Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population by Angharad R. Morgan, Wen-Jiun Lam, Dug-Yeo Han, Alan G. Fraser, Lynnette R. Ferguson

“…In this sample, we were able to demonstrate an association between CD and several different ULK1 SNPs and haplotypes. Phenotypic analysis showed an association with age of diagnosis 17–40 years and inflammatory behaviour. …”
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The role of HEPCAM in Jacobsen syndrome: A pediatric case report highlighting white matter abnormalities by Ghazaleh Ghorbannezhad, Reza Nejad Shahrokh Abadi, Farrokh Seilanian Toosi, Shima Shekari, Saeedeh Sadat Mirtooni, Narges Hashemi

“…Jacobsen syndrome (JS) is a rare contiguous gene deletion disorder characterized by a deletion at the terminal end of the long arm of chromosome 11. JS has various phenotypic features, such as neurodevelopmental delays and congenital heart defects. …”
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Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury by Elisa Garcia, Jorge Aguilar-Cevallos, Raul Silva-Garcia, Antonio Ibarra

“…The excessive inflammatory Th1 and Th17 phenotypes observed after SCI tilt the scale towards a proinflammatory environment, which exacerbates the deleterious mechanisms present after the injury. …”
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Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…Merkel cells (MCs), the neuroendocrine cells of the skin, were believed to be at the origin of MCC due to their phenotypic similarities. However, for several reasons, for example, heterogeneous differentiation of MCCs and postmitotic character of MCs, it is not very likely that MCC develops from differentiated MCs. …”
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Prefibrotic Myelofibrosis Presenting with Multiple Cerebral Embolic Infarcts and the Rare MPL W515S Mutation by Stephen E. Langabeer, Lisa Lee Tokar, Laura Kearney, Cathal O’Brien, Kowshika Thavarajah, Aisling Barrett, John McManus, Hilary O’Leary

“…This case provides additional, necessary, and phenotypic data for the rare MPN-associated MPL W515S mutation.…”
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Differentiation of Xanthomonas spp. Causing Bacterial Spot in Bulgaria Based on Biolog System by Mariya Stoyanova, Taca Vancheva, Penka Moncheva, Nevena Bogatzevska

“…According to the current data, the species are four (X. euvesicatoria, X. vesicatoria, X. gardneri, and X. perforans) and cause similar symptoms in plants but possess different phenotypic properties. This work provides the full metabolic characteristics obtained by Biolog system of bacterial spot’s xanthomonads based on a large selection of strains from different vegetable-producing regions of Bulgaria with accent on their major differentiating properties which could be used for species differentiation by metabolic profiles. …”
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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease by V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella

“…The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the “aging theory for COPD” was also discussed.…”
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Epidemiological Research Advances in Vascular Calcification in Diabetes by Haipeng Yao, Zhen Sun, Guangyao Zang, Lili Zhang, Lina Hou, Chen Shao, Zhongqun Wang

“…Vascular calcification is the transformation of arterial wall mesenchymal cells, particularly smooth muscle cells (SMCs), into osteoblast phenotypes by various pathological factors. Additionally, vascular transformation mediates the abnormal deposition of calcium salts in the vascular wall, such as intimal and media calcification. …”
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Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction by Barbara Rinaldi, Francesca Guida, Anna Furiano, Maria Donniacuo, Livio Luongo, Giulia Gritti, Konrad Urbanek, Giovanni Messina, Sabatino Maione, Francesco Rossi, Vito de Novellis

“…We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. …”
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Short Stature on a Boy: Mosaicism with an Isodicentric Y Chromosome by Catarina Silvestre, Juliette Dupont, Rosário Silveira Santos, Brígida Robalo, Carla Pereira, Maria Lurdes Sampaio

“…Mosaicism brings great variability into the clinical expression of numerical and structural chromosomal abnormalities. The phenotypic variability of 45,X/46,XY mosaicism extends from Turner syndrome to apparently physically normal males. …”
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The blues and rhythm by Kiyomichi Imamura, Ayaka Bota, Toshihiko Shirafuji, Toru Takumi

