Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes by Fresia Pareja, Rohit Bhargava, Virginia F. Borges, Edi Brogi, Rita Canas Marques, Fatima Cardoso, Christine Desmedt, Malini Harigopal, Sunil R. Lakhani, Adrian Lee, Jose Pablo Leone, Hannah Linden, Christopher J. Lord, Caterina Marchio, Sofia D. Merajver, Emad Rakha, Jorge S. Reis-Filho, Andrea Richardson, Elinor Sawyer, Pepper Schedin, Christopher J. Schwartz, Andrew Tutt, Naoto T. Ueno, Anne Vincent-Salomon, Britta Weigelt, Y. Hannah Wen, Stuart J. Schnitt, Steffi Oesterreich

“…Abstract Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. …”
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TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma by Hanrui Guo, Meiling Wang, Caiya Ni, Chun Yang, Chunxue Fu, Xiaoman Zhang, Xueling Chen, Xiangwei Wu, Jun Hou, Lianghai Wang

“…HCC cells were treated with conditioned medium from WT or Trem2 −/− macrophages, and their malignant phenotypes and underlying mechanisms were analyzed. …”
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Enhanced infectivity of bovine viral diarrhoea virus (BVDV) in arginase-producing bovine monocyte-derived macrophages by Lucas José Barone, Nancy Patricia Cardoso, Florencia Celeste Mansilla, Mariángeles Castillo, Alejandra Victoria Capozzo

“…Macrophages are not a homogenous population; they exist in different phenotypes, typically divided into two main categories: classically (pro-inflammatory) and alternatively activated (anti-inflammatory) or M1 and M2, respectively. …”
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Molecular Identification, Histopathology and Antibiotic Susceptibility Profiling of Aeromonas veronii Isolated from Oreochromis niloticus in Bangladesh by Sayed Mashequl Bari, Mohammad Muttakinul Islam, Aktia Amina, Marufa Khatun, A. M. Shahabuddin

“…Results Phenotypic and biochemical characterization showed similarities of the ‐collected isolates with Aeromonas veronii. …”
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…The lack of robustly validated targets and the complexity of parasite’s diseases have made phenotypic screening a preferential drug discovery strategy for the identification of new chemical entities. …”
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PRPF3-Associated Autosomal Dominant Retinitis Pigmentosa and CYP4V2-Associated Bietti’s Crystalline Corneoretinal Dystrophy Coexist in a Multigenerational Chinese Family by Xiaohong Meng, Qiyou Li, Hong Guo, Haiwei Xu, Shiying Li, Zhengqin Yin

“…To characterize the clinical and molecular genetic characteristics of a large, multigenerational Chinese family showing different phenotypes. Methods. A pedigree consisted of 56 individuals in 5 generations was recruited. …”
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Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

“…The SpsTAC2 gene was overexpressed in Arabidopsis and analyzed for phenotypic changes. The subcellular localization of SpsTAC2 was analyzed via Agrobacterium-mediated transient expression in onion (Allium cepa L.) epidermal cells. …”
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Evidence of vancomycin-resistant Staphylococcus aureus, multidrug-resistant S. aureus, and Enterococcus faecium-causing mastitis in Thailand and Cambodia by Sambo Na, Montira Intanon, Anyaphat Srithanasuwan, Wasana Chaisri, Witaya Suriyasathaporn

“…E. faecium isolates exhibited high resistance to tetracycline (100%) and penicillin (90%), with 60% classified as MDR. Phenotypic analysis identified VRSA in 11% of S. aureus isolates. …”
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CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis by Meijun Zhu, Bo-Ya Du, Yan-Qiu Tan, Yang Yang, Yang Zhang, Yong-Fei Wang

“…The loss-of-function mutants cpk1-1, cpk1-2, cngc5-1 cngc6-2 cngc9-1 (shrh1/short root hair 1), and cpk1 shrh1 show similar RH phenotypes, including shorter RHs, more RH branching, and dramatically attenuated cytosolic Ca2+ gradients at RH tips. …”
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LATE BLIGHT RESISTANCE OF HYBRIDS OBTAINED IN CROSSES OF <i> SOLANUM TUBEROSUM </i> L. WITH THE BOLIVIAN DIPLOID POTATO SPECIES by N. M. Zoteyeva, Yu. I. Karabitsina

“…In field and laboratory evaluation large share of resistant phenotypes was found. Both hybrids produced tubers in the field under long daylight conditions. …”
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POPULATION ASPECT IN ORGANIC AGRICULTURE by S. K. Temirbekova, J. D. Van Mansvelt

