Clinical Outcomes and Donor-specific Antibody Rebound 5 y After Kidney Transplant Enabled by Imlifidase Desensitization by Ian S. Jaffe, BS, Anna Runström, MSc, Vasishta S. Tatapudi, MD, Elaina P. Weldon, MSN, ACNP-BC, Cecilia L. Deterville, MS, Rebecca A. Dieter, PharmD, Robert A. Montgomery, MD, DPhil, Bonnie E. Lonze, MD, PhD, Massimo Mangiola, PhD

“…Dilution studies of sensitized serum enabled the identification of lower AMR risk phenotypes for persisting DSAs. Severe and/or opportunistic infections were not observed at greater than expected frequency. …”
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Diagnostic efficiency of exome-based sequencing in pediatric patients with epilepsy by Huafang Zou, Huafang Zou, Qian Zhang, Jianxiang Liao, Jianxiang Liao, Dongfang Zou, Zhanqi Hu, Bing Li, Li Chen, Jialun Wen, Xia Zhao, Victor Wei Zhang, Dezhi Cao, Dezhi Cao

“…Single-nucleotide variants (SNVs) and copy number variants (CNVs) were interpreted based on each patient’s phenotypic presentation. Additionally, data concerning clinical symptoms, neuroimaging findings, treatment responses, and prognostic outcomes were collected and analyzed.ResultsThe overall diagnostic yield was 32.8% (85/259), with a diagnostic yield of 40.0% for exome-based epilepsy panels, 30.1% for CES, and 27.8% for WES. …”
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PMAIP1-mediated glucose metabolism and its impact on the tumor microenvironment in breast cancer: Integration of multi-omics analysis and experimental validation by Yidong Zhang, Hang Xu, Xuedan Han, Qiyi Yu, Lufeng Zheng, Hua Xiao

“…Single-cell analysis was also conducted to explore the role of specific cell clusters in breast cancer, and Bayes deconvolution was used to further investigate the associations between cell clusters and tumor phenotypes of breast cancer. Results: Four significant prognostic genes (PMAIP1, PGK1, SIRT7, and SORBS1) were identified, and, through immune infiltration analysis, a combined prognostic model based on glucose metabolism and immune infiltration was established. …”
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Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics by Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon

“…We provide a genomic resource from a phenome-wide application of our models to more than 1,500 phenotypes from the UK Biobank. Using longitudinal, genetically determined expression, we implement a predictive causality framework, evaluating the prediction of future values of a target gene expression using prior values of a putative regulatory gene. …”
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TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques... by Ming Zhai, Zhijun Lei, Yefei Shi, Jiayun Shi, Yanxi Zeng, Shiyu Gong, Weixia Jian, Jianhui Zhuang, Qing Yu, Mark W. Feinberg, Wenhui Peng

“…Central to this process is the modulation of vascular smooth muscle cells (VSMCs) phenotypes, emphasizing their pivotal role in atherosclerotic plaque stability and healing post‐disruption. …”
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Analysis of variability in gestation length in sows and its association with litter traits at birth by Alexander Kramarenko, Olena Yulevich, Iryna Lіuta, Serhii Kramarenko

“…Meta-analysis revealed that the “general” estimates of the phenotypic correlation coefficient between gestation length and total litter size, the number of live piglets, and total litter weight at birth were significant and negative. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…Today‘s methods of NAFLD modelling can be divided into two extensive groups: induction of liver disease by genetic mutation, and phenotypic development of NAFLD due to alimentary factor. …”
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Forecasting Range Shifts in Terrestrial Alpine Insects Under Global Warming by Fabio Leonardo Meza‐Joya, Mary Morgan‐Richards, Steven A. Trewick

“…Alpine insects exhibit some potential to respond to rising temperatures via genetic change or phenotypic plasticity. Thus, future efforts should incorporate biological processes by using flexible hybrid niche modelling approaches to enhance the biological realism of predictions. …”
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Epidemiology of transthyretin (ATTR) amyloidosis: a systematic literature review by Diego Delgado, Firas Dabbous, Nitin Shivappa, Faizan Mazhar, Eric Wittbrodt, Divya Shridharmurthy, Krister Järbrink

“…Studies evaluating populations with genotypes and phenotypes of ATTR amyloidosis (variant and wild-type cardiomyopathy, polyneuropathy, and mixed) were included. …”
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Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study by BoWen Yang, XiaoYu Zeng, HanYu Wang, JiuHuan Feng, ShuFang Hou

