Molecular-genetic mechanisms underlying fruit and seed coloration in plants by V. F. Adzhieva, O. G. Babak, O. Y. Shoeva, A. V. Kilchevsky, E. K. Khlestkina

“…The data in plant genetics accumulated to date show that the inter- and intraspecies phenotypic diversity in coloration is mainly related with regulatory genes. …”
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Effects of Severe Hypoxia on Bone Marrow Mesenchymal Stem Cells Differentiation Potential by Claudia Cicione, Emma Muiños-López, Tamara Hermida-Gómez, Isaac Fuentes-Boquete, Silvia Díaz-Prado, Francisco J. Blanco

“…BM-MSCs from the donors displayed only few phenotypical differences in surface antigens expressions. …”
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Constructing the biomolecular networks associated with diabetic nephropathy and dissecting the effects of biomolecule variation underlying pathogenesis by Zi-Han Wang, Qi Dong, Qian Yan, Wan-Rong Yu, Dan-Dan Zhang, Ran Yi

“…These results underscore the significance of biomolecular networks in disease progression and highlighting the role of biomolecular variability contributes to personalized disease phenotyping and treatment.…”
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Establishment of a Breeding Approach Combined with Gamma Ray Irradiation and Tissue Regeneration for Highbush Blueberry by Xuan Yu, Haidi Yuan, Yihong Jin, Chuizheng Xia, Jiani Zhu, Jiali Che, Jiao Yang, Xiaofei Wang, Bingsong Zheng, Shufang Yang, Cristian Silvestri, Fuqiang Cui, Jianfang Zuo

“…We determined that the median lethal dose (LD₅₀) was approximately 56 Gy for leaf explants and 80 Gy for stem explants. Phenotypic variations, including changes in leaf color and growth characteristics, which may be due to altered plant response to environmental factors, were successfully observed in the first-generation (M1) plants. …”
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Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions by Sha He, Haiyan Ou, Cunyou Zhao, Jian Zhang

“…Genetic variations in the seed regions have vital effects on gene expression, phenotypic variation, and disease susceptibility in humans. …”
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Vitamin D Status and VDR Genotype in NF1 Patients: A Case-Control Study from Southern Brazil by Larissa Souza Mario Bueno, Clévia Rosset, Ernestina Aguiar, Fernando de Souza Pereira, Patrícia Izetti Ribeiro, Rosana Scalco, Camila Matzenbacher Bittar, Cristina Brinckmann Oliveira Netto, Guilherme Gischkow Rucatti, José Artur Chies, Suzi Alves Camey, Patricia Ashton-Prolla

“…We also did not observe an association between FokI and BsmI VDR gene polymorphisms and vitamin D levels in NF1 patients, suggesting that their deficient or insufficient biochemical phenotypes are not associated with these genetic variants. …”
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Using Quantitative Trait Locus Mapping and Genomic Resources to Improve Breeding Precision in Peaches: Current Insights and Future Prospects by Umar Hayat, Cao Ke, Lirong Wang, Gengrui Zhu, Weichao Fang, Xinwei Wang, Changwen Chen, Yong Li, Jinlong Wu

“…Genotype–environment interactions remain a critical challenge for modern breeding efforts, which can be addressed through high-throughput phenotyping and multi-environment trials. This work shows how combining genome-wide association studies and machine learning can improve the synthesis of multi-omics data and result in faster breeding cycles while preserving genetic diversity. …”
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Glycyrrhizic Acid Promotes M1 Macrophage Polarization in Murine Bone Marrow-Derived Macrophages Associated with the Activation of JNK and NF-κB by Yulong Mao, Baikui Wang, Xin Xu, Wei Du, Weifen Li, Youming Wang

“…The aim of this study is to investigate the effect of glycyrrhizic acid (GA) from licorice on macrophage polarization. Both phenotypic and functional activities of murine bone marrow-derived macrophages (BMDMs) treated by GA were assessed. …”
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Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential by E. De Luna-Bertos, J. Ramos-Torrecillas, O. García-Martínez, A. Guildford, M. Santin, C. Ruiz

“…The present study focusses on the effect of dexketoprofen, ketorolac, metamizole, and acetylsalicylic acid, at therapeutic doses, on different biochemical and phenotypic pathways in human osteoblast-like cells. …”
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Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway by Yaqiong Zhang, Bo Li, Wanhong Gu, Linna Fan, Xiaofan Wang, Meifen Xu, Minqi Zhu, Chong Jin

“…Abstract Background A recent study revealed the oncogenic role of box C/D small nucleolar RNA 52 (SNORD52) in hepatocellular carcinoma (HCC) by facilitating the aggressive phenotypes of hepatoma cells. However, the potential role of exosomal SNORD52 in macrophage polarization during HCC progression remains poorly understood. …”
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Cytoplasmic SALL4-A isoform expression as a diagnostic marker of less aggressive tumor behavior in gastric cancer by Saeed Rahmani, Amirhesam Babajani, Maryam Abolhasani, Roya Ghods, Elham Kalantari, Zahra Madjd

