Therapeutic effects of Pueraria lobata (Willd.) Ohwi root and Hovenia dulcis Thunb. extracts on alcoholic liver disease: Network pharmacology and experimental validation by Zhendong Chen, Yu Yue, Hongyan An, Haisu Yan, Hyeok-Joo Park, Pei Lin

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Pharmacological effects of fibroblast growth factor 21 are sex-specific in mice with the <em>lethal yellow</em> (A^y) mutation by E. N. Makarova, T. V. Yakovleva, N. Yu. Balyibina, K. O. Baranov, E. I. Denisova, A. D. Dubinina, N. A. Feofanova, N. M. Bazhan

“…Sex is an important biological variable that must be considered when conducting preclinical studies; however, in laboratory animal models, the pharmacological effects of FGF21 are well documented only for male mice. …”
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Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer’s disease by Sedef Kollarik, Sedef Kollarik, Sedef Kollarik, Dorita Bimbiryte, Aakriti Sethi, Inês Dias, Inês Dias, Inês Dias, Carlos G. Moreira, Daniela Noain, Daniela Noain, Daniela Noain, Daniela Noain

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GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study by Emma F. Magavern, Harshal Deshmukh, Geraldine Asselin, Elizabeth Theusch, Stella Trompet, Xiaohui Li, Raymond Noordam, Y.-D. Ida Chen, Teresa E. Seeman, Kent D. Taylor, Wendy S. Post, Jean-Claude Tardif, Dirk S. Paul, Emelia J. Benjamin, Nancy L. Heard-Costa, Ramachandran S. Vasan, Jerome I. Rotter, Ronald M. Krauss, J.Wouter Jukema, Paul M. Ridker, Patricia B. Munroe, Mark J. Caulfield, Daniel I. Chasman, Marie-Pierre Dubé, Graham A. Hitman, Helen R. Warren

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Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

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Pharmacological Vitamin C-induced high H2O2 generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids by Ali Mussa, Mahasin Hamid, Khalid Hajissa, Ahmad Hafiz Murtadha, Mohammad A. I. Al-Hatamleh, Noor Fatmawati Mokhtar, Vuk Uskoković, Magdalena Plebanski, Rohimah Mohamud, Rosline Hassan

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Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

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Optimal timing for lithium levels [version 2; peer review: 2 approved, 1 approved with reservations] by Kevin J Black

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An overview of bioactive components and phytopharmaceutical potentials of Hygrophila auriculata–A herbaceous medicinal plant by Megha Malpotra, Meenakshi Garg, Neha Singh, Susmita Dey Sadhu, Rajni Chopra, Bhupesh Sharma

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Stapled peptides: targeting protein-protein interactions in drug development by Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

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Anti-obesity mechanisms elucidation of essential oil components from Artemisiae Argyi Folium (Aiye) by the integration of GC-MS, network pharmacology, and molecular docking by Yongxiang Liu, Jinhai Luo, Maninder Meenu, Baojun Xu

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Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology by Mahbubeh Bozorgi, Zahra Memariani, Masumeh Mobli, Mohammad Hossein Salehi Surmaghi, Mohammad Reza Shams-Ardekani, Roja Rahimi

“…The present review summarizes comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of the five mentioned Pistacia species.…”
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Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microcirculatory Resistance Registry Data by Ji-Hun Jang, Man-Jong Lee, Kyu-Yong Ko, Jin-Hee Park, Yong-Soo Baek, Kwon Sung-Woo, Sung-Hee Shin, Seong-Ill Woo, Dae-Hyeok Kim, Young Ju Suh, Jun Kwan, Sang-Don Park

“…We aimed to identify mechanical and pharmacological revascularization strategies correlated with the index of microcirculatory resistance (IMR) in ST-elevation myocardial infarction (STEMI) patients. …”
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Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products by Catherina Caballero-George, Thomas Sorkalla, Daniel Jakobs, Jessica Bolaños, Huzefa Raja, Carol Shearer, Eldredge Bermingham, Hanns Häberlein

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<i>Zanthoxylum piperitum</i> Benn. Attenuates Monosodium Urate-Induced Gouty Arthritis: A Network Pharmacology Investigation of Its Anti-Inflammatory Mechanisms by Sung Wook Kim, Soo Hyun Jeong, Jong Uk Kim, Mi Hye Kim, Wonwoong Lee, Cheol-Jung Lee, Tae Han Yook, Gabsik Yang

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Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation by Weisheng Hu, Yinlan Wang, Yingjie Zhou, Junbao Shi, Zengyan Li, Xiaoling Jiang, Qinyuan Wu, Changming Zhong, Huilan Weng, Sijie Ouyang, Yuan Jing, Xianxiang Cai, Mingda Ye, Ning Huang

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A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate: Implications for Use as a Therapeutic for Parkinson’s Disease by Shankar J. Chinta, Subramanian Rajagopalan, Abirami Ganesan, Julie K. Andersen

“…Previously we demonstrated that pharmacological inhibition of a class of enzymes known as prolyl hydroxylases via 3,4-dihydroxybenzoate administration protected against MPTP-induced neurotoxicity, however the exact mechanisms involved were not elucidated. …”
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PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial by Mark N. Stein, Ecaterina E. Dumbrava, Benjamin A. Teply, Usama S. Gergis, Martin E. Guiterrez, Ran Reshef, Sumit K. Subudhi, Céline F. Jacquemont, Joseph H. Senesac, J. Henri Bayle, Charity D. Scripture, Monica S. Chatwal, Mehmet A. Bilen, Walter M. Stadler, Carlos R. Becerra

“…These results suggest that pharmacological activation of GoCAR-T® cells is feasible and may offer a promising avenue to control chimeric antigen receptor-T cell activity with continued dose-optimization to improve tolerability.…”
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Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

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Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking. by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

“…This study aimed to elucidate the chemical constituents of the ethanol extract of Rhizoma Musae (EERM) and investigate its fracture-healing mechanism using network pharmacology.<h4>Methods</h4>The chemical profile of EERM was characterized via UHPLC-Q-Exactive-MS/MS. …”
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