Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes by Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon

“…Results Here, we perform single-cell CRISPRi screens of 3513 regulatory elements associated with breast cancer to measure the impact of these regions on transcriptional phenotypes. Analysis of > 500,000 single-cell transcriptomes in two breast cancer cell lines shows that perturbation of BC-associated enhancers disrupts breast cancer gene programs. …”
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Hybridization potential and genetic influence of parental varieties on fruit size and set rate in Gleditsia sinensis by Qingying Zeng, Yang Zhao, Xiurong Wang, Fuhua Liu, Meixuan Xie, Xingfu Zhang

“…Therefore, G. fera can serve as an excellent male parent for interspecific hybridization with G. sinensis. The phenotypic traits of the current generation’s pods are primarily influenced by the additive effects of the maternal parent and the non-additive effects of both parents. …”
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The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature by Dimitrios Kazantzis, Genovefa Machairoudia, Panagiotis Theodossiadis, Irini Chatziralli

“…Future studies need to further validate these findings and try to establish a link between these ratios and retinal phenotypes.…”
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Methylobacterium populi VP2: Plant Growth-Promoting Bacterium Isolated from a Highly Polluted Environment for Polycyclic Aromatic Hydrocarbon (PAH) Biodegradation by Valeria Ventorino, Filomena Sannino, Alessandro Piccolo, Valeria Cafaro, Rita Carotenuto, Olimpia Pepe

“…The best putative degrading isolate, Methylobacterium populi VP2, was identified using a polyphasic approach on the basis of its phenotypic, biochemical, and molecular characterisation. …”
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Urban Cepaea nemoralis snails are less likely to have nematodes trapped within their shells by Dahirel, Maxime, Reyné, Hannah, De Wolf, Katrien, Bonte, Dries

“…We examined shells from the generalist snail Cepaea nemoralis sampled in three urban areas in Belgium for trapped nematodes, and attempted to link this to urbanization and shell phenotypic traits. We found that even a small degree of urbanization led to large decreases in the rates of shell encapsulation, and that larger snails were more likely to contain trapped nematodes. …”
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Human adaptation and diversification in the Microsporum canis complex by Xin Zhou, Sarah A. Ahmed, Chao Tang, Maria Eduarda Grisolia, José Francisco Ghignatti Warth, Kristen Webster, Andrea Peano, Silke Uhrlass, Claudia Cafarchia, Marie Pierre Hayette, Rosalie Sacheli, Tadeja Matos, Yingqian Kang, G. Sybren de Hoog, Peiying Feng

“…Molecular data, physicochemical properties and phenotypes suggest the adaptation of zoophilic M. canis to anthropophilic M. ferrugineum, with M. audouinii in an intermediate position.…”
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Genetic Contribution of Ningmai 9 Wheat to Its Derivatives Evaluated by Using SNP Markers by Peng Jiang, Ping-Ping Zhang, Xu Zhang, Hong-Xiang Ma

“…There was a great difference for the same allele ratio in either derivatives or chromosomes, though the average values of the same allele ratio in genomes A, B, and D were close to each other. The phenotypic difference in Ningmai 9, Ningmai 13, and Yangfumai 4 was consistent with their difference in genetic background by comparing previous reported QTLs. …”
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WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis by Carolyn B. McNabb, Ian D. Driver, Vanessa Hyde, Garin Hughes, Hannah L. Chandler, Hannah Thomas, Christopher Allen, Eirini Messaritaki, Carl J. Hodgetts, Craig Hedge, Maria Engel, Sophie F. Standen, Emma L. Morgan, Elena Stylianopoulou, Svetla Manolova, Lucie Reed, Matthew Ploszajski, Mark Drakesmith, Michael Germuska, Alexander D. Shaw, Lars Mueller, Holly Rossiter, Christopher W. Davies-Jenkins, Tom Lancaster, C. John Evans, David Owen, Gavin Perry, Slawomir Kusmia, Emily Lambe, Adam M. Partridge, Allison Cooper, Peter Hobden, Hanzhang Lu, Kim S. Graham, Andrew D. Lawrence, Richard G. Wise, James T. R. Walters, Petroc Sumner, Krish D. Singh, Derek K. Jones

“…Given the depth of neuroimaging phenotyping, leveraging ultra-high-gradient, high-field MRI, MEG and TMS, this dataset will facilitate multi-scale and multi-modal investigations of the healthy human brain.…”
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Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor by Hideyuki Kinoshita, Takeshi Ishii, Hiroto Kamoda, Yoko Hagiwara, Toshinori Tsukanishi, Sumihisa Orita, Kazuhide Inage, Naoya Hirosawa, Seiji Ohtori, Tsukasa Yonemoto

“…Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare inflammatory disorder with multiple phenotypes. The syndrome has identifiable radiologic characteristics that are the most important when making a diagnosis. …”
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Roles of Whole-Genome Sequencing in Determining Transmission and Risk Factors Associated with Carbapenem-Resistant Organisms at a Vietnam HealthCare Center of Orphan Children by Van Kim Nguyen, Pirom Noisumdaeng, Katiya Ivanovitch, Eugene Athan, Larry Croft, Phuong Toai Nguyen, Huu Phuc Pham Nguyen

