Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…We analyze numerically the conditions for the existence of steady states of the mathematical model of HIV-1 infection for the numerical values of model parameters corresponding to phenotypically different variants of the infectious disease course. …”
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis by Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian

“…Little is known about the modulatory role of serum exosomes in phenotypic switching of VSMC and vascular remodeling in TAK. …”
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Using the Bayesian Model Averaging Approach for Genomic Selection by Considering Skewed Error Distributions by Azadeh Ghazanfari, Afshin Fayyaz Movaghar

“…The Rice SNP-seek database was used to obtain real data, which included 152 single nucleotide polymorphisms (SNPs) with 6 phenotypes. Results: Numerical studies on simulated and real data showed that, although Occam’s window ran faster than the MC3 method, the latter method suggested better linear models for the data with both skew-normal and skew-t error distributions. …”
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Neurological and Neurobehavioral Disorders Associated with Toxoplasma gondii Infection in Humans by Maxwell A. Virus, Evie G. Ehrhorn, LeeAnna M. Lui, Paul H. Davis

“…Although most latent T. gondii infections in humans have traditionally been considered asymptomatic, studies in rodents suggest phenotypic neurological changes are possible. Consequently, several studies have examined the link between T. gondii infection and diseases such as schizophrenia, epilepsy, depression, bipolar disorder, dysphoria, Alzheimer’s disease, Parkinson’s disease, and obsessive-compulsive disorder (OCD). …”
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Persistent and extended COVID, post-COVID-19. New reflections in 2024 by Alfredo Darío Espinosa Brito

“…Although most therapeutic approaches in patients with persistent COVID are symptomatic and supportive, based on the clinical expertise of the professionals who care for the patients, recent advances in the description of clinical phenotypes, further research into molecular research and the search to identify specific biomarkers could provide new evidence on their pathogenic mechanisms and more personalized approaches to the clinical care of these patients, who constitute a real health and occupational problem in the world today. …”
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Diabetes in HFE Hemochromatosis by James C. Barton, Ronald T. Acton

“…The prevalence of type 2 diabetes diagnosed today in whites of European descent with and without HFE hemochromatosis is similar. Routine iron phenotyping or HFE genotyping of patients with type 2 diabetes is not recommended. …”
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Epigenetics: The New Frontier in the Landscape of Asthma by Bharti Chogtu, Dipanjan Bhattacharjee, Rahul Magazine

“…Though epigenetic research in asthma is in its nascent stages, it has led to very exciting results, especially with regard to explaining the massive influence of environment on development of asthma and its varied phenotypes. However, there remains a lot of work to be done, especially with regard to understanding how the interactions between immune system, epigenome, and environment lead to asthma. …”
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Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE) by Chi Bun Chan, Keqiang Ye

“…Moreover, the functions of PIKE in peripheral tissues as revealed by the unique phenotypes in PIKE knock-out mice will be discussed as well.…”
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Specific Roles of MicroRNAs in Their Interactions with Environmental Factors by Juan Wang, Qinghua Cui

“…More importantly, the interactions between miRNAs and EFs have been shown to play critical roles in determining abnormal phenotypes and diseases. In this paper, we propose an outline of the current knowledge about specific roles of miRNAs in their interactions with various EFs and analyze the literatures detailing miRNAs-EFs interactions in the context of various of diseases.…”
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Immune Optimization as a Preventive and Therapeutic Adjunct for the Management of Renin–Angiotensin–Aldosterone System Dysfunction Diseases: A Review by Michael T. Okafor, Queenet C. Onyebuchukwu, Germaine A. Okafor, Samuel C. Niteh, Chikere A. Anusiem

“…This review aimed to discuss the putative T cell and RAAS dysfunction-mediated model of diseases using their dysfunction in disease phenotypes as classic examples. Online searches on databases, such as Google Scholar, PubMed, Biomed Central, and SciELO, were carried out. …”
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RNA structure in alternative splicing regulation: from mechanism to therapy by Bao Nengcheng, Wang Zhechao, Fu Jiayan, Dong Haiyang, Jin Yongfeng

“…In this review, the molecular mechanisms of RNA secondary structure-mediated splicing regulation are summarized, with a focus on the complex interplay between aberrant RNA conformations and disease phenotypes resulted from splicing defects. This study also explores additional factors that reshape structural conformations, enriching our understanding of the mechanistic network underlying structure-mediated splicing regulation. …”
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Challenges of Analysing Gene-Environment Interactions in Mouse Models of Schizophrenia by Peter L. Oliver

“…The conclusions from this work have been varied, due in part to a lack of standardised methodology, although most have illustrated that phenotypes related to disorders such as schizophrenia are consistently modified. …”
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LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis. by Lin Zhu, Qianqian Meng, Weiyi Qian, Weiting Shao, Yuyue Lu, Shuai Jin, Afei Zhang, Shuang G Yan, Jingtao Lu

“…Through cellular experiments such as gene editing and phenotypic functions, we found that LARP3 promotes the occurrence and development of HCC and inhibits apoptosis. …”
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Domestication and varietal diversification of Old World cultivated cottons (Gossypium sp.) in the Antiquity by Christopher Viot

“…Many traditional varieties have been described for each of these two species; an evolution is apparent from perennial, rather primitive forms through to annual varieties and modern phenotypes, with adaptations to cultivation in diverse conditions, including cold climates and short summers. …”
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Expression of a mammalian RNA demethylase increases flower number and floral stem branching in Arabidopsis thaliana by Kasey Markel, Lucas Waldburger, Patrick M. Shih

“…In nearly all cases, perturbation of the RNA methylation machinery results in deleterious phenotypes. However, a recent landmark paper reported that transcriptome‐wide use of the human RNA demethylase FTO substantially increased the yield of rice and potatoes. …”
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Priestia megaterium cells are primed for surviving lethal doses of antibiotics and chemical stress by Manisha Guha, Abhyudai Singh, Nicholas C. Butzin

“…However, our findings reveal that primed cells contribute to an increase in persisters during transition and stationary phases, with no evidence supporting distinct phenotypes between Type I and Type II persisters.…”
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Strategies for the Development of Bioprotective Cultures in Food Preservation by Luana Virgínia Souza, Evandro Martins, Isabella Maria Fernandes Botelho Moreira, Antônio Fernandes de Carvalho

“…However, to make LAB cultures available in the market is not that easy, the strains should be characterized phenotypically and genotypically, and studies of safety and technological application are necessary to validate their bioprotection performance. …”
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Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells by Seulah Choi, Tae Sung Kim, Hui Xuan Lim

“…These results demonstrated that lutein may exhibit immunosuppressive activity by inhibiting the phenotypic and functional maturation of DCs, and provide new evidence for the value of lutein in the search for novel therapeutic agents in the treatment of inflammatory diseases. …”
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Evaluation of Diversity of Newly Bred Czech Sweet Cherry Cultivars in Extensive Plantations by Jiří Sedlák, Boris Krška, Liliia Pavliuk, Jana Čmejlová, František Paprštein, Jitka Blažková

“…The cultivars were evaluated phenotypically using standard descriptors for sweet cherries. …”
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Peritonitis due to Moraxella Osloensis: An Emerging Pathogen by Sreedhar Adapa, Purva Gumaste, Venu Madhav Konala, Nikhil Agrawal, Amarinder Singh Garcha, Hemant Dhingra

“…M. osloensis was identified by 16 S PCR phenotypic and sequencing techniques. Patient responded well to the treatment, with intraperitoneal cephalosporin, and repeat peritoneal fluid culture yielded no growth. …”
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