperl, Marta Kalousová, Tomáš Zima, Milan Macek, Joanna Pawlowska, A S Knisely, Stanislav Kmoch, Milan Jirsa

“…<h4>Results</h4>WES revealed biallelic variation in 3 ciliopathy genes (PKHD1, TMEM67 and IFT172) in 4 clinically unrelated index subjects (3 children and 1 adult), heterozygosity for a known variant in PPOX in one adult index subject, and homozygosity for an unreported splice-site variation in F11R in one child. Whereas phenotypes of the index patients with mutated PKHD1, TMEM67, and PPOX corresponded with those elsewhere reported, how F11R variation underlies liver disease remains unclear. …”
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Rapid Detection of Hybrid Maize Parental Lines Using Stacking Ensemble Machine Learning by M. Aqil, M. Azrai, M. J. Mejaya, N. A. Subekti, F. Tabri, N. N. Andayani, Rahma Wati, S. Panikkai, S. Suwardi, Z. Bunyamin, E. Roy, M. Muslimin, M. Yasin, E. Prakasa

“…The developed modern plant phenotyping model can be used to assist breeders/technicians in maintaining the quality of large-scale hybrid maize seed production activities in Indonesia.…”
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<i>Botrytis cinerea</i> PMT4 Is Involved in <i>O</i>-Glycosylation, Cell Wall Organization, Membrane Integrity, and Virulence by Verónica Plaza, Alice Pasten, Luz A. López-Ramírez, Héctor M. Mora-Montes, Julia Rubio-Astudillo, Evelyn Silva-Moreno, Luis Castillo

“…Expression of <i>bcpmt4</i> in <i>S. cerevisiae</i> Δ<i>Scpmt4</i> or Δ<i>Scpmt3</i> null mutants restored glycan levels like those observed in the parental strain. The phenotypic analysis showed that Δ<i>bcpmt4</i> null mutants exhibited significant changes in hyphal cell wall composition, including reduced mannan levels and increased amounts of chitin and glucan. …”
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Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene by O. V. Arkova, I. A. Drachkova, T. V. Arshinova, D. A. Rasskazov, V. V. Suslov, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, L. K. Savinkova

“…We also determined the half-life and Gibbs free energy of the complex of TBP with the АВСА9 promoter. Possible phenotypic manifestations of the candidate SNP marker rs367781716 are discussed.…”
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Enabling regulatory policy globally will promote realization of the potential of animal biotechnology by Eric Hallerman, Justin Bredlau, Luiz Sergio A. Camargo, Maria Lucia Zaidan Dagli, Margaret Karembu, Daniel Kovich, Anne Ndanu Muia, Mariana L. Murrone, Pedro Jesus Rocha-Salavarrieta, Rhodora Romero-Aldemita, Mark Tizard, Mark Walton, Diane Wray-Cahen

“…Advances in animal biotechnology, especially genome editing, can accelerate the incorporation of valued phenotypes in animals, including enhanced yield, disease resistance, resilience to changing climate, and improved animal welfare, as well as food qualities valued by consumers. …”
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Factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies in paediatric age: a prospective multicentre cohort study by Giorgio Bedogni, Roberto Berni Canani, Laura Carucci, Rita Nocerino, Serena Coppola, Pasqualina Capasso, Veronica Giglio

“…At 24-month follow-up, the rate of patients with allergic march was 0.46 (95% CI 0.38 to 0.55, n=57/123), without differences comparing the four phenotypes. The presence of multiple FAs at baseline was associated with an increased risk of developing allergic march (OR=2.22, 95% CI 1.07 to 4.61) at 24-month follow-up.Conclusions The results of the study suggest the potential role of modifiable and non-modifiable risk factors influencing the natural history of paediatric patients affected by non-IgE-GIFA.…”
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A bacterial membrane-disrupting protein stimulates animal metamorphosis by Kyle E. Malter, Tiffany L. Dunbar, Carl Westin, Emily Darin, Josefa Rivera Alfaro, Nicholas J. Shikuma

