Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling by Rafael Dariolli, Raphael Nir, Tova Mushlam, Glauco R. Souza, Stephen R. Farmer, Miguel L Batista, Jr.

“…However, existing adipose tissue models have limitations, particularly in the stable culture of fat cells that maintain physiologically relevant phenotypes, hindering a deeper understanding of adipocyte biology and the molecular mechanisms behind differentiation. …”
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Invasive Aspergillus niger Is the Sole Etiological Agent for CSOM : A Clinical Case from Nepal by Ajay Kumar Chaurasiya, Rabindra Bhakta Pradhananga, Niranjan Prasad Sah, Basista Prasad Rijal, Bharat Mani Pokhrel, Santosh Dulal

“…Aspergillus niger was microbially conformed by specifically characterizing the specific phenotypic biseriate structure of phialides and the black-coloured conidia. …”
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Genome-Wide Association Study of Metabolic Syndrome in Koreans by Seok Won Jeong, Myungguen Chung, Soo-Jung Park, Seong Beom Cho, Kyung-Won Hong

“…To reconsider the discarded true-positive loci, we attempted to include the functional variants (nonsynonymous SNPs [nsSNPs] and expression quantitative trait loci [eQTL]) among the top 5,000 SNPs based on the proportion of phenotypic variance explained by genotypic variance. …”
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Physical activities and breast cancer: a Mendelian randomization study by Lishan Ding, Qingliang Chen, Hao Liang, Meng Shen, Ming Zheng, Zhaojun Li

“…Material and methods Genome-wide association studies utilizing data from the UK Biobank baseline were employed to analyze PA phenotypes, encompassing 460,376 participants. Summary data for BC, comprising 122,977 cases and 105,974 controls, were obtained from the BC Association Consortium. …”
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Clinical features, pathological characteristics, and prognosis of patients with IgA nephropathy complicated with nephrotic syndrome by Li Tan, Lu-Hua Jin, Yi-Qin Wang, Wei Chen, Qiong Wen

“…In conclusions, significant differences in clinicopathological features and long-term prognosis were observed among NS-IgAN patients with varying pathological phenotypes.…”
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Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys by Ayaka Domon, Kentaro Katayama, Yuki Tochigi, Hiroetsu Suzuki

“…There was a marked difference in the etiology of DEK by gender: DM phenotypes including polyuria, polydipsia, and hyperglycemia (nonfasting blood glucose over 300 mg/dl) were found in male rats aged over 10 weeks but not in female rats. …”
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A genome-wide association study identified SNP markers and candidate genes associated with morphometric fruit quality traits in mangoes by Shamseldeen Eltaher, Jin Li, Barbie Freeman, Sukhwinder Singh, Gul Shad Ali

“…Conclusions To choose the most promising mango accessions for future breeding and for closing genetic gaps among the accessions and increasing genetic diversity, a new selection method is suggested based on phenotypic traits such as high-yielding mango fruit cultivars, number of reference alleles, and genetic distance among the selected genotypes. …”
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Effect of epigallocatechin-3-gallate (EGCG) on cognitive functioning and the expression of APP and BDNF in the hippocampus of rats with streptozotocin -induced Alzheimer-like disea... by Farnaz Ghayour Babaei, Ehsan Saburi, Fatemeh Forouzanfar, Mohadese Asgari, Zakieh Keshavarzi, Vahid Hajali

“…We aimed to investigate the potential therapeutic effects of the active substance of green tea, epigallocatechin-3-gallate (EGCG), on behavioral phenotypes and markers of neurogenesis in an Alzheimer disease (AD) rat model. …”
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Drosophila melanogaster inhabiting northern regions of European Russia are infected with Wolbachia which adversely affects their life span by N. V. Roshina, A. V. Symonenko, A. V. Krementsova, Е. A. Tsybul’ko, V. E. Alatortsev, E. G. Pasyukova, D. V. Mukha

“…In D. melanogaster, Wolbachia affects various life history traits, behaviour, sensitivity to stress and viral infection. The phenotypic effects of Wolbachia might evolve to promote its further spreading, increasing the interest in exploring the spread of Wolbachia, in particular, at the boundar­ies of the D. melanogaster habitat, in association with the effects on vital traits of host species. …”
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Response of the gut microbiome and metabolome to dietary fiber in healthy dogs by Amrisha Bhosle, Matthew I. Jackson, Aaron M. Walsh, Eric A. Franzosa, Dayakar V. Badri, Curtis Huttenhower