“…Variability of populations phenotypical structure was investigated with use of different effects: various dates of crops sawing, temperature factors, an light mode. …”
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Simple Imaging Techniques for Plant Growth Assessment by Shinsuke Agehara

“… Quantification of plant phenotypic traits, such as height, width, stem diameter, and leaf area, is often performed manually in the field; however, these measurements can be performed more quickly and precisely through simple imaging techniques using an image processing program. …”
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Simple Imaging Techniques for Plant Growth Assessment by Shinsuke Agehara

“… Quantification of plant phenotypic traits, such as height, width, stem diameter, and leaf area, is often performed manually in the field; however, these measurements can be performed more quickly and precisely through simple imaging techniques using an image processing program. …”
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Genetic investigation of patients with autosomal recessive ataxia and identification of two novel variants in the SQSTM1 and SYNE1 genes by Diana Mokhtari, Mohammad Jahanpanah, Nasim Jabbari, Hamed Azari, Sana Davarnia, Haleh Mokaber, Sara Arish, Rasol Molatefi, Vahid Abbasi, Behzad Davarnia

“…A large group of adult hereditary ataxias have autosomal dominant inheritance, and autosomal recessive cerebellar ataxias (ARCAs) are rare, with greater diversity in phenotypic and genotypic features. Therefore, comprehensive genetic testing is useful for identifying the genes responsible for ARCAs. …”
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Evaluation of Panicle Exsertion and Identification of QTL for Long Panicle Neck in Single-segment Substitution Lines of Wild Rice by Jiamei MOU, Chengxia LI, Rui TANG, Yanjie LIU, Xingxin DAI, Xuelin FU

“…Their average additive effect values were in the range of 1.74-4.08 cm, respectively, and the phenotypic contribution rates of the additive effects were 107.82%~481.80%. …”
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Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south indian population by Vikram Haridas, Praveenkumar Shetty, M Nirmal Kumar, K C Vasanthakumar, Kiran Haridas, Vitthal Khode, Anil Bargale

“…Early-onset of AS manifestations is seen in HLA B27 phenotypes than non-HLA B27 phenotypes. HLA B27 associated AS patients presented more severe axial manifestations such as bilateral sacroiliitis, erosions, and extra-articular features such as uveitis than non-HLA types. …”
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Metabolic Activity in Human Intermuscular Adipose Tissue Directs the Response of Resident PPARγ⁺ Macrophages to Fatty Acids by Xiaoying Chen, Sebastian Ludger Schubert, Aline Müller, Miguel Pishnamaz, Frank Hildebrand, Mahtab Nourbakhsh

“…Immunofluorescence analysis was used to detect macrophage phenotypes and mitochondrial activity. Preconfigured arrays were used to detect the expression of 34 different adipokines and chemokines. …”
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Novel candidate genes and genetic basis analysis of kernel starch content in tropical maize by Xiaoping Yang, Ranjan K. Shaw, Linzhuo Li, Fuyan Jiang, Xingming Fan

“…Results The integration of QTL mapping and genome-wide association analysis (GWAS) identified two SNPs, 8_166371888 and 8_178656036, which overlapped the QTL interval of qSC8-1, identified in the tropical maize line YML46. The phenotypic variance explained (PVE) by the QTL qSC8-1 was12.17%, while the SNPs 8_166371888 and 8_178656036 explained 10.19% and 5.72% of the phenotypic variance. …”
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Airborne Escherichia coli bacteria biosynthesize lipids in response to aerosolization stress by Brooke L. Smith, Meiyi Zhang, Maria D. King

“…The biosynthesis of lipids, particularly lipopolysaccharides, or lipooligosaccharides (LPS/LOS) is essential for OM repair. Here we show the phenotypic and genotypic changes of Escherichia coli MG1655 (E. coli) before and after exposure to short-term aerosolization, 5 min, and long-term indoor aerosolization, 30 min. …”
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Streptomyces learnhanii sp. nov., unveiling a Mangrove-Derived Novel “Modern Actinobacteria” in Malaysia by Jodi Woan-Fei Law, Vengadesh Letchumanan, Kar-Wai Hong, Sunny Hei Wong, Nurul Syakima Ab Mutalib, Ya-Wen He, Kok-Gan Chan, Loh Teng-Hern Tan

“…The taxonomy status of strain MUM 203JT was determined via a polyphasic approach comprising phenotypic observations, genomic and phylogenetic analyses, and chemotaxonomic analyses. …”
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