“…We conducted microbiological testing, including the MELAB Chromogenic CARBA agar plates, blood agar plates, and the BD PhoenixTM Automated Microbiology System to screen, isolate, and identify bacterial species and phenotypic tests for the antimicrobial susceptibility of carbapenem-resistant bacteria and the whole-genome sequencing for 12 CROs chosen to confirm the CRO transmission between HCWs and residents. …”
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Lethal End of Spectrum of Clots-Thrombotic Storm by Muhammad Asim Rana, Ahmed F. Mady, Abdullah Ali Lashari, Rehab Eltreafi, Nicola Fischer-Orr, Kamal Naser

“…Usually, younger female patients are affected; in some patients, there is an association with an autoimmune disorder like lupus erythematosus, and they show evidence of antiphospholipid antibodies or other phenotypic expressions of anticoagulation disorders. …”
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Arrhythmias and Sudden Cardiac Death in Beta-Thalassemia Major Patients: Noninvasive Diagnostic Tools and Early Markers by Vincenzo Russo, Enrico Melillo, Andrea A. Papa, Anna Rago, Celeste Chamberland, Gerardo Nigro

“…Beta-thalassemias are a group of inherited, autosomal recessive diseases, characterized by reduced or absent synthesis of beta-globin chains of the hemoglobin tetramer, resulting in variable phenotypes, ranging from clinically asymptomatic individuals to severe anemia. …”
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Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut by Mehari Endale, H. Ibrahim Aksoylar, Kasper Hoebe

“…Specifically, genome-wide (GWAS) and also next-generation sequencing (NGS)—including whole exome or genome sequencing—have uncovered a large number of susceptibility loci that predispose to autoimmune diseases and/or the two phenotypes of IBD. In addition, the generation of “IBD-prone” animal models using both reverse and forward genetic approaches has not only helped confirm the identification of susceptibility loci but also shed critical insight into the underlying molecular and cellular pathways that drive colitis development. …”
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Simultaneous gains for negatively correlated traits of interest in plantain by Geferson Rocha Santos, Letícia Casseano de Souza Santos, Rafael Nunes de Almeida, Hércules dos Santos Pereira, Inês de Moura Trindade, Irany Rodrigues Pretti, Dimmy Herllen Silveira Gomes Barbosa, Edson Perito Amorim, Sávio da Silva Berilli, Ana Paula Candido Gabriel Berilli

“…Abstract The objective of this work was to identify negative correlations between phenotypic characteristics (agronomic and physicochemical) in plantain (Musa paradisiaca), and to evaluate selection indices to obtain simultaneous gains for agronomically relevant characteristics. …”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…This study evaluated the cytotoxicity of fluorinated quaternary ammonium salts (FQAS) library in CRC-derived cell lines with premetastatic and metastatic phenotypes. The genetic and epigenetic background of the CRC cell lines and the selectivity of cytotoxicity compared to nontumor cells and between different CRC stages were also assessed. …”
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Overexpression of SlGRAS7 Affects Multiple Behaviors Leading to Confer Abiotic Stresses Tolerance and Impacts Gibberellin and Auxin Signaling in Tomato by Sidra Habib, Muhammad Waseem, Ning Li, Lu Yang, Zhengguo Li

“…Plants overexpressing SlGARS7 (SlGRAS7-OE) showed multiple phenotypes related to many behaviors, including plant height, root and shoot length, and flowering time. …”
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Genetic Variability and Selection Criteria in Rice Mutant Lines as Revealed by Quantitative Traits by Yusuff Oladosu, M. Y. Rafii, Norhani Abdullah, Mohammad Abdul Malek, H. A. Rahim, Ghazali Hussin, Mohammad Abdul Latif, Isiaka Kareem

“…Data were taken on vegetative traits and yield and its components, while genotypic and phenotypic coefficients, variance components, expected genetic advance, and heritability were calculated. …”
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Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients... by Ken Sugimoto, Tomohiro Katsuya, Kei Kamide, Tomomi Fujisawa, Izumi Shimaoka, Mitsuru Ohishi, Ryuichi Morishita, Toshio Ogihara, Hiromi Rakugi

“…There was no gene whose expression was associated with BP phenotypes or the polymorphisms of each gene. Conclusions. …”
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Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof... by E. I. Gultyaeva, L. A. Bespalova, I. B. Ablova, E. L. Shaydayuk, Zh. N. Khudokormova, D. R. Yakovleva, Yu. A. Titova

“…Among P. striiformis isolates, three phenotypes were identified using the International and European sets of differentiating cultivars – 111E231 (88 %), 111E247 (6 %) and 78E199 (6 %). …”
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Unveiling genetic basis of seedling emergence from deep soil depth under dry direct- seeded conditions in rice (Oryza sativa L.) by Vagish Mishra, Vagish Mishra, Shilpi Dixit, Shilpi Dixit, Swati Tyagi, Swati Tyagi, Challa Venkateswarlu, Challa Venkateswarlu, Pronob J. Paul, Pronob J. Paul, Anoop Kishor Singh Gurjar, Anoop Kishor Singh Gurjar, Shalabh Dixit, Nitika Sandhu, Smita Kurup, Arvind Kumar, Arvind Kumar, Pallavi Sinha, Pallavi Sinha, Vikas Kumar Singh, Vikas Kumar Singh, Uma Maheshwar Singh, Uma Maheshwar Singh

“…A total of 16 QTLs were identified for four traits, with phenotypic variance explained (PVE) ranging from 6.63% to 19.6% in the WS22. …”
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