Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases by Min Kyung Sung, Hyoeun Bang, Jung Kyoon Choi

“…Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE) data: type 2 diabetes mellitus (DM), hypertension (HT), and coronary artery disease (CAD). …”
Get full text

The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies by Liu S, Zhang G, Li N, Wang Z, Lu L

“…Age-related cellular and immune dysfunctions, including cellular senescence, senescence-associated secretory phenotypes (SASPs), and immunosenescence, significantly contribute to joint degeneration. …”
Get full text

Role of cytokines and nitric oxide in the induction of tuberculostatic macrophage functions by Vera L. Petricevich, Rosely C. B. Alves

“…The aim of this study was to determine phenotypic differences when BCG invades macrophages. …”
Get full text

Newly developed genomic SSR markers revealed the population structure and genetic characteristics of abaca (Musa textilis Nee) by Mariecris Rizalyn R. Mendoza, Antonio C. Laurena, Maria Genaleen Q. Diaz, Eureka Teresa M. Ocampo, Tonette P. Laude, Antonio G. Lalusin

“…These markers are pivotal for genetic studies of abaca, including trait-marker mapping and the differentiation of accessions even in the juvenile stage, when phenotypic differences may be subtle.…”
Get full text

The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review by Blake Collie, Jacopo Troisi, Martina Lombardi, Steven Symes, Sean Richards

“…Including larger cohorts, standardizing testing methods, and studying the individual phenotypes of endometriosis may lead to more separable results.…”
Get full text

Spherical harmonics texture extraction for versatile analysis of biological objects. by Oane Gros, Josiah B Passmore, Noa O Borst, Dominik Kutra, Wilco Nijenhuis, Timothy Fuqua, Lukas C Kapitein, Justin M Crocker, Anna Kreshuk, Simone Köhler

“…The characterization of phenotypes in cells or organisms from microscopy data largely depends on differences in the spatial distribution of image intensity. …”
Get full text

Microbial Profile of Fresh and Semicooked Nile Tilapia (Oreochromis niloticus) and Hygienic Practice of Fish Handlers in Hawassa, Ethiopia by Fasika Admasu, Abraham Mikru, Kassaye Balkew, Million Adane

“…The microbial load of 40 for each of raw and semicooked fillet samples was estimated by the standard plate count method, and the dominant flora as well as common bacterial pathogens were identified following phenotypic procedures. Moreover, a survey was conducted to assess the hygienic conditions and food safety practices of 30 fish handlers. …”
Get full text

Effect of the B chromosome-located long non-coding RNAs on gene expression in maize by Xin Liu, Wenjie Yue, Shiqi Lin, Yuxian Yang, Tong Chen, Xiaowen Shi

“…The maize B chromosome, which is dispensable and highly heterochromatic, has minimal impact on phenotypes at low copy numbers, making it a promising platform for engineering artificial chromosomes. …”
Get full text

The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response by Liqian Zhu, Clinton Jones, Gaiping Zhang

“…Macrophages are crucial members of the mononuclear phagocyte system essential to protect the host from invading pathogens and are central to the inflammatory response with their ability to acquire specialized phenotypes of inflammatory (M1) and anti-inflammatory (M2) and to produce a pool of inflammatory mediators. …”
Get full text

Brugada Syndrome and Pregnancy: Highlights on Antenatal and Prenatal Management by Laura Giambanco, Domenico Incandela, Antonio Maiorana, Walter Alio, Luigi Alio

“…Sudden cardiac death is the result of phenotypic manifestation of Brugada syndrome. Among asymptomatic Brugada patients, arrhythmia could be provoked by physical activity, fever, or pregnancy. …”
Get full text

Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion. by Harriet V Mears, George R Young, Theo Sanderson, Ruth Harvey, Jamie Barrett-Rodger, Rebecca Penn, Vanessa Cowton, Wilhelm Furnon, Giuditta De Lorenzo, Margaret Crawford, Daniel M Snell, Ashley S Fowler, Anob M Chakrabarti, Saira Hussain, Ciarán Gilbride, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Thomas P Peacock, Jérôme Nicod, Arvind H Patel, Massimo Palmarini, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David L V Bauer

