Analysis of depression in Brazil and the feasibility of incorporating pharmacogenomics as an auxiliary tool in antidepressant treatment by Rafaela Slaviero Pinheiro Cerdeira, Mario Hiroyuki Hirata

“…This conduct leads many patients to give up following pharmacological treatment. In this scenario, pharmacogenomics emerges as a possible supporting tool of the medical treatment. …”
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Cultured Human Airway Epithelial Cells (Calu-3): A Model of Human Respiratory Function, Structure, and Inflammatory Responses by Yan Zhu, Aaron Chidekel, Thomas H. Shaffer

“…In experiments with pharmacological agents, Lucinactant is protective of Calu-3 cells compared with Beractant and control, and perfluorocarbons also protect against hyperoxia-induced airway epithelial cell injury. …”
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Potential of germanium-based compounds in coronavirus infection by NAROKHA VIOLETTA, NIZHENKOVSKA IRYNA, KUZNETSOVA OLENA

“…The purpose of this review is to summarize the pharmacological potential of various germanium-based compounds studied nowadays, taking into account their mechanisms of action, and to analyze their prospects in the development of integrated approaches in the prevention and treatment of SARS-CoV-2 infection.…”
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Personality structure assessment of people with opiate addiction and people with internet addiction disorder by Milinović Milica, Tepšič-Ostojić Vesna

“…Neurobiological and pharmacological data suggest similarities between the pathophysiology of opiate addiction and pathological gambling. …”
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Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure by Georgios Aidonidis, Ioannis Kanonidis, Vasileios Koutsimanis, Till Neumann, Raimund Erbel, Georgios Sakadamis

“…Levosimendan is an inotropic drug with unique pharmacological advantages in patients with acute heart failure. …”
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Effects of <i>Echinacea purpurea</i> and Alkylamides on Respiratory Virus Replication and IL-8 Expression In Vitro by Keely Puchalski, Johanne A. Gerstel, Abiola Jimoh, Yalda Shokoohinia, Jeffrey Langland

“…Different classes of secondary metabolites of the plant, such as alkylamides, caffeic acid derivatives, polysaccharides, flavonoids, and glycoproteins, are believed to be biologically and pharmacologically active. Although previous research suggests that the alkylamides present in <i>Echinacea</i> may be responsible for reducing the symptoms associated with the common cold or flu through their immunomodulatory activity, the roles of specific alkylamides and their targets (i.e., immune and/or antiviral) have not been well-elucidated or established. …”
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Clumsiness and Disturbed Cerebellar Development: Insights From Animal Experiments by Albert Gramsbergen

“…This late development makes the cerebellar development particularly vulnerable to situations like an insufficient supply of nutrients, which may follow placental dysfunction, or to side effects of pharmacological treatments like the administration of corticosteroids in the postnatal period. …”
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Development and validation of the pain management competency scale for nurses and a nationwide survey of Chinese nurses by Yixue Wu, Xiang Pan, Lihui Gu, Yingge Tong, Siyi Chen, Ke Ni, Hangyan Du, Meng Yang, Jianyi Wang, Yi Chen, Yeling Wei, Lingling Luo, Wenqian Cheng

“…Results The PMCSN comprised six primary dimensions—Pain Assessment and Monitoring, Pharmacological Pain Management, Non-Pharmacological Pain Management, Management of Analgesic Adverse Effects, Patient/Family Education, and Professional Development—and includes 52 tertiary items. …”
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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Given this, exploring pharmacological alternatives for more effective management of DB associated with ASD is essential. …”
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Classifications for Proliferative Vitreoretinopathy (PVR): An Analysis of Their Use in Publications over the Last 15 Years by Salvatore Di Lauro, Mustafa R. Kadhim, David G. Charteris, J. Carlos Pastor

“…It was also noted whether classifications were used for comparison before and after pharmacological or surgical treatment. Results. 138 papers were included. 35 of them (25.4%) presented no classification reference or did not use any one. 103 publications (74.6%) used a standardized classification. …”
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NFAT5 Contributes to Osmolality-Induced MCP-1 Expression in Mesothelial Cells by Christoph Küper, Franz-X. Beck, Wolfgang Neuhofer

