Subregional pedoclimatic conditions with contrasted UV-radiation shape host-microbiome and metabolome phenotypes in the grape berry by Viviana Martins, Cécile Abdallah, António Teixeira, Carolina Moreira, Márcio Nóbrega, Arnaud Lanoue, Hernâni Gerós

“…Metabarcoding showed a trade-off between bacteria and fungal diversity among subregions, with Pseudomonas, Lactobacillus, Aspergillus and Penicillium acting as intraregional microbial markers. The high phenotypic plasticity of berries and the role of microbes in this process are relevant upon current projections for increased UV radiation and temperature in Southern European viticulture, in a climate change scenario, with predicted impacts on regional wine quality and on the development of adaptation strategies for resilient viticulture.…”
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Probabilistic genotype-phenotype maps reveal mutational robustness of RNA folding, spin glasses, and quantum circuits by Anna Sappington, Vaibhav Mohanty

“…Recent studies of genotype-phenotype maps have reported universally enhanced phenotypic robustness to genotype mutations, a feature essential to evolution. …”
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Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose by Lisa Deloch, Jana Fuchs, Michael Rückert, Rainer Fietkau, Benjamin Frey, Udo S. Gaipl

“…The latter innate immune cells show a high plasticity in their phenotype and are central in inflammatory processes. …”
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Phenotypic effects of the dwarfing gene Rht-17 in spring durum wheat under two climatic conditions by A. G. Chernook, P. Yu. Kroupin, L. A. Bespalova, V. V. Panchenko, V. Ya. Kovtunenko, M. S. Bazhenov, L. A. Nazarova, G. I. Karlov, A. Yu. Kroupina, M. G. Divashuk

“…Alleles of the genes, conferring a dwarfing phenotype, play a crucial role in wheat breeding, as they not only reduce plant height, ensuring their resistance to lodging, but also have a number of positive and negative pleiotropic effects on plant productivity. …”
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Improving polygenic prediction from summary data by learning patterns of effect sharing across multiple phenotypes. by Deborah Kunkel, Peter Sørensen, Vijay Shankar, Fabio Morgante

“…Polygenic prediction of complex trait phenotypes has become important in human genetics, especially in the context of precision medicine. …”
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Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice by Susanne Syberg, Solveig Petersen, Jens-Erik Beck Jensen, Alison Gartland, Jenni Teilmann, Iain Chessell, Thomas H. Steinberg, Peter Schwarz, Niklas Rye Jørgensen

“…In conclusion, we have shown that the genetic background of P2X7−/− mice strongly influences the bone phenotype of the P2X7−/− mice and that P2X7 has a more significant regulatory role in bone remodeling than found in previous studies.…”
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Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages by P. Allavena, M. Chieppa, G. Bianchi, G. Solinas, M. Fabbri, G. Laskarin, A. Mantovani

“…This study highlights that tumoral mucin-mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype.…”
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Biological age model using explainable automated CT-based cardiometabolic biomarkers for phenotypic prediction of longevity by Perry J. Pickhardt, Michael W. Kattan, Matthew H. Lee, B. Dustin Pooler, Ayis Pyrros, Daniel Liu, Ryan Zea, Ronald M. Summers, John W. Garrett

“…Here we show a personalized phenotypic CT biological age model that can be opportunistically-derived, regardless of clinical indication, to better inform risk assessment.…”
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Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients by Gati K. Panigrahi, Prakash P. Praharaj, Hiroki Kittaka, Asit R. Mridha, Olen M. Black, Rakesh Singh, Roger Mercer, Adrie van Bokhoven, Kathleen C. Torkko, Chapla Agarwal, Rajesh Agarwal, Zakaria Y. Abd Elmageed, Hariom Yadav, Santosh K. Mishra, Gagan Deep

“…Overall, these results support the usefulness of serum exosomes to noninvasively detect inflammatory phenotype and to discover novel biomarkers associated with PCa in African American men.…”
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Pathogenic Variants in the ABCA12 Gene Associated to Autosomal Recessive Congenital Ichthyosis: Report of an Attenuated Phenotype by Gabriela Mantilla Beltrán, Ana María Navarro Pinilla, Diego Andrés Padilla Mantilla, Alfonso Suárez Camacho, Mónica Paola Novoa Candia

