Management of Diabetes Mellitus in Patients with Chronic Liver Diseases by Yingying Zhao, Huichun Xing, Xiaomei Wang, Weini Ou, Hong Zhao, Ben Li, Yue Li, Ying Duan, Liwei Zhuang, Wei Li, Danying Cheng, Min Quan, Yu Zhang, Shibo Ji

“…Thus, in addition to pharmacological treatments and lifestyle interventions, effective control of cirrhosis might assist in a better management of diabetes. …”
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Effects of brain renin- angiotensin system inhibition in ISIAH rats with inherited stress-induced arterial hypertension by L. O. Klimov, M. A. Ryazanova, L. A. Fedoseeva, A. L. Markel

“…Inhibition was performed using widely used pharmacological agents, losartan and benazepril. Osmotic minipumps were used to deliver drugs to the lateral ventricle of the brain. …”
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Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway by Quanxin Ma, Kai Wang, Qinqin Yang, Shun Ping, Weichun Zhao, Qiyang Shou, Weimin Zhou, Minli Chen

“…Here, we studied the protective effects of V. axillare against acute lung injury (ALI), and we further explored the pharmacological mechanisms of this action. We found that pretreatment with V. axillare suppressed the release of proinflammatory cytokines in the serum of ALI mice. …”
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The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells by Ju Hee Yoon, Sung Hwan Jeong, Jeong Hee Hong

“…PM10-mediated Ca2+ signal and IL-8 expression were attenuated by several pharmacological blockades such as antioxidants, IP3-PLC blockers, and TRPM2 inhibitors. …”
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A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…These results led to over 5000 additional studies including carrier, prenatal and preimplantational tests or pharmacological and gene therapy treatments. Conclusion This strategy has shown promising improvements in the diagnostic rate, facilitating timely diagnosis and gradually expanding our services portfolio for rare diseases. …”
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Esophageal Motility Disorders: Current Concepts of Pathogenesis and Treatment by Peter J Kahrilas

“…Neuromuscular pathology is evident only with achalasia (myenteric plexus neurons destruction). Pharmacological therapies have limited efficacy with achalasia; more limited with DES; and none with the nonspecific motility disorders. …”
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In Vitro Evaluation of Antimicrobial Efficacy of Extracts Obtained from Raw and Fermented Wild Macrofungus, Lenzites quercina by Olusola Clement Ogidi, Victor Olusegun Oyetayo, Bamidele Juliet Akinyele

“…The antimicrobial effects of L. quercina extracts indicate that this wild macrofungus contains significant amount of pharmacological agents, which could be extracted to curb the menace of antibiotic resistances by pathogenic organisms.…”
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Experimental approach to obtaining subcutaneous xenograft of non-small cell lung cancer by E. A. Lukbanova, M. V. Mindar, E. A. Dzhenkova, A. Yu. Maksimov, A. S. Goncharova, Yu. S. Shatova, A. A. Maslov, A. V. Shaposhnikov, E. V. Zaikina, Yu. N. Lazutin

“…The created PDX models can be recommended as test systems for preclinical studies of the effectiveness of new pharmacological substances with potential antitumor activity.…”
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Surgical treatment methods in the course of psychiatric disorders: Deep brain stimulation—Novel insights and indications by Ugo Giordano, Jakub Mizera, Elżbieta Żak, Justyna Pilch, Paulina Tomecka, Tomasz Dudzik, Mikołaj Palczewski, Weronika Biziorek, Patryk Piotrowski

“…The method is supposed to offer promising results, especially in pharmacologically resistant forms of the upper-mentioned psychiatric disorders. …”
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Deltacoronavirus HKU11, HKU13, PDCoV (HKU15) and HKU17 spike pseudoviruses enter avian DF-1 cells via clathrin-mediated endocytosis in a Rab5-, Rab7- and pH-dependent manner by Qi-Zhang Liang, Chun-Miao Ji, Bin Wang, Wei Chen, Feng Cong, Yu Huang, Yao-Wei Huang

“…Pseudovirus entry was suppressed by means of pharmacological inhibitors, dominant-negative mutants, and siRNAs targeting various cellular proteins and signalling molecules, suggesting that PDCoV and avian DCoV pseudovirus entry into DF-1 cells depends on clathrin, dynamin-2, cathepsins and a low-pH environment but is independent of caveolae and macropinocytosis. …”
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Molecularly Imprinted Polymers-Coated CdTe Quantum Dots for Highly Sensitive and Selective Fluorescent Determination of Ferulic Acid by Zhihong Wang, Ruiqing Long, Mijun Peng, Te Li, Shuyun Shi