“…Hyperosmolality also induced activation of nuclear factor-κB (NF-κB). Accordingly, pharmacological inhibition of NF-κB significantly decreased osmolality-induced MCP-1 expression. …”
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Effect of turbinate reduction surgery on allergic rhinitis symptoms in hospitalized patients by Yusuf Kusuma Dewa, Andriana Tjitria Widi Wardani Sardjana, Moch. Agus Suprijono

“…Turbinate reduction surgery is a therapeutic option for allergic rhinitis refractory to pharmacological treatments. This study aimed to evaluate the effectiveness of turbinate reduction surgery in alleviating allergic rhinitis symptoms. …”
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Hypothermia with Extreme Bradycardia following Spinal Cord Infarction of Septic Origin by Philippe Hantson, Thierry Duprez

“…Among other autonomic dysfunctions complicating acute spinal cord injury, deep hypothermia is rare but may induce serious cardiovascular complications. There are few pharmacological options to influence hypothermia. A 66-year-old woman was transferred to the intensive care unit (ICU) for serious cardiac arrhythmias (atrial fibrillation and asystole) in the context of a deep hypothermia (axillary temperature below 32°C). …”
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Comparative role of affective–Cognitive behavior therapy and jacobson's progressive muscular relaxation in managing pain among patients with fibromyalgia by M T Lakshmi Saranya, R Sreehari, C B Mithun, P I Sangeetha

“…Conclusion: Considering the effect of ACBT in reducing the Pain and FM Impact scores, ACBT shall be considered as an add-on psychological intervention along with the pharmacological management to yield better outcomes in FM patients. …”
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Uveitis associated with elevation of intraocular pressure – what is the optimal therapy? by Agnieszka Kubicka-Trząska

“…The aim of the article is to present the classification and contemporary knowledge about the pathophysiology and pharmacological management of uveitis associated with increased IOP.…”
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Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease by Sitong Yi, Qingwei Cong, Ying Zhu, Qiumin Xu

“…However, its pathophysiological mechanism is complicated, and currently, it has no FDA-approved pharmacological therapies. In recent years, mesenchymal stem cell (MSC) therapy has attracted increasing attention in the treatment of hepatic diseases. …”
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Accessory Renal Artery Stenosis and Secondary Hypertension by Ariel A. Chung, Patricia R. Millner

“…Upon consultation with interventional radiology, pharmacologic treatment was recommended, and blood pressure control was ultimately achieved with a single agent. …”
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Simvastatin Does Not Affect Vitamin D Status, but Low Vitamin D Levels Are Associated with Dyslipidemia: Results from a Randomised, Controlled Trial by Lars Rejnmark, Peter Vestergaard, Lene Heickendorff, Leif Mosekilde

“…Our data do not support a pharmacological effect of statins on vitamin D status, but do suggest that vitamin D may influence plasma lipid profile and thus be of importance to cardiovascular health.…”
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Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization by María Pimentel-Santillana, Paqui G. Través, Raquel Pérez-Sen, Esmerilda G. Delicado, Paloma Martín-Sanz, María Teresa Miras-Portugal, Lisardo Boscá

“…The inhibition of P2Y responses by PGE2 involves the activation of PKCs and PKD, a response that can be suppressed after pharmacological inhibition of these protein kinases. In addition to this, PGE2 reduces the fibroblast migration induced by P2Y-agonists such as UTP. …”
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Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines by Gezina Tanya Mei Ling Oei, Hamid Aslami, Raphaela Priscilla Kerindongo, Renske Johanna Steenstra, Charlotte Jacqueline Peter Beurskens, Anita Maria Tuip-de Boer, Nicole Petra Juffermans, Markus Werner Hollmann, Benedikt Preckel, Nina Claudia Weber

“…Postconditioning of myocardial tissue employs short cycles of ischemia or pharmacologic agents during early reperfusion. Effects of helium postconditioning protocols on infarct size and the ischemia/reperfusion-induced immune response were investigated by measurement of protein and mRNA levels of proinflammatory cytokines. …”
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