“…A subgroup of this is the autosomal recessive congenital ichthyosis (ARCI), characterised by a severe phenotype and classified according to the molecular mechanisms that underlie the disease. …”
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Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation by M. A. Tikhonova, T. G. Amstislavskaya

“…Therefore, the study of sexual behavior appears to be an important step in modeling various animal pathologies and the effects of psychotropic drugs. We have performed phenotyping of animals with hereditary predisposition to catalepsy using our previous development, a model of male sexual arousal, and examined the relationship between catalepsy and sexual arousal. …”
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Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate by Jayalekshmi Haripriyan, Christy Rose Binu, Nitasha D Menon, Muralidharan Vanuopadath, Malavika B. Hari, N Namitha, Kesiya Binoy, Anil Kumar, Bipin G. Nair, Victor Nizet, Geetha B. Kumar

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High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis by Soon Sang Park, Tae Hoon Roh, Yoshiaki Tanaka, Young Hwa Kim, So Hyun Park, Tae-Gyu Kim, So Yeong Eom, Tae Jun Park, In-Hyun Park, Se-Hyuk Kim, Jang-Hee Kim

“…Specifically, tumor cells with p16INK4A-high expression display a senescent phenotype and are correlated with higher intra-tumoral immune cell infiltration. …”
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A Comparative Study on Phenotypic versus ITS-Based Molecular Identification of Dermatophytes Isolated in Dakar, Senegal by Khadim Diongue, Ludivine Bréchard, Mamadou Alpha Diallo, Mame Cheikh Seck, Mouhamadou Ndiaye, Aida Sadikh Badiane, Stéphane Ranque, Daouda Ndiaye

“…Classically, dermatophytes are identified by phenotypic methods even if these methods, sometimes, remain difficult or uncertain. …”
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Phenotypic traits differentiating the genetic resources of pea (<i>Pisum sativum</i> L.) by the type of use by E. V. Semenova, A. P. Boyko, L. Y. Novikova, M. A. Vishnyakova

“…It was for the first time that these accessions were studied for a set of phenotypic traits. The object of the study was a sample of 494 pea accessions originated from 43 countries and 18 regions and territories of the Russian Federation. …”
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Phenotypic variability of <i>Linum usitatissimum</i> L. accessions under the conditions of the Northern Trans-urals by K. P. Korolev, N. A. Bome, N. N. Kolokolova

“…Sixty flax accessions were studied in the fields of the south of Tyumen Province in 2017–2020. Phenotypic screening was performed according to the published lists of descriptors, taking into account outdoor seed germination, plant height, seed yield, flax straw, retted stalks, and fiber. …”
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Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes by Danielle A. Simmons, Sridhar Selvaraj, Tingshuo Chen, Gloria Cao, Talita Souto Camelo, Tyne L.M. McHugh, Selena Gonzalez, Renata M. Martin, Juste Simanauskaite, Nobuko Uchida, Matthew H. Porteus, Frank M. Longo

“…This study examined the efficacy of intrastriatally transplanted striatal progenitor cells (STRpcs) derived from these hPSCs against HD phenotypes in R6/2 mice. Engrafted STRpcs overexpressing BDNF alleviated motor and cognitive deficits and reduced mutant huntingtin aggregates. …”
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Assessment of Gastric Phenotypes Using Magnifying Narrow-Band Imaging for Differentiation of Gastric Carcinomas from Adenomas by Masaaki Kobayashi, Satoru Hashimoto, Ken Nishikura, Ken-Ichi Mizuno, Manabu Takeuchi, Yoichi Ajioka

“…Immunohistochemical studies have reported an obvious phenotypic difference between adenomas and carcinomas. …”
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Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China by Chao Yang, Xiaowei Chen, Min Li, Wenchang Yuan, Shunguang Li, Dexing Han, Junhui Feng, Haimin Luo, Minling Zheng, Jiaqi Liang, Cha Chen, Pinghua Qu, Song Li

“…However, there is limited knowledge of genomic prevalence characteristics and phenotypic features of S. aureus in AD patients in China. …”
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USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1 by Wensun Chen, Siqi Wu, Yifan Chen, Weijian Li, Yiqing Cao, Yingchun Liang, Xiyu Dai, Xinan Chen, Yilin Chen, Tian Chen, Shenghua Liu, Chen Yang, Haowen Jiang

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