Challenges in classifying human chromosomal heteromorphisms using banding cytogenetics: From controversial guidelines to the need for a universal scoring system by Sílvia Pires, Paula Jorge, Thomas Liehr, Natália Oliva-Teles

“…Although not completely devoid of genes, these regions are typically not transcribed into proteins and lack obvious phenotypic impact. Nonetheless, their clinical importance is increasingly under scrutiny, with several studies aiming to assess their influence on human diseases and susceptibilities, especially as they are seemingly part of the long noncoding RNAs in certain tissues. …”
Get full text

SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS by Pamela Milani, Stella Gagliardi, Emanuela Cova, Cristina Cereda

“…Considering that changes in SOD1 mRNA levels have been associated with sporadic ALS (SALS), a molecular understanding of the processes involved in the regulation of SOD1 gene expression could not only unravel novel regulatory pathways that may govern cellular phenotypes and changes in diseases but also might reveal therapeutic targets and treatments. …”
Get full text

PDK1/mTOR Signaling in Myeloid Cells Differentially Regulates the Early and Late Stages of Sepsis by Juan Du, Guoli Li, Mingxi Hua, Junyan Han, Yu Hao, Hui Zeng, Ang Li, Yaxian Kong

“…In the CLP mice, the myeloid cells play an important role in septic shock. The phenotypes and the activation state of the macrophage and neutrophil correlate with their metabolism. …”
Get full text

Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model by Kathryn M. Buller, Julie A. Wixey, Hanna E. Reinebrant

“…Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-injured neonates. …”
Get full text

Gene Polymorphisms in Chronic Periodontitis by Marja L. Laine, Bruno G. Loos, W. Crielaard

“…Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.…”
Get full text

The Responses of the Quantitative Characteristics of a Ramet Population of the Ephemeroid Rhizomatous Sedge Carex physodes to the Moisture Content of the Soil in Various Locations... by Buhailiqiemu Abudureheman, Huiliang Liu, Daoyuan Zhang, Kaiyun Guan, Yongkuan Zhang

“…In this study, the soil moisture content was measured, and the quantitative characteristics of this sedge species were compared. The phenotypic plasticity of each parameter and the linear regression relationships were analyzed. …”
Get full text

Depletion of Regulatory T Cells in a Mouse Experimental Glioma Model through Anti-CD25 Treatment Results in the Infiltration of Non-Immunosuppressive Myeloid Cells in the Brain by Wim Maes, Tina Verschuere, Anaïs Van Hoylandt, Louis Boon, Stefaan Van Gool

“…Interestingly, PC61-treated mice also showed a pronounced infiltration of CD11b+ myeloid cells in the brain. Phenotypically, these cells could not be considered as Gr-1+ myeloid-derived suppressor cells (MDSC) but were identified as F4/80+ macrophages and granulocytes.…”
Get full text

Cancer stem-like cells stay in a plastic state ready for tumor evolution by Jiali Xu, Houde Zhang, Zhihao Nie, Wenyou He, Yichao Zhao, Zhenhui Huang, Lin Jia, Zhiye Du, Baotong Zhang, Siyuan Xia

“…Therefore, CSCs are likely the nature of tumor cells that gain cell plasticity. However, the phenotypic plasticity of CSCs has never been systematically discussed. …”
Get full text

Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds by André Dutra Messias, Kelly Fernanda Martins, Adriana Cristina Motta, Eliana Aparecida de Rezende Duek

“…PLDLA-TMC scaffolds stimulated the proliferation and normal phenotypic manifestations of cultured osteoblasts. These results show that it was possible to produce a terpolymer from L-lactide, D,L-lactide, and TMC. …”
Get full text

Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae by Shiva Kumar Goud Gadila, John R. Caskey, Edward B. Breitschwerdt, Ricardo G. Maggi, Monica E. Embers

“…In this study we performed comparative transcriptomic analyses between the extracellular and intracellular B. henselae phenotypes. Overall, specific genes involved in invasion, virulence, extracellular adhesion of type 4 secretion system were downregulated following intracellular invasion of B. henselae. …”
Get full text

Intraspecific epigenomics divergence in brown bears (Ursus arctos): insights from genome-wide DNA methylation patterns by Paolo Colangelo, Paolo Colangelo, Ian Marc Bonapace, Laura Gramolini, Emanuela Solano, Emanuela Solano, Elisa Desiato, Paolo Franchini, Leonardo Gentile, Roberto Guadagnini, Oddmund Kleven, Jonas Kindberg, Jonas Kindberg, Alexander Kopatz, Paolo Ciucci

