Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis by Georg Auburger, Suzana Gispert, Nadine Brehm

“…We recently showed that the combination of PINK1-knockout with overexpression of A53T-SNCA in double mutant (DM) mice potentiates phenotypes and reduces survival. Now we studied brain hemispheres of DM mice at age of 18 months in a hypothesis-free approach, employing a quantitative label-free global proteomic mass spectrometry scan of posttranslational modifications focusing on methyl-arginine. …”
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A Data Mining Approach Identified Salivary Biomarkers That Discriminate between Two Obesity Measures by Ping Shi, J. Max Goodson

“…A data mining approach based on multiple algorithms is useful for identifying factors associated with phenotypes, especially in cases where relationships are not salient, and a consensus from multiple methods can help produce a more generalizable subset of features. …”
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Enhanced silk production and pupal weight in Bombyx mori through CRISPR/Cas9-mediated circadian Clock gene disruption. by Daniel J Brady, Alessio Saviane, Matteo Battistolli, Irene Varponi, Federica Barca, Kunihiro Shiomi, Silvia Cappellozza, Federica Sandrelli

“…Future research should focus on elucidating the molecular mechanisms driving these phenotypes and determining whether they result from circadian clock functions or pleiotropic effects of B. mori Clk. …”
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Breeding and selection of mini-pigs in the ICG SB RAS by S. V. Nikitin, S. P. Knyazev, K. S. Shatokhin, V. I. Zaporozhets, V. I. Ermolaev

“…We characterized the phenotypic diversity of the ICG mini-pigs in colours, weight categories, types of growth and features of constitution. …”
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Female Brain and Endocrinological Research-Veteran (FemBER-Vet) study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health ou... by Tamlyn Watermeyer, Elliott Atkinson, Glyn Howatson, Gill McGill, Christina Dodds, Paul Ansdell, Chinedu Udeh-Momoh

“…<h4>Methods</h4>The Female Brain and Endocrinological Research-Veteran (FemBER-Vet) Study will create a highly-phenotyped readiness cohort of ex-service persons as well as non-veterans to assess the impacts of, and risks associated with, military service on brain health, using state-of-the-art non-invasive cognitive, physiological and biomarker capture techniques. …”
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Influence of immune cells and inflammatory factors on Alzheimer’s disease axis: evidence from mediation Mendelian randomization study by Linzhu, Jianxin Zhang, Wenhui Fan, Chen Su, Zhi Jin

“…Data were collected from three sources: immune cell data (731 phenotypes), inflammatory factors (48 cytokines from 8,293 individuals), and AD data (35,274 cases, 59,163 controls). …”
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Pattems and models of flowering of some Gampanulaceae Juss. species by E. S. Fomin, T. I. Fomina

“…In combination with visualization tools, they can be used for augmenting plant phenotyping datasets with rendered images of synthetic plants for the purpose of training neural networks in this field.…”
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Clinical Features in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Systematic Review by Susanna Rizzi, Carlotta Spagnoli, Daniele Frattini, Francesco Pisani, Carlo Fusco

“…This systematic review on PubMed, Scopus databases, and other sources is aimed at describing the AADC whole phenotypic spectrum in order to facilitate its early diagnosis. …”
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LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17 by Chanjiao Yao, Lingjuan Zeng, Qin Liu, Xiaoxin Qiu, Chunyan Chen

“…Cells were transfected with lncRNA FAM225B- and PDIA4-related vectors to determine the malignant phenotypes using functional experiments. The mutual binding of lncRNA FAM225B and DDX17 was verified using RNA pull-down and RIP assays. …”
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Performance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study by Raynaud, Marie, Gagnaire, Pierre-Alexandre, Galtier, Nicolas

“…Knowledge of recombination rate variation along the genome provides important insights into genome and phenotypic evolution. Population genomic approaches offer an attractive way to infer the population-scaled recombination rate ρ=4Ner using the linkage disequilibrium information contained in DNA sequence polymorphism data. …”
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The use of artificial intelligence in induced pluripotent stem cell-based technology over 10-year period: A systematic scoping review. by Quan Duy Vo, Yukihiro Saito, Toshihiro Ida, Kazufumi Nakamura, Shinsuke Yuasa

