Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…Both phytocannabinoids contribute to physiological and pharmacological effects. Multiple preclinical studies conducted on animal models of AD have shown that THC specifically targets and modifies the pathological markers of AD while simultaneously enhancing cognitive function. …”
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Quadriceps Activation After Anterior Cruciate Ligament Reconstruction: The Early Bird Gets the Worm! by Ayrton MOIROUX--SAHRAOUI, Florian FORELLI, Jean MAZEAS, Alexandre JM RAMBAUD, Andreas BJERREGAARD, Jérôme RIERA

“…Early management focusing on pain modulation through modalities like ice, compression, and pharmacological agents help mitigate the inflammatory response and alleviate pain, thereby reducing the reflexive inhibition of quadriceps. …”
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Comparison of GLP-1RAs vs Other Pharmacotherapy for Obesity by Andrew Overholser, Eric Czech, Linda Speer, Joel Wilson, Alex Overholser

“…Objectives: This review will summarize evidence comparing the safety and efficacy of GLP-1RAs or GLP-1RAs/GIP agonists with other pharmacologic treatments to achieve and maintain weight loss, improve quality of life, and reduce morbidity in obese adults. …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…Treatment of achalasia can be pharmacological, endoscopic (pneumatic balloon dilation, peroral endoscopic myotomy, botulinum toxin injection), aimed at regulating the tone and motility of the esophagus and cardia while preserving all anatomical structures, and surgical (laparoscopic esophagocardiomyotomy, esophagectomy), in which the muscle fibers of the esophagus and esophagogastric junction are intersected or the altered esophagus is completely removed with simultaneous formation of an artificial esophagus from the stomach or colon (esophagoplasty).Conclusion. …”
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Metformin in COVID-19: a magical role beyond the hyperglycemia by Gaurav Kumar Chaubey, Rahul Dilawari, Radheshyam Modanwal, Sharmila Talukdar, Asmita Dhiman, Manoj Raje

“…In this review, we attempt to elucidate the role of classical anti-diabetic medicine metformin in the treatment of COVID-19 infections by highlighting the pharmacological role of this drug during elevated glucose levels and insulin resistance. …”
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Resource constraints, patient emotions, and therapy: experiences of healthcare providers in the screening and management of gestational diabetes mellitus in northern Ghana by Mohammed Bukari, Abdulai Abubakari, Hawa Malechi, Thomas Hinneh, Humphrey Garti, Faith Agbozo

“…The second theme was care-centred experiences, which explored patient emotions during GDM care, and the care they receive post-GDM diagnosis, with subthemes namely: raw emotions, non-pharmacological therapy, and pharmacotherapy. Conclusion Findings suggest the need for health system strengthening through the training and recruitment of dedicated skilled personnel, as well as government intervention through policy revision to cover the cost of GDM diagnostic tests. …”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Later, computational tools were utilised for evaluating pharmacological attributes such as bioavailability score, Lipinski rule, absorption, distribution, metabolism, excretion and toxicity. …”
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A Clinically-Reasoned Approach to Manual Therapy in Sports Physical Therapy by Steven Short, Matthew Tuttle, Dillon Youngman

“…Given the risks associated with pharmacological pain management, the cost of passive modalities like biophysical agents (electrical stimulation, photobiomodulation, ultrasound, etc), and the indications from the evidence-base when combined with active therapies, manual therapy can be a safe and effective treatment strategy to keep athletes active…”
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Physical activity and ageing: The role of physiotherapy in promoting healthy ageing by Shane Naidoo, Nirmala Naidoo

“…Clinical implications: The current research base in the field of ageing in SSA is limited, indicating the need for non-pharmacological interventions to manage the prevalence of NCDs, including in mental/cognitive health, where PA has a direct influence.…”
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A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure contr... by Philip Düsing, Stephan H. Schirmer, Sebastian Schäfer, Alexander Krogmann, Jan-Malte Sinning, Nikos Werner, Florian Bönner, Alexander Sedaghat, Cornelius Müller, Irina Eckardt, Georg Nickenig, Andreas Zietzer