“…This finding supports previous studies suggesting a role for the alteration of developmental pathways in shaping phenotypic novelties with potential adaptative significance. …”
Get full text

Analysis of Direct and Indirect Selection and Indices in Bread Wheat (Triticum aestivum L.) Segregating Progeny by Zine El Abidine Fellahi, Abderrahmane Hannachi, Hamenna Bouzerzour

“…Three selection methods including direct and indirect selection along with selection index based on the phenotypic values of eleven traits of agronomic interest were assessed for their application in F4 bread wheat progenies. …”
Get full text

PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs by Serena Vella, Pier Giulio Conaldi, Tullio Florio, Aldo Pagano

“…Neuroblastoma (NB) is the most common and aggressive pediatric cancer, characterized by a remarkable phenotypic diversity and high malignancy. The heterogeneous clinical behavior, ranging from spontaneous remission to fatal metastatic disease, is attributable to NB biology and genetics. …”
Get full text

Reproductive Technologies and Genomic Selection in Cattle by Patrice Humblot, Daniel Le Bourhis, Sebastien Fritz, Jean Jacques Colleau, Cyril Gonzalez, Catherine Guyader Joly, Alain Malafosse, Yvan Heyman, Yves Amigues, Michel Tissier, Claire Ponsart

“…Information brought by reproductive physiology will provide new markers and new improved phenotypes that will increase the efficiency of selection schemes for reproductive traits. …”
Get full text

Effects of Nuclear Genomes on Anther Development in Cytoplasmic Male Sterile Chicories (Cichorium intybus L.): Morphological Analysis by Ildephonse Habarugira, Theo Hendriks, Marie-Christine Quillet, Jean-Louis Hilbert, Caroline Rambaud

“…The Cichorium intybus flower development in fertile, cytoplasmic male sterility (CMS 524) and various phenotypes carrying the 524 male sterile cytoplasm was investigated macroscopically and by light microscopy. …”
Get full text

Blue light promotes conjunctival epithelial-mesenchymal transition and collagen deposition through ITGB4 by Qianjie Yang, Kuangqi Chen, Siyi Chen, Yinhao Wang, Yutong Xia, Jinbo Chen, Ye Shen

“…Western blotting, wound healing assays, transwell assay, and phalloidin staining assessed phenotypes of epithelial-mesenchymal transition (EMT). …”
Get full text

Dysmorphological Delineation of Orofaciodigital Syndrome Type I. Presentation of a Case and Literature Review by Noel Taboada Lugo, Ana María Rodríguez Díaz, Tairí Borges García

“…Its interest lies in presenting the phenotypic delineation of a rare syndrome, which can manifest with a mild clinical expression or associated with important dysmorphological alterations.…”
Get full text

Beyond Hormone Receptors: liquid biopsy tools to unveil new clinical meanings and empower therapeutic decision-making in Luminal-like metastatic breast cancer by Brenno Pastò, Riccardo Vida, Arianna Dri, Lorenzo Foffano, Serena Della Rossa, Lorenzo Gerratana, Fabio Puglisi

“…Immunohistochemical (IHC) tissue profiling is a standard practice in the management of metastatic breast cancer (mBC), that enables the identification of distinct biological phenotypes based on hormone receptors' expression. Luminal-like tumors primarily benefit from a first line treatment strategy combining endocrine therapy and cyclin-dependent kinase 4/6 inhibitors. …”
Get full text

Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration by Kangkang Zha, Zhiqiang Sun, Yu Yang, Mingxue Chen, Cangjiang Gao, Liwei Fu, Hao Li, Xiang Sui, Quanyi Guo, Shuyun Liu

“…Thus, there is an urgent need to develop strategies that promote MSC chondrogenic differentiation to give rise to durable and phenotypically correct regenerated cartilage. This review provides an overview of recent advances in enhancement strategies for MSC chondrogenic differentiation, including optimization of bioactive factors, culture conditions, cell type selection, coculture, gene editing, scaffolds, and physical stimulation. …”
Get full text

Morphofunctional variations of the Echinometra lucunter (Echinoidea) on Bahia Coast, Brazil by Walter Ramos Pinto Cerqueira, Yara Aparecida Garcia Tavares, Natalie Petrovna Semanovschi, Daniele Nascimento de Jesus

“…The environments with distinct characteristics and wide food availability associated with a broad spectrum of the trophic niche occupied by the populations point out modulations and specializations of morphofunctional strategies and the expression of phenotypes.…”
Get full text