“…Numerous studies have shown that interventions to circadian rhythms trigger depression-like phenotypes in human cases and animal models. Conversely, mood changes can affect circadian rhythms as symptoms of depression. …”
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Mental Health Across the Metabolic Spectrum by Vrinda Saxena, Isaac Marin-Valencia

“…Despite their high prevalence, psychiatric deficits in individuals with inborn errors of metabolism remain challenging to recognize and manage due to phenotypic variability, limited clinical training in neurometabolism, and gaps in research. …”
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The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer by Xiaojie Li, Wenying Zhou, Yanlan Liang, Changzhi Xu, Zhizhi Xie, Jiayin Liang, Bo Hu

“…The interaction between SIRPα and CD47 leads to a negative signal that prevents the phenotypic and functional maturation of DC and inhibits phagocytosis. …”
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Whole-genome phylogenetic analysis of Mycobacterium avium complex from clinical respiratory samples by Chew Ka Lip, Joelle Go, Nur Aisyah Binte Abu Bakar, Sophie Octavia, Raymond Tzer Pin Lin, Jeanette W. P. Teo

“…Based on susceptibility breakpoints that are available for clarithromycin, amikacin, linezolid, and moxifloxacin, low rates of clarithromycin (0.5%, 1/203) and amikacin (1.5%, 3/203) phenotypic resistance were observed. While linezolid and moxifloxacin resistance were 25.6% (52/2030) and 46.3% (94/203), respectively. …”
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Transgressive hybrids as hopeful holobionts by Benjamin Thomas Camper, Andrew Stephen Kanes, Zachary Tyler Laughlin, Riley Tate Manuel, Sharon Anne Bewick

“…Across numerous hybrid microbiota phenotypes, we find widespread evidence of transgressive segregation. …”
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Extinction Status, Challenges, and Conservation Approaches of South African Indigenous and Village Chickens: A Systematic Review by Sindisiwe Mbali Sithole, Khathutshelo Agree Nephawe, Takalani Judas Mpofu, Bohani Mtileni, Masindi Lottus Mphaphathi, Jabulani Nkululeko Ngcobo

“…Articles addressing origins, phenotypic and genetic diversity, the conservation of indigenous chickens, semen cryopreservation of indigenous chickens, climate change effects on indigenous chickens, and the use of extenders with indigenous chickens were included in this review. …”
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Genome-wide identification of short-chain dehydrogenases/reductases genes and functional characterization of ApSDR53C2 in melanin biosynthesis in Arthrinium phaeospermum by Jiao Liao, Yisi Wang, Han Liu, Sijia Liu, Peng Yan, Hang Chen, Shujiang Li, Shujiang Li

“…Knockout mutants, the co-knockout mutant, and backfill mutants of key ApSDRs were obtained for phenotypic and stress conditions analysis. We explored and validated the pathogenic mechanisms through cellulose membrane penetration experiments and analysis of melanin-related gene synthesis levels.Results and discussion180 ApSDRs were identified bioinformatically. …”
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Virulence profile of carbapenem-resistant Klebsiella pneumoniae strains by an in vivo model of Galleria mellonella by María Guembe, Rama Hafian, Marta Díaz-Navarro, Andrés Visedo, Flavio De Maio, Fulvia Pimpinelli, Ilaria Cavallo, Mauro Truglio, Francesca Sivori, Enea Gino Di Domenico

“…This study aimed to characterize the genotypic and phenotypic diversity of K. pneumoniae isolates and evaluate their virulence using the Galleria mellonella model. …”
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Trends and Gaps in Digital Precision Hypertension Management: Scoping Review by Namuun Clifford, Rachel Tunis, Adetimilehin Ariyo, Haoxiang Yu, Hyekyun Rhee, Kavita Radhakrishnan

“…The included articles were thematically analyzed based on their precision health focus: personalized interventions, prediction models, and phenotyping. Data were extracted and summarized for study and sample characteristics, precision health focus, digital health technology, disciplines involved, and characteristics of personalized interventions. …”
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Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Finally, Mendelian randomization analysis established a significant association between progesterone levels and multiple OA phenotypes. Conclusion In our study, IRAK3, ITGBL1, and RHOU were identified as potential novel diagnostic and therapeutic targets for OA. …”
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