Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Quantitative gene expression analysis revealed upregulated mRNA levels of selected Toll-like receptors. Flow cytometric phenotyping of CT-stimulated huPBLs identified raised numbers of CD25+-activated leukocytes. …”
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Analysis of Qualitative Indicators of Norway Spruce and Silver Fir Seed Stands in the Federation of Bosnia and Herzegovina by Dalibor Ballian, MIrzeta Memišević Hodžić

“…For this research, four measured and 19 observed phenotypic traits were analyzed in 11 Norway spruce and 14 silver fir seed stands. …”
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High interindividual variability of indoxyl sulfate production identified by an oral tryptophan challenge test by Ting-Yun Lin, Wei-Kai Wu, Szu-Chun Hung

“…There was no significant difference in baseline characteristics or CYP2E1 and SULT1A1-SNP genotyping distributions between the two IS-producing phenotypes. However, distinct differences in gut microbial composition were identified. …”
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E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90β and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells by Bo Tan, Jingwei Zhang, Wen Wang, Haibo Ma, Yuanyuan Yang

“…It is interesting to note that E3 ubiquitin ligase CHIP is involved in radiation resistance and stemness phenotypes in NSCLC, while the downstream mechanisms remain elusive. …”
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Breast Carcinoma, Intratumour Heterogeneity and Histological Grading, Using Geostatistics by Vénus Sharifi‐Salamatian, Anne de Roquancourt, Jean Paul Rigaut

“…Chromosomal patterns specific of a type of cancer are frequent even though phenotypic spatial heterogeneity is omnipresent. The latter is the usual cause of histological grading imprecision, a well documented problem, without any fully satisfactory solution up to now. …”
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Chronic Benign Tubular Albuminuria From Compound Heterozygous Variants in : A Case Report by Adam Pietrobon, Mark D. Elliott

“…Third, the location of CUBN variants dictates phenotypic consequences, with C-terminal variants leading to albuminuria without vitamin B12 deficiency.…”
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From dyspnea to Olympic qualification - A case report as a model for post-acute sequelae of COVID-19 by Baudrexl JC, Steinestel K, Gagiannis D

“…Based on our findings, multidisciplinary phenotyping of individual cases of pulmonary PASC appears to be of central importance as a basis for an individualised therapeutic approach. …”
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Tissue-specific resistance and susceptibility to the tomato brown rugose fruit virus (ToBRFV) conferred by Solanum pennellii loci by Edan Rochsar, Shai Torgeman, Kfir Bandel, Amnon Koren, Chen Klap, Aviv Dombrovsky, Dani Zamir

“…Results The BILs were inoculated and genotyped for 5000 single primer enrichment technology (SPET) markers and phenotyped for virus presence, using ELISA, and for visual symptoms in the terminal shoot, axillary shoots, and fruits. …”
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Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation by Dylan J. Sebo, Irshad Ali, Audrey R. Fetsko, Aubrey A. Trimbach, Michael R. Taylor

“…Here, we used zebrafish to further characterize this phenotypic heterogeneity of the CNS vasculature. Using transgenic reporters of Wnt/β-catenin transcriptional activity, we found an inverse correlation between activated Wnt/β-catenin signaling in endothelial cells (ECs) versus non-ECs within these distinct microenvironments. …”
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The role of plastid genes in a heterosis effect and the formation of morphophysiological traits in sunflower plants by A. V. Usatov, M. S. Makarenko, A. A. Kovalevich, A. М. Gubaidullina

“…Consequently, plastid genes, along with nuclear ones, participate in the expression of these phenotypic traits. As for the oil content in seeds, no heterosis effect was observed in the hybrids.…”
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New Parameters for Impedance–pH Monitoring in Diagnosing Gastroesophageal Reflux Disease and Predicting its Severity by O. A. Storonova, A. S. Trukhmanov, A. A. Makushina, A. V. Paraskevova, V. T. Ivashkin

“…The authors set out to assess the values of MNBI and the PSPW index as additional criteria improving the diagnostic efficacy of impedance-pH monitoring, the completeness of clinical phenotyping of gastroesophageal reflux disease (GERD), as well as determining the probability of a more severe disease course. …”
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Selection of Superior Sugar Beet Genotypes using the Analysis of Quantitative and Qualitative Traits by Mahdi Hassani, Ali Saremirad, Hamed Mansouri

“…Genotype 42 exhibited the least favorable condition in white sugar yield and ranked lowest. The phenotypic diversity coefficient ranged from 4.99% for sugar content to 22.53% for sodium content while the genetic diversity coefficient varied from 1.96% for potassium content to 14.23% for sodium content. …”
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Detection and Whole-Genome Characteristics of <i>Bordetella trematum</i> Isolated from Captive Snakes by Magdalena Zając, Inga Bona, Magdalena Skarżyńska, Renata Kwit, Anna Lalak, Ewelina Skrzypiec, Emilia Mikos-Wojewoda, Paulina Pasim, Dominika Wojdat, Weronika Koza, Dariusz Wasyl