“…We observe distinct phenotypes when the Nucleocapsid coding sequence is mutated compared to when the TRS alone is ablated. …”
Get full text

Agro-Morphological Characterization and Estimation of Genetic Parameters of Spring Maize Hybrids in the Inner Plains of Far-West Nepal by Prachi Bista, Sandesh Thapa, Sara Rawal, Deependra Dhakal, Darbin Joshi

“…Analysis of variance suggests that genotypes were significantly different for all traits except plant height and plant population. The phenotypic coefficient of variation (PCV) was higher than the genotypic coefficient of variation (GCV) for all traits. …”
Get full text

Left Ventricular Hypertrabeculation (LVHT) in Athletes: A Negligible Finding? by Rokas Jagminas, Rokas Šerpytis, Pranas Šerpytis, Sigita Glaveckaitė

“…Left ventricular hypertrabeculation (LVHT) used to be a rare phenotypic trait. With advances in diagnostic imaging techniques, LVHT is being recognised in an increasing number of people. …”
Get full text

Modulation of first-passage time for bursty gene expression via random signals by Qiuying Li, Lifang Huang, Jianshe Yu

“…Increasing experimental evidences suggest that cell phenotypic variations often depend on the accumulation of some special proteins. …”
Get full text

Bloodstream Infection Etiology among Children and Adults by Svetlana I. Kolesnichenko, Alyona V. Lavrinenko, Lyudmila L. Akhmaltdinova

“…Enterobacterales (39%) were the second cause of sepsis in adult patients. 62.5% of Enterobacterales strains isolated from adults were phenotypically identified as ESBL, while in pediatric patients, 25% of ESBL producers were isolated. …”
Get full text

Investigating a hybrid mixed population leads to recognizing a new species of Arctostaphylos (Ericaceae) by Tito Abbo, Morgan A. Stickrod, Alexander Krohn, V. Thomas Parker, Michael C. Vasey, William Waycott, Amy Litt

“…A principal component analysis of eight morphological characters shows that A. rudis individuals from Santa Barbara County tend to be phenotypically variable, occurring in a wide morphological cluster that overlaps with the tight clusters formed by A. purissima, A. crustacea, and Arctostaphylos from the Nipomo Mesa. …”
Get full text

Incidence Of Helicobacter Pylori Infection in Association With ABO Blood Groups by Amina Zehra, Maimoona Sabir, Sumaira Sarwar, Afsheen Ishfaq, Kishmain Ahmad, Afshan Saleem

“…ABO and Lewis antigen phenotypes were determined with a macroscopic agglutination technique. …”
Get full text

Relatedness Among Three Native Geese in Erbil Governorate Using Hematological and Molecular Methods by Mohsen A. Ahmed, Yousif M.S. Al-Barzinji, Lanja Assad Ismail

“…The high genetic distance (64.122%) and variation in phenotypic value such as live weight (2.375 to 3.600 kg/bird) for three native geese indicate that these native geese have a good amount of genetic resources to made genetically improvement in further and it means the three goose samples are independent breeds.  …”
Get full text

Prion meeting 2023: implications of a growing field by Tiago F. Outeiro, Tuane C. R. G. Vieira

“…Interestingly, the prion concept had been previously expanded to yeast proteins capable of replicating their conformation, seeding their own aggregation and transmitting phenotypic information. The prion concept has been more recently expanded to refer to misfolded proteins that are capable of converting a normal form of a protein into an abnormal form. …”
Get full text

MOLECULAR TYPING OF METHICILLIN-SUSCEPTIBLE STAPHYLOCOCCUS AUREUS (MSSA), ISOLATED FROM MONKEYS, BASED ON COAGULASE GENE POLYMORPHISM by V. A. Kalashnikova

“…The present study is devoted to the study of the polymorphism of a variable region of the coagulase gene and to the typing of Staphylococcus aureus isolates from monkeys of different species kept at Adler monkey farm. 115 Staphylococcus aureus isolates were studied using phenotypic and molecular genetic methods. Genotyping was performed using PCR, real-time PCR and PCR with subsequent restriction fragment length polymorphism analysis (PCR-RFLP). …”
Get full text