“…However, the causal relationship between these two phenotypes remains uncertain. This study aims to examine the bidirectional causal relationship between serum MMPs and three urologic cancers: kidney, prostate, and bladder cancer. …”
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Multimodal Imaging Characteristics of ADRP in a Family with p.Thr58Arg Substituted RHO Mutation by Misty Ruppert, John Pyun, K. V. Chalam, David Sierpina

“…Additionally, we compare the patient’s phenotypic findings to those of her offspring, who was also affected by adRP. …”
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Adipose-Derived Stem Cells in Bone Tissue Engineering: Useful Tools with New Applications by Gabriele Storti, Maria Giovanna Scioli, Bong-Sung Kim, Augusto Orlandi, Valerio Cervelli

“…The use of ASCs has offered significative new advancements in the efficacy of each of these elements. Notably, the phenotypic study of ASCs allowed discovering cell subpopulations, which have enhanced osteogenic and vasculogenic capacity. …”
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Localization of the quantitative trait loci related to lodging resistance in spring bread wheat (<i>Triticum aestivum</i> L.) by I. N. Leonova, E. V. Ageeva

“…Here we present the results of localization of the genomic regions associated with resistance to lodging, plant height, and upper internode diameter in Russian bread wheat varieties. Phenotypic screening of 97 spring varieties and breeding lines was carried out in the field conditions of the West Siberian region during 2017–2019. …”
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Online resources on gene networks containing human and animal data by E. V. Ignatieva, D. A. Afonnikov, N. A.  Kolchanov

“…Gene networks are molecular genetic systems that ensure the formation of phenotypic characteristics of organisms (molecular, biochemical, structural, morphological, behavioral, etc.) based on  information encoded in their genomes. …”
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Idiopathic giant cell myocarditis or cardiac sarcoidosis? A retrospective audit of a nationwide case series by Kaj Ekström, Anne Räisänen‐Sokolowski, Jukka Lehtonen, Hanna‐Kaisa Nordenswan, Mikko I. Mäyränpää, Markku Kupari

“…The possibility that they represent different phenotypes of a single disease has been debated. Methods and results We made a retrospective audit of 73 cases of GCM diagnosed in Finland since the late 1980s. …”
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Premonitory urge in tic disorders – a scoping review by John B. Wohlgemuth, Kelly H. Watson, Kayce D. Gill, David A. Isaacs

“…They are highly prevalent, frequently bothersome, and increasingly recognized as a central phenotypic feature in tic disorder populations. This scoping review aimed to systematically consolidate published knowledge and identify knowledge gaps regarding premonitory urges in primary tic disorders.MethodsSearch strategies were deployed in five databases and five topic-relevant journals. …”
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Genetic parameters of production and reproduction traits of Mediterranean buffaloes under tropical conditions by Iván A. Cárdenas, Miguel A. Chacón

“…For this reason, the zootechnical performance of a herd of Mediterranean buffaloes in Puerto Concha, Zulia state, Ven-ezuela, was evaluated. The phenotypic behavior and genetic parameters of the characteristics of milk yield (MY), lactation length (LL), calving interval (CI), age at first calving (AFC), and peak lactation (PLAC) were analyzed. …”
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Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome by Kathryn Jespersen, Chenxin Li, Rishi Batra, Christopher A. Stephenson, Paul Harding, Kylie Sestak, Ryan T. Foley, Harrison Greene, Trevor Meisinger, Jason R. Cook, B. Timothy Baxter, Wanfen Xiong

“…This might be mediated by inducing a contractile phenotypic change of SMC. Our results suggest that inhibiting Notch3 activation may provide a strategy to prevent and treat aortic aneurysms in MFS.…”
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Maintien du potentiel adaptatif chez les plantes domestiquées à propagation clonale by Doyle McKey, Marianne Elias, Benoît Pujol, Anne Duputié, Marc Delêtre, Delphine Renard

“…Cloning is the only efficient way to “capture” and multiply initially rare favourable phenotypes in habitually outcrossed plants such as manioc. …”
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An Extremely Rare SRD5A2 Gene c.485A>C Mutation in a Compound Heterozygous Newborn with Disorders of Sex Development First Identified in Vietnam by Phan Tuong Quynh Le, Thanh Nha Uyen Le, Thi Thanh Binh Nguyen, Minh Thao Nguyen, Thi Minh Thi Ha

“…Our finding has enriched the understanding of the spectrum of SRD5A2 variants and phenotypic correlation in Asian patients with 46,XY DSD.…”
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