First Description of KPC-2-Producing Klebsiella oxytoca Isolated from a Pediatric Patient with Nosocomial Pneumonia in Venezuela by Indira Labrador, María Araque

“…Therefore, rapid detection of KPC-carrying bacteria with phenotypic and confirmatory molecular tests is essential to establish therapeutic options and effective control measures.…”
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Early-Stage Luminal B-like Breast Cancer Exhibits a More Immunosuppressive Tumor Microenvironment than Luminal A-like Breast Cancer by Tânia Moura, Olga Caramelo, Isabel Silva, Sandra Silva, Manuela Gonçalo, Maria Antónia Portilha, João N. Moreira, Ana M. Gil, Paula Laranjeira, Artur Paiva

“…Methods: This study evaluated tumor samples from 40 female patients with luminal A and B breast cancer, utilizing flow cytometry to phenotypically characterize the immune cells and tumor cells present within the tumor tissue. …”
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Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin by Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee, Hyunju Cho

“…Overexpression of the hsPEX19-FV variant rescues HD-associated phenotypes in primary striatal neurons and in Drosophila. …”
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DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response by Esther Granot, Einat Jakobovich, Ruth Rabinowitz, Paloma Levy, Michael Schlesinger

“…From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. …”
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Morphological Evidence for a Subpopulation Selection Effect by Estrogen and Antiestrogen Treatments in the Heterogeneous MCF-7 Cell Line by Jacqueline Palmari, France Wallet, Julien Berard, Yolande Berthois, Pierre Marie Martin, Christophe Dussert

“…Modifications of the heterogeneity of the cell line are emphasised through phenotypic changes and modifications of the spatial organisation of the cells. …”
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Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model by Deyu Zheng, Xiaohua Jiang, Junpeng Zhao, Deyi Duan, Huanying Zhao, Qunyuan Xu

“…The results of immunohistochemistry showed that hGAD65 gene delivery by AAV2 successfully led to phenotypic changes of neurons in STN. And the levels of glutamic acid and GABA in the internal segment of the globus pallidus (GPi) and substantia nigra pars reticulata (SNr) were obviously lower than the control groups. …”
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Ultrastructural Changes in Clinical and Microbiota Isolates of Klebsiella pneumoniae Carriers of Genes blaSHV, blaTEM, blaCTX-M, or blaKPC When Subject to β-Lactam Antibiotics by Dyana Leal Veras, Ana Catarina de Souza Lopes, Grasielle Vaz da Silva, Gabriel Gazzoni Araújo Gonçalves, Catarina Fernandes de Freitas, Fernanda Cristina Gomes de Lima, Maria Amélia Vieira Maciel, Ana Paula Sampaio Feitosa, Luiz Carlos Alves, Fábio André Brayner

“…Our results demonstrate that K. pneumoniae isolates harboring different genes that encode for β-lactamases show cell alterations when subjected to different β-lactam antibiotics, thus suggesting that they possess residual activity in vitro, despite the phenotypic resistance presented in the isolates analyzed.…”
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A Novel Spontaneous Mutation of the SOX10 Gene Associated with Waardenburg Syndrome Type II by Sen Chen, Yuan Jin, Le Xie, Wen Xie, Kai Xu, Yue Qiu, Xue Bai, Hui-Min Zhang, Xiao-Zhou Liu, Xiao-Hui Wang, Wei-Jia Kong, Yu Sun

“…WS is classified into four types depending on the clinical phenotypes. Currently, pathogenic mutation of PAX3, MITF, EDNRB, EDN3, SNAI2, or SOX10 can cause corresponding types of WS. …”
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Karyotype uniformity in populations of the endemic Hemiancistrus fuliginosus (Loricariidae: Hypostomini) collected in the upper and middle Uruguai River by Jocicléia Thums Konerat, Vanessa Bueno, Ana Luiza de Brito Portela-Castro, Isabel Cristina Martins-Santos, Vladimir Pavan Margarido