“…Ferulic acid (FA), an important phenolic acid, is widely distributed in higher plants and presents many pharmacological effects. Therefore, sensitive determination of FA in complex matrix is necessary. …”
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Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice... by Revathee Rajajendram, Chau Ling Tham, Mohamad Nadeem Akhtar, Mohd Roslan Sulaiman, Daud Ahmad Israf

“…In conclusion, these findings demonstrate the potential of DMPF-1, a nonsteroidal compound, as an antiasthmatic agent for further pharmacological evaluation.…”
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Investigating the Role of Gut Microbiota in Pediatric Patients with Severe COVID-19 or MIS-C by Elena Franchitti, Paolo Bottino, Francesca Sidoti, Andrea Carpino, Giulia Pruccoli, Ugo Ramenghi, Cristina Costa, Ugo Ala, Emilia Parodi, Deborah Traversi

“…In 75% of cases, pharmacological treatments included antibiotics and corticosteroids, which influenced the microbiota composition. …”
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Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain by Secundino González Pardo, Lourdes González-Longoria Boada, Francisco López Muñoz

“…<br /><strong>Objective:</strong> to evaluate the efficacy of the analgesic response to cancer pain with the intranasal administration of ketamine as an adjuvant in pharmacological treatment. <br /><strong>Methods</strong>: research carried out in Ecuador pain clinic. …”
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Pharmacotherapies for Obesity: Past, Current, and Future Therapies by Lisa L. Ioannides-Demos, Loretta Piccenna, John J. McNeil

“…Past therapies for the treatment of obesity have typically involved pharmacological agents usually in combination with a calorie-controlled diet. …”
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From guideline to practice: three years of ICH S11 insights and recommendations by Diana Tavares, Hsiao-Tzu Chien, Hsiao-Tzu Chien, Maria Elzbieta Sheean, Peter Theunissen, Peter Theunissen, Peter van Meer, Peter van Meer, Peter van Meer, Karen Van Malderen

“…A thorough consideration of developmental aspects of the product’s pharmacological target, the clinical relevance of notable toxicity findings, and the clinical context of the medicine’s use fosters effective dialogue and improves regulatory alignment. …”
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Tumor organoids in cancer medicine: from model systems to natural compound screening by Rong Cong, Can Lu, Xinying Li, Zhijie Xu, Yaqin Wang, Shusen Sun

“…Publications were selected without date restrictions, using terms such as ‘organoid’, ‘natural product’, ‘pharmacological’, ‘extract’, ‘nanomaterial’ and ‘traditional uses’. …”
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The Plant-Derived Bauhinia bauhinioides Kallikrein Proteinase Inhibitor (rBbKI) Attenuates Elastase-Induced Emphysema in Mice by Bruno Tadeu Martins-Olivera, Rafael Almeida-Reis, Osmar Aparecido Theodoro-Júnior, Leandro Vilela Oliva, Natalia Neto dos Santos Nunes, Clarice Rosa Olivo, Marlon Vilela de Brito, Carla Máximo Prado, Edna Aparecida Leick, Mílton de Arruda Martins, Maria Luiza Vilela Oliva, Renato Fraga Righetti, Iolanda de Fátima Lopes Calvo Tibério

“…Conclusion. rBbKI reduced elastase-induced pulmonary inflammation and extracellular matrix remodeling. rBbKI may be a potential pharmacological tool for COPD treatment.…”
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Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract by Megha B. Abbigeri, Bothe Thokchom, Sapam Riches Singh, Santosh Mallikarjun Bhavi, B.P. Harini, Ramesh Babu Yarajarla

“…This study highlights the pharmacological importance of M.annua, particularly its aqueous root extract, in the eco-friendly synthesis of AgNPs with potential therapeutic implications. …”
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The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy by Gabriela De Nardi Sanches-da-Silva, Luiza Fonseca Sales Medeiros, Fabio Mitsuo Lima

“…Despite advances in pharmacological treatment, it is still difficult to eliminate latent reservoirs, becoming one of the main obstacles for viral eradication. …”
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