Decoding the mechanisms behind second primary cancers by Meiyuan Zeng, Anqi Lin, Aimin Jiang, Zhengang Qiu, Hongman Zhang, Shifu Chen, Mingyan Xu, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo

“…This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. …”
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Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells by Nicolas Espagnolle, Benjamin Hebraud, Jean-Gérard Descamps, Mélanie Gadelorge, Marie-Véronique Joubert, Laura Do Souto Ferreira, Murielle Roussel, Anne Huynh, Luc Sensébé, Louis Casteilla, Michel Attal, Hervé Avet-Loiseau, Frederic Deschaseaux, Philippe Bourin, Jill Corre

“…For the first time, we present a transcriptomic, phenotypic, and functional comparison of ASCs from MM patients and healthy donors (HDs) relying on their autologous MSC counterparts. …”
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Genetic divergence studies in little millet (Panicum sumatrense Roth. ex. Roem. & Schult) using D2 statistics and molecular markers by Kinal Patel, Arna Das*, Dhrumi Dalsaniya, Hadassah Mamidipalli, Sanjith Vasala and Harshal E. Patil2

“…Variability parameters revealed considerable variation among the genotypes for all the traits studied. Phenotypic parameters being higher than genotypic ones indicated only little environmental influence which was confirmed from high heritability and genetic advance. …”
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Advances in Murine Models of Diabetic Nephropathy by Li-li Kong, Hao Wu, Wen-peng Cui, Wen-hua Zhou, Ping Luo, Jing Sun, Hang Yuan, Li-ning Miao

“…Here we review the identified murine models of DN from the aspects of genetic background, type of diabetes, method of induction, gene deficiency, animal age and gender, kidney histopathology, and phenotypic alterations in the hope of enhancing our comprehension of genetic susceptibility and molecular mechanisms responsible for this disease and providing new clues as to how to choose appropriate animal models of DN.…”
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Water quality and neurodegenerative disease risk in the middle-aged and elderly population by Yujia Bao, Yongxuan Li, Yanqiu Zhou, Jingqi Zhou, Wei Mu, Xiaobei Deng, Chen Shen, Lefei Han, Jinjun Ran

“…We assembled a cohort of 397,265 participants from the UK Biobank to investigate the associations of water hardness with neurodegenerative diseases and brain imaging phenotypes through modeling. We found water hardness in 0–120 mg/L elevated the incidence risks of Alzheimer’s disease and vascular dementia compared to that in 120–300 mg/L, with hazard ratios of 1.13 (1.01, 1.27) and 1.24 (1.05, 1.46), respectively. …”
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Clinical Manifestations and Distribution of Cutaneous Leishmaniasis in Pakistan by Abaseen Khan Afghan, Masoom Kassi, Pashtoon Murtaza Kasi, Adil Ayub, Niamatullah Kakar, Shah Muhammad Marri

“…The increased clinical diversity and the spectrum of phenotypic manifestations noted underscore the fact that the diagnosis of CL should be not only considered when dealing with common skin lesions, but also highly suspected by dermatologists and even primary care physicians even when encountering uncommon pathologies. …”
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Targeted Next-Generation Resequencing of Gene Identifies Novel Multiple Variants Pattern in Severe Hereditary Factor V Deficiency by Piotr K. Janicki, Sonia Vaida, Hamid A. B. AL-Mondhiry

“…Each of the three missense variants was previously associated with separate phenotypes, including Factor V deficiency (R2102H), thrombosis (R513K) and frequent miscarriages (D107H). …”
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Genomic analysis of antimicrobial resistant Escherichia coli isolated from manure and manured agricultural grasslands by C. Tyrrell, C. M. Burgess, F. P. Brennan, D. Münzenmaier, D. Drissner, R. J. Leigh, F. Walsh

“…The E. coli isolates were phenotypically antimicrobial resistant, predominantly multidrug resistant. …”
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SOD1 Is Essential for the Viability of DT40 Cells and Nuclear SOD1 Functions as a Guardian of Genomic DNA by Eri Inoue, Keizo Tano, Hanako Yoshii, Jun Nakamura, Shusuke Tada, Masami Watanabe, Masayuki Seki, Takemi Enomoto

