Efficacy of Black Cumin (Nigella sativa) Ameliorate Organophosphate Toxicity in Pregnant Rats Based on Progesterone Levels and Fetal Bone Development by Viski Fitri Hendrawan, Galuh Chandra Agustina, Siska Aditya, Yudit Oktanella, Aulia Firmawati, Dewi Mariyam

“…Black cumin (Nigella sativa), also referred to as black cumin, is a versatile herbal treatment that has recently grown in popularity, it contains antimicrobial, antibacterial, antifungal, anti-inflammatory, analgesic, antipyretic, antiparasitic, antihistamine, antihypertensive, antitumor, anticancer, antidiabetic, and anti-asthmatic properties are just a few of the positive and pharmacological effects of active ingredients in black cumin, such as thymoquinone and other compounds. …”
Get full text

Classification of Epileptic Seizures by Simple Machine Learning Techniques: Application to Animals’ Electroencephalography Signals by Illia Pidvalnyi, Anna Kostenko, Oleksandr Sudakov, Dmytro Isaev, Oleksandr Maximyuk, Oleg Krishtal, Olena Iegorova, Ievgen Kabin, Zoya Dyka, Steffen Ortmann, Peter Langendorfer

“…Small electronic devices capable of doing that will improve the quality of life for epilepsy patients while also open new opportunities for pharmacological intervention. This paper presents a novel approach using machine learning techniques to detect seizures onset using intracranial electroencephalography (EEG) signals. …”
Get full text

Lifestyle components of the global oldest old assessed as effective nonpharmacologic strategies to maintain lifelong cognitive and functional health by Cécil J.W. Meulenberg

“…Besides the concurrent costs to provide healthcare for such an aging population are dramatically increasing and depend on pharmacological treatment. There is an urgent need to raise awareness for cost-saving healthier customs and to adjust lifestyles. …”
Get full text

Analysis of Polygala tenuifolia Transcriptome and Description of Secondary Metabolite Biosynthetic Pathways by Illumina Sequencing by Hongling Tian, Xiaoshuang Xu, Fusheng Zhang, Yaoqin Wang, Shuhong Guo, Xuemei Qin, Guanhua Du

“…Radix polygalae contains various saponins, xanthones, and oligosaccharide esters and these compounds are responsible for several pharmacological properties. To provide basic breeding information, enhance molecular biological analysis, and determine secondary metabolite biosynthetic pathways of P. tenuifolia, we applied Illumina sequencing technology and de novo assembly. …”
Get full text

Ultrasound-assisted extraction of phenolic compounds from ear mushrooms (Auricularia auricula-judae): Assessing composition and antioxidant activity during fruiting body developmen... by Albert Nugraha, Asadin Briliantama, M Umar Harun, Li Sing-Chung, Chin Xuan Tan, Vuanghao Lim, Amir Husni, Widiastuti Setyaningsih

“…Auricularia auricula-judae (ear mushroom) exhibits significant biological and pharmacological properties, particularly as an antioxidant due to its phenolic compounds. …”
Get full text

Unraveling the Relationship between Oral Habits and Anxiety: A Narrative Review by Ramya V. Jathanna, Ritesh Bangera, Mithun K. Naik, Vinod R. Jathanna, Sharanya Adhikari, Shivangi Vats

“…Integrated assessment and management strategies are needed to address both conditions effectively, with emphasis on behavioral interventions, pharmacological approaches, and multidisciplinary collaboration between dental and mental health professionals. …”
Get full text

Focusing on the recent progress of tea polyphenol chemistry and perspectives by Shiming Li, Liang Zhang, Xiaochun Wan, Jianfeng Zhan, Chi-Tang Ho

“…More intensive research is warranted to elucidate the mechanisms of action underlying the biological activity of flavoalkaloids and the pharmacological application of tea polyphenols in scavenging RCS and impeding detrimental AGEs.…”
Get full text

Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide by Georgios Gaitanis, Dora Gougopoulou, Eleni Kapsali, Ioannis D. Bassukas

“…In conclusion, the impressive and sustainable AK remission under anagrelide draws attention to a possible role of the phosphodiesterase 3 pathway, the major pharmacological target of anagrelide, as a potential therapeutic target for keratinocytic cancers.…”
Get full text

In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment by Taufik Muhammad Fakih, Aden Dhana Rizkita, Sintia Ayu Dewi, Muchtaridi Muchtaridi

“…Extensive research has been dedicated to exploring its phytochemical composition and pharmacological effects. Notably, the uniqueness of Cinnamomum lies in its terpenoid content, characterized by distinctive structures and significant biological implications. …”
Get full text

Disparity between High Satisfaction and Severe Pain in Patients after Caesarean Section: A Prospective Observational-Controlled Investigation by Thomas Hesse, Andreas Julich, James Paul, Klaus Hahnenkamp, Taras I. Usichenko

