The Genetic Basis of Congenital Cataracts: Advances in Diagnostics and Therapeutics by Agnieszka Starzyk, Piotr Charzewski

“…Emerging approaches, including gene therapy and pharmacological interventions like small-molecule chaperones, hold promise for addressing underlying genetic causes. …”
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THE GENUS AS, A POTENTIAL SOURCE OF ANTICANCER AGENT: AN UPDATED REVIEW

“…Pistachios have antioxidant, antifungal, antimicrobial, and anticancer  properties, among many other pharmacological benefits. The ability of pistachios to inhibit tumor growth  is supported by data indicating that they do so by modulating multiple apoptotic pathways in tumor cells.  …”
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A rare case of acute respiratory distress syndrome due to chlorine gas inhalation: Rapid progression with favorable ICU outcome by Dung Thai Pham, Bang Ngoc Dao, Dung Tien Nguyen, Ba Van Dang, Dung Tien Le, Hung Manh Do, Loc Tich Hoang, Minh Tuan Ngo, Duong Minh Vu

“…Despite the rapid disease progression, the patient responded well to aggressive ICU management, including oxygen therapy, mechanical ventilation, and pharmacological support. Remarkably, within seven days, the patient fully recovered and was discharged in stable condition. …”
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Virus-inspired biogenic delivery system for advancing cancer therapy by Di Sun, Hao Liang, Qianwen Mu, Chengchao Chu, Gang Liu, Chao Liu

“…In vaccine research, Virus-mimic nanovesicles have been effectively verified against cancer via the immunogenicity and the pharmacological effect of drug molecules delivered to mediate an immune response in the body. …”
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Controversy About Management of Osteoarthritis with Disease-modifying Anti-rheumatic Drugs by CUI Hanshu, LIU Bin

“…As its pathophysiological mechanisms are not well understood, it is hard to identify the specific targets of OA and standardize its pharmacological treatments. Some scholars believe that synovial inflammation is the main factor of pain and progression of OA, so disease-modifying anti-rheumatic drugs (DMARDs) for inflammatory arthritis could be used to treat OA. …”
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Literature Review: Pericranial Nerve Blocks for Chronic Migraines by Stephanie Wahab, Saurabh Kataria, Parker Woolley, Naanama O’Hene, Chima Odinkemere, Rosa Kim, Ivan Urits, Alan D. Kaye, Jamal Hasoon, Cyrus Yazdi, Christopher L Robinson

“…Current methods of migraine treatment include lifestyle changes, pharmacologic, and minimally invasive techniques such as peripheral nerve stimulation (PNS) and pericranial nerve blocks (PNB)…”
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Up-to-date methods of stomach functions investigation and their diagnostic potentials by Ya. S. Tsimmerman

“…Advantages of modern multichannel рН-meters, potential of acquiring of the supplemental information by original methods of intragastric рН-grams analysis with application of various pharmacological and stimulaion tests are analyzed. Methods of studying of gastric juice proteolytic activity are compared. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…ACSL4 emerged as a critical biomarker of this proliferative subtype, driving HB cell proliferation both in vitro and in vivo. Furthermore, pharmacological inhibition of ACSL4 using abemaciclib significantly suppressed tumor growth in xenograft models. …”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…Furthermore, we show that, in both yeast cells and mammalian cells, SY1 IBs are associated with mitochondria. Pharmacological inhibition of the sphingolipid metabolism pathway or knockout of its key genes results in a delayed IB maturation and increased SY1 cytotoxicity. …”
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Principles of diuretic therapy at liver cirrhosis by A. I. Dyadyk, T. Ye. Kugler, I. S. Malovichko, N. F. Yarovaya, I. V. Rakitskaya