“…We generated conditional SOD1 knockout cells from chicken DT40 cells and analyzed their phenotypes. The results revealed that SOD1 was essential for viability and that depletion of SOD1, especially nuclear SOD1, increased sister chromatid exchange (SCE) frequency, suggesting that superoxide is generated in or near the nucleus and that nuclear SOD1 functions as a guardian of the genome. …”
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DiGeorge Syndrome Presenting as Hypocalcaemia-Induced Seizures in Adulthood by Adrian Zammit, Deborah Grech Marguerat, Josephine Psaila, Alexander Attard

“…Presentation in adulthood is rare but must be borne in mind when dealing with cases of hypocalcaemia even in the absence of florid phenotypic features. A link with malignant disease has also been reported and should lead to prompt investigation of concerning masses.…”
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Nephrogenic Syndrome of Inappropriate Antidiuresis by D. Morin, J. Tenenbaum, B. Ranchin, T. Durroux

“…The pathophysiology of the disease requires fuller elucidation as the phenotypic variability observed in patients bearing the same mutations remains unexplained. …”
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Genetic diversity and character association studies for agro-morphological and quality traits of advanced breeding lines in field pea (Pisum sativum L.) by Kommineni Jagadeesh1*, C.S. Mahto1, Niraj Kumar1 and H. C. Lal2

“…The correlation analysis revealed that traits like primary branches per plant, pod length, seeds per pod, harvest index and biological seed yield per plant showed a note-worthy positive association at both genotypic and phenotypic levels. Path analysis revealed the correlation of pod length, harvest index and biological yield per plant was due to direct positive effects. …”
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𝛽-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload by Luca Melchiori, Sara Gardenghi, Stefano Rivella

“…The defects involved are extremely heterogeneous and give rise to a large phenotypic spectrum, with patients that are almost asymptomatic to cases in which regular blood transfusions are required to sustain life. …”
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TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

“…The implementation of multi-gene panel germline testing in different clinical settings has led to the identification of TP53 PV carriers outside the classic LFS-associated cancer phenotypes, leading to a broader cancer phenotypic redefinition and to the renaming of the condition as “heritable TP53-related cancer syndrome” (hTP53rc). …”
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Morphological evaluations in buffaloes (Bubal- us bubalis) in Venezuela by Luis Alfredo Pacheco-Díaz, José Atilio Aranguren-Méndez, Rafael Román-Bravo, Sharon Rivero-Hernández, Luis Edgardo Tovar-Briceño

“… The buffalo herds in Venezuela are characterized by a high phenotypic polymorphism, showing high diversity among individuals. …”
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Investigation of virulence factors in resistance and sensitive pseudomonas aeruginosa clinical isolates by Zeinab Waheed kadim, Hala Mouayed Radif

“…From 102 clinical specimens, only 33 isolates (32.35%) of P. aeruginosa were identified by Phenotypic characteristics, a biochemical test, the Vitek-2 compact system, and confirmed by Conventional Polymerase Chain Reaction (PCR). …”
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Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming by James Spyrou, David K. Gardner, Alexandra J. Harvey

“…The significance of metabolites during the reprogramming process is central to further elucidating how iPSC retain somatic cell characteristics and optimising culture conditions to generate iPSC with physiological phenotypes to ensure their reliable use in basic research and clinical applications. …”
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Principal Component and Cluster Analysis as a Tool in the Assessment of Tomato Hybrids and Cultivars by G. Evgenidis, E. Traka-Mavrona, M. Koutsika-Sotiriou

“…The Principal Component 2 revealed two smaller groups, a positive one with phenotypic traits and a negative one with tolerance to inbreeding. …”
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Moss-pathogen interactions: a review of the current status and future opportunities by Huan Zhang, Huan Zhang, Qilin Yang, Qilin Yang, Leyi Wang, Leyi Wang, Huawei Liu, Huawei Liu, Daoyuan Zhang, Daoyuan Zhang, Cheng-Guo Duan, Xiaoshuang Li, Xiaoshuang Li

“…This article reviews current research on moss-pathogen interactions, examining host-pathogen specificity, characterizing infection phenotypes and physiological responses, and comparing pathogen susceptibility and defense mechanisms between mosses and angiosperms. …”
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Aura phenomenon: a proposal for an etiology-based clinical classification by Umberto Pensato, Andrew M. Demchuk, Jens P. Dreier, Kevin C. Brennan, Simona Sacco, Michele Romoli

“…Conclusion This nuanced classification aims to aid in the diagnostic evaluation and phenotyping of aura phenomenon, ultimately improving the diagnosis and management of the different associated neurological conditions. …”
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