“…The disparity between the high level of pain and excellent satisfaction with POP treatment raises the ethical and biomedical considerations of restrictive pharmacological therapy of post-CS pain.…”
Get full text

Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains by Arun John, Vetrivel Umashankar, Subramanian Krishnakumar, Perinkulam Ravi Deepa

“…This has made FASN an attractive pharmacological target. Here, we have attempted to predict the theoretical models for the human enoyl reductase (ER) and β-ketoacyl reductase (KR) domains based on the porcine FASN crystal structure, which was the structurally closest template available at the time of this study. …”
Get full text

The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? by Catherine Gebhard, Catherine Gebhard, Susan Bengs, Susan Bengs, Achi Haider, Achi Haider, Michael Fiechter, Michael Fiechter, Michael Fiechter

“…Such malignant cascade of events might account, at least in part, for the excess female mortality seen in women with coronary artery disease and calls for sex-specific research toward pharmacologic or behavioral modulators to improve cardiovascular outcomes, particularly in women. …”
Get full text

Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats by Qishan Wang, Bin Liu, Xianping Li, Junying Zhao, Zongshen Zhang, Weicang Qiao, Xinyue Wei, Lijun Chen

“…The aging of the global population has made postmenopausal osteoporosis prevention essential; however, pharmacological treatments are limited. Herein, we evaluate the effect of calcium-fortified fresh milk (FM) in ameliorating postmenopausal osteoporosis in a rat model established using bilateral ovariectomy. …”
Get full text

Prevalence of Undiagnosed Attention Deficit Hyperactivity Disorder by Carissa Du, Daniel Zongliang Zhao, Latha Ganti

“…# Background Attention deficit/hyperactivity disorder (ADHD) is a disorder characterized by inattention, hyperactivity, and impulsivity. Primary pharmacologic interventions include stimulants and non-stimulants. …”
Get full text

Transcranial direct current stimulation combined with physical exercise in rotator cuff tendinopathy: a protocol for a blinded randomised controlled trial by César Augusto Medeiros Silva, Clécio Gabriel de Souza, Vinicius Batista Lima, Hannely Beatriz Menezes Cosme, Romário Nóbrega Santos Fonseca, Fuad Ahmad Hazime, Rodrigo Scattone da Silva, Rodrigo Pegado de Abreu Freitas

“…Pain neuromodulation techniques, such as transcranial direct current stimulation (tDCS), may offer complementary non-pharmacological options for pain relief by promoting central modulation and altering cortical excitability.Methods and analysis This protocol outlines a randomised, blinded clinical trial. …”
Get full text

Enhancing Akt Imaging through Targeted Reporter Expression by Limin Zhang, Mahaveer S. Bhojani, Brian D. Ross, Alnawaz Rehemtulla

“…The serine/threonine kinase PKB/Akt is a key mediator of survival and resistance to cancer therapy. Pharmacologic inhibition of Akt and its biologic sequelae may significantly impact the treatment of cancer. …”
Get full text

Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization? by Carole Guedj, David Meunier, Martine Meunier, Fadila Hadj-Bouziane

“…Here, we provide evidence of the co-occurrence of these two mechanisms at the whole-brain level, in resting-state conditions following a pharmacological stimulation of the LC-NE system. We propose that these two mechanisms are interdependent such that the LC-NE-dependent adjustment of the neural gain inferred from the clustering coefficient could drive functional brain network reorganizations through coherence in the gamma rhythm. …”
Get full text

Fungal-Host Interaction: Curcumin Modulates Proteolytic Enzyme Activity of Candida albicans and Inflammatory Host Response In Vitro by Emily Chen, Bruna Benso, Dalia Seleem, Luiz Eduardo Nunes Ferreira, Silvana Pasetto, Vanessa Pardi, Ramiro Mendonça Murata

“…Curcumin is used as a spice, food preservative, flavoring, and coloring agent that has been shown to have many pharmacological activities. Thus, this study evaluated the modulatory effects of curcumin on major virulence factors associated with the pathogenicity of C. albicans. …”
Get full text

A Comparative Study of Local Dietary Intake Among Subjects with Hypertensive Disorders of Pregnancy Attending Antenatal Care by Chibuike F. Chukwunyere, David O. Awonuga, Taiwo Olunuga, Ifeoma C. Udenze

“…The research by the Dietary Approaches to Stop Hypertension (DASH) group revealed that non-pharmacological measures and intervention such as diet can be used to control blood pressure. …”
Get full text

Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair by Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

“…Here, we report that inhibitors of glycogen synthase kinase 3 beta (GSK3β) and the homologous recombination DNA repair (HRR) pathway are synthetic lethal with FHIT loss in lung cancer. Pharmacological inhibition or siRNA depletion of GSK3β selectively suppressed the growth of FHIT-deficient lung cancer tumors in vitro and in animal models. …”
Get full text