“…Thus, our study corroborates findings in human cohorts and reinforces the role of personalized microbiomes even in seemingly phenotypically homogeneous subjects.IMPORTANCEConsumption of dietary fiber changes the composition of the gut microbiome and, to a larger extent, the associated metabolites. …”
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Candidate genes for domestication and resistance to cold climate according to whole genome sequencing data of Russian cattle and sheep breeds by N. S. Yudin, D. M. Larkin

“…It is known that different species of animals, when living in the same environmental conditions, can form similar phenotypes. The study of the convergent evolution of several species under the influence of the same environmental factor makes it possible to identify common mechanisms of genetic adaptation. …”
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Changes of Cell Adhesion Molecules and T Cell Subset Populations in Acute Myeloid Leukemia Patients Undergoing Intravenous Administration of Cytarabine Supplemented with Idarubicin by Jinhua Piao, Didi Wang, Siying Pei, Tangdong Ge, Jing Li, Pengxia Zhang

“…Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), IL-10, and IL-35 were measured by ELISA methods. Phenotypic characteristics of T cell subsets including CD4+, CD8+, CD4+IL-10 Tregs, and CD4+CD25+CD127−Foxp3+ Tregs were analyzed by flow cytometry. …”
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Phenetic analysis of natural apricot populations in the Mountainous Dagestan for endocarp (stone) features by D. M. Anatov

“…Studying the intraspecies diversity of fruit crop wild relatives is one of the leading trends in botanical and genetic resource research associated with identification and utilization of the phenotypic potential of the population and species, the initial stage in plant breeding and introduction processes, and a prerequisite to solving a number of problems posed by the theory of microevolution, biosystematics and population biology. …”
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Molecular Epidemiology and Antimicrobial Resistance of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae in Retail Cattle Meat by Nasrin Akter Liza, Hemayet Hossain, Md. Shahidur Rahman Chowdhury, Jarin Al Naser, Rayhan Mahmud Lasker, Asikur Rahman, Md. Ariful Haque, Md. Al Mamun, Md. Mukter Hossain, Md. Mahfujur Rahman

“…Antimicrobial resistance was observed against 12 antibiotics. According to the phenotypic resistance pattern determined through the disk diffusion method, all isolates (100%) were resistant to ampicillin, amoxicillin, cefuroxime, cefotaxime, and colistin. …”
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Faecalibacterium prausnitzii regulates carbohydrate metabolic functions of the gut microbiome in C57BL/6 mice by Peiling Geng, Ni Zhao, Yufan Zhou, Reuben S. Harris, Yong Ge

“…Collectively, our results reveal a crucial role of UT1 in facilitating the carbohydrate metabolism of the gut microbiome and expand our understanding of the genetic and phenotypic diversity of F. prausnitzii.…”
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Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal by Roshan Pandit, Balkrishna Awal, Sumesh Shreekhanda Shrestha, Govardhan Joshi, Basista Prasad Rijal, Narayan Prasad Parajuli

“…Escherichia coli (n = 154), the predominant pathogen associated with UTI, was further investigated for the existence of ESBL enzymes by using conventional phenotypic as well as molecular approaches. Among suspected cases of UTI, we found that 15.2% were having UTI and female patients of the reproductive age group were more affected (p<0.05). …”
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Genetic diversity assessment in pea cultivars and lines using the SSR analysis by K. P. Gainullina, B. R. Kuluev, F. A. Davletov

“…The key role in the breeding of new pea cultivars is played by source material representing the phenotypic and genotypic diversity of Pisum sativum L., searched for in plant genetic resources collections. …”
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Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Moreover, key genes involved in pyrimidine de novo synthesis, such as RRM2, were identified as potential drivers of tumor progression, providing new insights into the molecular mechanisms underlying aggressive prostate cancer phenotypes. In conclusion, pyrimidine metabolism plays a critical role in prostate cancer progression, influencing immune infiltration and drug sensitivity. …”
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Molecular mechanisms and comparative transcriptomics of diapause in two corn rootworm species (Diabrotica spp.) by Melise C. Lecheta, Chad Nielson, B. Wade French, Emily A.W. Nadeau, Nicholas M. Teets

“…Comparative transcriptomic analyses between WCR and NCR indicated that while many gene expression changes were conserved across species, overall gene expression profiles were distinct, indicating that many transcriptional changes are species-specific, despite the close phylogenetic relationship and phenotypic similarity between these species. This study sheds light on the suite of mechanisms that allow some organisms to pause the symphony of cellular events that occur during embryonic development and persist for several months as a tiny egg. …”
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Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort by J. Korduner, P. M. Nilsson, O. Melander, M. J. Gerl, G. Engström, E. Bachus, M. Magnusson, F. Ottosson

“…This unique and extensive biomarker profiling presents novel data on potentially differentiating traits between these two obese phenotypes.…”
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