“…MACs can also deliver Mif1 to human cell lines and cause parallel phenotypes, including cell surface binding, membrane disruption, calcium flux, and mitogen-activated protein kinase activation. …”
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TaWI12 may be involved in pistillody and leaf cracking in wheat by Yuhuan Guo, Yan Zhang, Yuhao Li, Yichao Wu, Mingli Liao, Zhengsong Peng, Zaijun Yang, Yonghong Zhou

“…We noticed two distinct phenotypic differences in the knockout mutant. First, we observed the different degrees of homologous conversion of stamens to pistils in the single mutant TaWI12-4D. …”
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Fecal carriage of carbapenemase and AmpC-β-lactamase producers among extended spectrum β-Lactamase-producing E. coli and Klebsiella spp. isolates in patients attending hospitals by Zakaria Garba, Isidore J. O. Bonkoungou, Namwin Siourimè Somda, Magloire H. Natama, Georges Somé, Lassana Sangaré, Nicolas Barro, Halidou Tinto

“…Carbapenemase and AmpC-β-lactamase production and phenotypic co-resistance were determined. Results Among the 277 ESBL-PE strains isolated, 203 were E. coli, and 74 were Klebsiella spp. …”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Cell growth was detected by CCK-8 and colony formation assays. Macrophage phenotypes were determined using flow cytometry. Immunofluorescence double staining was used to detect the tumor-associated macrophage (TAM) infiltration. …”
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Polymorphisms and dental age in non-syndromic cleft lip and palate: a cross-sectional study by Gabriela Fonseca-Souza, Lhorrany Alves-Souza, Maria Angélica Hueb de Menezes-Oliveira, Nikolaos Daratsianos, Svenja Beisel-Memmert, Christian Kirschneck, Rafaela Scariot, Juliana Feltrin-Souza, Erika Calvano Küchler

“…The Student T-test was used to compare the variations in DA between the phenotypes “with CL ± P” and “without CL ± P”, and the ANOVA two-way test was performed to compare the variations in DA among the genotypes (α = 0.05). …”
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A leap forward: exploring the advantages of single-step genome evaluation in Italian Mediterranean buffalo by Stefano Biffani, Mayra Gómez, Roberta Cimmino, Dario Rossi, Gianluigi Zullo, Riccardo Negrini, Alberto Cesarani, Giuseppe Campanile, Gianluca Neglia

“…The aim of this study was to test the feasibility of ssGBLUP and to present the first results of the implementation of a genomic evaluation for production and type traits in the IMB. Phenotypic information on production (270-day milk, mozzarella yield (MY), protein and fat kg and %, respectively) and morphology: feet and legs (FL) and mammary system (MS) were used for this study. …”
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Correlation Analysis of Twig and Leaf Characteristics and Leaf Thermal Dissipation of <i>Hippophae rhamnoides</i> in the Riparian Zone of the Taohe River in Gansu Province, China by Qun Li, Min Ma, Yurui Tang, Tingting Zhao, Chengzhang Zhao, Bo Li

“…The co-variation of plant branches and leaves and the timely adjustment of thermal dissipation in photoheterogeneous habitats reflect the phenotypic plasticity mechanism and self-protection strategy of riparian plants in adapting to heterogeneous environments.…”
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Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer by Asiye Busra Boz Er

“…Tumour heterogeneity, describing genetic, epigenetic, and phenotypic differences within and between tumours, complicates tumour treatment and contributes to drug resistance. …”
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Cloning and Functional Analysis of <i>BraTSD2</i> Associated with Root Swelling in Turnip (<i>Brassica rapa</i> L.) by Wenyue Huang, Shifan Zhang, Fei Li, Hui Zhang, Rifei Sun, Guoliang Li, Shujiang Zhang

“…The promoter of the turnip <i>BraTSD2</i> gene was expressed throughout the whole plant in <i>Arabidopsis thaliana</i>. Phenotypic observation and analysis of <i>A. thaliana</i> overexpression <i>BraTSD2</i> transgenic lines showed that plants overexpressing <i>BraTSD2</i> had fewer primary and lateral roots compared to the wild type, with lighter leaf color, and delayed development and flowering. …”
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