“…Nucleolar organizer regions (NORs) were located on the short arm in terminal position of the subtelocentric chromosome pair 25 in all population, in addition to Antas River population showed a structural polymorphism (three different phenotypes). Physical mapping of 5S rDNA showed cistrons in pericentromeric position on the short arm of the metacentric chromosome pair 12 in all the populations. …”
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Heritability Estimated Using 50K SNPs Indicates Missing Heritability Problem in Holstein Breeding by Donghyun Shin, Kyoung-Do Park, Sojoeng Ka, Heebal Kim, Kwang-hyeon Cho

“…Longer genomic regions tended to provide more phenotypic variation information, with a correlation of 0.46~0.53 between the estimate of variance explained by individual chromosomes and their physical length. …”
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Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases by Jiani Li, Chen Guo, Xiaofei Yang, Weinan Xie, Wenjing Mi, Chenglong Hua, Cheng Tang, Han Wang

“…Immunometabolic variations in macrophages critically influence their differentiation into pro-inflammatory or anti-inflammatory phenotypes, thereby contributing to immune homeostasis, defense against infection, and tissue repair. …”
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Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond by Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos

“…Subpopulations with specific phenotypic and functional properties have been characterized both in mouse models and human disease. …”
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Application of Metabolomics in Thyroid Cancer Research by Anna Wojakowska, Mykola Chekan, Piotr Widlak, Monika Pietrowska

“…Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. …”
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The Story of CD4+CD28− T Cells Revisited: Solved or Still Ongoing? by Kathrin Maly, Michael Schirmer

“…Here we focus on CD4+CD28− T cells in chronic immune-mediated diseases, summarizing various phenotypic and functional characteristics, which vary depending on the underlying disease, disease activity, and concurrent treatment. …”
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Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment by Tian Z, Wang X, Chen S, Guo Z, Di J, Xiang C

“…However, a comprehensive summary of biomaterial-driven modulation of mitochondrial function to control macrophage phenotypes is still lacking. This review highlights the critical role of mitochondrial function in macrophage polarization and discusses therapeutic strategies mediated by biomaterials, including mitochondria-targeted biomaterials. …”
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Biophysical Profiling of Tumor Cell Lines by Frederick Coffman, Rachid Hamid, Marion C. Cohen, Ralph Garippa, Stanley Cohen

“…Despite significant differences in genetic profiles, cancer cells share common phenotypic properties, including membrane-associated changes that facilitate invasion and metastasis. …”
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IMPLEMENTATION OF GENOME-WIDE SELECTION IN WHEAT by G. Charmet, E. Storlie

“…We present an example applying DArT markers to the INRA wheat breeding material in an attempt to implement whole genome selection as an alternative to phenotypic selection. This study assesses different models (GBLUP, Ridge Regression BLUP, Bayesian Ridge Regression and Lasso) and their ability to predict the yields of genotypes evaluated in a multi-site network from 2000 to 2009 in a highly unbalanced design. …”
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Effects of Drought Frequency on Growth Performance and Transpiration of Young Black Locust (Robinia pseudoacacia L.) by Dario Mantovani, Maik Veste, Dirk Freese

“…Due to its constant water use efficiency and the high phenotypic plasticity, black locust could become an important species to be cultivated on marginal land.…”
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OryzaGP: rice gene and protein dataset for named-entity recognition by Pierre Larmande, Huy Do, Yue Wang

“…Text mining has become an important research method in biology, with its original purpose to extract biological entities, such as genes, proteins and phenotypic traits, to extend knowledge from scientific papers. …”
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Clustering Large-Scale Biomedical Data to Model Dynamic Accumulation Processes in Disease Progression and Anti-Microbial Resistance Evolution by Kazeem A. Dauda, Olav N. L. Aga, Iain G. Johnston

“…Existing approaches for accumulation modelling are typically limited either in the number of features they consider or their ability to characterise interactions between these features – a limitation for the large-scale genetic and/or phenotypic datasets often found in modern biomedical applications. …”
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