“…AI technologies have been diversely applied in iPSC technology, encompassing the classification of cell types, assessment of disease-specific phenotypes in iPSC-derived cells, and the facilitation of drug screening using iPSC. …”
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Genetic Advancement and Variability of Released Common Bean (Phaseolus vulgaris L.) Varieties from 1974–2009 GC in Ethiopia by Nigussie Kefelegn, Frew Mekibib, Yigzaw Dessalegn

“…Most of the traits have a high phenotypic and genotypic coefficient of variation, heritability, and genetic advance, and selection was effective in the breeding program. …”
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From threats to solutions: A literature review of climate adaptation in anadromous salmon and trout by Lisa G. Crozier, Jared E. Siegel

“…Our analysis revealed several key themes, including the interwoven influences of climate and human activities on genetic variation, phenotypic traits, and population dynamics. We found that geographic patterns in genetic diversity are closely linked to climatic gradients, highlighting the importance to conservation strategies of variation in existing adaptive capacity. …”
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Prenatal Identification and Molecular Characterization of Two Simultaneous De Novo Interstitial Duplications of Chromosomal Regions 7p22.1p21.1 and 15q24.1 by Sabrina C. Burn, Kali Swift, Maria Palmquist

“…Continued observation of the neonate may reveal further phenotypic consequences of these two simultaneous de novo interstitial duplications.…”
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Actual bovine tuberculosis situation in the Republic of Dagestan by M. O. Baratov, P. S. Huseynova

“…Microscopic, conventional phenotypic and targeted biochemical tests indicate that pseudo-allergic reactions, revealed by tests, result from the atypical mycobacteria of the mentioned groups and species, which present in the animal organism, and seem to be responsible for the tuberculin sensibilization. …”
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Streptomyces sp. strain MUSC 5 from mangrove forest in Malaysia: Identification, antioxidant potential and chemical profiling of its methanolic extract by Hefa Mangzira Kemung, Loh Teng-Hern Tan, Kok-Gan Chan, Hooi-Leng Ser, Jodi Woan-Fei Law, Bey Hing Goh

“…The 16S rRNA genomic DNA extraction, phylogenetic analysis and phenotyping methods were used to confirm identity of strain. …”
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The Effect of Long-Term Exercise on the Production of Osteoclastogenic and Antiosteoclastogenic Cytokines by Peripheral Blood Mononuclear Cells and on Serum Markers of Bone Metabol... by J. Kelly Smith, Rhesa Dykes, David S. Chi

“…We also measured lymphocyte phenotypes and serum markers of bone formation (osteocalcin), bone resorption (C-terminal telopeptides of Type I collagen), and bone homeostasis (25 (OH) vitamin D, estradiol, testosterone, parathyroid hormone, and insulin-like growth factor 1). …”
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Improved constructs for bait RNA display in a bacterial three-hybrid assay by Linh D. Nguyen, Hannah LeBlanc, Katherine E. Berry

“…This system offers a straightforward path to identify and assess the consequences of mutations in RBPs with molecular phenotypes of interest. One limiting factor in detecting RNA–protein interactions in the B3H assay is RNA misfolding arising from incorrect base-pair interactions with neighboring RNA sequences in a hybrid RNA. …”
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Influence of leptin administration to pregnant mice on fetal gene expression and adaptation to sweet and fatty food in adult offspring of different sexes by E. I. Denisova, E. N. Makarova

“…The results suggest that the influence of maternal leptin on the expression of genes encoding growth factors and DNA methyltransferases in the fetal liver may mediate its programming effect on offspring metabolic phenotypes.…”
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Canopy temperature depression for droughtand heat stress tolerance in wheat breeding by S. B. Lepekhov

“…These QTLs often explain a small part of phenotypic variance (10–20 %, more likely less than 10 %), which complicates the pyramiding of canopy temperature genes through marker-assisted selection. …”
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