“…Therapeutic approach for edema syndrome at LC should be based on series of fundamental steps: edema pathophysiology understanding; comprehensive investigation of patients; assessment of edema severity and presence of complications; awareness of pharmacological features of diuretic drugs, their interaction and side effects; albumin or plasma substitutes administration, use of vasoconstrictors, transjugular intrahepatic portosystemic shunting and liver transplantation when required.…”
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Phytochemical profile, therapeutic potentials, nutritional composition, and food applications of ginger: a comprehensive review by Great Iruoghene Edo, Ufuoma Augustina Igbuku, Raghda S. Makia, Endurance Fegor Isoje, Tayser Sumer Gaaz, Emad Yousif, Agatha Ngukuran Jikah, Khalid Zainulabdeen, Patrick Othuke Akpoghelie, Rapheal Ajiri Opiti, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar

“…The compounds are responsible for the distinct aroma, flavor, and pharmacological activities such as anti-inflammatory, anti-oxidation, antimicrobial, anti-cancer, gastroprotective effects associated with ginger. …”
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Gastroesophageal reflux disease, resistant to proton pump inhibitors by V. O. Kaybysheva, A. S. Trukhmanov, V. T. Ivashkin

“…To discuss the factors, promoting development of resistance at treatment of gastroesophageal reflux disease (GERD), and possible means to overcome it.Original positions. Pharmacological therapy of GERD is focused on change of refluxate properties besides decreasing of its volume and aggressive properties by such classes of drugs, as antacids, alginates and hydrochloric acid secretion inhibitors. …”
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Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity by Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi

“…Here, we performed radioactive tracer studies in combination with pharmacological enzyme inhibition, followed by targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, and found three androgen metabolites—androstanedione, androsterone, and epiandrosterone—in mouse and human meibomian glands. …”
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Health Implications of Anabolic-Androgenic Steroids: Usage, Risks, and Treatment Approaches - The Literature Review by Krzysztof Jodłowski, Ewa Dubniewicz, Paula Majewska, Alicja Staszek, Wiktoria Łoskot, Jan Szwech, Mateusz Matczak, Karol Jasiński, Aleksandra Broda, Kacper Hoksa

“…The review explores the health implications of AAS use, highlighting the importance of an interdisciplinary approach to managing AAS-related health issues, emphasizing harm reduction, pharmacological interventions, and fertility preservation techniques. …”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…In addition, we briefly discussed potential pharmacological interventions for glucose metabolism to alleviate MDD, including glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, and pioglitazone, to encourage the development of new therapeutics.…”
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Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies by Piotr Robert Bakuła, Kamila Jałocha, Joanna Zygadło

“…This review examines emerging pharmacological and regenerative approaches, including disease-modifying osteoarthritis drugs (DMOADs), biologics, and cell-based therapies. …”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

“…These findings suggest two complementary mechanisms by which aspirin regulates the degradation of soluble and insoluble proteins, providing insights into its diverse pharmacological effects that can aid in future drug development efforts.…”
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Physical activity and depression by Monika Wojtasik, Katarzyna Żak, Adam Załóg, Maria Nowak, Edyta Pietryszak, Wojciech Kulej, Paulina Szołtek, Rafał Pardela, Marcel Paruzel, Martyna Łęcka

“…In a therapeutic context, the article examines how physical activity can be an effective complement to traditional methods of treating depression, both pharmacological and psychotherapeutic. The importance of adapting training programs to individual needs and preferences of patients is also emphasized. …”
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The effect of rehabilitation on remission following detoxification treatment in alcohol and substance use disorders: A pilot study by Mustafa Danisman, Gamze Zengin Ispir, Kubra Sezer Katar, Zehra Ucar Hasanli, Ziya Bilgin

“…In the treatment of ASUD, in addition to pharmacological treatment and the treatment of comorbid psychiatric disorders, the inclusion of rehabilitation in the treatment processes is also essential because of the high relapse rates after detoxification treatment. …”
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The role of diet and physical activity in PCOS - A Quick Review by Natalia Pawelec, Weronika Mazur, Artur Hawajski, Natalia Jankowska, Adrianna Świerzyńska, Alicja Kapciak, Julia Górny, Katarzyna Naja

“…These recommendations are often overlooked or undervalued, with patients frequently expecting immediate pharmacological treatment and not believing in the potential effects of lifestyle changes. …”
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