“…The findings provide valuable insights into this rare bacterium’s phenotypic and genomic characteristics, addressing an important knowledge gap in its ecology and AMR profile.…”
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Transcriptome response in a marine copepod under multigenerational exposure to ocean warming and Ni at an environmentally realistic concentration by Yunlei Zhang, Shiru Lin, Yaolu Niu, Xiaoping Zhou, Qingxian Lin

“…Currently, studies have concerned the combined effects of Ni and warming in marine organisms at the phenotypic level; however, the underlying molecular mechanisms are poorly known. …”
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Genotypic Characterization of Azotobacteria Isolated from Argentinean Soils and Plant-Growth-Promoting Traits of Selected Strains with Prospects for Biofertilizer Production by Esteban Julián Rubio, Marcela Susana Montecchia, Micaela Tosi, Fabricio Darío Cassán, Alejandro Perticari, Olga Susana Correa

“…Our survey constitutes a first approach to the knowledge of Azotobacter species inhabiting Argentinean soils in three contrasting geographical regions. Moreover, this phenotypic characterization constitutes an important contribution to the selection of Azotobacter strains for biofertilizer formulations.…”
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Ammonifying and phosphorus-solubilizing function of Aliikangiella maris sp. nov. isolated from Phaeocystis globosa bloom and algal–bacterial interactions by Fei Li, Fei Li, Ming-Ben Xu, Liang-Hao Pan, Jie Li, Cai-Bi Lan, Zhe Li, Shan Lu, Jun-Xiang Lai, Jun-Xiang Lai, Peng-Fu Li

“…Two novel Gram-negative, non-spore-forming, motile, rod-shaped, and yellow-pigmented bacteria were designated strains GXAS 306T and GXAS 311. According to phenotypic, chemotaxonomic, phylogenomic, and comparative genomic analyses data, strains GXAS 306T and GXAS 311 were considered to represent a novel species of the genus Aliikangiella. …”
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A One Health approach for the genomic characterization of antibiotic-resistant Campylobacter isolates using Nanopore whole-genome sequencing by Ana Hurtado, Medelin Ocejo, Beatriz Oporto, José Luis Lavín, Ruth Rodríguez, María Ángeles Marcos, Mikel Urrutikoetxea-Gutiérrez, Mikel Urrutikoetxea-Gutiérrez, Miriam Alkorta, Miriam Alkorta, Miriam Alkorta, José María Marimón, José María Marimón

“…The majority of the identified GDRs were present in isolates from different sources, and a good correlation was observed between GDR distribution and phenotypic susceptibility profiles (based on minimum inhibitory concentrations interpreted according to the EUCAST epidemiological cutoff values). …”
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Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization by Fang Zhang, Gang Huang, Bo Hu, Li-Ping Fang, E-Hong Cao, Xiao-Feng Xin, Yong Song, Yi Shi

“…Finally, we show that intranasal adoptive transfer of rHMGB1-activated DCs was sufficient to restore lung neutrophilic inflammation and the Th17 response in a DC-driven model of asthma, whereas the transfer of rHMGB1 plus anti-HMGB1-treated mDCs significantly reduced these inflammation phenotypes. These data suggest, for the first time, that HMGB1 drives the DC-polarized Th17-type response in allergic lung inflammation and that blocking HMGB1 may benefit the attenuation of neutrophilic airway inflammation in asthma.…”
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Quantifying intratumoral biomarker heterogeneity in tubo-ovarian high-grade serous carcinoma to optimize clinical translation by Aline Talhouk, Derek S. Chiu, Liliane Meunier, Kurosh Rahimi, Cécile Le Page, Monique Bernard, Diane Provencher, David G. Huntsman, Anne Marie Mes Masson, Martin Köbel

“…Abstract Intratumoral heterogeneity (ITH) is spatial, phenotypic, or molecular differences within the same tumor that have important implications for accurate tumor classification and assessment of predictive biomarkers. …”
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Behavior of Olive Genotypes Against Quick Decline Syndrome (QDS) Caused by <i>Xylella fastidiosa</i> subsp. <i>pauca</i> in Apulia by Mariangela Carlucci, Michele Antonio Savoia, Pompea Gabriella Lucchese, Valentina Fanelli, Isabella Mascio, Francesco Luigi Aurelio, Monica Marilena Miazzi, Andrea Pacifico, Cinzia Montemurro, Franco Nigro

“…This study integrates phenotypic responses with genetic knowledge to support the development of conservation strategies that will enhance the genetic diversity of Apulian olive cultivars. …”
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