“…Conclusion Cytoplasmic SALL4-A expression in GC is associated with less aggressive tumor phenotypes and shows promise as a diagnostic marker. …”
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Community structure of heritable viruses in a Drosophila-parasitoids complex by Varaldi, Julien, Lepetit, David, Burlet, Nelly, Faber, Camille, Baretje, Bérénice, Allemand, Roland

“…The diversity and phenotypic impacts related to the presence of heritable bacteria in insects have been extensively studied in the last decades. …”
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THE PGR NETWORKS IN FRANCE: COLLABORATION OF USERS AND THE GENETIC RESOURCE CENTRE ON SMALL GRAIN CEREALS by A. Didier, L. Bardy, E. Boulat, J. Koenig, A. Lapierre, F. Exbrayat, J. Bordes, F. Balfourier

“…The main species of Triticum (wheat), Hordeum (barley), Secale (rye), ×Triticosecale (triticale), Avena (oat) genera and their wild relatives are held in the collection. By combining phenotypic and genotypic data, the whole genetic resource collection has been structured into smaller functional groups of accessions, in order to facilitate the access and meet the increasing number of different requirements for the distribution of adapted samples of accessions.New panels are being processed to give breeders and scientists new useful tools to study, for instance, stress resistance or to develop association studies. …”
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Red flags to suspect inborn errors of immunity in patients with autoimmune diseases by Natalia Vélez, Juliette De Ávila, Jaime Cortés, Nelson Barrero, Leosirlay Rojas, Juan Manuel Bello, Consuelo Romero-Sánchez

“…Some autoimmune diseases, such as autoimmune cytopenias, systemic lupus erythematosus, and inflammatory bowel diseases, are increasingly recognized as phenotypes of inborn errors of immunity. The objective of this article was to identify red flags or clinical/laboratory markers to suspect inborn errors of immunity in patients with autoimmune cytopenias, systemic lupus erythematosus, and inflammatory bowel diseases through a systematic literature review. …”
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IL-34 Suppresses Candida albicans Induced TNFα Production in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2 by Rong Xu, Hong-Fan Sun, David W. Williams, Adam V. Jones, Ali Al-Hussaini, Bing Song, Xiao-Qing Wei

“…Resident macrophages exhibit phenotypic plasticity and may transform into inflammatory M1 macrophages for immunity or anti-inflammatory M2 macrophages for tissue repair. …”
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FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis by David Hunt, Siddharthan Chandran, Peter Connick, Peter Foley, Patrick K A Kearns, Sergio E Baranzini, Adam D Waldman, Sarah J Martin, Elizabeth Freyer, F J Carod-Artal, Lee Murphy, Amy Stenson, Jessie Chang, Rozanna Meijboom, Elizabeth N York, Yingdi Chen, Christine Weaver, Katarzyna Hafezi, Stacey Thomson, Adil Harroud, Margaret McLeod, Jonathon O'Riordan, Niall J J MacDougall

“…There is, therefore, a need for integrated predictive tools to inform individualised treatment decision making.Participants Established with the aim of addressing this need for individualised predictive tools, FutureMS is a nationally representative, prospective observational cohort study of 440 adults with a new diagnosis of relapsing-remitting MS living in Scotland at the time of diagnosis between May 2016 and March 2019.Findings to date The study aims to explore the pathobiology and determinants of disease heterogeneity in MS and combines detailed clinical phenotyping with imaging, genetic and biomarker metrics of disease activity and progression. …”
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Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences by Noemi Cifani, Maria Proietta, Maurizio Taurino, Luigi Tritapepe, Flavia Del Porto

“…Monocytes are a heterogeneous cell population distinguished into three subsets with distinctive phenotypic and functional properties: “classical” (CD14++CD16-), “intermediate” (CD14++CD16+), and “nonclassical” (CD14+CD16++). …”
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Features of the electrolyte distribution in various tissues in miniature pigs by A. V. Fatianova, V. A. Lavrinenko, O. V.  Trapezov, N. S. Yudin

“…The data obtained demonstrate that miniature pigs can be an informative animal model for  studying the influence of genetic (gender) and phenotypic (behavioral response) aspects on the parameters of water-electrolyte homeostasis.…”
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Social behavior and spatial orientation in rat strains with genetic predisposition to catatonia (GC) and stereotypes (PM) by V. S. Plekanchuk, O. I. Prokudina, M. A. Ryazanova

“…To determine whether the GC and PM rats have changes in social behavior and spatial learning, behavioral phenotyping was performed in the residentintruder test, three-chamber test, Barnes maze test. …”
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CAG Expansion in Androgen Receptor Gene of Infertile Men in Erbil Governorate by Dashne Abdulla Salih, Karim Jalal Karim

“…Spermatogenesis and male phenotypic development during puberty are mainly done by androgen and their function is regulated by the androgen receptor (AR) gene. …”
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