“…Therefore, optimal secondary prevention includes managing BP through lifestyle changes and pharmacological therapy. The CHANGE study aimed to provide evidence for optimizing secondary prevention in CCS patients using a smartphone application.MethodsThe CHANGE-Study is a prospective, randomized, controlled trial performed in 9 centers in Germany. …”
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Delirium management and current practice among Intensive Care Units Doctors, Khartoum [version 3; peer review: 1 approved, 2 approved with reservations] by Mudawi Mohammed Ahmed Abdallah, Sheema Hamid Seidna Hamid, Hana Eltayeb Salih Elamin, Ghada Omer Hamad Abd El-Raheem

“…Delirium was not regularly assessed in 13.9% of the patients. Non-pharmacological management was applied by 76.4% of doctors, and communication with patients was the most frequent (75%). …”
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Abrupt onset or exacerbation of anorexia nervosa following recent infections: a mini-review and a case report with an atypical manifestation of PANS by Lavalle Raffaele, Tournour Cristina, Rubano Serena, Delsedime Nadia, Panero Matteo, Abbate-Daga Giovanni

“…After significant weight loss and amenorrhea, she was hospitalized for 29 days, receiving psychiatric care, nutritional rehabilitation, and pharmacological treatment. Over 2 months of residential care and ongoing outpatient therapy, she improved notably, though mild body dysmorphophobia persisted. …”
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A new method of distracting attention: Is it effective for pain and fear during phlebotomy in children? by Mine Aydemir Sahin, Yeliz Cigerci, Hamide Nur Cevik Ozdemir

“…The musical blood collection tube can be used by health professionals as a non-pharmacological method to reduce the pain and fear of children during blood collection. …”
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Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review by Maya G. Pillai, Helen Antony

“…Clinical applications of NP-based immunotherapies, such as curcumin and resveratrol in cancer treatment, highlight their diverse pharmacological properties. However, despite these advancements, challenges persist in the clinical implementation of NPs. …”
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New Oral Anaticoagulant Prescribing Decisions amongst General Practitioners: Handle with Care by Ann Kirby, Aileen Murphy, Colin Bradley

“…The introduction of new oral anticoagulants (NOACs) offers a wider choice but they are more costly and their use also brings additional pharmacological considerations. **Objective:** This paper investigates if the identified risk factors (renal impairment, hepatic impairment, other co-morbidities & drug interactions) influence GPs’ NOAC prescribing decisions, using a multivariate probit model, while controlling for other GP characteristics. …”
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Effect of nanoemulsion carbonated hydroxyapatite-statin administration on Acp 5 and Runx-2 expression during orthodontic relapse in rats by Ananto Ali Alhasyimi, Niswati Fathmah Rosyida, Ika Dewi Ana

“…In the past two decades, numerous biological treatments have been developed to alleviate orthodontic relapse. Pharmacologic bone modulation is a viable approach to mitigate relapse. …”
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The link between hyperuricemia and diabetes: insights from a quantitative analysis of scientific literature by Lili Ma, Jing Wang, Li Ma, Xian Min Wang

“…Exploring pathological mechanisms and pharmacological interventions linked to diabetes concomitant with HUA has emerged as a focal point of research and a burgeoning trend within the field.ConclusionThis study is the first scientometric analysis to synthesize research trends on HUA and diabetes, revealing molecular mechanisms and treatment strategies and providing theoretical insights for future clinical use.…”
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Ketogenic metabolic therapy for schizoaffective disorder: a retrospective case series of psychotic symptom remission and mood recovery by Nicole Laurent, Erin L. Bellamy, Katherine A. Tague, Donika Hristova, Ally Houston

“…Standard treatments, primarily pharmacological, often fail to control symptoms fully and can lead to significant metabolic side effects. …”
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Zolpidem: Efficacy and Side Effects for Insomnia by Amber N. Edinoff, Natalie Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye

“…Even so, zolpidem could be a suitable pharmacological treatment for insomnia. Decisions for whether or not to prescribe it and the dosage should be made on a case-by-case basis, considering both the psychical and psychiatric risks posed to the patient with insomnia versus if the patient were to take zolpidem to treat their condition.…”
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Investigating the Safety of Fampridine in Patients with Different Stages of Multiple Sclerosis by Saeed Vaheb, Mahour Farzan, Alireza Afshari-Safavi, Narges Ebrahimi, Vahid Shaygannejad, Omid Mirmosayyeb

“…Nevertheless, this drug has been reported to possess some adverse effects (AEs) like seizure because of its pharmacological features. The aim of this study was to evaluate the incidence rate of post-medication side effects (SEs) of fampridine in MS patients. …”
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